#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q920F6 uniprotkb:O70576 intact:EBI-8351315|intact:MINT-4134790|ensembl:ENSMUSP00000023068 intact:EBI-8571608|ensembl:ENSMUSP00000040945|ensembl:ENSMUSP00000125523|intact:UNK-5365402|uniprotkb:B2RSV0 psi-mi:smc1b_mouse(display_long)|uniprotkb:Smc1b(gene name)|psi-mi:Smc1b(display_short)|uniprotkb:Smc1l2(gene name synonym) psi-mi:stag3_mouse(display_long)|uniprotkb:Stromalin-3(gene name synonym)|uniprotkb:Stag3(gene name)|psi-mi:Stag3(display_short)|uniprotkb:Stromal antigen 3(gene name synonym)|uniprotkb:SCC3 homolog 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Winters et al. (2014) pubmed:24797474|imex:IM-23050 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-9699307|imex:IM-23050-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_536718.1|ensembl:ENSMUSG00000022432(gene)|ensembl:ENSMUST00000023068(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR036277|mint:Q920F6 refseq:XP_011239250.1|ensembl:ENSMUSG00000036928(gene)|ensembl:ENSMUST00000048028(transcript)|ensembl:ENSMUST00000162245(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0000802"(transverse filament)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007065"(male meiosis sister chromatid cohesion)|go:"GO:0007066"(female meiosis sister chromatid cohesion)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0008278"(cohesin complex)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0034991"(nuclear meiotic cohesin complex)|interpro:IPR013721(STAG)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020839|interpro:IPR039662|mint:O70576|refseq:XP_006504659.1|refseq:NP_058660.2|dip:DIP-60731N go:"GO:0005634"(nucleus) comment:mint|function:"Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I" function:Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I|comment:mint figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/08/10 2014/10/16 rogid:1EEeJ21AepYX9+6+xmPXaVLtZ7810090 rogid:VStlV0vm44TtcEnvNQTLPTFy2ok10090 intact-crc:47E8F6F418D8130E|rigid:hhMLIIwSiY8HFtHYFSsk0Q8X+/s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q920F6 uniprotkb:Q8C5S7 intact:EBI-8351315|intact:MINT-4134790|ensembl:ENSMUSP00000023068 intact:EBI-8571691|ensembl:ENSMUSP00000002395|uniprotkb:Q3UIN9|intact:UNK-5513402|uniprotkb:Q9JK52 psi-mi:smc1b_mouse(display_long)|uniprotkb:Smc1b(gene name)|psi-mi:Smc1b(display_short)|uniprotkb:Smc1l2(gene name synonym) psi-mi:rec8_mouse(display_long)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:Rec8(gene name)|psi-mi:Rec8(display_short)|uniprotkb:Mei8(gene name synonym)|uniprotkb:Rec8L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Winters et al. (2014) pubmed:24797474|imex:IM-23050 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-9699307|imex:IM-23050-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_536718.1|ensembl:ENSMUSG00000022432(gene)|ensembl:ENSMUST00000023068(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR036277|mint:Q920F6 ensembl:ENSMUSG00000002324(gene)|ensembl:ENSMUST00000002395(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007141"(male meiosis I)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|go:"GO:0003682"(chromatin binding)|refseq:NP_064386.2|dip:DIP-60730N go:"GO:0005634"(nucleus) comment:mint|function:"Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I" comment:mint|function:Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/08/10 2014/10/16 rogid:1EEeJ21AepYX9+6+xmPXaVLtZ7810090 rogid:wcsRCrbsVBKW3reh5uW+EN080oU10090 intact-crc:47E8F6F418D8130E|rigid:hhMLIIwSiY8HFtHYFSsk0Q8X+/s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q920F6 uniprotkb:A2AU37 intact:EBI-8351315|intact:MINT-4134790|ensembl:ENSMUSP00000023068 intact:EBI-8572441|ensembl:ENSMUSP00000136918|intact:MINT-8174264|uniprotkb:F6KST0|uniprotkb:E5RTP6|intact:MINT-8174092 psi-mi:smc1b_mouse(display_long)|uniprotkb:Smc1b(gene name)|psi-mi:Smc1b(display_short)|uniprotkb:Smc1l2(gene name synonym) psi-mi:rd21l_mouse(display_long)|uniprotkb:Rad21l1(gene name)|psi-mi:Rad21l1(display_short)|uniprotkb:Gm14160(gene name synonym)|uniprotkb:Rad21l(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Winters et al. (2014) pubmed:24797474|imex:IM-23050 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-9699307|imex:IM-23050-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_536718.1|ensembl:ENSMUSG00000022432(gene)|ensembl:ENSMUST00000023068(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR036277|mint:Q920F6 ensembl:ENSMUSG00000074704(gene)|ensembl:ENSMUST00000180195(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0070197"(meiotic attachment of telomere to nuclear envelope)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|refseq:XP_006500105.1|refseq:XP_006500106.1|refseq:NP_001263329.1|dip:DIP-60729N go:"GO:0005634"(nucleus) comment:mint|function:"Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I" comment:mint figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/08/10 2014/10/16 rogid:1EEeJ21AepYX9+6+xmPXaVLtZ7810090 rogid:z8WZFTHSHhOOfT6F/EHl3GVaFEA10090 intact-crc:47E8F6F418D8130E|rigid:hhMLIIwSiY8HFtHYFSsk0Q8X+/s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q920F6 uniprotkb:Q9D3E6 intact:EBI-8351315|intact:MINT-4134790|ensembl:ENSMUSP00000023068 intact:EBI-8430060|uniprotkb:O08982|intact:MINT-4135756|uniprotkb:Q6P5D1|ensembl:ENSMUSP00000116205 psi-mi:smc1b_mouse(display_long)|uniprotkb:Smc1b(gene name)|psi-mi:Smc1b(display_short)|uniprotkb:Smc1l2(gene name synonym) psi-mi:stag1_mouse(display_long)|uniprotkb:Stag1(gene name)|psi-mi:Stag1(display_short)|uniprotkb:Sa1(gene name synonym)|uniprotkb:Stromal antigen 1(gene name synonym)|uniprotkb:SCC3 homolog 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Winters et al. (2014) pubmed:24797474|imex:IM-23050 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-9699307|imex:IM-23050-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_536718.1|ensembl:ENSMUSG00000022432(gene)|ensembl:ENSMUST00000023068(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR036277|mint:Q920F6 refseq:NP_033308.2|refseq:XP_006510986.1|refseq:XP_006510987.1|ensembl:ENSMUSG00000037286(gene)|ensembl:ENSMUST00000129269(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR013721(STAG)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020839|interpro:IPR039662|mint:Q9D3E6|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214 go:"GO:0005634"(nucleus) comment:mint|function:"Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I" function:Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis|comment:mint figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/08/10 2014/10/16 rogid:1EEeJ21AepYX9+6+xmPXaVLtZ7810090 rogid:s1WGi5ZDTZuZS4q0KFS/tvL+FXk10090 intact-crc:47E8F6F418D8130E|rigid:hhMLIIwSiY8HFtHYFSsk0Q8X+/s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q920F6 uniprotkb:Q9CW03 intact:EBI-8351315|intact:MINT-4134790|ensembl:ENSMUSP00000023068 intact:EBI-2550068|ensembl:ENSMUSP00000025930|uniprotkb:O35667|uniprotkb:Q9QUS3 psi-mi:smc1b_mouse(display_long)|uniprotkb:Smc1b(gene name)|psi-mi:Smc1b(display_short)|uniprotkb:Smc1l2(gene name synonym) psi-mi:smc3_mouse(display_long)|uniprotkb:Smc3(gene name)|psi-mi:Smc3(display_short)|uniprotkb:Bam(gene name synonym)|uniprotkb:Bmh(gene name synonym)|uniprotkb:Cspg6(gene name synonym)|uniprotkb:Mmip1(gene name synonym)|uniprotkb:Smc3l1(gene name synonym)|uniprotkb:Smcd(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome segregation protein SmcD(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:Mad member-interacting protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Winters et al. (2014) pubmed:24797474|imex:IM-23050 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-9699307|imex:IM-23050-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_536718.1|ensembl:ENSMUSG00000022432(gene)|ensembl:ENSMUST00000023068(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR036277|mint:Q920F6 ensembl:ENSMUSG00000024974(gene)|ensembl:ENSMUST00000025930(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9CW03|rcsb pdb:2WD5|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_031816.2|dip:DIP-57028N go:"GO:0005634"(nucleus) comment:mint|function:"Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I" - figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/08/10 2014/10/16 rogid:1EEeJ21AepYX9+6+xmPXaVLtZ7810090 rogid:9tJqVTJ2k3viYrJVtDfH2TekFIg10090 intact-crc:47E8F6F418D8130E|rigid:hhMLIIwSiY8HFtHYFSsk0Q8X+/s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q920F6 uniprotkb:O35638 intact:EBI-8351315|intact:MINT-4134790|ensembl:ENSMUSP00000023068 intact:EBI-2552452|uniprotkb:A2AFF5|ensembl:ENSMUSP00000063250|ensembl:ENSMUSP00000110724|uniprotkb:Q6NZN7 psi-mi:smc1b_mouse(display_long)|uniprotkb:Smc1b(gene name)|psi-mi:Smc1b(display_short)|uniprotkb:Smc1l2(gene name synonym) psi-mi:stag2_mouse(display_long)|uniprotkb:Sa2(gene name synonym)|uniprotkb:Sap2(gene name synonym)|uniprotkb:Stromal antigen 2(gene name synonym)|uniprotkb:SCC3 homolog 2(gene name synonym)|uniprotkb:Stag2(gene name)|psi-mi:Stag2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Winters et al. (2014) pubmed:24797474|imex:IM-23050 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-9699307|imex:IM-23050-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_536718.1|ensembl:ENSMUSG00000022432(gene)|ensembl:ENSMUST00000023068(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR036277|mint:Q920F6 refseq:XP_011249291.1|refseq:NP_001071180.1|refseq:NP_067440.3|ensembl:ENSMUSG00000025862(gene)|ensembl:ENSMUST00000069619(transcript)|ensembl:ENSMUST00000115072(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR013721(STAG)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020839|interpro:IPR039662|mint:O35638|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:XP_017173935.1|dip:DIP-56691N go:"GO:0005634"(nucleus) comment:mint|function:"Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I" - figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/08/10 2014/10/16 rogid:1EEeJ21AepYX9+6+xmPXaVLtZ7810090 rogid:slv+K6fE4lx5odAUZue0IodEYQk10090 intact-crc:47E8F6F418D8130E|rigid:hhMLIIwSiY8HFtHYFSsk0Q8X+/s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)