#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y6K9	uniprotkb:Q06A28	intact:EBI-81279|intact:EBI-356130|uniprotkb:Q7LBY6|uniprotkb:Q7Z7F1|ensembl:ENSP00000471166|ensembl:ENSP00000479662	intact:EBI-9826498	psi-mi:nemo_human(display_long)|uniprotkb:IKBKG(gene name)|psi-mi:IKBKG(display_short)|uniprotkb:FIP3(gene name synonym)|uniprotkb:NEMO(gene name synonym)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:FIP-3(gene name synonym)	psi-mi:rir1_muhvs(display_long)|uniprotkb:RIR1(gene name)|psi-mi:RIR1(display_short)|uniprotkb:M45(gene name synonym)|uniprotkb:Viral inhibitor of RIP activation(gene name synonym)|uniprotkb:m45.1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krause et al. (2014)	imex:IM-23215|pubmed:24942588	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10367(muhvs)|taxid:10367("Murid herpesvirus 1 (strain Smith)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826514|imex:IM-23215-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001308325.1|refseq:NP_001308326.1|refseq:NP_001093326.2|refseq:NP_001093327.1|refseq:NP_001138727.1|refseq:NP_003630.1|dip:DIP-27528N|ensembl:ENSG00000269335(gene)|ensembl:ENST00000594239(transcript)|ensembl:ENST00000611071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:Q9Y6K9|rcsb pdb:2JVX|rcsb pdb:2JVY|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:3CL3|rcsb pdb:3FX0|rcsb pdb:4BWN|rcsb pdb:5AAY|rcsb pdb:5LDE|rcsb pdb:6MI3|rcsb pdb:6MI4|rcsb pdb:6YEK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-4755510|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144	dip:DIP-29743N|go:"GO:0006260"(DNA replication)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR025735|interpro:IPR034716|interpro:IPR039718	-	-	crc64:BDDC93B8E71E40C7	figure legend:4A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2014/10/01	2014/10/16	rogid:9OeZIMeJvNtDEMoiLaKwVEpxSSM9606	rogid:mjrM2JaxmDuym0xoHSw4fE7NKc010367	intact-crc:8527670F3C9A8E59|rigid:Uf2/cgaJPkVR8NA4VBPuckspZiU	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06A28	uniprotkb:O88522	intact:EBI-9826498	intact:EBI-998011|uniprotkb:Q924H4|ensembl:ENSMUSP00000109762|ensembl:ENSMUSP00000109763|ensembl:ENSMUSP00000109768|ensembl:ENSMUSP00000126770	psi-mi:rir1_muhvs(display_long)|uniprotkb:RIR1(gene name)|psi-mi:RIR1(display_short)|uniprotkb:M45(gene name synonym)|uniprotkb:Viral inhibitor of RIP activation(gene name synonym)|uniprotkb:m45.1(gene name synonym)	psi-mi:nemo_mouse(display_long)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:Ikbkg(gene name)|psi-mi:Ikbkg(display_short)|uniprotkb:Nemo(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krause et al. (2014)	imex:IM-23215|pubmed:24942588	taxid:10367(muhvs)|taxid:10367("Murid herpesvirus 1 (strain Smith)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826548|imex:IM-23215-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29743N|go:"GO:0006260"(DNA replication)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR025735|interpro:IPR034716|interpro:IPR039718	go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:O88522|rcsb pdb:2V4H|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3F89|rcsb pdb:3JSV|rcsb pdb:4OWF|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-4755510|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0010628"(positive regulation of gene expression)|reactome:R-MMU-975144|ensembl:ENSMUSG00000004221(gene)|ensembl:ENSMUST00000114127(transcript)|ensembl:ENSMUST00000114128(transcript)|ensembl:ENSMUST00000114133(transcript)|ensembl:ENSMUST00000164101(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|refseq:XP_011245829.1|refseq:NP_001154895.1|refseq:NP_034677.2|refseq:XP_006527913.1|refseq:XP_006527914.1|refseq:XP_006527915.1|dip:DIP-29811N	-	crc64:BDDC93B8E71E40C7	-	figure legend:7|comment:Detected 1hpi indicative for virion-associated M45.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2014/10/01	2014/10/16	rogid:mjrM2JaxmDuym0xoHSw4fE7NKc010367	rogid:xdq9J5m7CDC1X/4TfHZVGSYKq8U10090	intact-crc:4A2A75AE7A96DC4F|rigid:qFX2OjuMF/6WZ6kV8G76XSpZ+tU	false	ha tag:c-c|necessary binding region:1156-1174	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06A28	uniprotkb:Q60855	intact:EBI-9826498	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:rir1_muhvs(display_long)|uniprotkb:RIR1(gene name)|psi-mi:RIR1(display_short)|uniprotkb:M45(gene name synonym)|uniprotkb:Viral inhibitor of RIP activation(gene name synonym)|uniprotkb:m45.1(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krause et al. (2014)	imex:IM-23215|pubmed:24942588	taxid:10367(muhvs)|taxid:10367("Murid herpesvirus 1 (strain Smith)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826548|imex:IM-23215-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29743N|go:"GO:0006260"(DNA replication)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR025735|interpro:IPR034716|interpro:IPR039718	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	-	crc64:BDDC93B8E71E40C7	-	figure legend:7|comment:Detected 1hpi indicative for virion-associated M45.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2014/10/01	2014/10/16	rogid:mjrM2JaxmDuym0xoHSw4fE7NKc010367	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	intact-crc:4A2A75AE7A96DC4F|rigid:qFX2OjuMF/6WZ6kV8G76XSpZ+tU	false	ha tag:c-c|necessary binding region:1156-1174	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06A28	uniprotkb:O88522	intact:EBI-9826498	intact:EBI-998011|uniprotkb:Q924H4|ensembl:ENSMUSP00000109762|ensembl:ENSMUSP00000109763|ensembl:ENSMUSP00000109768|ensembl:ENSMUSP00000126770	psi-mi:rir1_muhvs(display_long)|uniprotkb:RIR1(gene name)|psi-mi:RIR1(display_short)|uniprotkb:M45(gene name synonym)|uniprotkb:Viral inhibitor of RIP activation(gene name synonym)|uniprotkb:m45.1(gene name synonym)	psi-mi:nemo_mouse(display_long)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:Ikbkg(gene name)|psi-mi:Ikbkg(display_short)|uniprotkb:Nemo(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krause et al. (2014)	imex:IM-23215|pubmed:24942588	taxid:10367(muhvs)|taxid:10367("Murid herpesvirus 1 (strain Smith)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826528|imex:IM-23215-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29743N|go:"GO:0006260"(DNA replication)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR025735|interpro:IPR034716|interpro:IPR039718	go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:O88522|rcsb pdb:2V4H|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3F89|rcsb pdb:3JSV|rcsb pdb:4OWF|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-4755510|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0010628"(positive regulation of gene expression)|reactome:R-MMU-975144|ensembl:ENSMUSG00000004221(gene)|ensembl:ENSMUST00000114127(transcript)|ensembl:ENSMUST00000114128(transcript)|ensembl:ENSMUST00000114133(transcript)|ensembl:ENSMUST00000164101(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|refseq:XP_011245829.1|refseq:NP_001154895.1|refseq:NP_034677.2|refseq:XP_006527913.1|refseq:XP_006527914.1|refseq:XP_006527915.1|dip:DIP-29811N	-	crc64:BDDC93B8E71E40C7	-	figure legend:4A, 5A|comment:Detected 15hpi.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2014/10/01	2014/10/16	rogid:mjrM2JaxmDuym0xoHSw4fE7NKc010367	rogid:xdq9J5m7CDC1X/4TfHZVGSYKq8U10090	intact-crc:E7450B9908261CC5|rigid:qFX2OjuMF/6WZ6kV8G76XSpZ+tU	false	ha tag:c-c|necessary binding region:1122-1174	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06A28	uniprotkb:Q60855	intact:EBI-9826498	intact:EBI-529119|uniprotkb:Q3U0J3|uniprotkb:Q8CD90|ensembl:ENSMUSP00000021844|ensembl:ENSMUSP00000129831	psi-mi:rir1_muhvs(display_long)|uniprotkb:RIR1(gene name)|psi-mi:RIR1(display_short)|uniprotkb:M45(gene name synonym)|uniprotkb:Viral inhibitor of RIP activation(gene name synonym)|uniprotkb:m45.1(gene name synonym)	psi-mi:ripk1_mouse(display_long)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)|uniprotkb:Ripk1(gene name)|psi-mi:Ripk1(display_short)|uniprotkb:Rinp(gene name synonym)|uniprotkb:Rip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krause et al. (2014)	imex:IM-23215|pubmed:24942588	taxid:10367(muhvs)|taxid:10367("Murid herpesvirus 1 (strain Smith)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9826528|imex:IM-23215-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29743N|go:"GO:0006260"(DNA replication)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR025735|interpro:IPR034716|interpro:IPR039718	refseq:NP_033094.3|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|refseq:XP_006516670.1|refseq:XP_006516672.1|ensembl:ENSMUSG00000021408(gene)|ensembl:ENSMUST00000021844(transcript)|ensembl:ENSMUST00000167374(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|dip:DIP-34962N|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901026"(ripoptosome assembly involved in necroptotic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q60855|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3295583|reactome:R-MMU-3371378|reactome:R-MMU-5213460|reactome:R-MMU-5218900|reactome:R-MMU-5357786|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-69416|reactome:R-MMU-75893|reactome:R-MMU-937041	-	crc64:BDDC93B8E71E40C7	-	figure legend:4A, 5A|comment:Detected 15hpi.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2014/10/01	2014/10/16	rogid:mjrM2JaxmDuym0xoHSw4fE7NKc010367	rogid:GvihCfN74Xs5oEVwbSSzu/roj5A10090	intact-crc:E7450B9908261CC5|rigid:qFX2OjuMF/6WZ6kV8G76XSpZ+tU	false	ha tag:c-c|necessary binding region:1122-1174	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)