#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62340	uniprotkb:P52655	intact:EBI-7640256|ensembl:ENSMUSP00000093470|ensembl:ENSMUSP00000114223|uniprotkb:O95753|intact:MINT-1348231|uniprotkb:Q9Z2Z0	intact:EBI-389518|uniprotkb:Q3KNQ9|ensembl:ENSP00000452454	psi-mi:tbpl1_mouse(display_long)|uniprotkb:Tbpl1(gene name)|psi-mi:Tbpl1(display_short)|uniprotkb:Tlp(gene name synonym)|uniprotkb:Tlp21(gene name synonym)|uniprotkb:Tlf(gene name synonym)|uniprotkb:Trf2(gene name synonym)|uniprotkb:Trp(gene name synonym)|uniprotkb:TATA box-binding protein-related factor 2(gene name synonym)|uniprotkb:TBP-like factor(gene name synonym)|uniprotkb:TBP-related protein(gene name synonym)|uniprotkb:21 kDa TBP-like protein(gene name synonym)	psi-mi:tf2aa_human(display_long)|uniprotkb:GTF2A1(gene name)|psi-mi:GTF2A1(display_short)|uniprotkb:TF2A1(gene name synonym)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym)|uniprotkb:Transcription initiation factor TFIIA 42 kDa subunit(gene name synonym)|uniprotkb:TFIIAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2014)	pubmed:24835508|imex:IM-22599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9524851|imex:IM-22599-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000071359(gene)|ensembl:ENSMUST00000095794(transcript)|ensembl:ENSMUST00000127698(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001675"(acrosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006235"(dTTP biosynthetic process)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0140223"(general transcription initiation factor activity)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR015445(TATA-Box binding protein-like)|refseq:NP_035733.1|refseq:XP_006512793.1	refseq:NP_056943.1|refseq:NP_963889.1|refseq:NP_001265869.1|ensembl:ENSG00000165417(gene)|ensembl:ENST00000553612(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|rcsb pdb:1NVP|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M4S|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-9018519|dip:DIP-33225N	-	function:Does not bind the TATA box. Has DNA-binding ability|comment:mint	-	figure legend:f1|comment:"In this study, we first investigated in detail the intracellular  TFIIA-binding strength of those mutants by co-immunoprecipitation assays. It was  confirmed that wild-type TLP and R55E exhibited significant binding to TFIIA, whereas N37E did not bind to TFIIA (Fig. 1). We further investigated  processed and unprocessed forms of TFIIAα/β and found that R52E binds to the α  and β subunits of TFIIA but does not bind to uncleaved TFIIAαβ (Fig. 1, lane 12)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2014/05/13	2014/10/16	rogid:xMdqGuzUlbzGS1MsLP100y1CiVc10090	rogid:yatX/WS3e+54rhzDnTzIiI17JSY9606	intact-crc:73C7C033003A5559|rigid:VPFcKURYkGZtgVJrQvRy4EKCWAw	false	tandem tag:?-?|mutation disrupting interaction:37-37	binding-associated region:2-274	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62340	uniprotkb:P52655	intact:EBI-7640256|ensembl:ENSMUSP00000093470|ensembl:ENSMUSP00000114223|uniprotkb:O95753|intact:MINT-1348231|uniprotkb:Q9Z2Z0	intact:EBI-389518|uniprotkb:Q3KNQ9|ensembl:ENSP00000452454	psi-mi:tbpl1_mouse(display_long)|uniprotkb:Tbpl1(gene name)|psi-mi:Tbpl1(display_short)|uniprotkb:Tlp(gene name synonym)|uniprotkb:Tlp21(gene name synonym)|uniprotkb:Tlf(gene name synonym)|uniprotkb:Trf2(gene name synonym)|uniprotkb:Trp(gene name synonym)|uniprotkb:TATA box-binding protein-related factor 2(gene name synonym)|uniprotkb:TBP-like factor(gene name synonym)|uniprotkb:TBP-related protein(gene name synonym)|uniprotkb:21 kDa TBP-like protein(gene name synonym)	psi-mi:tf2aa_human(display_long)|uniprotkb:GTF2A1(gene name)|psi-mi:GTF2A1(display_short)|uniprotkb:TF2A1(gene name synonym)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym)|uniprotkb:Transcription initiation factor TFIIA 42 kDa subunit(gene name synonym)|uniprotkb:TFIIAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2014)	pubmed:24835508|imex:IM-22599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9524851|imex:IM-22599-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000071359(gene)|ensembl:ENSMUST00000095794(transcript)|ensembl:ENSMUST00000127698(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001675"(acrosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006235"(dTTP biosynthetic process)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0140223"(general transcription initiation factor activity)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR015445(TATA-Box binding protein-like)|refseq:NP_035733.1|refseq:XP_006512793.1	refseq:NP_056943.1|refseq:NP_963889.1|refseq:NP_001265869.1|ensembl:ENSG00000165417(gene)|ensembl:ENST00000553612(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|rcsb pdb:1NVP|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M4S|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-9018519|dip:DIP-33225N	-	function:Does not bind the TATA box. Has DNA-binding ability|comment:mint	-	figure legend:f1|comment:"In this study, we first investigated in detail the intracellular  TFIIA-binding strength of those mutants by co-immunoprecipitation assays. It was  confirmed that wild-type TLP and R55E exhibited significant binding to TFIIA, whereas N37E did not bind to TFIIA (Fig. 1). We further investigated  processed and unprocessed forms of TFIIAα/β and found that R52E binds to the α  and β subunits of TFIIA but does not bind to uncleaved TFIIAαβ (Fig. 1, lane 12)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2014/05/13	2014/10/16	rogid:xMdqGuzUlbzGS1MsLP100y1CiVc10090	rogid:yatX/WS3e+54rhzDnTzIiI17JSY9606	intact-crc:73C7C033003A5559|rigid:VPFcKURYkGZtgVJrQvRy4EKCWAw	false	tandem tag:?-?|mutation disrupting interaction:37-37	binding-associated region:275-376	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52655	uniprotkb:P62380	intact:EBI-389518|uniprotkb:Q3KNQ9|ensembl:ENSP00000452454	intact:EBI-716225|uniprotkb:O95753|uniprotkb:Q9BWD5|uniprotkb:Q9Z2Z0|uniprotkb:A8K8F5|ensembl:ENSP00000237264|ensembl:ENSP00000478795	psi-mi:tf2aa_human(display_long)|uniprotkb:GTF2A1(gene name)|psi-mi:GTF2A1(display_short)|uniprotkb:TF2A1(gene name synonym)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym)|uniprotkb:Transcription initiation factor TFIIA 42 kDa subunit(gene name synonym)|uniprotkb:TFIIAL(gene name synonym)	psi-mi:tbpl1_human(display_long)|uniprotkb:TATA box-binding protein-related factor 2(gene name synonym)|uniprotkb:TLF(gene name synonym)|uniprotkb:21 kDa TBP-like protein(gene name synonym)|uniprotkb:TBPL1(gene name)|psi-mi:TBPL1(display_short)|uniprotkb:TLP(gene name synonym)|uniprotkb:TLP21(gene name synonym)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRP(gene name synonym)|uniprotkb:TBP-related protein(gene name synonym)|uniprotkb:TBP-like factor(gene name synonym)|uniprotkb:Second TBP of unique DNA protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Suzuki et al. (2014)	pubmed:24835508|imex:IM-22599	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9524891|imex:IM-22599-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056943.1|refseq:NP_963889.1|refseq:NP_001265869.1|ensembl:ENSG00000165417(gene)|ensembl:ENST00000553612(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|rcsb pdb:1NVP|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M4S|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-9018519|dip:DIP-33225N	refseq:NP_004856.1|refseq:NP_001240605.1|go:"GO:0006235"(dTTP biosynthetic process)|ensembl:ENSG00000028839(gene)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007289"(spermatid nucleus differentiation)|ensembl:ENST00000237264(transcript)|ensembl:ENST00000613034(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001675"(acrosome assembly)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0140223"(general transcription initiation factor activity)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR015445(TATA-Box binding protein-like)|refseq:XP_016867002.1	-	-	-	figure legend:f6f|comment:"We then examined effect of etoposide on TLP-TFIIA  interaction. A co-immunoprecipitation experiment revealed that TLP and TFIIA form an  intracellular complex in etoposide-treated cells upon DNA damage (Fig. 6F)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2014/05/13	2014/10/16	rogid:yatX/WS3e+54rhzDnTzIiI17JSY9606	rogid:xMdqGuzUlbzGS1MsLP100y1CiVc9606	intact-crc:D996087F12664B27|rigid:bXWHoxUJHmSQVCx+ALSPk8tHQuc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)