#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-2620068 uniprotkb:Q02548 - intact:EBI-296331|uniprotkb:A3QVP6|uniprotkb:A3QVP7|uniprotkb:A3QVP8|uniprotkb:O75933|ensembl:ENSP00000350844|intact:EBI-2809225|uniprotkb:Q5SFM2|uniprotkb:Q6S728|uniprotkb:Q6S729|uniprotkb:Q6S730|uniprotkb:Q6S731|uniprotkb:Q6S732|uniprotkb:C0KTF6|uniprotkb:C0KTF7|uniprotkb:C0KTF8|uniprotkb:C0KTF9|uniprotkb:C0KTG0 psi-mi:mll_enl_human_protein(display_short)|psi-mi:EBI-2620068(display_long) psi-mi:pax5_human(display_long)|uniprotkb:PAX5(gene name)|psi-mi:PAX5(display_short)|uniprotkb:B-cell-specific transcription factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9513632|imex:IM-22518-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q03111(multiple parent)|uniprotkb:Q03164(multiple parent) refseq:NP_057953.1|ensembl:ENSG00000196092(gene)|ensembl:ENST00000358127(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|refseq:NP_001267476.1|refseq:NP_001267477.1|refseq:NP_001267478.1|refseq:NP_001267479.1|refseq:NP_001267481.1|refseq:NP_001267482.1|refseq:NP_001267483.1|refseq:NP_001267484.1|refseq:NP_001267485.1|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:1K78|rcsb pdb:1MDM|reactome:R-HSA-8939245 - no-uniprot-update:An amino acid sequence which is not represented in UniProt - figure legend:5Bii|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/04/28 2014/10/16 - rogid:zq0Ew8GL7Svag27Dk2KlJ3OMEFs9606 intact-crc:E4A67B16B1F5A7B5 false flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) intact:EBI-2890930 uniprotkb:Q02548 - intact:EBI-296331|uniprotkb:A3QVP6|uniprotkb:A3QVP7|uniprotkb:A3QVP8|uniprotkb:O75933|ensembl:ENSP00000350844|intact:EBI-2809225|uniprotkb:Q5SFM2|uniprotkb:Q6S728|uniprotkb:Q6S729|uniprotkb:Q6S730|uniprotkb:Q6S731|uniprotkb:Q6S732|uniprotkb:C0KTF6|uniprotkb:C0KTF7|uniprotkb:C0KTF8|uniprotkb:C0KTF9|uniprotkb:C0KTG0 psi-mi:mll_af9_human_protein(display_short)|psi-mi:EBI-2890930(display_long) psi-mi:pax5_human(display_long)|uniprotkb:PAX5(gene name)|psi-mi:PAX5(display_short)|uniprotkb:B-cell-specific transcription factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9513622|imex:IM-22518-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q03164(multiple parent)|uniprotkb:P42568(multiple parent) refseq:NP_057953.1|ensembl:ENSG00000196092(gene)|ensembl:ENST00000358127(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|refseq:NP_001267476.1|refseq:NP_001267477.1|refseq:NP_001267478.1|refseq:NP_001267479.1|refseq:NP_001267481.1|refseq:NP_001267482.1|refseq:NP_001267483.1|refseq:NP_001267484.1|refseq:NP_001267485.1|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:1K78|rcsb pdb:1MDM|reactome:R-HSA-8939245 - no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:MLL derived protein of the protein corresponds to the CxxC-RD2 portion of the parent protein, only. - figure legend:5Bi|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/04/28 2014/10/16 rogid:dbe/f+B0o5xYoJoBDcoLm5NTboQ9606 rogid:zq0Ew8GL7Svag27Dk2KlJ3OMEFs9606 intact-crc:DBE788A23C373767|rigid:kq+5o9qOcfCZcX7yf5oRdZD239w false flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) intact:EBI-9513644 uniprotkb:Q02548 - intact:EBI-296331|uniprotkb:A3QVP6|uniprotkb:A3QVP7|uniprotkb:A3QVP8|uniprotkb:O75933|ensembl:ENSP00000350844|intact:EBI-2809225|uniprotkb:Q5SFM2|uniprotkb:Q6S728|uniprotkb:Q6S729|uniprotkb:Q6S730|uniprotkb:Q6S731|uniprotkb:Q6S732|uniprotkb:C0KTF6|uniprotkb:C0KTF7|uniprotkb:C0KTF8|uniprotkb:C0KTF9|uniprotkb:C0KTG0 psi-mi:mll_ell_fusion_protein(display_short)|psi-mi:EBI-9513644(display_long) psi-mi:pax5_human(display_long)|uniprotkb:PAX5(gene name)|psi-mi:PAX5(display_short)|uniprotkb:B-cell-specific transcription factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9513647|imex:IM-22518-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q03164(multiple parent)|uniprotkb:P55199(multiple parent) refseq:NP_057953.1|ensembl:ENSG00000196092(gene)|ensembl:ENST00000358127(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|refseq:NP_001267476.1|refseq:NP_001267477.1|refseq:NP_001267478.1|refseq:NP_001267479.1|refseq:NP_001267481.1|refseq:NP_001267482.1|refseq:NP_001267483.1|refseq:NP_001267484.1|refseq:NP_001267485.1|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:1K78|rcsb pdb:1MDM|reactome:R-HSA-8939245 - no-uniprot-update:An amino acid sequence which is not represented in UniProt - figure legend:5Biii|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/04/28 2014/10/16 - rogid:zq0Ew8GL7Svag27Dk2KlJ3OMEFs9606 intact-crc:231A774E7E63D007 false flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02548 uniprotkb:Q03164 intact:EBI-296331|uniprotkb:A3QVP6|uniprotkb:A3QVP7|uniprotkb:A3QVP8|uniprotkb:O75933|ensembl:ENSP00000350844|intact:EBI-2809225|uniprotkb:Q5SFM2|uniprotkb:Q6S728|uniprotkb:Q6S729|uniprotkb:Q6S730|uniprotkb:Q6S731|uniprotkb:Q6S732|uniprotkb:C0KTF6|uniprotkb:C0KTF7|uniprotkb:C0KTF8|uniprotkb:C0KTF9|uniprotkb:C0KTG0 intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3 psi-mi:pax5_human(display_long)|uniprotkb:PAX5(gene name)|psi-mi:PAX5(display_short)|uniprotkb:B-cell-specific transcription factor(gene name synonym) psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9513612|imex:IM-22518-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057953.1|ensembl:ENSG00000196092(gene)|ensembl:ENST00000358127(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|refseq:NP_001267476.1|refseq:NP_001267477.1|refseq:NP_001267478.1|refseq:NP_001267479.1|refseq:NP_001267481.1|refseq:NP_001267482.1|refseq:NP_001267483.1|refseq:NP_001267484.1|refseq:NP_001267485.1|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:1K78|rcsb pdb:1MDM|reactome:R-HSA-8939245 go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222 - - - figure legend:5B/C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/04/28 2014/10/16 rogid:zq0Ew8GL7Svag27Dk2KlJ3OMEFs9606 rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606 intact-crc:960CDB5C4BBC8A3A|rigid:p/3cdNLc7N4J1zuhVlSbpckVo5A false ha tag:n-n sufficient binding region:1-400|flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02548 uniprotkb:Q8TD98 intact:EBI-296331|uniprotkb:A3QVP6|uniprotkb:A3QVP7|uniprotkb:A3QVP8|uniprotkb:O75933|ensembl:ENSP00000350844|intact:EBI-2809225|uniprotkb:Q5SFM2|uniprotkb:Q6S728|uniprotkb:Q6S729|uniprotkb:Q6S730|uniprotkb:Q6S731|uniprotkb:Q6S732|uniprotkb:C0KTF6|uniprotkb:C0KTF7|uniprotkb:C0KTF8|uniprotkb:C0KTF9|uniprotkb:C0KTG0 intact:EBI-2638899 psi-mi:pax5_human(display_long)|uniprotkb:PAX5(gene name)|psi-mi:PAX5(display_short)|uniprotkb:B-cell-specific transcription factor(gene name synonym) psi-mi:q8td98_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9513545|imex:IM-22518-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057953.1|ensembl:ENSG00000196092(gene)|ensembl:ENST00000358127(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|refseq:NP_001267476.1|refseq:NP_001267477.1|refseq:NP_001267478.1|refseq:NP_001267479.1|refseq:NP_001267481.1|refseq:NP_001267482.1|refseq:NP_001267483.1|refseq:NP_001267484.1|refseq:NP_001267485.1|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:1K78|rcsb pdb:1MDM|reactome:R-HSA-8939245 interpro:IPR007797(AF-4 proto-oncoprotein)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR043639 - - - figure legend:5A,B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/04/28 2014/10/16 rogid:zq0Ew8GL7Svag27Dk2KlJ3OMEFs9606 rogid:f+HdRad9i3mscKfHdJ/n9MOLbTw9606 intact-crc:EAFE1E00495C533C|rigid:baD0ubwiR+gF75qqscHk4ATAnMA false ha tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02548 uniprotkb:Q03164-PRO_0000390949 intact:EBI-296331|uniprotkb:A3QVP6|uniprotkb:A3QVP7|uniprotkb:A3QVP8|uniprotkb:O75933|ensembl:ENSP00000350844|intact:EBI-2809225|uniprotkb:Q5SFM2|uniprotkb:Q6S728|uniprotkb:Q6S729|uniprotkb:Q6S730|uniprotkb:Q6S731|uniprotkb:Q6S732|uniprotkb:C0KTF6|uniprotkb:C0KTF7|uniprotkb:C0KTF8|uniprotkb:C0KTF9|uniprotkb:C0KTG0 intact:EBI-2610266 psi-mi:pax5_human(display_long)|uniprotkb:PAX5(gene name)|psi-mi:PAX5(display_short)|uniprotkb:B-cell-specific transcription factor(gene name synonym) psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9513691|imex:IM-22518-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057953.1|ensembl:ENSG00000196092(gene)|ensembl:ENST00000358127(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|refseq:NP_001267476.1|refseq:NP_001267477.1|refseq:NP_001267478.1|refseq:NP_001267479.1|refseq:NP_001267481.1|refseq:NP_001267482.1|refseq:NP_001267483.1|refseq:NP_001267484.1|refseq:NP_001267485.1|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:1K78|rcsb pdb:1MDM|reactome:R-HSA-8939245 intact:EBI-591370(chain-parent) - - comment:Amino acids 1 � 2718. An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718 figure legend:5D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jm1)|taxid:9606(Human JM1 pre-B lymphoblast cell line from a patient with immunoblastic B cell lymphoma/leukemia.) - 2014/04/28 2014/10/16 rogid:zq0Ew8GL7Svag27Dk2KlJ3OMEFs9606 rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606 intact-crc:4126B7DD8E0D81AF|rigid:BXeGjlIJActBqEBKQ1j6hWR88XI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03164-PRO_0000390949 uniprotkb:Q02548 intact:EBI-2610266 intact:EBI-296331|uniprotkb:A3QVP6|uniprotkb:A3QVP7|uniprotkb:A3QVP8|uniprotkb:O75933|ensembl:ENSP00000350844|intact:EBI-2809225|uniprotkb:Q5SFM2|uniprotkb:Q6S728|uniprotkb:Q6S729|uniprotkb:Q6S730|uniprotkb:Q6S731|uniprotkb:Q6S732|uniprotkb:C0KTF6|uniprotkb:C0KTF7|uniprotkb:C0KTF8|uniprotkb:C0KTF9|uniprotkb:C0KTG0 psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:pax5_human(display_long)|uniprotkb:PAX5(gene name)|psi-mi:PAX5(display_short)|uniprotkb:B-cell-specific transcription factor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9513706|imex:IM-22518-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_057953.1|ensembl:ENSG00000196092(gene)|ensembl:ENST00000358127(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|refseq:NP_001267476.1|refseq:NP_001267477.1|refseq:NP_001267478.1|refseq:NP_001267479.1|refseq:NP_001267481.1|refseq:NP_001267482.1|refseq:NP_001267483.1|refseq:NP_001267484.1|refseq:NP_001267485.1|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:1K78|rcsb pdb:1MDM|reactome:R-HSA-8939245 - comment:Amino acids 1 � 2718. An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718 - figure legend:5D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-reh)|taxid:9606(Homo sapiens REH B cell precursor leukemia cells) - 2014/04/28 2014/10/16 rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606 rogid:zq0Ew8GL7Svag27Dk2KlJ3OMEFs9606 intact-crc:C87DBAD5D1F6DD99|rigid:BXeGjlIJActBqEBKQ1j6hWR88XI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O60563 ensembl:ENSG00000111276 intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76 intact:EBI-2891650 psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short) psi-mi:cdkn1b_human_gene(display_short)|psi-mi:ENSG00000111276(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9513798|imex:IM-22518-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N - - - - figure legend:4G|agonist:Bortezomib; a Boron containing proteasome inhibitor which induces Cell Cycle Arrest and apoptosis.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM) - 2014/04/28 2014/10/16 rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606 - intact-crc:9531DB8AF6126E9C false - sufficient binding region:?-?|sufficient binding region:?-? - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:Q02548 ensembl:ENSG00000111276 intact:EBI-296331|uniprotkb:A3QVP6|uniprotkb:A3QVP7|uniprotkb:A3QVP8|uniprotkb:O75933|ensembl:ENSP00000350844|intact:EBI-2809225|uniprotkb:Q5SFM2|uniprotkb:Q6S728|uniprotkb:Q6S729|uniprotkb:Q6S730|uniprotkb:Q6S731|uniprotkb:Q6S732|uniprotkb:C0KTF6|uniprotkb:C0KTF7|uniprotkb:C0KTF8|uniprotkb:C0KTF9|uniprotkb:C0KTG0 intact:EBI-2891650 psi-mi:pax5_human(display_long)|uniprotkb:PAX5(gene name)|psi-mi:PAX5(display_short)|uniprotkb:B-cell-specific transcription factor(gene name synonym) psi-mi:cdkn1b_human_gene(display_short)|psi-mi:ENSG00000111276(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Liu et al. (2014) pubmed:24735925|imex:IM-22518 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9514045|imex:IM-22518-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_057953.1|ensembl:ENSG00000196092(gene)|ensembl:ENST00000358127(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|refseq:NP_001267476.1|refseq:NP_001267477.1|refseq:NP_001267478.1|refseq:NP_001267479.1|refseq:NP_001267481.1|refseq:NP_001267482.1|refseq:NP_001267483.1|refseq:NP_001267484.1|refseq:NP_001267485.1|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:1K78|rcsb pdb:1MDM|reactome:R-HSA-8939245 - - - - figure legend:5G|agonist:Bortezomib; a Boron containing proteasome inhibitor which induces Cell Cycle Arrest and apoptosis.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM) - 2014/04/28 2014/10/16 rogid:zq0Ew8GL7Svag27Dk2KlJ3OMEFs9606 - intact-crc:0461653481EA50C4 false - sufficient binding region:?-? - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr)