#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q923J1	uniprotkb:Q8N488	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9673646|imex:IM-22990-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2B, 4A, 4B, Supp. Fig. 3H|comment:Binding required kinase activity of TRMP7. TPEN block is relieved by Zn2+, but not by Ca2+, Mn2+, or Cu2+|antagonist:TPEN, a heavy metal chelator|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2014/10/16	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606	intact-crc:9CF6346450AAD52B|rigid:VrE3qdv58+6wDvVUWQz4eYXWxFM	false	necessary binding region:1397-1444|ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:Q9C086	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-715611|ensembl:ENSP00000233331	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:in80b_human(display_long)|uniprotkb:PAP-1-associated protein 1(gene name synonym)|uniprotkb:High mobility group AT-hook 1-like 4(gene name synonym)|uniprotkb:INO80B(gene name)|psi-mi:INO80B(display_short)|uniprotkb:HMGA1L4(gene name synonym)|uniprotkb:PAPA1(gene name synonym)|uniprotkb:ZNHIT4(gene name synonym)|uniprotkb:Zinc finger HIT domain-containing protein 4(gene name synonym)|uniprotkb:IES2 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9673779|imex:IM-22990-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_112578.2|interpro:IPR029523|mint:Q9C086|rcsb pdb:6HTS|reactome:R-HSA-5689603|reactome:R-HSA-5696394|interpro:IPR007529(Zinc finger, HIT-type)|ensembl:ENSG00000115274(gene)|ensembl:ENST00000233331(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0031011"(Ino80 complex)|go:"GO:0043044"|go:"GO:0046872"(metal ion binding)|interpro:IPR006880(PAPA-1-like conserved region)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2B, 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:4nwc9Jv4wjrMHJTe7kMJt1Z0nks9606	intact-crc:3983D35F56D05F2D|rigid:NFHbpLoP0N3qacz2p9hTopHBLDM	false	ha tag:c-c|necessary binding region:1299-1396	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:Q15910	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-530054|uniprotkb:Q15755|uniprotkb:Q92857|uniprotkb:B2RAQ1|uniprotkb:B3KS30|uniprotkb:B7Z1D6|uniprotkb:B7Z7L6|uniprotkb:Q96FI6|intact:EBI-746496|ensembl:ENSP00000419711|uniprotkb:Q75MG3	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ezh2_human(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)|uniprotkb:EZH2(gene name)|psi-mi:EZH2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9673826|imex:IM-22990-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:XP_011514186.1|refseq:NP_001190176.1|refseq:NP_001190177.1|refseq:NP_001190178.1|refseq:NP_004447.2|refseq:NP_694543.1|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|ensembl:ENSG00000106462(gene)|ensembl:ENST00000460911(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0006348"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q15910|rcsb pdb:2C6V|rcsb pdb:4MI0|rcsb pdb:4MI5|rcsb pdb:5GSA|rcsb pdb:5H14|rcsb pdb:5H15|rcsb pdb:5H17|rcsb pdb:5H19|rcsb pdb:5H24|rcsb pdb:5H25|rcsb pdb:5HYN|rcsb pdb:5IJ7|rcsb pdb:5IJ8|rcsb pdb:5LS6|rcsb pdb:5U5T|rcsb pdb:5U62|rcsb pdb:5WG6|rcsb pdb:5WUK|rcsb pdb:6C23|rcsb pdb:6C24|rcsb pdb:6P5L|rcsb pdb:6U4Y|rcsb pdb:6WKR|rcsb pdb:7AT8|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214841|reactome:R-HSA-5617472|reactome:R-HSA-8943724|reactome:R-HSA-8953750|reactome:R-HSA-9609690|go:"GO:0070734"(histone H3-K27 methylation)|reactome:R-HSA-9710421|go:"GO:0048511"(rhythmic process)|dip:DIP-34002N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2B, 4A, Supp Fig 3H|comment:Binding did not require TRMP7 kinase activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:ZjwjEGDmMsyQ/33rYN7PimxvcUk9606	intact-crc:5F6C5B8E727C480E|rigid:FvP4sFCnv2ROhTrws6x0ic2OEkg	false	ha tag:c-c|sufficient binding region:1445-1863	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:Q96EB6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9688115|imex:IM-22990-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supp. Fig. 3E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:h3zVepuhRhzlINCluVuAn71Btjc9606	intact-crc:23AF33C641A8BDDC|rigid:CEoPOec/984KNK2ZCuMW1jvmrTQ	false	ha tag:c-c|necessary binding region:1398-1444	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:Q8N163	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9687963|imex:IM-22990-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supp. Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606	intact-crc:4054D8A512742DAB|rigid:/6SX0ClNSksimy2Bxur3liOvG1w	false	sufficient binding region:1445-1863|ha tag:c-c	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:O75530	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-923794|intact:EBI-2839778|intact:EBI-1177693|uniprotkb:A8K7V5|uniprotkb:Q6NTH2|uniprotkb:Q7LDA5|uniprotkb:Q7LDG8|uniprotkb:Q86VV2|uniprotkb:Q9UNY7|uniprotkb:O00149|ensembl:ENSP00000263360|ensembl:ENSP00000500834	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:eed_human(display_long)|uniprotkb:EED(gene name)|psi-mi:EED(display_short)|uniprotkb:WD protein associating with integrin cytoplasmic tails 1(gene name synonym)|uniprotkb:Embryonic ectoderm development protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9673690|imex:IM-22990-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_003788.2|refseq:NP_001294936.1|dip:DIP-36673N|ensembl:ENSG00000074266(gene)|ensembl:ENST00000263360(transcript)|ensembl:ENST00000672825(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0008047"(enzyme activator activity)|go:"GO:0021510"(spinal cord development)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070734"(histone H3-K27 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:O75530|rcsb pdb:3IIW|rcsb pdb:3IIY|rcsb pdb:3IJ0|rcsb pdb:3IJ1|rcsb pdb:3IJC|rcsb pdb:3JPX|rcsb pdb:3JZG|rcsb pdb:3JZH|rcsb pdb:3JZN|rcsb pdb:3K26|rcsb pdb:3K27|rcsb pdb:4W2R|rcsb pdb:4X3E|rcsb pdb:5GSA|rcsb pdb:5H13|rcsb pdb:5H14|rcsb pdb:5H15|rcsb pdb:5H17|rcsb pdb:5H19|rcsb pdb:5H24|rcsb pdb:5H25|rcsb pdb:5HYN|rcsb pdb:5IJ7|rcsb pdb:5IJ8|rcsb pdb:5K0M|rcsb pdb:5LS6|rcsb pdb:5TTW|rcsb pdb:5U5H|rcsb pdb:5U5K|rcsb pdb:5U5T|rcsb pdb:5U62|rcsb pdb:5U69|rcsb pdb:5U6D|rcsb pdb:5U8A|rcsb pdb:5U8F|rcsb pdb:5WG6|rcsb pdb:5WP3|rcsb pdb:5WUK|rcsb pdb:6B3W|rcsb pdb:6C23|rcsb pdb:6C24|rcsb pdb:6SFB|rcsb pdb:6SFC|rcsb pdb:6U4Y|rcsb pdb:6V3X|rcsb pdb:6V3Y|rcsb pdb:6W7F|rcsb pdb:6W7G|rcsb pdb:6WKR|rcsb pdb:6YVI|rcsb pdb:6YVJ|rcsb pdb:7KSO|rcsb pdb:7KSR|rcsb pdb:7KTP|rcsb pdb:7KXT|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214841|reactome:R-HSA-5617472|reactome:R-HSA-8943724|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9710421	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA9606	intact-crc:141356B5F5BDD580|rigid:3Ohek/YrhoSPF5S4GW2U5pUSMag	false	ha tag:c-c|necessary binding region:1397-1444	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:Q9Y230	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9673765|imex:IM-22990-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606	intact-crc:3EC87305A33ED053|rigid:9MP+hpy1CkUoZ3Uv66O0bHNseg8	false	ha tag:c-c|sufficient binding region:1444-1863	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:O00571	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9673797|imex:IM-22990-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606	intact-crc:3E42E8C3C44657DC|rigid:ziNV1lTjClY2yCDqvkPHpCQbBTo	false	ha tag:c-c|necessary binding region:1397-1444	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:A2A432	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-3043864|ensembl:ENSMUSP00000059276|ensembl:ENSMUSP00000110771|uniprotkb:Q3TU30|uniprotkb:Q8BSL3|uniprotkb:Q8CHD6|uniprotkb:Q91YZ7|uniprotkb:Q99KS9|uniprotkb:Q9CZM5	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:cul4b_mouse(display_long)|uniprotkb:Cul4b(gene name)|psi-mi:Cul4b(display_short)|uniprotkb:Kiaa0695(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9687884|imex:IM-22990-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000031095(gene)|ensembl:ENSMUST00000050083(transcript)|ensembl:ENSMUST00000115118(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-110314|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-8951664|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:NP_001103612.1|refseq:NP_082564.3	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supp. Fig. 3C|comment:Cul4B binds active and kinase-dead mutant TRPM7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/28	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:gy/AfT1IOeV2CLhAJxdybZhcpPA10090	intact-crc:99CEBE8E995AF045|rigid:BTWosqFcj6I9xl7qOogs7/akZtU	false	necessary binding region:1299-1863|ha tag:c-c	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:Q06587	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-752313|uniprotkb:Q5JP96|uniprotkb:Q5SQW2|uniprotkb:Q86V19|uniprotkb:A8JZZ0|ensembl:ENSP00000363787|ensembl:ENSP00000372699|ensembl:ENSP00000396271|ensembl:ENSP00000396439|ensembl:ENSP00000400572|ensembl:ENSP00000412190	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ring1_human(display_long)|uniprotkb:RING finger protein 1(gene name synonym)|uniprotkb:Polycomb complex protein RING1(gene name synonym)|uniprotkb:RING1(gene name)|psi-mi:RING1(display_short)|uniprotkb:RNF1(gene name synonym)|uniprotkb:Really interesting new gene 1 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9673754|imex:IM-22990-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_002922.2|dip:DIP-42043N|ensembl:ENSG00000204227(gene)|ensembl:ENSG00000206287(gene)|ensembl:ENSG00000226788(gene)|ensembl:ENSG00000228520(gene)|ensembl:ENSG00000231115(gene)|ensembl:ENSG00000235107(gene)|ensembl:ENST00000374656(transcript)|ensembl:ENST00000383212(transcript)|ensembl:ENST00000415941(transcript)|ensembl:ENST00000427374(transcript)|ensembl:ENST00000430233(transcript)|ensembl:ENST00000436128(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016607"(nuclear speck)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR042741|mint:Q06587|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|reactome:R-HSA-8953750|interpro:IPR043540	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:oAdj6hshWi4/CoFFW3ZwyO4LKOU9606	intact-crc:C8462373A47DE08E|rigid:2MSGCTFU2RjLNOVbZnEX45DMVt0	false	sufficient binding region:1397-1863|ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:Q99496	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-722416|uniprotkb:Q5TEN1|uniprotkb:Q5TEN2|uniprotkb:B2RBS7|uniprotkb:B3KRH1|ensembl:ENSP00000356480	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ring2_human(display_long)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING finger protein BAP-1(gene name synonym)|uniprotkb:Protein DinG(gene name synonym)|uniprotkb:Huntingtin-interacting protein 2-interacting protein 3(gene name synonym)|uniprotkb:RNF2(gene name)|psi-mi:RNF2(display_short)|uniprotkb:BAP1(gene name synonym)|uniprotkb:DING(gene name synonym)|uniprotkb:HIPI3(gene name synonym)|uniprotkb:RING1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9673708|imex:IM-22990-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_009143.1|refseq:XP_011508153.1|refseq:XP_011508154.1|dip:DIP-40034N|ensembl:ENSG00000121481(gene)|ensembl:ENST00000367510(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q99496|rcsb pdb:2H0D|rcsb pdb:3GS2|rcsb pdb:3H8H|rcsb pdb:3IXS|rcsb pdb:3RPG|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:7ND1|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|reactome:R-HSA-8953750	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2B, Supp. fig. 3H|comment:Binding was increased when TRPM7 was catalytically active and also dependant on the presence of zinc.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:pqAjSEwOUdfuogKW6fodqsUSHIk9606	intact-crc:B0E1A7259E2005F4|rigid:zJIvzG140TuYZv/eLHQDLHjc2DU	false	necessary binding region:1397-1444|ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q923J1	uniprotkb:Q9WTM5	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2549911|ensembl:ENSMUSP00000103400|ensembl:ENSMUSP00000147502	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ruvb2_mouse(display_long)|uniprotkb:Ruvbl2(gene name)|psi-mi:Ruvbl2(display_short)|uniprotkb:p47 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000003868(gene)|ensembl:ENSMUST00000107771(transcript)|ensembl:ENSMUST00000211214(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051117"(ATPase binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9WTM5|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_035434.1|refseq:XP_006540785.1|refseq:XP_006540786.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:tHnjngaz5qWy9sPXagFLp3TRDtA10090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:O00571	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q921E6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q9CQJ4	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q61188	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q02248	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q6ZPV2	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-3043902|ensembl:ENSMUSP00000051845|uniprotkb:A2AQP8|uniprotkb:Q6P7V0|uniprotkb:Q6PCP1|uniprotkb:Q8C9T7	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ino80_mouse(display_long)|uniprotkb:Ino80(gene name)|psi-mi:Ino80(display_short)|uniprotkb:Inoc1(gene name synonym)|uniprotkb:Kiaa1259(gene name synonym)|uniprotkb:DNA helicase-related INO80 complex homolog 1(gene name synonym)|uniprotkb:DNA helicase-related protein INO80(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000034154(gene)|ensembl:ENSMUST00000049920(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031011"(Ino80 complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042393"(histone binding)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043044"|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR020838|interpro:IPR027417|interpro:IPR031047|interpro:IPR038718|mint:Q6ZPV2|reactome:R-MMU-5689603|reactome:R-MMU-5696394|refseq:NP_080850.2	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:4TfoC8GVpirZZMPsohrCRYf8A3I10090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:P60122	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-1634999|uniprotkb:O35753|ensembl:ENSMUSP00000032165	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ruvb1_mouse(display_long)|uniprotkb:Ruvbl1(gene name)|psi-mi:Ruvbl1(display_short)|uniprotkb:Tip49(gene name synonym)|uniprotkb:Tip49a(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:DNA helicase p50(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_062659.1|ensembl:ENSMUSG00000030079(gene)|ensembl:ENSMUST00000032165(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:P60122|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-5696394|reactome:R-MMU-606279	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:fZiQ7AurvKII0LYc+haBswAXfZ410090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q00899	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-6921536|ensembl:ENSMUSP00000021692	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tyy1_mouse(display_long)|uniprotkb:Yy1(gene name)|psi-mi:Yy1(display_short)|uniprotkb:Ucrbp(gene name synonym)|uniprotkb:Delta transcription factor(gene name synonym)|uniprotkb:NF-E1(gene name synonym)|uniprotkb:UCR-motif DNA-binding protein(gene name synonym)|uniprotkb:Yin and yang 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUST00000021692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|ensembl:ENSMUSG00000021264(gene)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006403"(RNA localization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010225"(response to UV-C)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048468"(cell development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0051276"(chromosome organization)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017114(Transcription factor yin and yang)|interpro:IPR036236|mint:Q00899|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-9018519|refseq:NP_033563.2|dip:DIP-59285N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:TVKas6Dv9iMdl/6BfK+3FUIZnzs10090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q8CCI5	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-929290|uniprotkb:Q9WVK2|uniprotkb:B2RRB6|ensembl:ENSMUSP00000098677	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:rybp_mouse(display_long)|uniprotkb:Rybp(gene name)|psi-mi:Rybp(display_short)|uniprotkb:Dedaf(gene name synonym)|uniprotkb:Death effector domain-associated factor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661222|imex:IM-22990-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_062717.2|ensembl:ENSMUSG00000072872(gene)|ensembl:ENSMUST00000101118(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8CCI5|reactome:R-MMU-8939243|reactome:R-MMU-8953750	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:6BAe40LmdbvRNKWeg5yGRcHgGRY10090	intact-crc:7AFE4476EF442AA7|rigid:Qte1cUYJo+GGi/STvUA9sG5VJyg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q3U1J4	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2552275|ensembl:ENSMUSP00000025649|uniprotkb:Q99LV3|uniprotkb:Q9QYK0|uniprotkb:Q3U8G3|uniprotkb:Q9WV39|uniprotkb:Q3UJC4|uniprotkb:Q3U4D0	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddb1_mouse(display_long)|uniprotkb:Ddb1(gene name)|psi-mi:Ddb1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9687866|imex:IM-22990-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000024740(gene)|ensembl:ENSMUST00000025649(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|refseq:NP_056550.1|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|mint:Q3U1J4|reactome:R-MMU-110314|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-8951664|go:"GO:0005654"(nucleoplasm)|dip:DIP-56812N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supp. Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:dvNwCrG9In1FV2j/+PrsSMvqFnk10090	intact-crc:1DDEBD53E65447D8|rigid:ci84LzeYOogVPy+y1fwQKFqLdt0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q923J1	uniprotkb:Q8N488	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9687802|imex:IM-22990-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 2C, 4C|comment:Binding was dependent on the presence of zinc, half-maximal binding of RYBP to zinc was at a an approximate concentration of zinc = 4nM.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/15	2015/05/22	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606	intact-crc:D7EA3EB20246271B|rigid:VrE3qdv58+6wDvVUWQz4eYXWxFM	false	ha tag:c-c|necessary binding region:1299-1444	sufficient binding region:22-47|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q923J1	uniprotkb:P54823	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-3647041|ensembl:ENSMUSP00000128421|ensembl:ENSMUSP00000149620|uniprotkb:O54979|uniprotkb:Q3UFI3|uniprotkb:Q8BW68	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddx6_mouse(display_long)|uniprotkb:Ddx6(gene name)|psi-mi:Ddx6(display_short)|uniprotkb:Hlr2(gene name synonym)|uniprotkb:Rck(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:Oncogene RCK homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|mint:P54823|reactome:R-MMU-430039|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|ensembl:ENSMUSG00000032097(gene)|ensembl:ENSMUST00000170489(transcript)|ensembl:ENSMUST00000217034(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_001104296.1|refseq:NP_031867.1|refseq:NP_851841.2|refseq:XP_011240693.1|refseq:XP_011240694.1|refseq:XP_017168613.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:Q80hxmsbz9kQgOP9Gflto87Sp/M10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q64213	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-8312835|uniprotkb:O08817|uniprotkb:Q61454|uniprotkb:P70167|uniprotkb:Q921Z4|intact:MINT-4134251|uniprotkb:E9QK02	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:sf01_mouse(display_long)|uniprotkb:Sf1(gene name)|psi-mi:Sf1(display_short)|uniprotkb:Zfm1(gene name synonym)|uniprotkb:Zfp162(gene name synonym)|uniprotkb:Mammalian branch point-binding protein(gene name synonym)|uniprotkb:Zinc finger protein 162(gene name synonym)|uniprotkb:Transcription factor ZFM1(gene name synonym)|uniprotkb:Zinc finger gene in MEN1 locus(gene name synonym)|uniprotkb:CW17(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030238"(male sex determination)|go:"GO:0030575"(nuclear body organization)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045131"(pre-mRNA branch point binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR031150|interpro:IPR032570|interpro:IPR036612|reactome:R-MMU-72163|dip:DIP-60453N|mint:Q64213	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	comment:mint|function:"Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor"	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:ykXZgj4QmBT8zKv15henuho9qvs10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8VHE6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-8314581|ensembl:ENSMUSP00000069751|uniprotkb:Q8BWG1|intact:MINT-4093714|uniprotkb:E9QKD7	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:dyh5_mouse(display_long)|uniprotkb:Dnah5(gene name)|psi-mi:Dnah5(display_short)|uniprotkb:Dnahc5(gene name synonym)|uniprotkb:Axonemal beta dynein heavy chain 5(gene name synonym)|uniprotkb:Ciliary dynein heavy chain 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000022262(gene)|ensembl:ENSMUST00000067048(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005858"(axonemal dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030286"(dynein complex)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0036157"(outer dynein arm)|go:"GO:0036158"(outer dynein arm assembly)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051649"(establishment of localization in cell)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q8VHE6|go:"GO:0007507"(heart development)|refseq:NP_579943.3	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	comment:mint|function:Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles|function:"Defects in Dnah5 are the cause of primary ciliary dyskinesia (PCD). PCD is characterized by recurrent respiratory infections, situs inversus and ciliary immotility and hydrocephalus"	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:JgldMbKr9Z/DKNlk7NaOplTX5T410090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9WUM4	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-8316222|ensembl:ENSMUSP00000004646|intact:MINT-4091604|uniprotkb:Q8VCQ5|uniprotkb:Q499X7	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:cor1c_mouse(display_long)|uniprotkb:Coro1c(gene name)|psi-mi:Coro1c(display_short)|uniprotkb:Coronin-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000004530(gene)|ensembl:ENSMUST00000004646(transcript)|go:"GO:0000147"(actin cortical patch assembly)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0090148"(membrane fission)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097750"(endosome membrane tubulation)|go:"GO:0140285"(endosome fission)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027333|interpro:IPR036322|mint:Q9WUM4|refseq:NP_035909.2	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	comment:mint|function:May be involved in cytokinesis, motility, and signal transduction	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:Td/jSJSpQwBMVL43ZWfzJdkcURA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8R0W0	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-8384332|intact:MINT-1866986	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:epipl_mouse(display_long)|uniprotkb:Eppk1(gene name)|psi-mi:Eppk1(display_short)|uniprotkb:EPPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_659097.2|interpro:IPR035915|mint:Q8R0W0|interpro:IPR043197|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042995"(cell projection)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045178"(basal part of cell)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0071944"(cell periphery)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1905041"(regulation of epithelium regeneration)|go:"GO:1990254"(keratin filament binding)|interpro:IPR001101(Plectin repeat)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	comment:mint	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:TlPwlGuldUFZOPP6H68duhKYwXY10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q7TMM9	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2255578|ensembl:ENSMUSP00000060246	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tbb2a_mouse(display_long)|uniprotkb:Tubb2(gene name synonym)|uniprotkb:Tubb2a(gene name)|psi-mi:Tubb2a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_033476.1|ensembl:ENSMUSG00000058672(gene)|ensembl:ENSMUST00000056427(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q7TMM9|reactome:R-MMU-190840|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3371497|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:XN9uTGU0KxQjMod0AGnM+XJoHyk10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9ERU9	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-643756|uniprotkb:E9QM01|uniprotkb:Q61992|uniprotkb:Q8C9K9|ensembl:ENSMUSP00000003310	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:rbp2_mouse(display_long)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Ranbp2(gene name)|psi-mi:Ranbp2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_035370.2|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000003226(gene)|ensembl:ENSMUST00000003310(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:Q9ERU9|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:cjIAIF0uuxSMRXErJiJc+OBJpAw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P68369	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-400542|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q3TGF0|uniprotkb:Q3TIW2|uniprotkb:Q3TPJ1|uniprotkb:Q3ULN1|uniprotkb:Q5XJF8|ensembl:ENSMUSP00000094778	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tba1a_mouse(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-1(gene name synonym)|uniprotkb:Tuba1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_035783.1|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|ensembl:ENSMUSG00000072235(gene)|ensembl:ENSMUST00000097014(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68369|rcsb pdb:6JZD|reactome:R-MMU-190840|reactome:R-MMU-2132295	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P68373	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-3647590|uniprotkb:P05216|uniprotkb:Q9CSE9|ensembl:ENSMUSP00000051033	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tba1c_mouse(display_long)|uniprotkb:Tuba1c(gene name)|psi-mi:Tuba1c(display_short)|uniprotkb:Tuba6(gene name synonym)|uniprotkb:Alpha-tubulin 6(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-6(gene name synonym)|uniprotkb:Tubulin alpha-6 chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_033474.1|ensembl:ENSMUSG00000043091(gene)|ensembl:ENSMUST00000058914(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045121"(membrane raft)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68373|reactome:R-MMU-190840|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3371497|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|go:"GO:0005881"(cytoplasmic microtubule)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:/v0eESwae8IubY6sq0wcTeeXHaQ10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P32067	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-911168|ensembl:ENSMUSP00000088365|ensembl:ENSMUSP00000130313	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:la_mouse(display_long)|uniprotkb:La ribonucleoprotein(gene name synonym)|uniprotkb:La autoantigen homolog(gene name synonym)|uniprotkb:Ssb(gene name)|psi-mi:Ssb(display_short)|uniprotkb:Ss-b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000068882(gene)|ensembl:ENSMUST00000090852(transcript)|ensembl:ENSMUST00000166411(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0008033"(tRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042780"(tRNA 3'-end processing)|go:"GO:0071045"(nuclear histone mRNA catabolic process)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002344(Lupus La protein)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014886(RNA binding motif)|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|mint:P32067|refseq:NP_001103615.1|refseq:NP_033304.1|dip:DIP-37706N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:egWOrzRVef4SX0jdKpzPTWEzrjQ10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9DBR1	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2365150|uniprotkb:Q3TI26|uniprotkb:Q3TKF2|uniprotkb:Q3UZT9|uniprotkb:Q61489|uniprotkb:Q99KS7|ensembl:ENSMUSP00000028921	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:xrn2_mouse(display_long)|uniprotkb:Xrn2(gene name)|psi-mi:Xrn2(display_short)|uniprotkb:Dhm1(gene name synonym)|uniprotkb:Protein Dhm1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_036047.2|ensembl:ENSMUSG00000027433(gene)|ensembl:ENSMUST00000028921(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000738"(DNA catabolic process, exonucleolytic)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001147"(transcription termination site sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006397"(mRNA processing)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR017151(5'-3' exoribonuclease 2)|interpro:IPR027073|interpro:IPR041412|mint:Q9DBR1|reactome:R-MMU-6791226	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:Bq3eDLXS2Tfo1TRmJ8pp1ePNzEc10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P02469	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-6662997|ensembl:ENSMUSP00000002979|ensembl:ENSMUSP00000132778|uniprotkb:E9PXZ9	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:lamb1_mouse(display_long)|uniprotkb:Lamb1(gene name)|psi-mi:Lamb1(display_short)|uniprotkb:Lamb-1(gene name synonym)|uniprotkb:Lamb1-1(gene name synonym)|uniprotkb:Laminin B1 chain(gene name synonym)|uniprotkb:Laminin-1 subunit beta(gene name synonym)|uniprotkb:Laminin-10 subunit beta(gene name synonym)|uniprotkb:Laminin-12 subunit beta(gene name synonym)|uniprotkb:Laminin-2 subunit beta(gene name synonym)|uniprotkb:Laminin-6 subunit beta(gene name synonym)|uniprotkb:Laminin-8 subunit beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:XP_006515055.2|ensembl:ENSMUSG00000002900(gene)|ensembl:ENSMUST00000002979(transcript)|ensembl:ENSMUST00000169088(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005607"(laminin-2 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0007611"(learning or memory)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0021812"(neuronal-glial interaction involved in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042476"(odontogenesis)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043256"(laminin complex)|go:"GO:0043257"(laminin-8 complex)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8874081|go:"GO:0070831"(basement membrane assembly)|reactome:R-MMU-8957275|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR013015(Laminin IV)|mint:P02469|rcsb pdb:4AQS|rcsb pdb:5MC9|refseq:XP_006515056.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:cUuVqY2JMeRrS9sDYudPy7hSIL010090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q6P4T2	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-6878408|ensembl:ENSMUSP00000099509|uniprotkb:Q69ZZ3	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:u520_mouse(display_long)|uniprotkb:Snrnp200(gene name)|psi-mi:Snrnp200(display_short)|uniprotkb:Kiaa0788(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000003660(gene)|ensembl:ENSMUST00000103220(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:Q6P4T2|reactome:R-MMU-72163|reactome:R-MMU-72165|refseq:NP_796188.2	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:P0APWhAjy05E6VYhOWEmHdw2QHw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P50636	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-3508340|uniprotkb:Q3UGT2|uniprotkb:Q9QUJ5|ensembl:ENSMUSP00000022890	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:rn19a_mouse(display_long)|uniprotkb:Rnf19a(gene name)|psi-mi:Rnf19a(display_short)|uniprotkb:Geg-154(gene name synonym)|uniprotkb:Rnf19(gene name synonym)|uniprotkb:Xybp(gene name synonym)|uniprotkb:Double ring-finger protein(gene name synonym)|uniprotkb:Gametogenesis-expressed protein GEG-154(gene name synonym)|uniprotkb:RING finger protein 19A(gene name synonym)|uniprotkb:UBCM4-interacting protein 117(gene name synonym)|uniprotkb:XY body protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_038951.1|ensembl:ENSMUSG00000022280(gene)|ensembl:ENSMUST00000022890(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:P50636|reactome:R-MMU-983168	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:kmmYnA5DGyrDuK1Px3uyV6iqlG810090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P60710	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8C170	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673425|uniprotkb:Q3TRT5|uniprotkb:Q4VBD3|uniprotkb:Q80Y92|uniprotkb:Q8C0U0|ensembl:ENSMUSP00000119401	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:myo9a_mouse(display_long)|uniprotkb:Myo9a(gene name)|psi-mi:Myo9a(display_short)|uniprotkb:Myr7(gene name synonym)|uniprotkb:Unconventional myosin-9a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:XP_006511283.1|ensembl:ENSMUSG00000039585(gene)|ensembl:ENSMUST00000128341(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0150011"(regulation of neuron projection arborization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027417|interpro:IPR028558|interpro:IPR029071|interpro:IPR036023|interpro:IPR036961|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013424	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:TBpKzCsIACwONl1YbEiwrEfsk4Q10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q69ZU6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673461|uniprotkb:Q3TP01|uniprotkb:Q3UWV1	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ths7a_mouse(display_long)|uniprotkb:Thsd7a(gene name)|psi-mi:Thsd7a(display_short)|uniprotkb:Gm837(gene name synonym)|uniprotkb:Kiaa0960(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	mint:Q69ZU6|interpro:IPR000884(Thrombospondin, type I)|refseq:NP_001158277.1|interpro:IPR036383|interpro:IPR044004|go:"GO:0001525"(angiogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0098846"(podocyte foot)|reactome:R-MMU-5173214	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:/qTgHz4eRmV8fo7eOtIiStWEzrw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q3UHD6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-6910393|ensembl:ENSMUSP00000102904|uniprotkb:Q7TQL6|uniprotkb:Q80TZ1|uniprotkb:Q9CYB5	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:snx27_mouse(display_long)|uniprotkb:Snx27(gene name)|psi-mi:Snx27(display_short)|uniprotkb:Kiaa0488(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	go:"GO:0006886"(intracellular protein transport)|go:"GO:0007165"(signal transduction)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016197"(endosomal transport)|go:"GO:0030904"(retromer complex)|ensembl:ENSMUSG00000028136(gene)|ensembl:ENSMUST00000107283(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0071203"(WASH complex)|go:"GO:0005768"(endosome)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|interpro:IPR000159(Ras-association)|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0005769"(early endosome)|interpro:IPR001683(Phox-like)|interpro:IPR028667|interpro:IPR029071|go:"GO:0005829"(cytosol)|interpro:IPR036034|go:"GO:0005886"(plasma membrane)|interpro:IPR036871|interpro:IPR037827|interpro:IPR037831|interpro:IPR037833|interpro:IPR037835|mint:Q3UHD6|refseq:NP_001075953.1|refseq:NP_083997.1|dip:DIP-60337N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:+pFe87lSKQPJuMDWsiMU4iXhGOw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8BXJ2	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673394|uniprotkb:Q32NY5|uniprotkb:Q6PCQ4|uniprotkb:Q80X25|uniprotkb:Q810H8|uniprotkb:Q8BY31	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tref1_mouse(display_long)|uniprotkb:Trerf1(gene name)|psi-mi:Trerf1(display_short)|uniprotkb:Transcriptional-regulating protein 132(gene name synonym)|uniprotkb:Zinc finger transcription factor TReP-132(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	interpro:IPR000949(ELM2)|interpro:IPR009057(Homeodomain-like)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR017884|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|refseq:NP_001091092.1|refseq:NP_766210.1|interpro:IPR036236|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016575"(histone deacetylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0071393"(cellular response to progesterone stimulus)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:ZB8SY+WpE0Sd0HtmSRBY2uSBxoo10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P80317	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-772389	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tcpz_mouse(display_long)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Cct6a(gene name)|psi-mi:Cct6a(display_short)|uniprotkb:Cct6(gene name synonym)|uniprotkb:Cctz(gene name synonym)|uniprotkb:Cctz1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_033968.1|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|interpro:IPR027410|mint:P80317|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|reactome:R-MMU-390471|reactome:R-MMU-6814122|reactome:R-MMU-9013418	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:E8vqHRMvDBqKtAu5/6UPh1mSYLw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P80314	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-772351|uniprotkb:Q9R1U0|ensembl:ENSMUSP00000036288	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tcpb_mouse(display_long)|uniprotkb:CCT-beta(gene name synonym)|uniprotkb:Cct2(gene name)|psi-mi:Cct2(display_short)|uniprotkb:Cctb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_031662.2|refseq:XP_006513224.1|dip:DIP-32343N|ensembl:ENSMUSG00000034024(gene)|ensembl:ENSMUST00000047672(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80314|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6798695|reactome:R-MMU-6814122|reactome:R-MMU-9013418|reactome:R-MMU-9013422	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:1CGHdF6g9ZqNbyRmQ5l3eUgD5Ow10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P80316	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-772379|uniprotkb:Q3TIE0|uniprotkb:Q3U530|uniprotkb:Q3UCU4|uniprotkb:Q3UJK9|uniprotkb:Q3UWA9|uniprotkb:Q542K3|uniprotkb:Q6ZQJ1|ensembl:ENSMUSP00000022842	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tcpe_mouse(display_long)|uniprotkb:CCT-epsilon(gene name synonym)|uniprotkb:Cct5(gene name)|psi-mi:Cct5(display_short)|uniprotkb:Ccte(gene name synonym)|uniprotkb:Kiaa0098(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_031663.1|refseq:NP_001334964.1|ensembl:ENSMUSG00000022234(gene)|ensembl:ENSMUST00000022842(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012718(T-complex protein 1, epsilon subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80316|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:UpEEjKLyd92Zl4VnOTTlziuwAGA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P80313	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-309306|ensembl:ENSMUSP00000032078	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tcph_mouse(display_long)|uniprotkb:Cct7(gene name)|psi-mi:Cct7(display_short)|uniprotkb:Ccth(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_031664.3|ensembl:ENSMUSG00000030007(gene)|ensembl:ENSMUST00000032078(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80313|reactome:R-MMU-390471|reactome:R-MMU-6814122|reactome:R-MMU-9013418|reactome:R-MMU-9013422	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:ds2hAlDoiHN/urDfVMjJhNumSqo10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9QZH1	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9672880	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:q9qzh1_mouse(display_long)|uniprotkb:Dnah11(gene name)|psi-mi:Dnah11(display_short)|uniprotkb:Dnahc11(gene name synonym)|uniprotkb:Lrd(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	interpro:IPR035699|interpro:IPR035706|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR026983|interpro:IPR024743|interpro:IPR024317|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR027417|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR041228|interpro:IPR041466|interpro:IPR041589|interpro:IPR041658|interpro:IPR043157|interpro:IPR043160|go:"GO:0003341"(cilium movement)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0003356"(regulation of cilium beat frequency)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0007611"(learning or memory)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0035545"(determination of left/right asymmetry in nervous system)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0097728"(9+0 motile cilium)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0120134"(proximal portion of axoneme)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:iMKKrRviVknv5KwneCNQyVjE1YQ10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:E9Q557	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-688046|ensembl:ENSMUSP00000115062	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:desp_mouse(display_long)|uniprotkb:Dsp(gene name)|psi-mi:Dsp(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_076331.2|ensembl:ENSMUSG00000054889(gene)|ensembl:ENSMUST00000124830(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:E9Q557|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696273	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	comment:AfCS Y2H protein. Translated from nucleotide sequence.|comment:"Similar to DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) (95%)"	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:AQF1MrZZW8M5RfagBI7P4b3qQPA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P80318	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-772361|ensembl:ENSMUSP00000001452	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tcpg_mouse(display_long)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:Matricin(gene name synonym)|uniprotkb:mTRiC-P5(gene name synonym)|uniprotkb:Cct3(gene name)|psi-mi:Cct3(display_short)|uniprotkb:Cctg(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_033966.1|dip:DIP-32344N|ensembl:ENSMUSG00000001416(gene)|ensembl:ENSMUST00000001452(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80318|rcsb pdb:1GML|rcsb pdb:1GN1|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:+jrWcoDzrkHivHA/h3aApt0gBFU10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q02257	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-1751183|uniprotkb:Q8CGD3|intact:EBI-4280673|ensembl:ENSMUSP00000001592|ensembl:ENSMUSP00000103026	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:plak_mouse(display_long)|uniprotkb:Jup(gene name)|psi-mi:Jup(display_short)|uniprotkb:Desmoplakin-3(gene name synonym)|uniprotkb:Desmoplakin III(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_034723.1|refseq:XP_006532378.1|refseq:XP_006532379.1|ensembl:ENSMUSG00000001552(gene)|ensembl:ENSMUST00000001592(transcript)|ensembl:ENSMUST00000107403(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002159"(desmosome assembly)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030057"(desmosome)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071665"(gamma-catenin-TCF7L2 complex)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR030461|mint:Q02257|reactome:R-MMU-418990|reactome:R-MMU-5218920|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9013407	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:vGVqOkILXpeS3KOS5oPBztoWuts10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P80315	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-772370|ensembl:ENSMUSP00000133523	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tcpd_mouse(display_long)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:A45(gene name synonym)|uniprotkb:Cct4(gene name)|psi-mi:Cct4(display_short)|uniprotkb:Cctd(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_033967.1|ensembl:ENSMUSG00000007739(gene)|ensembl:ENSMUST00000173867(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80315|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:/40BY5vhE/fuloWu9L2k7ujy9Nc10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P11983	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-772338|uniprotkb:Q3TJ96|uniprotkb:Q3TKU1|uniprotkb:Q3U5T8|uniprotkb:Q3U7I8|uniprotkb:Q3UAA8|uniprotkb:Q3UB80|uniprotkb:Q3UE48|intact:EBI-2291308|uniprotkb:P11984|ensembl:ENSMUSP00000116108	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tcpa_mouse(display_long)|uniprotkb:CCT-alpha(gene name synonym)|uniprotkb:Tailless complex polypeptide 1B(gene name synonym)|uniprotkb:Tcp1(gene name)|psi-mi:Tcp1(display_short)|uniprotkb:Ccta(gene name synonym)|uniprotkb:Cct1(gene name synonym)|uniprotkb:Tailless complex polypeptide 1A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001277641.1|refseq:NP_038714.2|dip:DIP-32342N|ensembl:ENSMUSG00000068039(gene)|ensembl:ENSMUST00000151287(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P11983|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:mSINCow3H5FzUCTXpqwkI18OI9o10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8K3Z0	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9672760|ensembl:ENSMUSP00000105262	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:nod2_mouse(display_long)|uniprotkb:Nod2(gene name)|psi-mi:Nod2(display_short)|uniprotkb:Card15(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	dip:DIP-46115N|ensembl:ENSMUSG00000055994(gene)|ensembl:ENSMUST00000109634(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002253"(activation of immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002710"(negative regulation of T cell mediated immunity)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0006965"(positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016888"(endodeoxyribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032498"(detection of muramyl dipeptide)|go:"GO:0032500"(muramyl dipeptide binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR018228|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|reactome:R-MMU-168638|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5689896|reactome:R-MMU-9020702	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:Q4csMmsXifCS580ehelz9RncDfw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8BUZ3	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9672746|ensembl:ENSMUSP00000052320	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tigd4_mouse(display_long)|uniprotkb:Tigd4(gene name)|psi-mi:Tigd4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_997161.1|ensembl:ENSMUSG00000047819(gene)|ensembl:ENSMUST00000062623(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR007889(Helix-turn-helix, Psq)|interpro:IPR009057(Homeodomain-like)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:aJTTdBfPg6CM6pX8/jJtBx+SXsA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q501J6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-911206|uniprotkb:Q6P5G1|uniprotkb:Q8BIN2|ensembl:ENSMUSP00000155307	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddx17_mouse(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:Ddx17(gene name)|psi-mi:Ddx17(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001035277.1|refseq:NP_951061.1|refseq:NP_951062.1|ensembl:ENSMUSG00000055065(gene)|ensembl:ENSMUST00000229877(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0061614"(miRNA transcription)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q501J6|reactome:R-MMU-3899300	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:uGXMsVmy7MWcTaJPNlkof05dS8I10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9WV34	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-444614|ensembl:ENSMUSP00000017458|uniprotkb:Q3T9W1|uniprotkb:Q3TT52|uniprotkb:Q3URK8|uniprotkb:B1AQF8	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:mpp2_mouse(display_long)|uniprotkb:Protein MPP2(gene name synonym)|uniprotkb:Discs large homolog 2(gene name synonym)|uniprotkb:Mpp2(gene name)|psi-mi:Mpp2(display_short)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_057904.1|ensembl:ENSMUSG00000017314(gene)|ensembl:ENSMUST00000017458(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035602|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q9WV34|go:"GO:0098919"(structural constituent of postsynaptic density)|refseq:XP_006533746.1|refseq:XP_006533747.1|refseq:XP_006533748.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:KythGhvpyj7gkND18iMe73LgdtM10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9QWT9	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2552204|ensembl:ENSMUSP00000134572|uniprotkb:Q9JKZ0|uniprotkb:Q8BV06|uniprotkb:O35230|uniprotkb:Q4A1N2|uniprotkb:Q497Y3|uniprotkb:Q99L84|uniprotkb:Q6PG90|uniprotkb:O08671	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:kifc1_mouse(display_long)|uniprotkb:Kifc1(gene name)|psi-mi:Kifc1(display_short)|uniprotkb:Kifc4(gene name synonym)|uniprotkb:Kifc5a(gene name synonym)|uniprotkb:Kifc5b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001182227.1|refseq:NP_444403.2|ensembl:ENSMUSG00000079553(gene)|ensembl:ENSMUST00000173492(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0051301"(cell division)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|go:"GO:0047496"(vesicle transport along microtubule)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:UiW6wpgFSTq5jJC7qwk5pabE3zA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q61656	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-643076|uniprotkb:E9Q105	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddx5_mouse(display_long)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD1(gene name synonym)|uniprotkb:Ddx5(gene name)|psi-mi:Ddx5(display_short)|uniprotkb:Tnz2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|reactome:R-MMU-3899300|reactome:R-MMU-72163|reactome:R-MMU-9018519|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009299"(mRNA transcription)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|dip:DIP-32293N|mint:Q61656	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:X5OQN/Gdq852njTrHnlDliAjrQY10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q99K43	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-644779|uniprotkb:E9QPF0|uniprotkb:Q8CE25|ensembl:ENSMUSP00000043379	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:prc1_mouse(display_long)|uniprotkb:Prc1(gene name)|psi-mi:Prc1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001272926.1|reactome:R-MMU-5625900|interpro:IPR032921|ensembl:ENSMUSG00000038943(gene)|ensembl:ENSMUST00000047558(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0070938"(contractile ring)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR007145(MAP65/ASE1)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:Xu052dxwVt00LivzQdjuZFKxtEc10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9CQC6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9672730|uniprotkb:Q3THS5|uniprotkb:Q3UZ94|ensembl:ENSMUSP00000051935	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:bzw1_mouse(display_long)|uniprotkb:Bzw1(gene name)|psi-mi:Bzw1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_080100.1|ensembl:ENSMUSG00000051223(gene)|ensembl:ENSMUST00000050552(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043510	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:4dzFp6AN4tymPA5rHNYlHCCmSaY10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q80TF4	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673336|uniprotkb:A2AL86|uniprotkb:A2AL87|uniprotkb:A2AL88|uniprotkb:A2AL89|uniprotkb:Q9DBY7|ensembl:ENSMUSP00000110972	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:klh13_mouse(display_long)|uniprotkb:Klhl13(gene name)|psi-mi:Klhl13(display_short)|uniprotkb:Bklhd2(gene name synonym)|uniprotkb:Kiaa1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001297395.1|refseq:XP_011245791.1|refseq:XP_011245794.1|refseq:XP_011245795.1|refseq:XP_011245796.1|refseq:XP_017174099.1|refseq:NP_001277405.1|refseq:NP_080443.1|ensembl:ENSMUSG00000036782(gene)|ensembl:ENSMUST00000115317(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|mint:Q80TF4|reactome:R-MMU-8951664|reactome:R-MMU-983168	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:toLcULHqvUiIszWbXJHgVMsXTEg10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q80XJ3	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673303|uniprotkb:J3QM46|uniprotkb:J3QQ36|uniprotkb:Q6P9J6|uniprotkb:Q80TL5|uniprotkb:Q8BV10|uniprotkb:Q8C0F2|ensembl:ENSMUSP00000137609	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ttc28_mouse(display_long)|uniprotkb:Ttc28(gene name)|psi-mi:Ttc28(display_short)|uniprotkb:Kiaa1043(gene name synonym)|uniprotkb:Tprbk(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001254551.1|ensembl:ENSMUSG00000033209(gene)|ensembl:ENSMUST00000156290(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024983	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:g+jPV3YhaOM0UGC0EG3553OaF2w10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:E9QAF4	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673292|ensembl:ENSMUSP00000073047|ensembl:ENSMUSP00000146187	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:e9qaf4_mouse(display_long)|uniprotkb:Phldb3(gene name)|psi-mi:Phldb3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:XP_017177646.1|refseq:NP_001096083.1|ensembl:ENSMUSG00000074277(gene)|ensembl:ENSMUST00000073325(transcript)|ensembl:ENSMUST00000206422(transcript)|go:"GO:0019899"(enzyme binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:MgiN4IZBOdBapMr+WTDPe7fcebw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9Z2E1	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-5716946|uniprotkb:E9QMV9|uniprotkb:Q811D9|uniprotkb:Q9Z2D9|ensembl:ENSMUSP00000073701	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:mbd2_mouse(display_long)|uniprotkb:Mbd2(gene name)|psi-mi:Mbd2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_034903.2|refseq:NP_001298000.1|ensembl:ENSMUSG00000024513(gene)|ensembl:ENSMUST00000074058(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9Z2E1|reactome:R-MMU-427413|reactome:R-MMU-73728	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:WxzH0gNkMXwFmBK/RWr2/RqWjXM10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P05213	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2311600|uniprotkb:Q3TY23|uniprotkb:Q3U8B1|uniprotkb:Q3UAW8|uniprotkb:Q4KMW2|ensembl:ENSMUSP00000076777	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tba1b_mouse(display_long)|uniprotkb:Tuba1b(gene name)|psi-mi:Tuba1b(display_short)|uniprotkb:Tuba2(gene name synonym)|uniprotkb:Tubulin alpha-2 chain(gene name synonym)|uniprotkb:Alpha-tubulin 2(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_035784.1|ensembl:ENSMUSG00000023004(gene)|ensembl:ENSMUST00000077577(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|reactome:R-MMU-190840|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3371497|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8955332|reactome:R-MMU-9013407|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:D4YpuLCXl/S+53qV7P7sF81aARY10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8BW72	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673139|uniprotkb:A2A8L8|uniprotkb:Q3UKM5|uniprotkb:Q3UM81|uniprotkb:Q3UWV2|uniprotkb:Q6ZQ72|uniprotkb:Q8K137|ensembl:ENSMUSP00000095524|ensembl:ENSMUSP00000102011|ensembl:ENSMUSP00000102014	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:kdm4a_mouse(display_long)|uniprotkb:Kdm4a(gene name)|psi-mi:Kdm4a(display_short)|uniprotkb:Jhdm3a(gene name synonym)|uniprotkb:Jmjd2(gene name synonym)|uniprotkb:Jmjd2a(gene name synonym)|uniprotkb:Kiaa0677(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001155295.1|refseq:NP_759014.2|refseq:XP_006503073.1|ensembl:ENSMUSG00000033326(gene)|ensembl:ENSMUST00000097911(transcript)|ensembl:ENSMUST00000106403(transcript)|ensembl:ENSMUST00000106406(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|reactome:R-MMU-3214842|reactome:R-MMU-5693565	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:bacSD4SxSjPDGZRdvVXgMoCeSDU10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:E9Q4N7	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-6900614|ensembl:ENSMUSP00000111463	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ari1b_mouse(display_long)|uniprotkb:Arid1b(gene name)|psi-mi:Arid1b(display_short)|uniprotkb:BRG1-associated factor 250b(gene name synonym)|uniprotkb:Baf250b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0035060"(brahma complex)|go:"GO:0043044"|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060996"(dendritic spine development)|go:"GO:0071565"(nBAF complex)|go:"GO:0097026"(dendritic cell dendrite assembly)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021906|interpro:IPR033388|interpro:IPR036431|interpro:IPR038040|reactome:R-MMU-3214858|reactome:R-MMU-8939243|go:"GO:0005737"(cytoplasm)|ensembl:ENSMUSG00000069729(gene)|ensembl:ENSMUST00000115797(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001078824.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	crc64:51AA79A5AE8B30A9	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:H3ws7v++z/2CHUEuPL35HFP+b1c10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9JI57	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673183|uniprotkb:Q547E0|uniprotkb:Q80WJ8|uniprotkb:Q80WJ9|uniprotkb:Q80WK0|uniprotkb:Q80WK1|uniprotkb:Q8R4X5|uniprotkb:Q8R4X6|uniprotkb:Q8R4X7|uniprotkb:Q8R4X8|uniprotkb:Q8VHD5|uniprotkb:Q8VI58|uniprotkb:Q9EQE7|uniprotkb:Q9ESZ6|uniprotkb:Q9ESZ7|ensembl:ENSMUSP00000098217	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:gt2d1_mouse(display_long)|uniprotkb:Gtf2ird1(gene name)|psi-mi:Gtf2ird1(display_short)|uniprotkb:Ben(gene name synonym)|uniprotkb:Binding factor for early enhancer(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001334417.1|refseq:XP_017176527.1|refseq:XP_017176528.1|refseq:NP_001074931.1|refseq:NP_001074932.1|refseq:NP_001074935.1|refseq:NP_001074936.1|refseq:NP_001074938.1|refseq:NP_001074939.1|refseq:NP_001231865.1|refseq:NP_065064.2|ensembl:ENSMUSG00000023079(gene)|ensembl:ENSMUST00000100652(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0014886"(transition between slow and fast fiber)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|interpro:IPR036647|mint:Q9JI57	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:FuFR0UjN0B9NGFRRIIF56yYOHbw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P68368	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2642970|uniprotkb:Q3TY31|uniprotkb:P05215|ensembl:ENSMUSP00000140657	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tba4a_mouse(display_long)|uniprotkb:Tuba4a(gene name)|psi-mi:Tuba4a(display_short)|uniprotkb:Tuba4(gene name synonym)|uniprotkb:Tubulin alpha-4 chain(gene name synonym)|uniprotkb:Alpha-tubulin 4(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_033473.1|ensembl:ENSMUSG00000026202(gene)|ensembl:ENSMUST00000186213(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68368|reactome:R-MMU-114608|reactome:R-MMU-190840|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|reactome:R-MMU-2132295	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P68372	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2553564|uniprotkb:P05217|uniprotkb:Q3UJ73|uniprotkb:Q3TKF0|uniprotkb:Q99JZ6|ensembl:ENSMUSP00000042342	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tbb4b_mouse(display_long)|uniprotkb:Tubb4b(gene name)|psi-mi:Tubb4b(display_short)|uniprotkb:Tubb2c(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000036752(gene)|ensembl:ENSMUST00000043584(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045298"(tubulin complex)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68372|reactome:R-MMU-190840|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|refseq:NP_666228.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:4LwMs7E7eILMjB9Z/1bstAp22CY10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P99024	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-350896|uniprotkb:P05218|uniprotkb:Q3TFB6|uniprotkb:Q3THH9|uniprotkb:Q3TIL1|uniprotkb:Q3UAV4|uniprotkb:Q3UF52|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|uniprotkb:B1B178|ensembl:ENSMUSP00000001566	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tbb5_mouse(display_long)|uniprotkb:Tubb5(gene name)|psi-mi:Tubb5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_035785.1|interpro:IPR023123|interpro:IPR036525|interpro:IPR018316|interpro:IPR037103|mint:P99024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6798695|reactome:R-MMU-8854518|ensembl:ENSMUSG00000001525(gene)|ensembl:ENSMUST00000001566(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051225"(spindle assembly)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:O35737	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-299747|ensembl:ENSMUSP00000070503|ensembl:ENSMUSP00000104770	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:hnrh1_mouse(display_long)|uniprotkb:Hnrnph1(gene name)|psi-mi:Hnrnph1(display_short)|uniprotkb:Hnrph(gene name synonym)|uniprotkb:Hnrph1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000007850(gene)|ensembl:ENSMUST00000069304(transcript)|ensembl:ENSMUST00000109142(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:O35737|reactome:R-MMU-6803529|reactome:R-MMU-72163|reactome:R-MMU-72203|refseq:NP_067485.1|refseq:XP_017170179.1|refseq:XP_017170180.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:nBSCiXDDfkwqslFAXPXlDzC+5e410090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P70335	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:O55098	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-6396706|ensembl:ENSMUSP00000099885|uniprotkb:B1ATW8	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:stk10_mouse(display_long)|uniprotkb:Stk10(gene name)|psi-mi:Stk10(display_short)|uniprotkb:Lok(gene name synonym)|uniprotkb:Lymphocyte-oriented kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000020272(gene)|ensembl:ENSMUST00000102821(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000401"(regulation of lymphocyte migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022165|interpro:IPR042743|mint:O55098|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|go:"GO:0046777"(protein autophosphorylation)|refseq:NP_033314.2	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:WAvUJKRFz2J5rouW+6Kzzg2Ve+A10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q64455	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673020|uniprotkb:Q3UH64|uniprotkb:Q3UHL5|uniprotkb:Q541R5|uniprotkb:Q8CIW9|uniprotkb:Q8K3Q2	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ptprj_mouse(display_long)|uniprotkb:Ptprj(gene name)|psi-mi:Ptprj(display_short)|uniprotkb:Byp(gene name synonym)|uniprotkb:Scc1(gene name synonym)|uniprotkb:HPTP beta-like tyrosine phosphatase(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Susceptibility to colon cancer 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	interpro:IPR041201|reactome:R-MMU-202427|reactome:R-MMU-6798695|reactome:R-MMU-6807004|reactome:R-MMU-9706369|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|refseq:NP_033008.3|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029021|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR036116|go:"GO:0001570"(vasculogenesis)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000272"(negative regulation of signaling receptor activity)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:nmFd85KTkQW6FyVMnVCP6fwaZwo10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:O35516	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-646516|uniprotkb:Q06008|uniprotkb:Q60941|ensembl:ENSMUSP00000078741|uniprotkb:G5E8J0	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:notc2_mouse(display_long)|uniprotkb:Motch B(gene name synonym)|uniprotkb:Notch2(gene name)|psi-mi:Notch2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_035058.2|dip:DIP-6008N|ensembl:ENSMUSG00000027878(gene)|ensembl:ENSMUST00000079812(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001889"(liver development)|go:"GO:0001890"(placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046849"(bone remodeling)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0072576"(liver morphogenesis)|go:"GO:1990705"(cholangiocyte proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001204"(regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022336|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:T3w0+N9gMVnbeATWbj5GW4hocwg10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q66JQ7	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2552633|uniprotkb:A3KGI4|ensembl:ENSMUSP00000028799|uniprotkb:Q9CV38|uniprotkb:Q8CCH6	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:knl1_mouse(display_long)|uniprotkb:Knl1(gene name)|psi-mi:Knl1(display_short)|uniprotkb:Cancer susceptibility candidate gene 5 protein homolog(gene name synonym)|uniprotkb:Casc5(gene name synonym)|uniprotkb:Kinetochore-null protein 1(gene name synonym)|uniprotkb:Protein CASC5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000027326(gene)|ensembl:ENSMUST00000028799(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016604"(nuclear body)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051301"(cell division)|interpro:IPR037388|interpro:IPR043651|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-606279|reactome:R-MMU-68877|reactome:R-MMU-9648025	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:zDcVNhZyyMDNu4bbhBRlx0N1V0Y10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P60122	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-1634999|uniprotkb:O35753|ensembl:ENSMUSP00000032165	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ruvb1_mouse(display_long)|uniprotkb:Ruvbl1(gene name)|psi-mi:Ruvbl1(display_short)|uniprotkb:Tip49(gene name synonym)|uniprotkb:Tip49a(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:DNA helicase p50(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_062659.1|ensembl:ENSMUSG00000030079(gene)|ensembl:ENSMUST00000032165(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:P60122|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-5696394|reactome:R-MMU-606279	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:fZiQ7AurvKII0LYc+haBswAXfZ410090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q6ZQF0	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-527248|uniprotkb:Q6P6P0|uniprotkb:Q80Y33|uniprotkb:Q8BUI0|uniprotkb:Q8BUK1|uniprotkb:Q8R348|uniprotkb:Q91VX3|uniprotkb:Q922X8|ensembl:ENSMUSP00000035164	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:topb1_mouse(display_long)|uniprotkb:DNA topoisomerase II-binding protein 1(gene name synonym)|uniprotkb:Topbp1(gene name)|psi-mi:Topbp1(display_short)|uniprotkb:Kiaa0259(gene name synonym)|uniprotkb:DNA topoisomerase II-beta-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_795953.2|ensembl:ENSMUSG00000032555(gene)|ensembl:ENSMUST00000035164(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR044737|rcsb pdb:5U6K|reactome:R-MMU-5685938|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69473|refseq:XP_006511770.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:5LhKSrOCf8HROVlXy9mKpHmdPqE10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q68G58	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9673070|uniprotkb:Q8BYE9|uniprotkb:Q8R018|uniprotkb:Q8R328|uniprotkb:Q9CS12|uniprotkb:Q8BJP7|uniprotkb:Q8BTR7|uniprotkb:Q8BUZ2	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:apex2_mouse(display_long)|uniprotkb:Apex2(gene name)|psi-mi:Apex2(display_short)|uniprotkb:Ape2(gene name synonym)|uniprotkb:APEX nuclease 2(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:XP_011246180.1|interpro:IPR004808(Exodeoxyribonuclease III xth)|interpro:IPR020847|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR010666(Zinc finger, GRF-type)|refseq:NP_084219.1|interpro:IPR036691|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006284"(base-excision repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008311"(double-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:u09Pt+37lm6M2j1gn5ze20L8Eb410090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:A2ASS6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9672947|uniprotkb:A2ASS5|uniprotkb:A2ASS7	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:titin_mouse(display_long)|uniprotkb:Ttn(gene name)|psi-mi:Ttn(display_short)|uniprotkb:Connectin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	interpro:IPR040849|rcsb pdb:6YJ0|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR004168(PPAK motif)|interpro:IPR000719(Protein kinase, core)|interpro:IPR015129(Titin Z)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR036116|interpro:IPR036179|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021591"(ventricular system development)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031672"(A band)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043056"(forward locomotion)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060419"(heart growth)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:xDsiEoYt/F9ZCvYym/wgnXdwYbU10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9WTM5	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2549911|ensembl:ENSMUSP00000103400|ensembl:ENSMUSP00000147502	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ruvb2_mouse(display_long)|uniprotkb:Ruvbl2(gene name)|psi-mi:Ruvbl2(display_short)|uniprotkb:p47 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000003868(gene)|ensembl:ENSMUST00000107771(transcript)|ensembl:ENSMUST00000211214(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051117"(ATPase binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9WTM5|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_035434.1|refseq:XP_006540785.1|refseq:XP_006540786.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:tHnjngaz5qWy9sPXagFLp3TRDtA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:O70372	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9662790|uniprotkb:O35432|uniprotkb:Q9JK99|ensembl:ENSMUSP00000022104	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tert_mouse(display_long)|uniprotkb:Tert(gene name)|psi-mi:Tert(display_short)|uniprotkb:Telomerase catalytic subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_033380.1|dip:DIP-60451N|ensembl:ENSMUSG00000021611(gene)|ensembl:ENSMUST00000022104(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|reactome:R-MMU-171319|reactome:R-MMU-201722|go:"GO:0042635"(positive regulation of hair cycle)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:F9g0os+mTs3PtmY8O9/SbGNdHg410090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P0C6F1	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9662756|uniprotkb:B1AR18|uniprotkb:O08826|uniprotkb:Q8C0U5|ensembl:ENSMUSP00000047329	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:dyh2_mouse(display_long)|uniprotkb:Dnah2(gene name)|psi-mi:Dnah2(display_short)|uniprotkb:Dnahc2(gene name synonym)|uniprotkb:Axonemal beta dynein heavy chain 2(gene name synonym)|uniprotkb:Ciliary dynein heavy chain 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000005237(gene)|ensembl:ENSMUST00000035539(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005858"(axonemal dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0031514"(motile cilium)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036156"(inner dynein arm)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060285"(cilium-dependent cell motility)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:JAHlnfNKG3kfEflr+3DEIGkgdzU10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8BFZ3	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2693747|ensembl:ENSMUSP00000052086	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:actbl_mouse(display_long)|uniprotkb:Actbl2(gene name)|psi-mi:Actbl2(display_short)|uniprotkb:Kappa-actin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_780706.1|ensembl:ENSMUSG00000055194(gene)|ensembl:ENSMUST00000054716(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0007409"(axonogenesis)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0045202"(synapse)|go:"GO:0048870"(cell motility)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:Q8BFZ3	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:OBTnGqn28Mc9uRapk7IOxAoxbZY10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8BZ21	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9662202|uniprotkb:Q8BW52|uniprotkb:Q8BYH1|uniprotkb:Q8C1F3	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:kat6a_mouse(display_long)|uniprotkb:Kat6a(gene name)|psi-mi:Kat6a(display_short)|uniprotkb:Moz(gene name synonym)|uniprotkb:Myst3(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger homolog(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	reactome:R-MMU-3214847|reactome:R-MMU-6804758|interpro:IPR031280|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR005818(Histone H1/H5)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR019787|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040706|interpro:IPR036388|interpro:IPR036390|go:"GO:0000786"(nucleosome)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042393"(histone binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:khkUEdQBcClAbgXaxjShqxn3oxQ10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q60875	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-772191|uniprotkb:E9QNW9|uniprotkb:O09115|uniprotkb:Q3TBI4|uniprotkb:Q3TJ16|uniprotkb:Q8CHE1|uniprotkb:Q923E0|uniprotkb:Q9ESG7|ensembl:ENSMUSP00000029694	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:arhg2_mouse(display_long)|uniprotkb:Kiaa0651(gene name synonym)|uniprotkb:Lbcl1(gene name synonym)|uniprotkb:Lfc(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 1(gene name synonym)|uniprotkb:LBC'S first cousin(gene name synonym)|uniprotkb:Oncogene LFC(gene name synonym)|uniprotkb:Rhobin(gene name synonym)|uniprotkb:Arhgef2(gene name)|psi-mi:Arhgef2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001185840.1|refseq:NP_001185841.1|refseq:NP_001185842.1|refseq:NP_032513.3|refseq:XP_006501130.1|ensembl:ENSMUSG00000028059(gene)|ensembl:ENSMUST00000029694(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002102"(podosome)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071802"(negative regulation of podosome assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q60875|rcsb pdb:5WI4|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:Le4PMm1AT/ManVpetNT2wBsUlok10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8C854	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-4285350|uniprotkb:Q6ZPT3|uniprotkb:Q8QZZ1|uniprotkb:Q60690|uniprotkb:Q6P930|ensembl:ENSMUSP00000123088	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:myef2_mouse(display_long)|uniprotkb:Myef2(gene name)|psi-mi:Myef2(display_short)|uniprotkb:Kiaa1341(gene name synonym)|uniprotkb:Mef2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001155889.1|refseq:XP_006498947.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034630|interpro:IPR034631|interpro:IPR034632|interpro:IPR035979|interpro:IPR000504(RNA recognition motif, RNP-1)|mint:Q8C854|ensembl:ENSMUSG00000027201(gene)|ensembl:ENSMUST00000152367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|refseq:XP_017171620.1|refseq:XP_017171621.1|refseq:XP_017171623.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:ZnM8NqQUhlLdO7gzhs09ckrZUPw10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P10126	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-773865|uniprotkb:Q61511|uniprotkb:Q6ZWN2|uniprotkb:Q8BMB8|uniprotkb:Q8BVS8|uniprotkb:Q99KU5|ensembl:ENSMUSP00000042457	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ef1a1_mouse(display_long)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Eef1a1(gene name)|psi-mi:Eef1a1(display_short)|uniprotkb:Eef1a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	dip:DIP-46609N|refseq:NP_034236.2|ensembl:ENSMUSG00000037742(gene)|ensembl:ENSMUST00000042235(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P10126|reactome:R-MMU-156842|reactome:R-MMU-3371511|reactome:R-MMU-6798695|reactome:R-MMU-8876725	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:85G9Uje743KzA02bB/rmKuq2HbU10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9D219	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9662251|uniprotkb:B2RQC0|uniprotkb:Q67FX9|uniprotkb:Q8BUJ8|uniprotkb:Q8VE74|ensembl:ENSMUSP00000046152|ensembl:ENSMUSP00000131692	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:bcl9_mouse(display_long)|uniprotkb:Bcl9(gene name)|psi-mi:Bcl9(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_084209.3|refseq:XP_006502351.1|refseq:XP_006502352.1|refseq:XP_006502353.1|ensembl:ENSMUSG00000038256(gene)|ensembl:ENSMUST00000046521(transcript)|ensembl:ENSMUST00000166341(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015668(B Cell Lymphoma 9)|interpro:IPR024670|reactome:R-MMU-201722	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:QYz6njS6nDJLwQwSs46dnRHr2Mc10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q3U1J4	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2552275|ensembl:ENSMUSP00000025649|uniprotkb:Q99LV3|uniprotkb:Q9QYK0|uniprotkb:Q3U8G3|uniprotkb:Q9WV39|uniprotkb:Q3UJC4|uniprotkb:Q3U4D0	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddb1_mouse(display_long)|uniprotkb:Ddb1(gene name)|psi-mi:Ddb1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000024740(gene)|ensembl:ENSMUST00000025649(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|refseq:NP_056550.1|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|mint:Q3U1J4|reactome:R-MMU-110314|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-8951664|go:"GO:0005654"(nucleoplasm)|dip:DIP-56812N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:dvNwCrG9In1FV2j/+PrsSMvqFnk10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:B1AY13	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9662176|uniprotkb:Q8BLI7|ensembl:ENSMUSP00000092538	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ubp24_mouse(display_long)|uniprotkb:Usp24(gene name)|psi-mi:Usp24(display_short)|uniprotkb:Deubiquitinating enzyme 24(gene name synonym)|uniprotkb:Ubiquitin thioesterase 24(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 24(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_899048.2|ensembl:ENSMUSG00000028514(gene)|ensembl:ENSMUST00000094933(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR029071|interpro:IPR033382|interpro:IPR038765|mint:B1AY13|reactome:R-MMU-5689880	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:piuoMxUZPd2jM/4a9+alnjXjQ0810090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8VDP4	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2931660|ensembl:ENSMUSP00000036924|uniprotkb:Q6PIB1|uniprotkb:Q8BWR5|uniprotkb:Q8C0F0|uniprotkb:Q8R3G6	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ccar2_mouse(display_long)|uniprotkb:Ccar2(gene name)|psi-mi:Ccar2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000033712(gene)|ensembl:ENSMUST00000035612(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR028811|mint:Q8VDP4|reactome:R-MMU-3371453|refseq:NP_666167.3|refseq:XP_006518959.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:4KqmxaC2o3+yWOF9dwQ9kQ7AMqs10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:E9Q557	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-688046|ensembl:ENSMUSP00000115062	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:desp_mouse(display_long)|uniprotkb:Dsp(gene name)|psi-mi:Dsp(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_076331.2|ensembl:ENSMUSG00000054889(gene)|ensembl:ENSMUST00000124830(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:E9Q557|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696273	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	comment:AfCS Y2H protein. Translated from nucleotide sequence.|comment:"Similar to DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) (95%)"	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:AQF1MrZZW8M5RfagBI7P4b3qQPA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q80VF8	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-4282502	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:q80vf8_mouse(display_long)|uniprotkb:Cad(gene name)|psi-mi:Cad(display_short)|uniprotkb:Cad-pending(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR036901|interpro:IPR032466|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0016597"(amino acid binding)|go:"GO:0016812"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides")|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046872"(metal ion binding)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:zZbrI7EBG3zA1CcwaTo+X4Byi6810090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q8VDD5	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-400906|intact:EBI-777674|uniprotkb:Q3UHT9|uniprotkb:Q3UHU4|uniprotkb:Q6KAN6|uniprotkb:Q811I2|ensembl:ENSMUSP00000016771	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:myh9_mouse(display_long)|uniprotkb:Myh9(gene name)|psi-mi:Myh9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_071855.2|ensembl:ENSMUSG00000022443(gene)|ensembl:ENSMUST00000016771(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0097513"(myosin II filament)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q8VDD5|reactome:R-MMU-2029482|reactome:R-MMU-5627123|dip:DIP-29546N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	caution:This sequence has been withdrawn from Uniprot.|crc64:AAAC0E83A0A4F24A	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:qYfcGuWOF9npzsKD3zXTuLeP9iE10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q6P5F9	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-2550236|ensembl:ENSMUSP00000020538|ensembl:ENSMUSP00000099933|ensembl:ENSMUSP00000099934|ensembl:ENSMUSP00000105178	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:xpo1_mouse(display_long)|uniprotkb:Xpo1(gene name)|psi-mi:Xpo1(display_short)|uniprotkb:Crm1(gene name synonym)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	rcsb pdb:3NC0|rcsb pdb:3NC1|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3769402|reactome:R-MMU-450520|reactome:R-MMU-5663220|reactome:R-MMU-5687128|reactome:R-MMU-68877|reactome:R-MMU-69273|reactome:R-MMU-9634638|reactome:R-MMU-9648025|reactome:R-MMU-9707616|rcsb pdb:3NBZ|ensembl:ENSMUSG00000020290(gene)|ensembl:ENSMUST00000020538(transcript)|ensembl:ENSMUST00000102869(transcript)|ensembl:ENSMUST00000102870(transcript)|ensembl:ENSMUST00000109551(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0042176"(regulation of protein catabolic process)|rcsb pdb:3GJX|rcsb pdb:3NBY|refseq:NP_001030303.1|refseq:NP_598775.2|refseq:XP_006514493.1|dip:DIP-48612N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:k02EX8YlQCgjt5EyEXvTFHQNPCI10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9CQE8	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-912160|ensembl:ENSMUSP00000022341	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:rtraf_mouse(display_long)|uniprotkb:RTRAF(gene name)|psi-mi:RTRAF(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_080804.1|ensembl:ENSMUSG00000021807(gene)|ensembl:ENSMUST00000022341(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0072686"(mitotic spindle)|interpro:IPR019265|mint:Q9CQE8	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:AP73IJnWMs4jwKTGnIC+q1GcBRc10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:O70481	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-645659|uniprotkb:A2AQ54|uniprotkb:Q5BKR8|uniprotkb:Q792M3|uniprotkb:Q8BN40|uniprotkb:Q8C5K3|ensembl:ENSMUSP00000028728	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ubr1_mouse(display_long)|uniprotkb:N-recognin-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-I(gene name synonym)|uniprotkb:Ubr1(gene name)|psi-mi:Ubr1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase UBR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_033487.2|ensembl:ENSMUSG00000027272(gene)|ensembl:ENSMUST00000028728(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000502"(proteasome complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR044046|reactome:R-MMU-983168	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:MSaRJnUGFioOkUOT0B0XM6ZxPtg10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:B1AR51	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9661433|ensembl:ENSMUSP00000079494	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:b1ar51_mouse(display_long)|uniprotkb:Dnah9(gene name)|psi-mi:Dnah9(display_short)|uniprotkb:Dnahc9(gene name synonym)|uniprotkb:RP23-215H18.2-001(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001093103.1|ensembl:ENSMUSG00000056752(gene)|ensembl:ENSMUST00000080665(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0031514"(motile cilium)|go:"GO:0036157"(outer dynein arm)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0120135"(distal portion of axoneme)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR030443|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:BdK9oKMKy5wHmmwEAqKxSELI0qc10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q64487	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-771834|uniprotkb:Q64486|uniprotkb:Q64488|uniprotkb:Q64495|intact:EBI-6132324|intact:EBI-5778480|uniprotkb:G3X9S7|uniprotkb:Q8VBV0|ensembl:ENSMUSP00000102910	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ptprd_mouse(display_long)|uniprotkb:Ptprd(gene name)|psi-mi:Ptprd(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_035341.2|ensembl:ENSMUSG00000028399(gene)|ensembl:ENSMUST00000107289(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030182"(neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4Y61|rcsb pdb:4YFD|rcsb pdb:4YFE|rcsb pdb:4YFG|rcsb pdb:4YH7|rcsb pdb:5XWT|rcsb pdb:5XWU|rcsb pdb:5Y32|rcsb pdb:6KIP|rcsb pdb:7CEG|reactome:R-MMU-388844|reactome:R-MMU-8849932	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:FkLHZVFqjCRQ5GQ+76uKWFhBYYg10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q69ZT9	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9661389|uniprotkb:B9EHP9|uniprotkb:Q6AXF5|uniprotkb:Q6PCX1|uniprotkb:Q8C8T3|ensembl:ENSMUSP00000070488	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:tbc30_mouse(display_long)|uniprotkb:Tbc1d30(gene name)|psi-mi:Tbc1d30(display_short)|uniprotkb:Kiaa0984(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_083333.1|ensembl:ENSMUSG00000052302(gene)|ensembl:ENSMUST00000064107(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR032738|interpro:IPR035969	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:Ad+8r2MdaFmGmXDgUi14V7+e9zU10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:O08583	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-6464301|ensembl:ENSMUSP00000026125|uniprotkb:Q0VBL5|uniprotkb:Q8CBM4|uniprotkb:Q9JJW7	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:thoc4_mouse(display_long)|uniprotkb:Alyref(gene name)|psi-mi:Alyref(display_short)|uniprotkb:Aly(gene name synonym)|uniprotkb:Ref1(gene name synonym)|uniprotkb:Refbp1(gene name synonym)|uniprotkb:THOC4(gene name synonym)|uniprotkb:Ally of AML-1 and LEF-1(gene name synonym)|uniprotkb:Aly/REF export factor(gene name synonym)|uniprotkb:REF1-I(gene name synonym)|uniprotkb:RNA and export factor-binding protein 1(gene name synonym)|uniprotkb:Transcriptional coactivator Aly/REF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000025134(gene)|ensembl:ENSMUST00000026125(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0051028"(mRNA transport)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR025715|interpro:IPR035979|mint:O08583|rcsb pdb:1NO8|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|refseq:NP_035698.1|dip:DIP-59977N	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:DZAvcQrp7S1uipKsc/Wpxgb+gJI10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P60843	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-6665935|ensembl:ENSMUSP00000127034|uniprotkb:P04765|uniprotkb:Q61516	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:if4a1_mouse(display_long)|uniprotkb:Eif4a1(gene name)|psi-mi:Eif4a1(display_short)|uniprotkb:Ddx2a(gene name synonym)|uniprotkb:Eif4a(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000059796(gene)|ensembl:ENSMUST00000163666(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P60843|rcsb pdb:6XKI|reactome:R-MMU-1169408|reactome:R-MMU-156827|reactome:R-MMU-429947|reactome:R-MMU-72649|reactome:R-MMU-72662|reactome:R-MMU-72702|reactome:R-MMU-72706|refseq:NP_659207.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:e+2gp47oHrpxFbrBFSM4qTf3r7E10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9D2M8	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-911251|uniprotkb:Q8BGH6|uniprotkb:Q8CE99|uniprotkb:Q8K2V7|uniprotkb:Q9CYD7|uniprotkb:Q9ERI8|uniprotkb:A6X924|ensembl:ENSMUSP00000111443	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ub2v2_mouse(display_long)|uniprotkb:Ubc-like protein MMS2(gene name synonym)|uniprotkb:Ube2v2(gene name)|psi-mi:Ube2v2(display_short)|uniprotkb:Mms2(gene name synonym)|uniprotkb:Uev2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001152823.1|refseq:NP_076074.2|ensembl:ENSMUSG00000022674(gene)|ensembl:ENSMUST00000115777(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042275"(error-free postreplication DNA repair)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9D2M8|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-8866654|reactome:R-MMU-983168	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:nY0ENcwjbooLvqOoe1NdM4Dp4J410090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q5RJY2	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9661405|uniprotkb:E9QK24|uniprotkb:Q6ZPT7|uniprotkb:Q8BNA4|ensembl:ENSMUSP00000054474	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:g2e3_mouse(display_long)|uniprotkb:G2e3(gene name)|psi-mi:G2e3(display_short)|uniprotkb:Kiaa1333(gene name synonym)|uniprotkb:G2/M phase-specific HECT-type E3 ubiquitin transferase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001015099.2|refseq:NP_001161435.1|refseq:NP_001161436.1|interpro:IPR000569(HECT)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR034732|interpro:IPR035983|interpro:IPR042012|interpro:IPR042013|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|ensembl:ENSMUSG00000035293(gene)|ensembl:ENSMUST00000054308(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:VuDFAtSJRgjiZkzTbwrqtyPqcIY10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q501J6	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-911206|uniprotkb:Q6P5G1|uniprotkb:Q8BIN2|ensembl:ENSMUSP00000155307	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddx17_mouse(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:Ddx17(gene name)|psi-mi:Ddx17(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001035277.1|refseq:NP_951061.1|refseq:NP_951062.1|ensembl:ENSMUSG00000055065(gene)|ensembl:ENSMUST00000229877(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0061614"(miRNA transcription)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q501J6|reactome:R-MMU-3899300	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:uGXMsVmy7MWcTaJPNlkof05dS8I10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q62167	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:O35737	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-299747|ensembl:ENSMUSP00000070503|ensembl:ENSMUSP00000104770	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:hnrh1_mouse(display_long)|uniprotkb:Hnrnph1(gene name)|psi-mi:Hnrnph1(display_short)|uniprotkb:Hnrph(gene name synonym)|uniprotkb:Hnrph1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	ensembl:ENSMUSG00000007850(gene)|ensembl:ENSMUST00000069304(transcript)|ensembl:ENSMUST00000109142(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:O35737|reactome:R-MMU-6803529|reactome:R-MMU-72163|reactome:R-MMU-72203|refseq:NP_067485.1|refseq:XP_017170179.1|refseq:XP_017170180.1	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:nBSCiXDDfkwqslFAXPXlDzC+5e410090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q80ZK9	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-9662821|ensembl:ENSMUSP00000040647	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:wdtc1_mouse(display_long)|uniprotkb:Wdtc1(gene name)|psi-mi:Wdtc1(display_short)|uniprotkb:Gm695(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_955010.1|refseq:XP_006538806.1|refseq:XP_006538807.1|ensembl:ENSMUSG00000037622(gene)|ensembl:ENSMUST00000043305(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0055082"(cellular chemical homeostasis)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019734|interpro:IPR036322|reactome:R-MMU-8951664	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:4M6FI8xJ26iVLB9MvyaEXpjMCbI10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q05512	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-771728|uniprotkb:Q3T9L3|uniprotkb:Q6PDR4|uniprotkb:Q8BR95	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:mark2_mouse(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:Mark2(gene name)|psi-mi:Mark2(display_short)|uniprotkb:Emk(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001073857.1|refseq:NP_001073858.1|refseq:NP_001073859.1|refseq:NP_031954.2|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028375|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001764"(neuron migration)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045180"(basal cortex)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:RiipGX3uA3cvQACWclxzpLcJQVU10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:P52332	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-646320|uniprotkb:Q62126	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:jak1_mouse(display_long)|uniprotkb:Janus kinase 1(gene name synonym)|uniprotkb:Jak1(gene name)|psi-mi:Jak1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	dip:DIP-41965N|mint:P52332|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|reactome:R-MMU-1059683|reactome:R-MMU-110056|reactome:R-MMU-112411|reactome:R-MMU-1169408|reactome:R-MMU-1266695|reactome:R-MMU-5673001|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020591|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912526|reactome:R-MMU-912694|reactome:R-MMU-9674555|reactome:R-MMU-9705462	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:UIkyfJs6ggPxf4nXciyTLPqerSA10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q9R1R2	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-775991|uniprotkb:Q3UMU5|ensembl:ENSMUSP00000053384|ensembl:ENSMUSP00000102401|ensembl:ENSMUSP00000114822	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:trim3_mouse(display_long)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:RING finger protein HAC1(gene name synonym)|uniprotkb:Trim3(gene name)|psi-mi:Trim3(display_short)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Rnf22(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9661302|imex:IM-22990-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_001272799.1|refseq:NP_001272800.1|refseq:NP_001272802.1|refseq:NP_061368.1|ensembl:ENSMUSG00000036989(gene)|ensembl:ENSMUST00000057525(transcript)|ensembl:ENSMUST00000106789(transcript)|ensembl:ENSMUST00000147044(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:Q9R1R2	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Supplementary Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mes13)|taxid:10090(Mus musculus)	-	2014/07/15	2019/04/15	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:fOQH1BPgmOXrJXOb8VYYFpNX0UQ10090	intact-crc:FA4B8BFE1CD3C26B|rigid:R8+Tm5rWxgGG7gMD3QQYWiNVLdE	false	sufficient binding region:1364-1863|calmodulin binding peptide plus protein a tag:n-n|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q923J1	uniprotkb:Q99496	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-722416|uniprotkb:Q5TEN1|uniprotkb:Q5TEN2|uniprotkb:B2RBS7|uniprotkb:B3KRH1|ensembl:ENSP00000356480	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:ring2_human(display_long)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING finger protein BAP-1(gene name synonym)|uniprotkb:Protein DinG(gene name synonym)|uniprotkb:Huntingtin-interacting protein 2-interacting protein 3(gene name synonym)|uniprotkb:RNF2(gene name)|psi-mi:RNF2(display_short)|uniprotkb:BAP1(gene name synonym)|uniprotkb:DING(gene name synonym)|uniprotkb:HIPI3(gene name synonym)|uniprotkb:RING1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9688153|imex:IM-22990-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_009143.1|refseq:XP_011508153.1|refseq:XP_011508154.1|dip:DIP-40034N|ensembl:ENSG00000121481(gene)|ensembl:ENST00000367510(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q99496|rcsb pdb:2H0D|rcsb pdb:3GS2|rcsb pdb:3H8H|rcsb pdb:3IXS|rcsb pdb:3RPG|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:7ND1|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|reactome:R-HSA-8953750	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2014/10/16	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:pqAjSEwOUdfuogKW6fodqsUSHIk9606	intact-crc:112139C40C374D3D|rigid:zJIvzG140TuYZv/eLHQDLHjc2DU	false	ha tag:c-c|necessary binding region:1299-1444	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q923J1	uniprotkb:Q8N488	intact:EBI-8010314|uniprotkb:Q8CE54|uniprotkb:Q9CUT2|uniprotkb:Q921Y5|intact:MINT-2524821|uniprotkb:A2AI58|uniprotkb:Q8C7S7|uniprotkb:Q925B2|uniprotkb:Q9JLQ1|ensembl:ENSMUSP00000099513	intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494	psi-mi:trpm7_mouse(display_long)|uniprotkb:Trpm7(gene name)|psi-mi:Trpm7(display_short)|uniprotkb:Chak(gene name synonym)|uniprotkb:Ltrpc7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym)|uniprotkb:Transient receptor potential-phospholipase C-interacting kinase(gene name synonym)	psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Krapivinsky et al. (2014)	pubmed:24855944|imex:IM-22990	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9688137|interpro:IPR0005634|imex:IM-22990-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067425.2|refseq:NP_001157797.1|ensembl:ENSMUSG00000027365(gene)|ensembl:ENSMUST00000103224(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043196"(varicosity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q923J1|rcsb pdb:1IA9|rcsb pdb:1IAH|rcsb pdb:1IAJ|rcsb pdb:5ZX5|rcsb pdb:6BWD|rcsb pdb:6BWF|reactome:R-MMU-3295583	refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)	-	comment:mint|function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"	-	figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2014/10/16	rogid:ZHJlPU2xkJ/SONyBbsuD9XMTmKA10090	rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606	intact-crc:E5A16468B4B55322|rigid:VrE3qdv58+6wDvVUWQz4eYXWxFM	false	ha tag:c-c|necessary binding region:1299-1444	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)