#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20783	uniprotkb:Q96PQ0	intact:EBI-1025994|uniprotkb:Q6FH50|ensembl:ENSP00000328738|uniprotkb:B7Z1T5	intact:EBI-9826869|uniprotkb:Q9P2L7|ensembl:ENSP00000422185	psi-mi:ntf3_human(display_long)|uniprotkb:Neurotrophic factor(gene name synonym)|uniprotkb:HDNF(gene name synonym)|uniprotkb:Nerve growth factor 2(gene name synonym)|uniprotkb:NTF3(gene name)|psi-mi:NTF3(display_short)	psi-mi:sorc2_human(display_long)|uniprotkb:SORCS2(gene name)|psi-mi:SORCS2(display_short)|uniprotkb:KIAA1329(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915188|imex:IM-23264-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001096124.1|refseq:NP_002518.1|refseq:XP_011519265.1|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR002072(Nerve growth factor)|interpro:IPR015578(Neurotrophin-3)|interpro:IPR019846|interpro:IPR020408|interpro:IPR029034|rcsb pdb:1B8K|rcsb pdb:1BND|rcsb pdb:1NT3|rcsb pdb:3BUK|reactome:R-HSA-9025046|reactome:R-HSA-9034013|reactome:R-HSA-9034015|reactome:R-HSA-9034793|reactome:R-HSA-9034864|reactome:R-HSA-9603381|ensembl:ENSG00000185652(gene)|ensembl:ENST00000331010(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0021675"(nerve development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|dip:DIP-346N	refseq:NP_065828.2|ensembl:ENSG00000184985(gene)|ensembl:ENST00000507866(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022409|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:1WGO	-	-	-	figure legend:Fig. 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/01	2014/11/04	rogid:E2ZTORtat5r2YRbDmEB3Qt+ojMQ9606	rogid:D58OQh7IAcJiOZw8c/71M6YlgTE9606	intact-crc:C6098323001B5DC7|rigid:SI/vJSH2OEkpb4CcLu6wcOWbxhU	false	glutathione s tranferase tag:?-?|sufficient binding region:19-97	sufficient binding region:51-1079	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23560	uniprotkb:Q96PQ0	intact:EBI-1026003|uniprotkb:Q9BYY7|uniprotkb:Q9UC24|uniprotkb:A7LA85|uniprotkb:A7LA92|uniprotkb:Q598Q1|uniprotkb:Q6DN19|uniprotkb:Q6YNR2|uniprotkb:Q6YNR3|uniprotkb:D3DQZ2|ensembl:ENSP00000349084|ensembl:ENSP00000379302|ensembl:ENSP00000379305|ensembl:ENSP00000379307|ensembl:ENSP00000389345|ensembl:ENSP00000400502|ensembl:ENSP00000432035|ensembl:ENSP00000432376|ensembl:ENSP00000432727|ensembl:ENSP00000435564|ensembl:ENSP00000435805|ensembl:ENSP00000437138	intact:EBI-9826869|uniprotkb:Q9P2L7|ensembl:ENSP00000422185	psi-mi:bdnf_human(display_long)|uniprotkb:Abrineurin(gene name synonym)|uniprotkb:BDNF(gene name)|psi-mi:BDNF(display_short)	psi-mi:sorc2_human(display_long)|uniprotkb:SORCS2(gene name)|psi-mi:SORCS2(display_short)|uniprotkb:KIAA1329(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915169|imex:IM-23264-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137277.1|refseq:NP_001137278.1|refseq:NP_001137279.1|refseq:NP_001137280.1|refseq:NP_001137281.1|refseq:NP_001137282.1|refseq:NP_001137283.1|refseq:NP_001137284.1|refseq:NP_001137285.1|refseq:NP_001137286.1|refseq:NP_001137288.1|refseq:NP_001700.2|refseq:NP_733927.1|refseq:NP_733928.1|refseq:NP_733929.1|refseq:NP_733930.1|refseq:NP_733931.1|refseq:XP_011518582.1|ensembl:ENST00000439476(transcript)|ensembl:ENST00000525528(transcript)|ensembl:ENST00000525950(transcript)|ensembl:ENST00000530861(transcript)|ensembl:ENST00000532997(transcript)|ensembl:ENST00000533131(transcript)|ensembl:ENST00000533246(transcript)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016607"(nuclear speck)|go:"GO:0021675"(nerve development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048668"(collateral sprouting)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020430|interpro:IPR029034|rcsb pdb:1B8M|rcsb pdb:1BND|reactome:R-HSA-9022702|reactome:R-HSA-9024909|reactome:R-HSA-9026519|reactome:R-HSA-9026527|reactome:R-HSA-9028335|reactome:R-HSA-9028731|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-9032845|ensembl:ENSG00000176697(gene)|ensembl:ENST00000356660(transcript)|ensembl:ENST00000395978(transcript)|ensembl:ENST00000395981(transcript)|ensembl:ENST00000395983(transcript)|ensembl:ENST00000418212(transcript)|dip:DIP-5719N	refseq:NP_065828.2|ensembl:ENSG00000184985(gene)|ensembl:ENST00000507866(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022409|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:1WGO	-	-	-	figure legend:Fig. 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/01	2014/11/04	rogid:ViQaPrafdzqN17LGUTSwDrBT/bU9606	rogid:D58OQh7IAcJiOZw8c/71M6YlgTE9606	intact-crc:A5F3A3C941A0D92A|rigid:ixjj+GZCipUcjbqZaDkNV/AfzU4	false	glutathione s tranferase tag:?-?|sufficient binding region:58-126..126	sufficient binding region:51-1079	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01138-PRO_0000019599	uniprotkb:Q96PQ0	intact:EBI-9345310	intact:EBI-9826869|uniprotkb:Q9P2L7|ensembl:ENSP00000422185	psi-mi:p01138-pro_0000019599(display_long)|uniprotkb:NGF(gene name)|psi-mi:NGF(display_short)|uniprotkb:NGFB(gene name synonym)	psi-mi:sorc2_human(display_long)|uniprotkb:SORCS2(gene name)|psi-mi:SORCS2(display_short)|uniprotkb:KIAA1329(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9827043|imex:IM-23264-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1028250(chain-parent)	refseq:NP_065828.2|ensembl:ENSG00000184985(gene)|ensembl:ENST00000507866(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022409|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:1WGO	-	chain-seq-start:19|chain-seq-end:121	-	figure legend:Fig. 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/01	2022/01/20	rogid:kf/IEcIAxdvMTHhpOo2UlcAEAJI9606	rogid:D58OQh7IAcJiOZw8c/71M6YlgTE9606	intact-crc:C1F4A795CA038585|rigid:NXkr6hW2rfDVP9o4/9MJPPhdx+Y	false	glutathione s tranferase tag:?-?	sufficient binding region:51-1079	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01139-PRO_0000019602	uniprotkb:Q96PQ0	intact:EBI-9915105	intact:EBI-9826869|uniprotkb:Q9P2L7|ensembl:ENSP00000422185	psi-mi:p01139-pro_0000019602(display_long)|uniprotkb:Ngf(gene name)|psi-mi:Ngf(display_short)|uniprotkb:Ngfb(gene name synonym)	psi-mi:sorc2_human(display_long)|uniprotkb:SORCS2(gene name)|psi-mi:SORCS2(display_short)|uniprotkb:KIAA1329(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915116|imex:IM-23264-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-9826976(chain-parent)	refseq:NP_065828.2|ensembl:ENSG00000184985(gene)|ensembl:ENST00000507866(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022409|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:1WGO	-	chain-seq-start:122|chain-seq-end:241	-	figure legend:Fig. 3A|comment:The mature form of NFG binds weakly as compared to the pro NGF|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.0x10^-9(molar)	2014/10/01	2014/11/03	rogid:K3AcpF/fNLitcmWg2dyhjtqRbiw10090	rogid:D58OQh7IAcJiOZw8c/71M6YlgTE9606	intact-crc:46702865A3202CEB|rigid:wsxJR8kfSH5Ksw0c9Yi7xUGGwKw	false	-	sufficient binding region:51-1079	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01139	uniprotkb:Q96PQ0	intact:EBI-9826976|uniprotkb:Q63864|uniprotkb:Q6LDB7|ensembl:ENSMUSP00000040345	intact:EBI-9826869|uniprotkb:Q9P2L7|ensembl:ENSP00000422185	psi-mi:ngf_mouse(display_long)|uniprotkb:Ngf(gene name)|psi-mi:Ngf(display_short)|uniprotkb:Ngfb(gene name synonym)	psi-mi:sorc2_human(display_long)|uniprotkb:SORCS2(gene name)|psi-mi:SORCS2(display_short)|uniprotkb:KIAA1329(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9827035|imex:IM-23264-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106168.1|refseq:NP_038637.1|refseq:XP_006501171.1|dip:DIP-59840N|ensembl:ENSMUSG00000027859(gene)|ensembl:ENSMUST00000035952(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031904"(endosome lumen)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048666"(neuron development)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|interpro:IPR029034|rcsb pdb:1BET|rcsb pdb:1BTG|rcsb pdb:1SGF|rcsb pdb:3IJ2|rcsb pdb:4EAX|rcsb pdb:4XPJ|rcsb pdb:5LSD|rcsb pdb:6FFY|reactome:R-MMU-167060|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-177504|reactome:R-MMU-187042|reactome:R-MMU-198203|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:0031954"(positive regulation of protein autophosphorylation)	refseq:NP_065828.2|ensembl:ENSG00000184985(gene)|ensembl:ENST00000507866(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022409|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:1WGO	-	-	-	figure legend:Fig. 3A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.0x10^-9(molar)	2014/10/01	2014/11/03	rogid:0iMgi2FIeSIisDsL1KEKr37dtWE10090	rogid:D58OQh7IAcJiOZw8c/71M6YlgTE9606	intact-crc:92EB46D1ACD5D34A|rigid:VMs4Yeh64p0spfZke0qGTEWbXAA	false	sufficient binding region:19-241	sufficient binding region:51-1079	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08138	uniprotkb:Q96PQ0	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	intact:EBI-9826869|uniprotkb:Q9P2L7|ensembl:ENSP00000422185	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:sorc2_human(display_long)|uniprotkb:SORCS2(gene name)|psi-mi:SORCS2(display_short)|uniprotkb:KIAA1329(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915264|imex:IM-23264-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	refseq:NP_065828.2|ensembl:ENSG00000184985(gene)|ensembl:ENST00000507866(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022409|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:1WGO	-	-	-	figure legend:Fig. 3G|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/01	2014/11/04	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rogid:D58OQh7IAcJiOZw8c/71M6YlgTE9606	intact-crc:A3652BA6F52CA7E4|rigid:ENZF+eXby8/IqAqPukvgmbaSdbs	false	his tag:c-c|sufficient binding region:29-250|fc-igg tag:c-c	sufficient binding region:51-1079	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9EPR5	uniprotkb:Q9Z0W1	intact:EBI-9915438|uniprotkb:B2RSI2|uniprotkb:B2RSI4|ensembl:ENSMUSP00000041828	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	psi-mi:sorc2_mouse(display_long)|uniprotkb:Sorcs2(gene name)|psi-mi:Sorcs2(display_short)	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9826913|imex:IM-23264-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112151.2|ensembl:ENSMUSG00000029093(gene)|ensembl:ENSMUST00000037370(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:6FFY|rcsb pdb:6FG9	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)	-	-	-	figure legend:Fig. 3E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cerebellum)|taxid:10090(Mus musculus brain cerebellum)	-	2014/10/01	2019/07/08	rogid:FLAsJT/zCRlPcm39EvgoC5WUHmM10090	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	intact-crc:A45FE5A8275357EB|rigid:t5gMYxFMNXdhUU5C16uXvHCYpWY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07174	uniprotkb:Q96PQ0	intact:EBI-1038810	intact:EBI-9826869|uniprotkb:Q9P2L7|ensembl:ENSP00000422185	psi-mi:tnr16_rat(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:sorc2_human(display_long)|uniprotkb:SORCS2(gene name)|psi-mi:SORCS2(display_short)|uniprotkb:KIAA1329(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915366|imex:IM-23264-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3177|refseq:NP_036742.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009986"(cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|rcsb pdb:1NGR|rcsb pdb:1SG1|rcsb pdb:2MIC|rcsb pdb:2MJO|rcsb pdb:3BUK|rcsb pdb:3IJ2|rcsb pdb:4F42|rcsb pdb:4F44|reactome:R-RNO-193634|reactome:R-RNO-193692|reactome:R-RNO-205017|reactome:R-RNO-205025|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-209563|go:"GO:0051897"(positive regulation of protein kinase B signaling)|mint:P07174|dip:DIP-5715N	refseq:NP_065828.2|ensembl:ENSG00000184985(gene)|ensembl:ENST00000507866(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022409|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:1WGO	-	-	-	figure legend:Fg. 3D, 3F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/01	2014/11/03	rogid:lscumOKfwxDCsoAs1EZfp6iFwz410116	rogid:D58OQh7IAcJiOZw8c/71M6YlgTE9606	intact-crc:234EF33A500E6423|rigid:gn4qBebJ8uRoAeUJIU3cJ+T1ZlM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z0W1	uniprotkb:Q9EPR5	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	intact:EBI-9915438|uniprotkb:B2RSI2|uniprotkb:B2RSI4|ensembl:ENSMUSP00000041828	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:sorc2_mouse(display_long)|uniprotkb:Sorcs2(gene name)|psi-mi:Sorcs2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915497|imex:IM-23264-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)	refseq:NP_112151.2|ensembl:ENSMUSG00000029093(gene)|ensembl:ENSMUST00000037370(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:6FFY|rcsb pdb:6FG9	go:"GO:0030426"(growth cone)|go:"GO:0030175"(filopodium)|go:"GO:0043005"(neuron projection)	-	-	figure legend:Fig. 4C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2014/10/01	2019/07/08	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	rogid:FLAsJT/zCRlPcm39EvgoC5WUHmM10090	intact-crc:D09F8707A461B245|rigid:t5gMYxFMNXdhUU5C16uXvHCYpWY	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P21237	uniprotkb:Q9EPR5	intact:EBI-6857044|ensembl:ENSMUSP00000106672|ensembl:ENSMUSP00000106673|ensembl:ENSMUSP00000106674|ensembl:ENSMUSP00000106675|ensembl:ENSMUSP00000106676|ensembl:ENSMUSP00000106678|ensembl:ENSMUSP00000106679|ensembl:ENSMUSP00000106680|ensembl:ENSMUSP00000135762|uniprotkb:A2AII2|uniprotkb:Q8CCH9	intact:EBI-9915438|uniprotkb:B2RSI2|uniprotkb:B2RSI4|ensembl:ENSMUSP00000041828	psi-mi:bdnf_mouse(display_long)|uniprotkb:Bdnf(gene name)|psi-mi:Bdnf(display_short)	psi-mi:sorc2_mouse(display_long)|uniprotkb:Sorcs2(gene name)|psi-mi:Sorcs2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915553|imex:IM-23264-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001041607.1|refseq:NP_001041604.1|refseq:NP_001041606.1|refseq:NP_001272345.1|refseq:NP_001272346.1|refseq:NP_001272347.1|refseq:NP_001272348.1|refseq:NP_001272349.1|refseq:NP_001272350.1|refseq:NP_001272351.1|ensembl:ENSMUSG00000048482|ensembl:ENSMUSG00000048482|refseq:NP_001303239.1|ensembl:ENSMUSG00000048482(gene)|ensembl:ENSMUST00000111043(transcript)|ensembl:ENSMUST00000111044(transcript)|ensembl:ENSMUST00000111045(transcript)|ensembl:ENSMUST00000111046(transcript)|ensembl:ENSMUST00000111047(transcript)|ensembl:ENSMUST00000111049(transcript)|ensembl:ENSMUST00000111050(transcript)|ensembl:ENSMUST00000111051(transcript)|ensembl:ENSMUST00000176893(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005169"(neurotrophin TRKB receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007412"(axon target recognition)|go:"GO:0007416"(synapse assembly)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007631"(feeding behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008038"(neuron recognition)|go:"GO:0008083"(growth factor activity)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016358"(dendrite development)|go:"GO:0016607"(nuclear speck)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0021675"(nerve development)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031099"(regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0042493"|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0042596"(fear response)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048668"(collateral sprouting)|go:"GO:0048670"(regulation of collateral sprouting)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061193"(taste bud development)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0099083"(retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990708"(conditioned place preference)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020430|interpro:IPR029034|reactome:R-MMU-9026527|reactome:R-MMU-9028731|reactome:R-MMU-9032759|go:"GO:1901215"(negative regulation of neuron death)|dip:DIP-5724N	refseq:NP_112151.2|ensembl:ENSMUSG00000029093(gene)|ensembl:ENSMUST00000037370(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:6FFY|rcsb pdb:6FG9	go:"GO:0030424"(axon)	-	-	figure legend:Fig. 7F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2014/10/01	2014/11/03	rogid:04C7zS8naUpZ/8ZYTgpHqj7pNNw10090	rogid:FLAsJT/zCRlPcm39EvgoC5WUHmM10090	intact-crc:5E1FE6D05D99FF15|rigid:wDqlLlduf7hxFTgTHE4dvZ49ouQ	false	sufficient binding region:19-249	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q9Z0W1	uniprotkb:Q9EPR5	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	intact:EBI-9915438|uniprotkb:B2RSI2|uniprotkb:B2RSI4|ensembl:ENSMUSP00000041828	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:sorc2_mouse(display_long)|uniprotkb:Sorcs2(gene name)|psi-mi:Sorcs2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915540|imex:IM-23264-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)	refseq:NP_112151.2|ensembl:ENSMUSG00000029093(gene)|ensembl:ENSMUST00000037370(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:6FFY|rcsb pdb:6FG9	go:"GO:0030424"(axon)	-	-	figure legend:Fig. 7F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2014/10/01	2019/07/08	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	rogid:FLAsJT/zCRlPcm39EvgoC5WUHmM10090	intact-crc:C2142873754FD34D|rigid:t5gMYxFMNXdhUU5C16uXvHCYpWY	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:P01139	uniprotkb:Q9EPR5	intact:EBI-9826976|uniprotkb:Q63864|uniprotkb:Q6LDB7|ensembl:ENSMUSP00000040345	intact:EBI-9915438|uniprotkb:B2RSI2|uniprotkb:B2RSI4|ensembl:ENSMUSP00000041828	psi-mi:ngf_mouse(display_long)|uniprotkb:Ngf(gene name)|psi-mi:Ngf(display_short)|uniprotkb:Ngfb(gene name synonym)	psi-mi:sorc2_mouse(display_long)|uniprotkb:Sorcs2(gene name)|psi-mi:Sorcs2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915545|imex:IM-23264-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106168.1|refseq:NP_038637.1|refseq:XP_006501171.1|dip:DIP-59840N|ensembl:ENSMUSG00000027859(gene)|ensembl:ENSMUST00000035952(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031904"(endosome lumen)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048666"(neuron development)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|interpro:IPR029034|rcsb pdb:1BET|rcsb pdb:1BTG|rcsb pdb:1SGF|rcsb pdb:3IJ2|rcsb pdb:4EAX|rcsb pdb:4XPJ|rcsb pdb:5LSD|rcsb pdb:6FFY|reactome:R-MMU-167060|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-177504|reactome:R-MMU-187042|reactome:R-MMU-198203|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:0031954"(positive regulation of protein autophosphorylation)	refseq:NP_112151.2|ensembl:ENSMUSG00000029093(gene)|ensembl:ENSMUST00000037370(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:6FFY|rcsb pdb:6FG9	go:"GO:0030424"(axon)	-	-	figure legend:Fig. 7F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2014/10/01	2014/11/03	rogid:0iMgi2FIeSIisDsL1KEKr37dtWE10090	rogid:FLAsJT/zCRlPcm39EvgoC5WUHmM10090	intact-crc:67D4C94EEFF1BD18|rigid:lSg6eldfZdLiDDiAybnk6k9D488	false	sufficient binding region:19-241	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q9EPR5	uniprotkb:Q9Z0W1	intact:EBI-9915438|uniprotkb:B2RSI2|uniprotkb:B2RSI4|ensembl:ENSMUSP00000041828	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	psi-mi:sorc2_mouse(display_long)|uniprotkb:Sorcs2(gene name)|psi-mi:Sorcs2(display_short)	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Glerup et al. (2014)	imex:IM-23264|pubmed:24908487	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9915599|imex:IM-23264-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112151.2|ensembl:ENSMUSG00000029093(gene)|ensembl:ENSMUST00000037370(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR000601(PKD)|interpro:IPR006581(VPS10)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|interpro:IPR035986|rcsb pdb:6FFY|rcsb pdb:6FG9	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)	-	-	-	figure legend:Fig. 7G|comment:SorCS2 and p75NTR located in proximity in injured but not in uninjured sciatic nerve fibers.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2014/10/01	2019/07/08	rogid:FLAsJT/zCRlPcm39EvgoC5WUHmM10090	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	intact-crc:934001A5F7C9D298|rigid:t5gMYxFMNXdhUU5C16uXvHCYpWY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)