#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q12809 uniprotkb:Q12809 intact:EBI-720643|uniprotkb:O75418|uniprotkb:O75680|uniprotkb:Q9BT72|uniprotkb:Q9BUT7|uniprotkb:Q9H3P0|uniprotkb:A5H1P7|uniprotkb:D3DX04|uniprotkb:C4PFH9|uniprotkb:Q708S9|ensembl:ENSP00000262186 intact:EBI-720643|uniprotkb:O75418|uniprotkb:O75680|uniprotkb:Q9BT72|uniprotkb:Q9BUT7|uniprotkb:Q9H3P0|uniprotkb:A5H1P7|uniprotkb:D3DX04|uniprotkb:C4PFH9|uniprotkb:Q708S9|ensembl:ENSP00000262186 psi-mi:kcnh2_human(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv11.1(gene name synonym)|uniprotkb:Ether-a-go-go-related gene potassium channel 1(gene name synonym)|uniprotkb:Eag homolog(gene name synonym)|uniprotkb:KCNH2(gene name)|psi-mi:KCNH2(display_short)|uniprotkb:ERG(gene name synonym)|uniprotkb:ERG1(gene name synonym)|uniprotkb:HERG(gene name synonym) psi-mi:kcnh2_human(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv11.1(gene name synonym)|uniprotkb:Ether-a-go-go-related gene potassium channel 1(gene name synonym)|uniprotkb:Eag homolog(gene name synonym)|uniprotkb:KCNH2(gene name)|psi-mi:KCNH2(display_short)|uniprotkb:ERG(gene name synonym)|uniprotkb:ERG1(gene name synonym)|uniprotkb:HERG(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Li et al. (2014) pubmed:24931372|imex:IM-22920 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-9543631|imex:IM-22920-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000229.1|refseq:NP_001191727.1|refseq:NP_742053.1|refseq:NP_742054.1|dip:DIP-48929N|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035690"|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086008"(voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086011"(membrane repolarization during action potential)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098915"(membrane repolarization during ventricular cardiac muscle cell action potential)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902282"(voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:1902937"(inward rectifier potassium channel complex)|go:"GO:1903765"(negative regulation of potassium ion export across plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003967(Potassium channel, voltage-dependent, ERG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:1BYW|rcsb pdb:1UJL|rcsb pdb:2L0W|rcsb pdb:2L1M|rcsb pdb:2L4R|rcsb pdb:2LE7|rcsb pdb:2N7G|rcsb pdb:4HP9|rcsb pdb:4HQA|rcsb pdb:5VA1|rcsb pdb:5VA2|rcsb pdb:5VA3|rcsb pdb:6SYG|ensembl:ENSG00000055118(gene)|ensembl:ENST00000262186(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003064"(regulation of heart rate by hormone)|reactome:R-HSA-1296072|reactome:R-HSA-5576890 refseq:NP_000229.1|refseq:NP_001191727.1|refseq:NP_742053.1|refseq:NP_742054.1|dip:DIP-48929N|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035690"|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086008"(voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086011"(membrane repolarization during action potential)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098915"(membrane repolarization during ventricular cardiac muscle cell action potential)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902282"(voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:1902937"(inward rectifier potassium channel complex)|go:"GO:1903765"(negative regulation of potassium ion export across plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000014(PAS)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR001610(PAC motif)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003967(Potassium channel, voltage-dependent, ERG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:1BYW|rcsb pdb:1UJL|rcsb pdb:2L0W|rcsb pdb:2L1M|rcsb pdb:2L4R|rcsb pdb:2LE7|rcsb pdb:2N7G|rcsb pdb:4HP9|rcsb pdb:4HQA|rcsb pdb:5VA1|rcsb pdb:5VA2|rcsb pdb:5VA3|rcsb pdb:6SYG|ensembl:ENSG00000055118(gene)|ensembl:ENST00000262186(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003064"(regulation of heart rate by hormone)|reactome:R-HSA-1296072|reactome:R-HSA-5576890 - - - figure legend:f2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/05/30 2014/10/16 rogid:GgrMfHJ+Gzu6yqgwiNxcMoDKbuY9606 rogid:GgrMfHJ+Gzu6yqgwiNxcMoDKbuY9606 intact-crc:76A3BE3CEAA07C93|rigid:imi9NmfAysxxCdFFeAVpMKfTKJ4 false binding-associated region:1-135 binding-associated region:734-864 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)