#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88351	uniprotkb:P14340	intact:EBI-447960|uniprotkb:Q9R1J6	intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:polg_den2n(display_long)	psi-mi:"MI:0727"(lexa b52 complementation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9825940|imex:IM-23247-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY	-	-	-	figure legend:no figure|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/09/30	2014/10/16	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065	intact-crc:C5E49AA2D066DC3C|rigid:0nqqfha/iNxVC2GWeMfSytP2fSk	false	-	sufficient binding region:1346..1346-2093..2093	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14340	uniprotkb:P25963	intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579	intact:EBI-307386|ensembl:ENSP00000216797|uniprotkb:B2R8L6	psi-mi:polg_den2n(display_long)	psi-mi:ikba_human(display_long)|uniprotkb:NFKBIA(gene name)|psi-mi:NFKBIA(display_short)|uniprotkb:IKBA(gene name synonym)|uniprotkb:MAD3(gene name synonym)|uniprotkb:NFKBI(gene name synonym)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Major histocompatibility complex enhancer-binding protein MAD3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826056|imex:IM-23247-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY	ensembl:ENSG00000100906(gene)|ensembl:ENST00000216797(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|refseq:NP_065390.1|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P25963|rcsb pdb:1IKN|rcsb pdb:1NFI|rcsb pdb:6TTU|rcsb pdb:6Y1J|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607764|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|reactome:R-HSA-9020702|reactome:R-HSA-933542|dip:DIP-139N	-	-	-	figure legend:"S1A and S1D (left)"|comment:"A 2B-Pro fragment with a NS3  his51ala mutation (corresponding pos. 1526 in UniProt AC P14340) also interacts."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/30	2014/11/24	rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065	rogid:LXYgOHjWhEj5sPeyBEi9kV4ZBP89606	intact-crc:CD9864409ACBEDC3|rigid:j21CYzp4OLgePztVn227x9kPobg	false	flag tag:c-c|sufficient binding region:1476..1476-1660..1660	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15653	uniprotkb:P14340	intact:EBI-352889|uniprotkb:Q96BJ7|uniprotkb:A8K3F4|ensembl:ENSP00000312988|ensembl:ENSP00000489138	intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579	psi-mi:ikbb_human(display_long)|uniprotkb:NFKBIB(gene name)|psi-mi:NFKBIB(display_short)|uniprotkb:IKBB(gene name synonym)|uniprotkb:TRIP9(gene name synonym)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 9(gene name synonym)	psi-mi:polg_den2n(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826073|imex:IM-23247-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002494.2|refseq:NP_001230045.1|dip:DIP-27532N|ensembl:ENSG00000104825(gene)|ensembl:ENSG00000282905(gene)|ensembl:ENST00000313582(transcript)|ensembl:ENST00000635517(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-445989|reactome:R-HSA-933542	interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY	-	-	-	figure legend:"S1B and S1F (left)"|comment:"A 2b-pro fragment (aa 1346-1660) with a NS3 his51ala mutation (corresponding to pos. 1526 in UniProt AC P14340) also interacts."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/30	2014/11/24	rogid:m+XrIumqGrdaVN62BGyCdgLjhy09606	rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065	intact-crc:1C6C4FA0DB5B88C6|rigid:chaQosyTdF7E1sEDUcjbglR6Twg	false	-	sufficient binding region:1346..1346-2093..2093|flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P25963	uniprotkb:P14340	intact:EBI-307386|ensembl:ENSP00000216797|uniprotkb:B2R8L6	intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579	psi-mi:ikba_human(display_long)|uniprotkb:NFKBIA(gene name)|psi-mi:NFKBIA(display_short)|uniprotkb:IKBA(gene name synonym)|uniprotkb:MAD3(gene name synonym)|uniprotkb:NFKBI(gene name synonym)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Major histocompatibility complex enhancer-binding protein MAD3(gene name synonym)	psi-mi:polg_den2n(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9825957|imex:IM-23247-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100906(gene)|ensembl:ENST00000216797(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|refseq:NP_065390.1|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P25963|rcsb pdb:1IKN|rcsb pdb:1NFI|rcsb pdb:6TTU|rcsb pdb:6Y1J|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607764|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|reactome:R-HSA-9020702|reactome:R-HSA-933542|dip:DIP-139N	interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY	-	-	-	figure legend:"1B and S1D (right)"|comment:"A 2b-pro fragment (aa 1346-1660) with a NS3 his51ala mutation (corresponding to pos. 1526 in UniProt AC P14340) also interacts."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/30	2014/11/24	rogid:LXYgOHjWhEj5sPeyBEi9kV4ZBP89606	rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065	intact-crc:E1AFE6B3C6A04D3F|rigid:j21CYzp4OLgePztVn227x9kPobg	false	-	flag tag:c-c|sufficient binding region:1476..1476-1660..1660	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14340	uniprotkb:Q15653	intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579	intact:EBI-352889|uniprotkb:Q96BJ7|uniprotkb:A8K3F4|ensembl:ENSP00000312988|ensembl:ENSP00000489138	psi-mi:polg_den2n(display_long)	psi-mi:ikbb_human(display_long)|uniprotkb:NFKBIB(gene name)|psi-mi:NFKBIB(display_short)|uniprotkb:IKBB(gene name synonym)|uniprotkb:TRIP9(gene name synonym)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9825981|imex:IM-23247-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY	refseq:NP_002494.2|refseq:NP_001230045.1|dip:DIP-27532N|ensembl:ENSG00000104825(gene)|ensembl:ENSG00000282905(gene)|ensembl:ENST00000313582(transcript)|ensembl:ENST00000635517(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-445989|reactome:R-HSA-933542	-	-	-	figure legend:"1D and S1F (right)"|comment:"A 2b-pro fragment (aa1346-1660) with a NS3 his51ala mutation (corresponding to pos. 1526 in UniProt AC P14340) also interacts."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/30	2014/11/24	rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065	rogid:m+XrIumqGrdaVN62BGyCdgLjhy09606	intact-crc:6B6C2ECDD7A10D60|rigid:chaQosyTdF7E1sEDUcjbglR6Twg	false	flag tag:c-c|sufficient binding region:1476..1476-1660..1660	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15653	uniprotkb:P14340-PRO_0000037965	intact:EBI-352889|uniprotkb:Q96BJ7|uniprotkb:A8K3F4|ensembl:ENSP00000312988|ensembl:ENSP00000489138	intact:EBI-9825968	psi-mi:ikbb_human(display_long)|uniprotkb:NFKBIB(gene name)|psi-mi:NFKBIB(display_short)|uniprotkb:IKBB(gene name synonym)|uniprotkb:TRIP9(gene name synonym)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 9(gene name synonym)	psi-mi:p14340-pro_0000037965(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9825992|imex:IM-23247-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002494.2|refseq:NP_001230045.1|dip:DIP-27532N|ensembl:ENSG00000104825(gene)|ensembl:ENSG00000282905(gene)|ensembl:ENST00000313582(transcript)|ensembl:ENST00000635517(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-445989|reactome:R-HSA-933542	intact:EBI-465733(chain-parent)	-	-	chain-seq-start:1476|chain-seq-end:2093	figure legend:1D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/30	2014/10/16	rogid:m+XrIumqGrdaVN62BGyCdgLjhy09606	rogid:qE927OPm9G/AGJot3Q5zZtg+K8A11065	intact-crc:00628B1B30FB06A3|rigid:WjmBmoblNdFxFcTsL26tlYGSw5M	false	-	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14340-PRO_0000037965	uniprotkb:P25963	intact:EBI-9825968	intact:EBI-307386|ensembl:ENSP00000216797|uniprotkb:B2R8L6	psi-mi:p14340-pro_0000037965(display_long)	psi-mi:ikba_human(display_long)|uniprotkb:NFKBIA(gene name)|psi-mi:NFKBIA(display_short)|uniprotkb:IKBA(gene name synonym)|uniprotkb:MAD3(gene name synonym)|uniprotkb:NFKBI(gene name synonym)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Major histocompatibility complex enhancer-binding protein MAD3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9825974|imex:IM-23247-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-465733(chain-parent)	ensembl:ENSG00000100906(gene)|ensembl:ENST00000216797(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|refseq:NP_065390.1|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P25963|rcsb pdb:1IKN|rcsb pdb:1NFI|rcsb pdb:6TTU|rcsb pdb:6Y1J|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607764|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|reactome:R-HSA-9020702|reactome:R-HSA-933542|dip:DIP-139N	-	chain-seq-start:1476|chain-seq-end:2093	-	figure legend:1B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/30	2014/10/16	rogid:qE927OPm9G/AGJot3Q5zZtg+K8A11065	rogid:LXYgOHjWhEj5sPeyBEi9kV4ZBP89606	intact-crc:E86AA4A77D0AAEB5|rigid:dHFIsxU7T3Tl37drN1nAuCc9024	false	flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15653	uniprotkb:P14340-PRO_0000037965	intact:EBI-352889|uniprotkb:Q96BJ7|uniprotkb:A8K3F4|ensembl:ENSP00000312988|ensembl:ENSP00000489138	intact:EBI-9825968	psi-mi:ikbb_human(display_long)|uniprotkb:NFKBIB(gene name)|psi-mi:NFKBIB(display_short)|uniprotkb:IKBB(gene name synonym)|uniprotkb:TRIP9(gene name synonym)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 9(gene name synonym)	psi-mi:p14340-pro_0000037965(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826012|imex:IM-23247-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002494.2|refseq:NP_001230045.1|dip:DIP-27532N|ensembl:ENSG00000104825(gene)|ensembl:ENSG00000282905(gene)|ensembl:ENST00000313582(transcript)|ensembl:ENST00000635517(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-445989|reactome:R-HSA-933542	intact:EBI-465733(chain-parent)	-	-	chain-seq-start:1476|chain-seq-end:2093	figure legend:1F|comment:"Bands corresponding to uncleaved NS2B-NS3 and cleaved NS3 detetcted (NS3 antibody)."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hmec-1)|taxid:9606(Human HMEC-1 immortalized  microvascular endothelial cell line)	-	2014/09/30	2014/10/16	rogid:m+XrIumqGrdaVN62BGyCdgLjhy09606	rogid:qE927OPm9G/AGJot3Q5zZtg+K8A11065	intact-crc:3ACECF6A8E7DCF68|rigid:WjmBmoblNdFxFcTsL26tlYGSw5M	false	-	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14340-PRO_0000037965	uniprotkb:P25963	intact:EBI-9825968	intact:EBI-307386|ensembl:ENSP00000216797|uniprotkb:B2R8L6	psi-mi:p14340-pro_0000037965(display_long)	psi-mi:ikba_human(display_long)|uniprotkb:NFKBIA(gene name)|psi-mi:NFKBIA(display_short)|uniprotkb:IKBA(gene name synonym)|uniprotkb:MAD3(gene name synonym)|uniprotkb:NFKBI(gene name synonym)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Major histocompatibility complex enhancer-binding protein MAD3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lin et al. (2014)	pubmed:24973451|imex:IM-23247	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826008|imex:IM-23247-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-465733(chain-parent)	ensembl:ENSG00000100906(gene)|ensembl:ENST00000216797(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|refseq:NP_065390.1|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P25963|rcsb pdb:1IKN|rcsb pdb:1NFI|rcsb pdb:6TTU|rcsb pdb:6Y1J|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607764|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|reactome:R-HSA-9020702|reactome:R-HSA-933542|dip:DIP-139N	-	chain-seq-start:1476|chain-seq-end:2093	-	figure legend:1F|comment:"Bands corresponding to uncleaved NS2B-NS3 and cleaved NS3 detetcted (NS3 antibody)."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hmec-1)|taxid:9606(Human HMEC-1 immortalized  microvascular endothelial cell line)	-	2014/09/30	2014/10/16	rogid:qE927OPm9G/AGJot3Q5zZtg+K8A11065	rogid:LXYgOHjWhEj5sPeyBEi9kV4ZBP89606	intact-crc:135DD231B2ECBB08|rigid:dHFIsxU7T3Tl37drN1nAuCc9024	false	flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)