#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07207	uniprotkb:Q23985	intact:EBI-103438|uniprotkb:O97458|uniprotkb:P04154|uniprotkb:Q9W4T8|ensemblmetazoa:FBpp0070483|ensemblmetazoa:FBpp0293201	intact:EBI-190618|intact:EBI-1630243|uniprotkb:Q86P53|uniprotkb:Q9W3Z1|uniprotkb:A9YJA9|uniprotkb:A9YJB1|uniprotkb:A9YJB7|uniprotkb:B3LF71|ensemblmetazoa:FBpp0070876	psi-mi:notch_drome(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:CG3936(orf name)	psi-mi:dtx_drome(display_long)|uniprotkb:dx(gene name)|psi-mi:dx(display_short)|uniprotkb:Probable E3 ubiquitin-protein ligase deltex(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase deltex(gene name synonym)|uniprotkb:CG3929(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shimizu et al. (2014)	imex:IM-23016|pubmed:24855951	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692388|imex:IM-23016-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476859.2|flybase:FBgn0004647|ensemblmetazoa:FBgn0004647(gene)|ensemblmetazoa:FBtr0070507(transcript)|ensemblmetazoa:FBtr0304659(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002213"(defense response to insect)|go:"GO:0003682"(chromatin binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007297"(ovarian follicle cell migration)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007391"(dorsal closure)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007423"(sensory organ development)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0009608"(response to symbiont)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0007478"(leg disc morphogenesis)|go:"GO:0016330"(second mitotic wave involved in compound eye morphogenesis)|go:"GO:0016348"(imaginal disc-derived leg joint morphogenesis)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0022416"(chaeta development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030713"(ovarian follicle cell stalk formation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030720"(oocyte localization involved in germarium-derived egg chamber formation)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0007498"(mesoderm development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0035153"(epithelial cell type specification, open tracheal system)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035167"(larval lymph gland hemopoiesis)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035172"(hemocyte proliferation)|go:"GO:0007616"(long-term memory)|go:"GO:0035204"(negative regulation of lamellocyte differentiation)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0036011"(imaginal disc-derived leg segmentation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0040008"(regulation of growth)|go:"GO:0042686"(regulation of cardioblast cell fate specification)|go:"GO:0042688"(crystal cell differentiation)|go:"GO:0042691"(positive regulation of crystal cell differentiation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045316"(negative regulation of compound eye photoreceptor development)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0045466"(R7 cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048052"(R1/R6 cell differentiation)|go:"GO:0048056"(R3/R4 cell differentiation)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0048477"(oogenesis)|go:"GO:0048542"(lymph gland development)|go:"GO:0048627"(myoblast development)|go:"GO:0048664"(neuron fate determination)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048749"(compound eye development)|go:"GO:0048803"(imaginal disc-derived male genitalia morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050699"(WW domain binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060288"(formation of a compartment boundary)|go:"GO:0060289"(compartment boundary maintenance)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1990433"(CSL-Notch-Mastermind transcription factor complex)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|rcsb pdb:1OT8|rcsb pdb:2JMF|refseq:NP_001245510.1|dip:DIP-5N	refseq:NP_511064.2|flybase:FBgn0000524|dip:DIP-18159N|ensemblmetazoa:FBgn0000524(gene)|ensemblmetazoa:FBtr0070914(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035220"(wing disc development)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004170(WWE)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018123|interpro:IPR037197|interpro:IPR039396|interpro:IPR039398|interpro:IPR039399|rcsb pdb:2A90|reactome:R-DME-2122948|reactome:R-DME-983168	-	-	-	figure legend:Fig. 1C, 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2014/08/20	2014/10/16	rogid:T1iHJGMHXkhxbFRybmSDlizN7oQ7227	rogid:BROv2MEe94OPExr6R/P0jYwR7WY7227	intact-crc:23A463D909E73F49|rigid:p7wXGhJ96oL7pd7e5R8WGj8DkOg	false	mutation disrupting interaction strength:2027-2027	venus fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)