#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:15996"	uniprotkb:P01116	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9688979|imex:IM-22639-14	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006184"(obsolete GTP catabolic process)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp. 2D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	intact-crc:CA36CCCDFF99C0CC	false	32p radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548863|imex:IM-22639-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	go:"GO:0003924"(GTPase activity)|go:"GO:0006184"(obsolete GTP catabolic process)|go:"GO:0005525"(GTP binding)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2B, Supp. 2D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:58F7E667D4698EEA	false	32p radiolabel:?-?	mutation decreasing interaction rate:75-75|mutation increasing interaction rate:75-75(IPR005225)|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548941|imex:IM-22639-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2A...|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:4E6048549498DF32	false	32p radiolabel:?-?	glutathione s tranferase tag:n-n|sufficient binding region:19-178(IPR005225)|mutation disrupting interaction:30-30	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548941|imex:IM-22639-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2A...|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:4E6048549498DF32	false	-	glutathione s tranferase tag:n-n|sufficient binding region:19-178(IPR005225)|mutation disrupting interaction:30-30	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548771|imex:IM-22639-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:65D4FD6383373CF1	false	32p radiolabel:?-?	glutathione s tranferase tag:n-n|sufficient binding region:19-178(IPR005225)|mutation disrupting interaction:30-30	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:17552"	uniprotkb:Q8CFP6	intact:EBI-1265684	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548813|imex:IM-22639-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	-	-	figure legend:2Ai|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:9A05621A2B110B68	false	-	mutation disrupting interaction:30-30|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548813|imex:IM-22639-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2Ai|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:9A05621A2B110B68	false	32p radiolabel:?-?	mutation disrupting interaction:30-30|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548831|imex:IM-22639-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2Aii|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:1D4675621A2B110B	false	32p radiolabel:?-?	glutathione s tranferase tag:n-n|mutation disrupting interaction:30-30	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:43000"	uniprotkb:Q8CFP6	intact:EBI-1388758	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:guanosine 5'-[gamma-thio]triphosphate(display_short)|psi-mi:"CHEBI:43000"(display_long)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548831|imex:IM-22639-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	-	-	figure legend:2Aii|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:1D4675621A2B110B	false	-	glutathione s tranferase tag:n-n|mutation disrupting interaction:30-30	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
chebi:"CHEBI:17552"	uniprotkb:Q8CFP6	intact:EBI-1265684	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9549027|imex:IM-22639-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	-	-	figure legend:Supp. 2C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:23FD59AC565A0D12	false	-	glutathione s tranferase tag:n-n|mutation disrupting interaction:30-30	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9549027|imex:IM-22639-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp. 2C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:23FD59AC565A0D12	false	32p radiolabel:?-?	glutathione s tranferase tag:n-n|mutation disrupting interaction:30-30	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9549029|imex:IM-22639-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp 2C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:E0D9E9D31C223365	false	32p radiolabel:?-?	mutation disrupting interaction:30-30|sufficient binding region:19-178(IPR005225)|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9549031|imex:IM-22639-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp 2C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:C0EDC03FE71A96E0	false	32p radiolabel:?-?	mutation disrupting interaction:30-30|glutathione s tranferase tag:n-n|sufficient binding region:19-178(IPR005225)	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9549031|imex:IM-22639-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp 2C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:C0EDC03FE71A96E0	false	-	mutation disrupting interaction:30-30|glutathione s tranferase tag:n-n|sufficient binding region:19-178(IPR005225)	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:43000"	uniprotkb:Q8CFP6	intact:EBI-1388758	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:guanosine 5'-[gamma-thio]triphosphate(display_short)|psi-mi:"CHEBI:43000"(display_long)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9549025|imex:IM-22639-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	-	-	figure legend:Supp. 2C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:89E428A5E1BD91E5	false	-	mutation disrupting interaction:30-30|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:Q8CFP6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9549025|imex:IM-22639-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp. 2C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2016/08/15	-	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:89E428A5E1BD91E5	false	32p radiolabel:?-?	mutation disrupting interaction:30-30|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P31938	uniprotkb:Q8CFP6	intact:EBI-298860|ensembl:ENSMUSP00000005066	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548980|imex:IM-22639-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	-	-	figure legend:4F|comment:In the presence of excessive GDP the interaction was reduced.  The authors conclude that RBJ interacted with MEK1 in its GTP-bound status.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2014/10/16	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:C994DB6338645F33|rigid:BoZS0zWcAPU+wNqayPAqP5JF5/E	false	his tag:c-c	sufficient binding region:19-208(IPR005225)|glutathione s tranferase tag:n-n|mutation decreasing interaction:30-30	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CFP6	uniprotkb:P31938	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	intact:EBI-298860|ensembl:ENSMUSP00000005066	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548998|imex:IM-22639-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	-	-	-	figure legend:6H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2014/10/16	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	intact-crc:32E2E10DD345DA71|rigid:BoZS0zWcAPU+wNqayPAqP5JF5/E	false	glutathione s tranferase tag:n-n	his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CFP6	uniprotkb:P31938	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	intact:EBI-298860|ensembl:ENSMUSP00000005066	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548998|imex:IM-22639-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	-	-	-	figure legend:6H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2014/10/16	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	intact-crc:32E2E10DD345DA71|rigid:BoZS0zWcAPU+wNqayPAqP5JF5/E	false	glutathione s tranferase tag:n-n	sufficient binding region:32-51	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P31938	uniprotkb:Q8CFP6	intact:EBI-298860|ensembl:ENSMUSP00000005066	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548906|imex:IM-22639-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	-	-	-	figure legend:4B/F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2014/10/16	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	intact-crc:9313F96930854135|rigid:BoZS0zWcAPU+wNqayPAqP5JF5/E	false	his tag:c-c	glutathione s tranferase tag:n-n|sufficient binding region:19-208(IPR005225)|mutation decreasing interaction:30-30	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CFP6	uniprotkb:P63085	intact:EBI-9548773|uniprotkb:Q8BX00|uniprotkb:Q923I0|ensembl:ENSMUSP00000020986|ensembl:ENSMUSP00000106803|ensembl:ENSMUSP00000151848	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:djc27_mouse(display_long)|uniprotkb:Dnajc27(gene name)|psi-mi:Dnajc27(display_short)|uniprotkb:Rabj(gene name synonym)|uniprotkb:Rbj(gene name synonym)|uniprotkb:Rab and DnaJ domain-containing protein(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	imex:IM-22639|pubmed:24746703	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9548921|imex:IM-22639-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694722.2|ensembl:ENSMUSG00000020657(gene)|ensembl:ENSMUST00000020986(transcript)|ensembl:ENSMUST00000049584(transcript)|ensembl:ENSMUST00000219923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR036869	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	-	-	figure legend:4B/F,6H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2014/10/16	rogid:cKuRpHgeiJEbd0LzDFAMSVIWTCA10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:4A63DC2AC95CA805|rigid:kculeIWe88F3+ucz/AoI9rrh04E	false	necessary binding region:1-18(IPR005225)|glutathione s tranferase tag:n-n	his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)