#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49137	uniprotkb:P09917	intact:EBI-993299|uniprotkb:Q8IYD6|uniprotkb:Q5SY30|uniprotkb:Q5SY41|ensembl:ENSP00000356070	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:mapk2_human(display_long)|uniprotkb:MAPKAPK2(gene name)|psi-mi:MAPKAPK2(display_short)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207055|imex:IM-22623-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENSG00000162889(gene)|ensembl:ENST00000367103(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048839"(inner ear development)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:P49137|rcsb pdb:1KWP|rcsb pdb:1NXK|rcsb pdb:1NY3|rcsb pdb:2JBO|rcsb pdb:2JBP|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2OZA|rcsb pdb:2P3G|rcsb pdb:2PZY|rcsb pdb:3A2C|rcsb pdb:3FPM|rcsb pdb:3FYJ|rcsb pdb:3FYK|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450302|rcsb pdb:3GOK|rcsb pdb:3KA0|rcsb pdb:3KC3|rcsb pdb:3KGA|rcsb pdb:3M2W|rcsb pdb:3M42|rcsb pdb:3R2B|rcsb pdb:3R2Y|rcsb pdb:3R30|rcsb pdb:3WI6|rcsb pdb:4TYH|rcsb pdb:6T8X|rcsb pdb:6TCA|reactome:R-HSA-171007|reactome:R-HSA-199920|reactome:R-HSA-2142691|reactome:R-HSA-2559580|reactome:R-HSA-3371453|reactome:R-HSA-4420097|refseq:NP_004750.1|refseq:NP_116584.2|dip:DIP-35671N	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 2, Table 1|causality statement:P49137 is required for phosphorylation of P09917|resulting-ptm:P09917 Ser-271 O-phospho-L-serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:iOzgeWqkVeJtasBfXoF50t7R2dE9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:6E7C3DBE6ED947FF|rigid:uH6GKKRA2rEfGqIFFuyEI7UzN5o	false	-	phosphorylated residue:271-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07947	uniprotkb:P09917	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207225|imex:IM-22623-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Table 2|causality statement:P07947 is required for phosphorylation of P09917|resulting-ptm:P09917 Tyr-42, Tyr-53 and Tyr-445 O4'-phospho-L-tyrosine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:1A662611AC3408BA|rigid:IDddd7cSr8Qa7XSVahVAqnydeM4	false	-	phosphorylated residue:445-445|phosphorylated residue:53-53|phosphorylated residue:42-42	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P17612	uniprotkb:P09917	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207166|imex:IM-22623-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Table 1|causality statement:P17612 is required for phosphorylation of P09917|resulting-ptm:P09917 Ser-271, Ser-447, Ser-523 and Ser-670 O-phospho-L-serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:961026F83A664E91|rigid:fyFPiRXRvNvuQC+N0Jmu/7zHRM8	false	-	porphyrin modified residue:670-670|phosphorylated residue:271-271|phosphorylated residue:523-523|porphyrin modified residue:447-447	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P09917	uniprotkb:P08631	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207213|imex:IM-22623-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Table 2|causality statement:P08631 is required for phosphorylation of P09917|resulting-ptm:P09919 Tyr-42, Tyr-53 an Tyr-94 O4'-phospho-L-tyrosine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	intact-crc:3B45906F92409DC1|rigid:50sJA3NVUM9Ce79WBAyOxlWrjMs	false	phosphorylated residue:42-42|phosphorylated residue:94-94|phosphorylated residue:53-53	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09917	uniprotkb:P09769	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	intact:EBI-1383732|uniprotkb:Q9UIQ3|uniprotkb:D3DPL7|ensembl:ENSP00000363115|ensembl:ENSP00000363116|ensembl:ENSP00000363117|ensembl:ENSP00000382126	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:fgr_human(display_long)|uniprotkb:SRC2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:FGR(gene name)|psi-mi:FGR(display_short)|uniprotkb:p55-Fgr(gene name synonym)|uniprotkb:"Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog"(gene name synonym)|uniprotkb:p58-Fgr(gene name synonym)|uniprotkb:p58c-Fgr(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207193|imex:IM-22623-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	refseq:NP_001036194.1|refseq:NP_001036212.1|refseq:XP_006710515.1|refseq:NP_005239.1|refseq:XP_011539312.1|dip:DIP-1049N|ensembl:ENSG00000000938(gene)|ensembl:ENST00000374003(transcript)|ensembl:ENST00000374004(transcript)|ensembl:ENST00000374005(transcript)|ensembl:ENST00000399173(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009615"(response to virus)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016235"(aggresome)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035693|interpro:IPR036028|interpro:IPR036860|mint:P09769|reactome:R-HSA-2029481|reactome:R-HSA-432142|reactome:R-HSA-6798695|reactome:R-HSA-9664323|reactome:R-HSA-9664422	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Table 2|causality statement:P09769 is required for phosphorylation of P09917|resulting-ptm:P09917 Tyr-42, Tyr-53 and Tyr-445 O4'-phospho-L-tyrosine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	rogid:rRgt5ZNh4lZSDL7R3neLMgDna2I9606	intact-crc:F21DB056C298D577|rigid:skByJ8WDlLCT4WiSZZzvI645pJY	false	phosphorylated residue:42-42|phosphorylated residue:53-53|phosphorylated residue:445-445	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13555	uniprotkb:P09917	intact:EBI-1383465|uniprotkb:O00561|uniprotkb:Q5SWX4|uniprotkb:Q8NIA4|uniprotkb:O15378|uniprotkb:Q13556|uniprotkb:Q5SQZ3|uniprotkb:Q5SQZ4|uniprotkb:Q8N4I3|uniprotkb:Q13279|uniprotkb:Q13282|uniprotkb:Q7KYX5|uniprotkb:A0A0A0MS52|uniprotkb:A0A0A0MT11	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:kcc2g_human(display_long)|uniprotkb:CAMK(gene name synonym)|uniprotkb:CAMK-II(gene name synonym)|uniprotkb:CAMK2G(gene name)|psi-mi:CAMK2G(display_short)|uniprotkb:CAMKG(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207248|imex:IM-22623-6	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001213.2|refseq:NP_751909.1|refseq:NP_751913.1|refseq:XP_005270260.1|refseq:NP_001307827.1|refseq:NP_001191421.1|dip:DIP-51315N|mint:Q13555|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0016020"(membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:2UX0|rcsb pdb:2V7O|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 3b|comment:"After in-vitro kinase assay with CaMK II and 5-LO, gel based MS analysis failed to  detect any phosphopeptide. However, this is in contrast with immunoblotting  experiments which indicated phosphorylation of 5-LO at both Ser271 and Ser523  (Fig. 3)."|causality statement:Q13555 is required for phosphorylation of P09917|resulting-ptm:P09917 Ser-271 and Ser-523 O-phospho-L-serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2018/04/06	rogid:qtCEps5UkV7tprB2QmjCDK5YyIo9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:C82D59B622C2D5E4|rigid:PoI2CcY6ny9JhEeoVPI2t3QIr8c	false	-	phosphorylated residue:523-523|phosphorylated residue:271-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P17612	uniprotkb:P09917	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207361|imex:IM-22623-10	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 3a|resulting-ptm:P09917 Ser-271 and Ser-523 O-phospho-L-serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:FDCDDDE373D43383|rigid:fyFPiRXRvNvuQC+N0Jmu/7zHRM8	false	-	phosphorylated residue:523-523|phosphorylated residue:271-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07947	uniprotkb:P09917	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207343|imex:IM-22623-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:58524E2E56BBB9FF|rigid:IDddd7cSr8Qa7XSVahVAqnydeM4	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P09769	uniprotkb:P09917	intact:EBI-1383732|uniprotkb:Q9UIQ3|uniprotkb:D3DPL7|ensembl:ENSP00000363115|ensembl:ENSP00000363116|ensembl:ENSP00000363117|ensembl:ENSP00000382126	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:fgr_human(display_long)|uniprotkb:SRC2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:FGR(gene name)|psi-mi:FGR(display_short)|uniprotkb:p55-Fgr(gene name synonym)|uniprotkb:"Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog"(gene name synonym)|uniprotkb:p58-Fgr(gene name synonym)|uniprotkb:p58c-Fgr(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207349|imex:IM-22623-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036194.1|refseq:NP_001036212.1|refseq:XP_006710515.1|refseq:NP_005239.1|refseq:XP_011539312.1|dip:DIP-1049N|ensembl:ENSG00000000938(gene)|ensembl:ENST00000374003(transcript)|ensembl:ENST00000374004(transcript)|ensembl:ENST00000374005(transcript)|ensembl:ENST00000399173(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009615"(response to virus)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016235"(aggresome)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035693|interpro:IPR036028|interpro:IPR036860|mint:P09769|reactome:R-HSA-2029481|reactome:R-HSA-432142|reactome:R-HSA-6798695|reactome:R-HSA-9664323|reactome:R-HSA-9664422	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:rRgt5ZNh4lZSDL7R3neLMgDna2I9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:D302EAAE22793CC8|rigid:skByJ8WDlLCT4WiSZZzvI645pJY	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P09917	uniprotkb:P08631	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Markoutsa et al. (2014)	pubmed:24860872|imex:IM-22623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9207331|imex:IM-22623-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/17	2014/10/27	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	intact-crc:E42F678464A22013|rigid:50sJA3NVUM9Ce79WBAyOxlWrjMs	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)