#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78380	uniprotkb:P40227	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356687|uniprotkb:Q3KP28|uniprotkb:Q75LP4|uniprotkb:Q96S46|ensembl:ENSP00000275603|intact:EBI-5912031|uniprotkb:A6NCD2	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpz_human(display_long)|uniprotkb:CCT6A(gene name)|psi-mi:CCT6A(display_short)|uniprotkb:CCT6(gene name synonym)|uniprotkb:CCTZ(gene name synonym)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Tcp20(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Acute morphine dependence-related protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518125|imex:IM-22595-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_001753.1|ensembl:ENSG00000146731(gene)|ensembl:ENST00000275603(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P40227|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|refseq:NP_001009186.1|dip:DIP-33558N	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:st1 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:kX6/rTGZbGuVLNgBW6IxdNlU46U9606	intact-crc:DF9D489FC2DF04EE|rigid:oYBtSct56Qrk2/jsSO/opgGAUgk	false	binding-associated region:1-33|biotin tag:?-?	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78380	uniprotkb:P50991	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518125|imex:IM-22595-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:st1 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606	intact-crc:DF9D489FC2DF04EE|rigid:oYBtSct56Qrk2/jsSO/opgGAUgk	false	binding-associated region:1-33|biotin tag:?-?	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78380	uniprotkb:P49368	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518125|imex:IM-22595-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:st1 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606	intact-crc:DF9D489FC2DF04EE|rigid:oYBtSct56Qrk2/jsSO/opgGAUgk	false	binding-associated region:1-33|biotin tag:?-?	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78380	uniprotkb:Q99832	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518125|imex:IM-22595-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:st1 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606	intact-crc:DF9D489FC2DF04EE|rigid:oYBtSct56Qrk2/jsSO/opgGAUgk	false	binding-associated region:1-33|biotin tag:?-?	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78380	uniprotkb:Q9BU08	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-9518127	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:q9bu08_human(display_long)|uniprotkb:T-complex protein 1 subunit epsilon(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518125|imex:IM-22595-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	interpro:IPR027410|mint:Q9BU08|interpro:IPR012718(T-complex protein 1, epsilon subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:st1 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:8z0k1Ykl5sRjFLxnClewu73+JcM9606	intact-crc:DF9D489FC2DF04EE|rigid:oYBtSct56Qrk2/jsSO/opgGAUgk	false	binding-associated region:1-33|biotin tag:?-?	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78380	uniprotkb:P17987	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518125|imex:IM-22595-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:st1 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:DF9D489FC2DF04EE|rigid:oYBtSct56Qrk2/jsSO/opgGAUgk	false	binding-associated region:1-33|biotin tag:?-?	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P78380	uniprotkb:P17987	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518189|imex:IM-22595-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:f3b f5b|comment:"Western  blot analysis showed that CCT1 coimmunoprecipitated with LOX-1 in untreated cells but not inOxLDL-treated cells (Fig. 5B). Thus, our findings indicate that OxLDL suppressed the CCT  interaction with LOX-1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:5F38405733D777DF|rigid:rWQpyPrretr8XFyYi4D+OnB41O8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78380	uniprotkb:P50991	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518195|imex:IM-22595-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606	intact-crc:80204C295CF1D2F1|rigid:95Fq6GL4X6XTF0KvVGmP8p+Sv/E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15075	uniprotkb:P78380	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518233|imex:IM-22595-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	go:"GO:0034498"(early endosome to Golgi transport)	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/05/06	2014/10/16	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	intact-crc:74B5427597B8E0D8|rigid:acxBp7sjD4Y3o7OxhzNfyc2Abm0	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q15075	uniprotkb:P17987	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518233|imex:IM-22595-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	go:"GO:0034498"(early endosome to Golgi transport)	-	-	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/05/06	2014/10/16	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:74B5427597B8E0D8|rigid:acxBp7sjD4Y3o7OxhzNfyc2Abm0	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P20645	uniprotkb:P78380	intact:EBI-2907262|ensembl:ENSP00000000412|uniprotkb:A8K528|uniprotkb:D3DUV5	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	psi-mi:mprd_human(display_long)|uniprotkb:M6PR(gene name)|psi-mi:M6PR(display_short)|uniprotkb:MPR46(gene name synonym)|uniprotkb:MPRD(gene name synonym)|uniprotkb:46 kDa mannose 6-phosphate receptor(gene name synonym)	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518243|imex:IM-22595-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000003056(gene)|ensembl:ENST00000000412(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0033299"(secretion of lysosomal enzymes)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000296(Cation-dependent mannose-6-phosphate receptor)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR028927|interpro:IPR044865|mint:P20645|rcsb pdb:1JUQ|reactome:R-HSA-432720|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_002346.1|refseq:XP_005253433.1	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	go:"GO:0005770"(late endosome)	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/05/06	2014/10/16	rogid:Nx1pgku9M1SjHH42s5ZAY7c7eDc9606	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	intact-crc:4718E0B2CD34FFD6|rigid:vtvxJBskjNUcR/ln8PR7YFv80x4	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P20645	uniprotkb:P17987	intact:EBI-2907262|ensembl:ENSP00000000412|uniprotkb:A8K528|uniprotkb:D3DUV5	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:mprd_human(display_long)|uniprotkb:M6PR(gene name)|psi-mi:M6PR(display_short)|uniprotkb:MPR46(gene name synonym)|uniprotkb:MPRD(gene name synonym)|uniprotkb:46 kDa mannose 6-phosphate receptor(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518243|imex:IM-22595-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000003056(gene)|ensembl:ENST00000000412(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0033299"(secretion of lysosomal enzymes)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000296(Cation-dependent mannose-6-phosphate receptor)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR028927|interpro:IPR044865|mint:P20645|rcsb pdb:1JUQ|reactome:R-HSA-432720|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_002346.1|refseq:XP_005253433.1	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	go:"GO:0005770"(late endosome)	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/05/06	2014/10/16	rogid:Nx1pgku9M1SjHH42s5ZAY7c7eDc9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:4718E0B2CD34FFD6|rigid:vtvxJBskjNUcR/ln8PR7YFv80x4	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P78380	uniprotkb:P17987	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518208|imex:IM-22595-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	go:"GO:0031410"(cytoplasmic vesicle)	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:f3c f5a sf3|comment:"However, in HUVECs treated with DiI-OxLDL, the colocalization of LOX-1 and CCT1 within  these vesicles decreased (Fig. 5A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:753CC4D922F6B0B7|rigid:rWQpyPrretr8XFyYi4D+OnB41O8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P78380	uniprotkb:P17987	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9519369|imex:IM-22595-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:9B7EA76E50CF377A|rigid:rWQpyPrretr8XFyYi4D+OnB41O8	false	biotin tag:?-?|binding-associated region:1-33	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P78380	uniprotkb:P17987	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9518221|imex:IM-22595-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:f4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:DA122968DE5BD8EB|rigid:rWQpyPrretr8XFyYi4D+OnB41O8	false	biotin tag:?-?|binding-associated region:1-33	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78380	uniprotkb:P50991	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bakthavatsalam et al. (2014)	imex:IM-22595|pubmed:24846140	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9519326|imex:IM-22595-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998	-	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	-	figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/06	2014/10/16	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606	intact-crc:047334BAB98E92F4|rigid:95Fq6GL4X6XTF0KvVGmP8p+Sv/E	false	binding-associated region:1-33|biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)