#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O54943	uniprotkb:P97784	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0013"(biophysical)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692973|imex:IM-23038-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Fig. 6A|comment:"Zinc binding stabilizes the purified CRY1/PER2 complex as demonstrated by the higher melting temperature of the wild-type complex compared to the zinc-free CRY1/PER2(cys1210ala/cys1213ala) mutant complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:6E6A705E11B25B92|rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	mutation decreasing interaction strength:1210-1210,1213-1213|sufficient binding region:1119-1252	sufficient binding region:1-496	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54943	uniprotkb:P97784	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9693005|imex:IM-23038-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Fig. 7C, Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:AE534C948C6AF45B	false	mutation decreasing interaction strength:1210-1210,1213-1213|v5 tag:n-n	mutation disrupting interaction strength:412-412,414-414	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:29105"	uniprotkb:O54943	intact:EBI-968340	intact:EBI-1266779|uniprotkb:O54954	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9693005|imex:IM-23038-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	-	-	-	figure legend:Fig. 7C, Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	-	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	intact-crc:AE534C948C6AF45B	false	radiolabel:?-?	mutation decreasing interaction strength:1210-1210,1213-1213|v5 tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P97784	uniprotkb:O54943	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0013"(biophysical)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692807|imex:IM-23038-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	-	-	-	figure legend:Supp. Fig. 4D, 7|comment:Only copurified CRY/PER2 complex binds zinc, while single mCRY1 and mPER2 proteins are zinc-free in solution|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	intact-crc:01AE869186C7C95B	false	his tag:c-c|sufficient binding region:1-496	sufficient binding region:1132-1252|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	uniprotkb:P97784	intact:EBI-968340	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0013"(biophysical)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692807|imex:IM-23038-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Supp. Fig. 4D, 7|comment:Only copurified CRY/PER2 complex binds zinc, while single mCRY1 and mPER2 proteins are zinc-free in solution|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	-	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:01AE869186C7C95B	false	-	his tag:c-c|sufficient binding region:1-496	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97784	uniprotkb:O54943	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692846|imex:IM-23038-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	intact-crc:2AA67E6167393B6D|rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	sufficient binding region:1-496	his tag:n-n|sufficient binding region:1119-1252|mutation disrupting interaction strength:1167-1167,1193-1193,1181-1181|mutation decreasing interaction strength:1167-1167|mutation decreasing interaction strength:1193-1193,1167-1167	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O54943	uniprotkb:P97784	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692946|imex:IM-23038-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Fig. 5C, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:683AA470D4D6DD0D|rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	mutation decreasing interaction strength:1193-1193,1167-1167|mutation decreasing interaction strength:1167-1167|sufficient binding region:1119-1252|mutation disrupting interaction strength:1167-1167,1193-1193,1181-1181	sufficient binding region:1-496	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P97784	uniprotkb:O54943	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9693024|imex:IM-23038-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.8x10^-8(molar)	2014/08/21	2014/10/16	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	intact-crc:8B0B5DE75D2D6921|rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	sufficient binding region:1-496	sufficient binding region:1119-1252	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97784	uniprotkb:O54943	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692891|imex:IM-23038-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	-	-	-	figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.3x10^-9(molar)	2014/08/21	2014/10/16	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	intact-crc:990604C369E9803F	false	sufficient binding region:1-496	sufficient binding region:1119-1252	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	uniprotkb:P97784	intact:EBI-968340	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692891|imex:IM-23038-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.3x10^-9(molar)	2014/08/21	2014/10/16	-	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:990604C369E9803F	false	-	sufficient binding region:1-496	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54943	uniprotkb:P97784	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0091"(chromatography technology)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9693045|imex:IM-23038-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Supp Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:99CAED00977B4666|rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	his tag:n-n|sufficient binding region:1119-1252	his tag:c-c|sufficient binding region:1-496	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P97784	uniprotkb:O54943	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0091"(chromatography technology)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9693049|imex:IM-23038-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	-	-	-	figure legend:Supp. Fig. 6|comment:"The presence of zinc in the complexes was analyzed in parallel by atomic absorption spectroscopy (ICP-OES)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	intact-crc:42D3DE02932B43A4	false	sufficient binding region:1-496|his tag:c-c	his tag:n-n|sufficient binding region:1119-1252	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:29105"	uniprotkb:P97784	intact:EBI-968340	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0091"(chromatography technology)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9693049|imex:IM-23038-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Supp. Fig. 6|comment:"The presence of zinc in the complexes was analyzed in parallel by atomic absorption spectroscopy (ICP-OES)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	-	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:42D3DE02932B43A4	false	-	sufficient binding region:1-496|his tag:c-c	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P97784	uniprotkb:O54943	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692690|imex:IM-23038-1|wwpdb:4ct0	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	-	-	-	figure legend:Supp. Table 1|3d-resolution:2.45A|3d-r-factors:Rworking = 0.19 Rfree = 0.23|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	intact-crc:3B048ACA47A6B1D5|rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	sufficient binding region:1-496|his tag:c-c	his tag:n-n|sufficient binding region:1132-1252	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97784	uniprotkb:O54943	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692733|imex:IM-23038-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	-	-	-	figure legend:Supp. Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	intact-crc:469E62D9AE3A68D0	false	his tag:c-c|sufficient binding region:1-496	his tag:n-n|sufficient binding region:1132-1252	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	uniprotkb:P97784	intact:EBI-968340	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692733|imex:IM-23038-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Supp. Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	-	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:469E62D9AE3A68D0	false	-	his tag:c-c|sufficient binding region:1-496	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54943	uniprotkb:P97784	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0016"(circular dichroism)	Schmalen et al. (2014)	pubmed:24855952|imex:IM-23038	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9697658|imex:IM-23038-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:Supp Table 2|comment:Unbound C-terminal mPER2 region Is mainly  unstructured; upon binding to mCRY1-PHR, it adopts a helical fold.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/21	2014/10/16	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	intact-crc:050E2978732D406A|rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	sufficient binding region:1132-1252	sufficient binding region:1-496	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)