#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P00044	uniprotkb:P00431	intact:EBI-5393|uniprotkb:D6VWL9|ensemblfungi:YJR048W	intact:EBI-4389|uniprotkb:Q6Q5M9|uniprotkb:D6VXC7|ensemblfungi:YKR066C	psi-mi:cyc1_yeast(display_long)|uniprotkb:CYC1(gene name)|psi-mi:CYC1(display_short)|uniprotkb:Cytochrome c aerobic isoform(gene name synonym)|uniprotkb:J1653(orf name)|uniprotkb:YJR048W(locus name)	psi-mi:ccpr_yeast(display_long)|uniprotkb:CCP1(gene name)|psi-mi:CCP1(display_short)|uniprotkb:CCP(gene name synonym)|uniprotkb:CPO(gene name synonym)|uniprotkb:YKR066C(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Schilder et al. (2014)	imex:IM-22560|pubmed:24726731	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9345867|imex:IM-22560-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012582.1|sgd:S000003809|reactome:R-SCE-611105|reactome:R-SCE-111457|reactome:R-SCE-3299685|dip:DIP-4265N|ensemblfungi:YJR048W(gene)|ensemblfungi:YJR048W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|rcsb pdb:1CHH|rcsb pdb:1CHI|rcsb pdb:1CHJ|rcsb pdb:1CIE|rcsb pdb:1CIF|rcsb pdb:1CIG|rcsb pdb:1CIH|rcsb pdb:1CRG|rcsb pdb:1CRH|rcsb pdb:1CRI|rcsb pdb:1CRJ|rcsb pdb:1CSU|rcsb pdb:1CSV|rcsb pdb:1CSW|rcsb pdb:1CSX|rcsb pdb:1CTY|rcsb pdb:1CTZ|rcsb pdb:1FHB|rcsb pdb:1IRV|rcsb pdb:1IRW|rcsb pdb:1KYO|rcsb pdb:1LMS|rcsb pdb:1NMI|rcsb pdb:1RAP|rcsb pdb:1RAQ|rcsb pdb:1S6V|rcsb pdb:1U74|rcsb pdb:1YCC|rcsb pdb:1YFC|rcsb pdb:1YIC|rcsb pdb:2B0Z|rcsb pdb:2B10|rcsb pdb:2B11|rcsb pdb:2B12|rcsb pdb:2BCN|rcsb pdb:2GB8|rcsb pdb:2HV4|rcsb pdb:2JQR|rcsb pdb:2JTI|rcsb pdb:2LIR|rcsb pdb:2LIT|rcsb pdb:2MHM|rcsb pdb:2N18|rcsb pdb:2ORL|rcsb pdb:2PCC|rcsb pdb:2YCC|rcsb pdb:3CX5|rcsb pdb:3TYI|rcsb pdb:4MU8|reactome:R-SCE-5620971|rcsb pdb:4N0K|rcsb pdb:4P4Q|rcsb pdb:4Q5P|rcsb pdb:4QAO|rcsb pdb:4YE1|rcsb pdb:5CIB|rcsb pdb:5CIC|rcsb pdb:5CID|rcsb pdb:5CIE|rcsb pdb:5CIF|rcsb pdb:5CIG|rcsb pdb:5CIH|rcsb pdb:5KKE|rcsb pdb:5KLU|rcsb pdb:5KPF|rcsb pdb:5LFT|rcsb pdb:5LYC|rcsb pdb:5NCV|rcsb pdb:5T7H|rcsb pdb:5T8W|rcsb pdb:6EGY|rcsb pdb:6EGZ|rcsb pdb:6GD6|rcsb pdb:6GD7|rcsb pdb:6GD8|rcsb pdb:6GD9|rcsb pdb:6GDA|rcsb pdb:6P41|rcsb pdb:6P42|rcsb pdb:6P43|rcsb pdb:6RGI|rcsb pdb:6RSI|rcsb pdb:6RSJ|rcsb pdb:6RSK|rcsb pdb:6RSL|rcsb pdb:6S8Y|rcsb pdb:6SUY|rcsb pdb:6Y0J	refseq:NP_012992.1|sgd:S000001774|dip:DIP-6251N|ensemblfungi:YKR066C(gene)|ensemblfungi:YKR066C_mRNA(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004130"(cytochrome-c peroxidase activity)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0020037"(heme binding)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR002016(Haem peroxidase, plant/fungal/bacterial)|interpro:IPR002207(Plant ascorbate peroxidase)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019793|interpro:IPR019794|interpro:IPR044831|rcsb pdb:1A2F|rcsb pdb:1A2G|rcsb pdb:1AA4|rcsb pdb:1AC4|rcsb pdb:1AC8|rcsb pdb:1AEB|rcsb pdb:1AED|rcsb pdb:1AEE|rcsb pdb:1AEF|rcsb pdb:1AEG|rcsb pdb:1AEH|rcsb pdb:1AEJ|rcsb pdb:1AEK|rcsb pdb:1AEM|rcsb pdb:1AEN|rcsb pdb:1AEO|rcsb pdb:1AEQ|rcsb pdb:1AES|rcsb pdb:1AET|rcsb pdb:1AEU|rcsb pdb:1AEV|rcsb pdb:1BEJ|rcsb pdb:1BEK|rcsb pdb:1BEM|rcsb pdb:1BEP|rcsb pdb:1BEQ|rcsb pdb:1BES|rcsb pdb:1BJ9|rcsb pdb:1BVA|rcsb pdb:1CCA|rcsb pdb:1CCB|rcsb pdb:1CCC|rcsb pdb:1CCE|rcsb pdb:1CCG|rcsb pdb:1CCI|rcsb pdb:1CCJ|rcsb pdb:1CCK|rcsb pdb:1CCL|rcsb pdb:1CCP|rcsb pdb:1CMP|rcsb pdb:1CMQ|rcsb pdb:1CMT|rcsb pdb:1CPD|rcsb pdb:1CPE|rcsb pdb:1CPF|rcsb pdb:1CPG|rcsb pdb:1CYF|rcsb pdb:1DCC|rcsb pdb:1DJ1|rcsb pdb:1DJ5|rcsb pdb:1DS4|rcsb pdb:1DSE|rcsb pdb:1DSG|rcsb pdb:1DSO|rcsb pdb:1DSP|rcsb pdb:1EBE|rcsb pdb:1JCI|rcsb pdb:1JDR|rcsb pdb:1KOK|rcsb pdb:1KRJ|rcsb pdb:1KXM|rcsb pdb:1KXN|rcsb pdb:1MK8|rcsb pdb:1MKQ|rcsb pdb:1MKR|rcsb pdb:1ML2|rcsb pdb:1RYC|rcsb pdb:1S6V|rcsb pdb:1S73|rcsb pdb:1SBM|rcsb pdb:1SDQ|rcsb pdb:1SOG|rcsb pdb:1STQ|rcsb pdb:1U74|rcsb pdb:1U75|rcsb pdb:1Z53|rcsb pdb:1ZBY|rcsb pdb:1ZBZ|rcsb pdb:2ANZ|rcsb pdb:2AQD|rcsb pdb:2AS1|rcsb pdb:2AS2|rcsb pdb:2AS3|rcsb pdb:2AS4|rcsb pdb:2AS6|rcsb pdb:2B0Z|rcsb pdb:2B10|rcsb pdb:2B11|rcsb pdb:2B12|rcsb pdb:2BCN|rcsb pdb:2CCP|rcsb pdb:2CEP|rcsb pdb:2CYP|rcsb pdb:2EUN|rcsb pdb:2EUO|rcsb pdb:2EUP|rcsb pdb:2EUQ|rcsb pdb:2EUR|rcsb pdb:2EUS|rcsb pdb:2EUT|rcsb pdb:2EUU|rcsb pdb:2GB8|rcsb pdb:2IA8|rcsb pdb:2ICV|rcsb pdb:2JTI|rcsb pdb:2N18|rcsb pdb:2PCB|rcsb pdb:2PCC|rcsb pdb:2RBT|rcsb pdb:2RBU|rcsb pdb:2RBV|rcsb pdb:2RBW|rcsb pdb:2RBX|rcsb pdb:2RBY|rcsb pdb:2RBZ|rcsb pdb:2RC0|rcsb pdb:2RC1|rcsb pdb:2RC2|rcsb pdb:2V23|rcsb pdb:2V2E|rcsb pdb:2X07|rcsb pdb:2X08|rcsb pdb:2XIL|rcsb pdb:2XJ5|rcsb pdb:2XJ8|rcsb pdb:2Y5A|rcsb pdb:2YCG|rcsb pdb:3CCP|rcsb pdb:3CCX|rcsb pdb:3E2N|rcsb pdb:3E2O|rcsb pdb:3EXB|rcsb pdb:3M23|rcsb pdb:3M25|rcsb pdb:3M26|rcsb pdb:3M27|rcsb pdb:3M28|rcsb pdb:3M29|rcsb pdb:3M2A|rcsb pdb:1CMU|rcsb pdb:3M2B|rcsb pdb:3M2C|rcsb pdb:3M2D|rcsb pdb:3M2E|rcsb pdb:3M2F|rcsb pdb:3M2G|rcsb pdb:3M2H|rcsb pdb:3M2I|rcsb pdb:3R98|rcsb pdb:3R99|rcsb pdb:4A6Z|rcsb pdb:4A71|rcsb pdb:4A78|rcsb pdb:4A7M|rcsb pdb:4CCP|rcsb pdb:4CCX|rcsb pdb:4CVI|rcsb pdb:4CVJ|rcsb pdb:4JB4|rcsb pdb:4NFG|rcsb pdb:4P4Q|rcsb pdb:4XV4|rcsb pdb:4XV5|rcsb pdb:4XV6|rcsb pdb:4XV7|rcsb pdb:4XV8|rcsb pdb:4XVA|rcsb pdb:5CCP|rcsb pdb:5CIB|rcsb pdb:5CIC|rcsb pdb:5CID|rcsb pdb:5CIE|rcsb pdb:5CIF|rcsb pdb:5CIG|rcsb pdb:5CIH|rcsb pdb:5D6M|rcsb pdb:5EJT|rcsb pdb:5EJX|rcsb pdb:6CCP|rcsb pdb:6H08|rcsb pdb:6P41|rcsb pdb:6P42|rcsb pdb:6P43|rcsb pdb:6Y1T|rcsb pdb:6Y2Y|rcsb pdb:7CCP	-	crc64:1F8B6CB3B60C0BE8	crc64:A5D26385DA6F0A0B	figure legend:f1 f2 f3 f4|comment:"Numerous resonances shifted in the spectrum, indicating a fast-exchange binding process. The KB  values were determined for the WT or MTS-V28C complex by fitting the CSP curves to a 1:1 binding  model (Fig. 1). The KB determined for the complex with WT Cc is KB = 2 ± 1 x 105 M-1, which is the  same within error as previously reported. [39,40] The binding constant for the complex with MTSV28C  was found to be the same within error, KB = 3 ± 1 x 105 M-1. These values were then used to  extrapolate average amide shifts, Δδavg, for 100% bound CcP (Fig. S3). For the WT complex, the  overall CSP pattern was similar to that described previously. [41] The CSPs for WT and MTS-V28C in  this study were also identical within the error margins (±0.011 ppm) except for 20 peaks showing  slightly larger differences (Table S2). The Δδavg values were used to create a CSP map (Fig. 2). For  both WT and MTS-V28C Cc, the CSP effects on CcP were localized around the binding interface  where Cc is expected to be in the stereospecific complex. The few peaks with significant differences in  Δδavg for MTS-V28C (Table S2) are in the centre of the binding interface (square box in Fig. 2).  However, overall the differences between the two CSP maps are small and the KB values (Fig. 1) are  the same within error, indicating that the effects of the tag on complex formation are minimal."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/31	2014/10/16	rogid:cWXa1LrFw3TdUGFHfMlKBZkDQsg559292	rogid:LkPXY1wuYoCFzMQPSsAtXZrRi8w559292	intact-crc:380E9D99639FF00B|rigid:6KCKzcT6eGJC4u28h8edSPsDbhY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)