#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:64310"	uniprotkb:P00519	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P29317	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-702104|uniprotkb:Q8N3Z2|uniprotkb:B5A968|intact:EBI-28989000|ensembl:ENSP00000351209	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:epha2_human(display_long)|uniprotkb:Tyrosine-protein kinase receptor ECK(gene name synonym)|uniprotkb:Epithelial cell kinase(gene name synonym)|uniprotkb:EPHA2(gene name)|psi-mi:EPHA2(display_short)|uniprotkb:ECK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_004422.2|ensembl:ENSP00000351209|dip:DIP-96N|ensembl:ENSG00000142627(gene)|ensembl:ENST00000358432(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007411"(axon guidance)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019838"(growth factor binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060035"(notochord cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0070160"(tight junction)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904238"(pericyte cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034263|interpro:IPR036116|mint:P29317|rcsb pdb:1MQB|rcsb pdb:2E8N|rcsb pdb:2K9Y|rcsb pdb:2KSO|rcsb pdb:2X10|rcsb pdb:2X11|rcsb pdb:3C8X|rcsb pdb:3CZU|rcsb pdb:3FL7|rcsb pdb:3HEI|rcsb pdb:3HPN|rcsb pdb:3KKA|rcsb pdb:3MBW|rcsb pdb:3MX0|rcsb pdb:3SKJ|rcsb pdb:4P2K|rcsb pdb:4PDO|rcsb pdb:4TRL|rcsb pdb:5EK7|rcsb pdb:5I9U|rcsb pdb:5I9V|rcsb pdb:5I9W|rcsb pdb:5I9X|rcsb pdb:5I9Y|rcsb pdb:5I9Z|rcsb pdb:5IA0|rcsb pdb:5IA1|rcsb pdb:5IA2|rcsb pdb:5IA3|rcsb pdb:5IA4|rcsb pdb:5IA5|rcsb pdb:5NJZ|rcsb pdb:5NK0|rcsb pdb:5NK1|rcsb pdb:5NK2|rcsb pdb:5NK3|rcsb pdb:5NK4|rcsb pdb:5NK5|rcsb pdb:5NK6|rcsb pdb:5NK7|rcsb pdb:5NK8|rcsb pdb:5NK9|rcsb pdb:5NKA|rcsb pdb:5NKB|rcsb pdb:5NKC|rcsb pdb:5NKD|rcsb pdb:5NKE|rcsb pdb:5NKF|rcsb pdb:5NKG|rcsb pdb:5NKH|rcsb pdb:5NKI|rcsb pdb:5NZ9|rcsb pdb:6B9L|rcsb pdb:6F7M|rcsb pdb:6F7N|rcsb pdb:6FNF|rcsb pdb:6FNG|rcsb pdb:6FNH|rcsb pdb:6HES|rcsb pdb:6HET|rcsb pdb:6HEU|rcsb pdb:6HEV|rcsb pdb:6HEW|rcsb pdb:6HEX|rcsb pdb:6HEY|rcsb pdb:6NJZ|rcsb pdb:6NK0|rcsb pdb:6NK1|rcsb pdb:6NK2|rcsb pdb:6NKP|rcsb pdb:6Q7B|rcsb pdb:6Q7C|rcsb pdb:6Q7D|rcsb pdb:6Q7E|rcsb pdb:6Q7F|rcsb pdb:6Q7G|rcsb pdb:6RW2|rcsb pdb:7B7N|rcsb pdb:7CZE|rcsb pdb:7CZF|rcsb pdb:7KJA|rcsb pdb:7KJB|rcsb pdb:7KJC|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:9VFikLd4ftRmEyBpY0JHdpHINT09606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P53671	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1384350|uniprotkb:Q7KZ80|uniprotkb:Q96E10|uniprotkb:Q99464|uniprotkb:A8K6H5|uniprotkb:Q9UFU0|uniprotkb:Q7L3H5|ensembl:ENSP00000332687	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:limk2_human(display_long)|uniprotkb:LIMK2(gene name)|psi-mi:LIMK2(display_short)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_005560.1|refseq:NP_057952.1|refseq:NP_001026971.1|ensembl:ENSG00000182541(gene)|ensembl:ENST00000331728(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016310"(phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0060322"(head development)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53671|rcsb pdb:1X6A|rcsb pdb:4TPT|rcsb pdb:5NXD|reactome:R-HSA-3928662|reactome:R-HSA-416572|reactome:R-HSA-5627117	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:9Tt4TJshssdjMGb89YS+XrgJxDw9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q709F0	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-2880718|ensembl:ENSP00000264990|uniprotkb:Q8WUT6|uniprotkb:Q08AF0|uniprotkb:Q658Y2|uniprotkb:Q658N9|uniprotkb:Q6ZND2|uniprotkb:Q9H9R3	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:acd11_human(display_long)|uniprotkb:ACAD11(gene name)|psi-mi:ACAD11(display_short)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	ensembl:ENSG00000240303(gene)|ensembl:ENST00000264990(transcript)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR002575(Aminoglycoside phosphotransferase)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|interpro:IPR041726|mint:Q709F0|rcsb pdb:2WBI|reactome:R-HSA-77289|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|refseq:NP_115545.3	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:Qknz1ZNcvX0q/3f5TuGQkJ6oHSk9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q9NSY1	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1383367|uniprotkb:O94791|uniprotkb:Q8IYF2|uniprotkb:Q8N2G7|uniprotkb:Q8NHG9|uniprotkb:Q9NTG8|uniprotkb:Q4W5H2|intact:EBI-28972938|ensembl:ENSP00000424668	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:bmp2k_human(display_long)|uniprotkb:BMP2K(gene name)|psi-mi:BMP2K(display_short)|uniprotkb:BIKE(gene name synonym)|uniprotkb:HRIHFB2017(orf name)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	ensembl:ENSP00000424668|ensembl:ENST00000502871|ensembl:ENSP00000421768|refseq:NP_060063.2|refseq:NP_942595.1|ensembl:ENSG00000138756(gene)|ensembl:ENST00000502613(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR026105|interpro:IPR028182|rcsb pdb:4W9W|rcsb pdb:4W9X|rcsb pdb:5I3O|rcsb pdb:5I3R|rcsb pdb:5IKW|go:"GO:0019208"(phosphatase regulator activity)	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:ckhpP0erhSRURf04YvQFCsYZ8rY9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q9H6S1	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-359973|intact:EBI-1384309|uniprotkb:Q86W99|uniprotkb:Q9BQF1|uniprotkb:A8K3M2|ensembl:ENSP00000419371|uniprotkb:C9JB40|uniprotkb:H7BXU6	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:azi2_human(display_long)|uniprotkb:AZI2(gene name)|psi-mi:AZI2(display_short)|uniprotkb:NAP1(gene name synonym)|uniprotkb:TBKBP2(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase-associated protein 1(gene name synonym)|uniprotkb:TILP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_001127904.1|refseq:NP_001127905.1|refseq:NP_071906.1|ensembl:ENSG00000163512(gene)|ensembl:ENST00000479665(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042110"(T cell activation)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR024581|rcsb pdb:5EP6|rcsb pdb:5Z7G|rcsb pdb:5Z7L|refseq:XP_005265449.1|dip:DIP-27605N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:lfjd4cD2rm6NOjdh3XTTuFxnK9A9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q13043	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q9UM73	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-357361|ensembl:ENSP00000373700|uniprotkb:Q4ZFX9|uniprotkb:Q53QQ6|uniprotkb:Q53RZ4|uniprotkb:Q59FI3|uniprotkb:Q9Y4K6	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:alk_human(display_long)|uniprotkb:ALK(gene name)|psi-mi:ALK(display_short)|uniprotkb:Anaplastic lymphoma kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	ensembl:ENSG00000171094(gene)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016310"(phosphorylation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030534"(adult behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036269"(swimming behavior)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENST00000389048(transcript)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048666"(neuron development)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090648"(response to environmental enrichment)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000998(MAM)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR026830|interpro:IPR036055|mint:Q9UM73|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2XB7|rcsb pdb:2XBA|rcsb pdb:2XP2|rcsb pdb:2YFX|rcsb pdb:2YHV|rcsb pdb:2YJR|rcsb pdb:2YJS|rcsb pdb:2YS5|rcsb pdb:2YT2|rcsb pdb:3L9P|rcsb pdb:3LCS|rcsb pdb:3LCT|rcsb pdb:4ANL|rcsb pdb:4ANQ|rcsb pdb:4ANS|rcsb pdb:4CCB|rcsb pdb:4CCU|rcsb pdb:4CD0|rcsb pdb:3AOX|rcsb pdb:4CLI|rcsb pdb:4CLJ|rcsb pdb:4CMO|rcsb pdb:4CMT|rcsb pdb:4CMU|rcsb pdb:4CNH|rcsb pdb:4CTB|rcsb pdb:4CTC|rcsb pdb:4DCE|rcsb pdb:4FNW|rcsb pdb:4FNX|rcsb pdb:4FNY|rcsb pdb:4FNZ|rcsb pdb:4FOB|rcsb pdb:4FOC|rcsb pdb:4FOD|rcsb pdb:4JOA|rcsb pdb:4MKC|rcsb pdb:4TT7|rcsb pdb:4Z55|rcsb pdb:5A9U|rcsb pdb:5AA9|rcsb pdb:5AAA|rcsb pdb:5AAB|rcsb pdb:5AAC|rcsb pdb:5FTO|rcsb pdb:5FTQ|rcsb pdb:5IMX|rcsb pdb:5IUG|rcsb pdb:5IUH|rcsb pdb:5IUI|rcsb pdb:5KZ0|rcsb pdb:5VZ5|rcsb pdb:6AT9|rcsb pdb:6CDT|rcsb pdb:6E0R|rcsb pdb:6EBW|rcsb pdb:6EDL|rcsb pdb:6MX8|rcsb pdb:7BTT|rcsb pdb:7JY4|rcsb pdb:7JYR|rcsb pdb:7JYS|rcsb pdb:7JYT|rcsb pdb:5AA8|refseq:NP_004295.2|dip:DIP-5954N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:AVut3q3smPUsklP/IahGM8qzDM49606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P30530	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q14164	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:O43353	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P16591	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P54760	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-702121|uniprotkb:Q9BTA5|uniprotkb:Q9BXP0|uniprotkb:B5A970|uniprotkb:B5A971|uniprotkb:B5A972|uniprotkb:Q7Z635|ensembl:ENSP00000350896	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:ephb4_human(display_long)|uniprotkb:Tyrosine-protein kinase TYRO11(gene name synonym)|uniprotkb:EPHB4(gene name)|psi-mi:EPHB4(display_short)|uniprotkb:HTK(gene name synonym)|uniprotkb:TYRO11(gene name synonym)|uniprotkb:Hepatoma transmembrane kinase(gene name synonym)|uniprotkb:MYK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_004435.3|rcsb pdb:2VWW|rcsb pdb:2VWX|rcsb pdb:2VWY|rcsb pdb:2VWZ|rcsb pdb:2VX0|rcsb pdb:2VX1|rcsb pdb:2X9F|rcsb pdb:2XVD|rcsb pdb:2YN8|rcsb pdb:3ZEW|rcsb pdb:4AW5|rcsb pdb:4BB4|rcsb pdb:6FNI|rcsb pdb:6FNJ|rcsb pdb:6FNK|rcsb pdb:6FNL|rcsb pdb:6FNM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034290|interpro:IPR036116|interpro:IPR037636|mint:P54760|rcsb pdb:2BBA|rcsb pdb:2E7H|rcsb pdb:2HLE|rcsb pdb:2QKQ|ensembl:ENSG00000196411(gene)|ensembl:ENST00000358173(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|rcsb pdb:2VWU|rcsb pdb:2VWV	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:tpDaNm/4fKYTvUt4gneu97+0Cxw9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q12866	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-2804911|uniprotkb:Q9HBB4|ensembl:ENSP00000295408|ensembl:ENSP00000389152	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:mertk_human(display_long)|uniprotkb:MER(gene name synonym)|uniprotkb:Proto-oncogene c-Mer(gene name synonym)|uniprotkb:Receptor tyrosine kinase MerTK(gene name synonym)|uniprotkb:MERTK(gene name)|psi-mi:MERTK(display_short)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	ensembl:ENSG00000153208(gene)|ensembl:ENST00000295408(transcript)|ensembl:ENST00000421804(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0016028"(rhabdomere)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060068"(vagina development)|go:"GO:0097350"(neutrophil clearance)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q12866|rcsb pdb:2DBJ|rcsb pdb:2P0C|rcsb pdb:3BPR|rcsb pdb:3BRB|rcsb pdb:3TCP|rcsb pdb:4M3Q|rcsb pdb:4MH7|rcsb pdb:5K0K|rcsb pdb:5K0X|rcsb pdb:5TC0|rcsb pdb:5TD2|rcsb pdb:5U6C|rcsb pdb:6MEP|rcsb pdb:7AAX|rcsb pdb:7AAY|rcsb pdb:7AAZ|rcsb pdb:7AB0|rcsb pdb:7AB1|rcsb pdb:7AB2|rcsb pdb:4MHA|rcsb pdb:7AVX|rcsb pdb:7AVY|rcsb pdb:7AVZ|rcsb pdb:7AW0|rcsb pdb:7AW1|rcsb pdb:7AW2|rcsb pdb:7AW3|rcsb pdb:7AW4|rcsb pdb:7CQE|rcsb pdb:7OAM|reactome:R-HSA-202733|refseq:NP_006334.2	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:d1TXRqQHZG+X91BEM32fecg/0bU9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q9H2G2	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1022272|uniprotkb:O00211|uniprotkb:Q6P1Z4|uniprotkb:Q86WU7|uniprotkb:Q86WW1|uniprotkb:Q92603|uniprotkb:Q9NQL0|uniprotkb:Q9NQL1|uniprotkb:D3DRA0|uniprotkb:D3DRA1|ensembl:ENSP00000358770	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:slk_human(display_long)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 2(gene name synonym)|uniprotkb:CTCL tumor antigen se20-9(gene name synonym)|uniprotkb:SLK(gene name)|psi-mi:SLK(display_short)|uniprotkb:KIAA0204(gene name synonym)|uniprotkb:STK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_055535.2|refseq:NP_001291672.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022165|mint:Q9H2G2|rcsb pdb:2J51|rcsb pdb:2JFL|rcsb pdb:2JFM|rcsb pdb:2UV2|rcsb pdb:4USF|rcsb pdb:6HVD|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000065613(gene)|ensembl:ENST00000369755(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:T9Ej6CkWUmqEmPLcptvF2/f1Q+09606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q9Y4K4	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1279|uniprotkb:Q8IYF6|intact:EBI-28975988|ensembl:ENSP00000013125|intact:EBI-16771202|uniprotkb:A0A0A0MQR1	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:m4k5_human(display_long)|uniprotkb:MAP4K5(gene name)|psi-mi:MAP4K5(display_short)|uniprotkb:MAPK/ERK kinase kinase kinase 5(gene name synonym)|uniprotkb:Kinase homologous to SPS1/STE20(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_006566.2|refseq:NP_942089.1|ensembl:ENSP00000013125|refseq:XP_006720076.1|ensembl:ENSG00000012983(gene)|ensembl:ENST00000013125(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:4L02JMxhTz+eogNl/rYe9wfx0YE9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P51617	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-358664|uniprotkb:Q7Z5V4|uniprotkb:Q96RL2|intact:EBI-28987029|ensembl:ENSP00000358997|uniprotkb:D3DWW4|uniprotkb:D3DWW3|uniprotkb:Q96C06	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:irak1_human(display_long)|uniprotkb:IRAK1(gene name)|psi-mi:IRAK1(display_short)|uniprotkb:IRAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:P51617|rcsb pdb:6BFN|ensembl:ENSG00000184216(gene)|ensembl:ENST00000369980(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007568"(aging)|go:"GO:0010008"(endosome membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|refseq:NP_001020413.1|refseq:NP_001020414.1|refseq:NP_001560.2|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-6811558|reactome:R-HSA-8986944|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975871|ensembl:ENST00000369974|ensembl:ENSP00000358997|ensembl:ENST00000393687|ensembl:ENSP00000377291|ensembl:ENSP00000358991|dip:DIP-397N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:q+oAzeVuuQvO24HkoHx6PKK7XUY9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q05397	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q92844	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q8IVH8	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:A7MCY6	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-359969|uniprotkb:Q14DW3|uniprotkb:O94873|uniprotkb:B2RZG6|ensembl:ENSP00000354777	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:tbkb1_human(display_long)|uniprotkb:TBKBP1(gene name)|psi-mi:TBKBP1(display_short)|uniprotkb:SINTBAD(gene name synonym)|uniprotkb:KIAA0775(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_055541.1|ensembl:ENSG00000198933(gene)|ensembl:ENST00000361722(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|interpro:IPR024581|interpro:IPR041641|mint:A7MCY6|refseq:XP_005257916.1|refseq:XP_005257917.1|refseq:XP_005257918.1|refseq:XP_005257919.1|dip:DIP-27604N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:Hf7hEVRztbT681BKO7sMjh1EwX09606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q04771	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q12933	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q13233	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-49776|ensembl:ENSP00000382423	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q9BZL6	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1384325|uniprotkb:Q8TB08|uniprotkb:Q9P0T6|uniprotkb:Q9Y3X8|uniprotkb:M0R2R2|uniprotkb:Q8NCK8|uniprotkb:B4DTS2|uniprotkb:M0QZW1|ensembl:ENSP00000291281|ensembl:ENSP00000393978	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:kpcd2_human(display_long)|uniprotkb:PKD2(gene name synonym)|uniprotkb:nPKC-D2(gene name synonym)|uniprotkb:HSPC187(orf name)|uniprotkb:PRKD2(gene name)|psi-mi:PRKD2(display_short)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_001073349.1|refseq:NP_001073350.1|refseq:NP_001073351.1|refseq:NP_057541.2|refseq:XP_005258773.2|ensembl:ENSG00000105287(gene)|ensembl:ENST00000291281(transcript)|ensembl:ENST00000433867(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0008219"(cell death)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9BZL6|rcsb pdb:2COA|rcsb pdb:3BGM|rcsb pdb:4NNX|rcsb pdb:4NNY|reactome:R-HSA-1660661|interpro:IPR020454	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:Sy4Lim5BpD4r3h7+1hknKP1o4OQ9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:O60285	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1046789|uniprotkb:A7MD39|uniprotkb:Q96KA8|ensembl:ENSP00000261402|intact:EBI-28968258	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:nuak1_human(display_long)|uniprotkb:AMPK-related protein kinase 5(gene name synonym)|uniprotkb:NUAK1(gene name)|psi-mi:NUAK1(display_short)|uniprotkb:ARK5(gene name synonym)|uniprotkb:KIAA0537(gene name synonym)|uniprotkb:OMPHK1(gene name synonym)|uniprotkb:Omphalocele kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_055655.1|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-6804756|go:"GO:2000772"(regulation of cellular senescence)|ensembl:ENSG00000074590(gene)|ensembl:ENST00000261402(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007155"(cell adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|ensembl:ENSP00000261402	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:6P4GR2fFthBsniiqq/yy3Sxm9Sg9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P42684	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	crc64:ED93869BC2B14FAA	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P29597	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1383454|uniprotkb:Q6QB10|uniprotkb:Q96CH0|ensembl:ENSP00000264818|ensembl:ENSP00000431885	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:tyk2_human(display_long)|uniprotkb:TYK2(gene name)|psi-mi:TYK2(display_short)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_003322.3|refseq:XP_011526547.1|dip:DIP-1062N|ensembl:ENSG00000105397(gene)|ensembl:ENST00000264818(transcript)|ensembl:ENST00000525621(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016045(Tyrosine protein kinase, non-receptor, TYK2, N-terminal)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019749|interpro:IPR020635|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:P29597|rcsb pdb:3LXN|rcsb pdb:3LXP|interpro:IPR008266(Tyrosine protein kinase, active site)|rcsb pdb:3NYX|rcsb pdb:3NZ0|rcsb pdb:3ZON|rcsb pdb:4GFO|rcsb pdb:4GIH|rcsb pdb:4GII|rcsb pdb:4GJ2|rcsb pdb:4GJ3|rcsb pdb:4GVJ|rcsb pdb:4OLI|rcsb pdb:4PO6|rcsb pdb:4PY1|rcsb pdb:4WOV|rcsb pdb:5C01|rcsb pdb:5C03|rcsb pdb:5F1Z|rcsb pdb:5F20|rcsb pdb:5TKD|rcsb pdb:5WAL|rcsb pdb:6AAM|rcsb pdb:6DBK|rcsb pdb:6DBM|rcsb pdb:6NSL|rcsb pdb:6NZE|rcsb pdb:6NZF|rcsb pdb:6NZH|rcsb pdb:6NZP|rcsb pdb:6NZQ|rcsb pdb:6NZR|rcsb pdb:6OVA|rcsb pdb:6VNS|rcsb pdb:6VNV|rcsb pdb:6VNX|rcsb pdb:6VNY|rcsb pdb:6X8F|rcsb pdb:6X8G|rcsb pdb:7AX4|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-8854691|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:HH4VIIlFEIQtLoXSDzxmu9nBvZs9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:O14965	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q14289	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P23458	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-1383438|uniprotkb:Q59GQ2|uniprotkb:Q9UD26|ensembl:ENSP00000343204|ensembl:ENSP00000499884|ensembl:ENSP00000499900|ensembl:ENSP00000500296|ensembl:ENSP00000500485|ensembl:ENSP00000500841	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:jak1_human(display_long)|uniprotkb:JAK1(gene name)|psi-mi:JAK1(display_short)|uniprotkb:JAK1A(gene name synonym)|uniprotkb:JAK1B(gene name synonym)|uniprotkb:Janus kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_001308785.1|refseq:NP_002218.2|refseq:NP_001307852.1|refseq:NP_001308781.1|refseq:NP_001308782.1|refseq:NP_001308783.1|refseq:NP_001308784.1|dip:DIP-133N|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-909733|ensembl:ENSG00000162434(gene)|ensembl:ENST00000342505(transcript)|ensembl:ENST00000671929(transcript)|ensembl:ENST00000671954(transcript)|ensembl:ENST00000672179(transcript)|ensembl:ENST00000672247(transcript)|ensembl:ENST00000672434(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:P23458|rcsb pdb:3EYG|rcsb pdb:3EYH|rcsb pdb:4E4L|rcsb pdb:4E4N|rcsb pdb:4E5W|rcsb pdb:4EHZ|rcsb pdb:4EI4|rcsb pdb:4FK6|rcsb pdb:4GS0|rcsb pdb:4I5C|rcsb pdb:4IVB|rcsb pdb:4IVC|rcsb pdb:4IVD|rcsb pdb:4K6Z|rcsb pdb:4K77|rcsb pdb:4L00|rcsb pdb:4L01|rcsb pdb:5E1E|rcsb pdb:5HX8|rcsb pdb:5IXD|rcsb pdb:5IXI|rcsb pdb:5KHW|rcsb pdb:5KHX|rcsb pdb:5L04|rcsb pdb:5WO4|rcsb pdb:6AAH|rcsb pdb:6BBU|rcsb pdb:6C7Y|rcsb pdb:6DBN|rcsb pdb:6ELR|rcsb pdb:6GGH|rcsb pdb:6HZU|rcsb pdb:6N77|rcsb pdb:6N78|rcsb pdb:6N79|rcsb pdb:6N7A|rcsb pdb:6N7B|rcsb pdb:6N7C|rcsb pdb:6N7D|rcsb pdb:6RSB|rcsb pdb:6RSC|rcsb pdb:6RSD|rcsb pdb:6RSE|rcsb pdb:6RSH|rcsb pdb:6SM8|rcsb pdb:6SMB|rcsb pdb:6TPE|rcsb pdb:6TPF|rcsb pdb:6W8L|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1169408|reactome:R-HSA-1266695|reactome:R-HSA-449836|reactome:R-HSA-5673001|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020591|reactome:R-HSA-9020956|reactome:R-HSA-9020958	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:gEEiBAxwXnGGFWwO7OC0l0KjmSY9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:P53667	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-444403|ensembl:ENSP00000336740|uniprotkb:O15283|uniprotkb:Q15820|uniprotkb:Q15821|uniprotkb:Q75MU3|uniprotkb:Q9Y5Q1|uniprotkb:D3DXF4|uniprotkb:D3DXF5|uniprotkb:B7Z6I8	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:limk1_human(display_long)|uniprotkb:LIMK1(gene name)|psi-mi:LIMK1(display_short)|uniprotkb:LIMK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_001191355.1|refseq:NP_002305.1|ensembl:ENSG00000106683(gene)|ensembl:ENST00000336180(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043005"(neuron projection)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53667|rcsb pdb:3S95|rcsb pdb:5HVJ|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:5NXC|rcsb pdb:6WLY|rcsb pdb:7ATS|rcsb pdb:7ATU|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-416572|reactome:R-HSA-5627117|reactome:R-HSA-5627123|dip:DIP-31605N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:UvM2/wj5ZR6w0/JbJ5GvCY/b/fU9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q9UHD2	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q12851	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-49783|uniprotkb:Q86VU3|ensembl:ENSP00000294066	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:m4k2_human(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 2(gene name synonym)|uniprotkb:Germinal center kinase(gene name synonym)|uniprotkb:Rab8-interacting protein(gene name synonym)|uniprotkb:B lymphocyte serine/threonine-protein kinase(gene name synonym)|uniprotkb:MAP4K2(gene name)|psi-mi:MAP4K2(display_short)|uniprotkb:GCK(gene name synonym)|uniprotkb:RAB8IP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_004570.2|refseq:NP_001294919.1|ensembl:ENSG00000168067(gene)|ensembl:ENST00000294066(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006955"(immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:UBzaZ9UYKmUXyRbPy6rqnf/lHeM9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q04912	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-2637518|uniprotkb:B5A944|uniprotkb:B5A945|uniprotkb:B5A946|uniprotkb:B5A947|ensembl:ENSP00000296474|uniprotkb:A0A087WZG2	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:ron_human(display_long)|uniprotkb:MST1R(gene name)|psi-mi:MST1R(display_short)|uniprotkb:PTK8(gene name synonym)|uniprotkb:RON(gene name synonym)|uniprotkb:p185-Ron(gene name synonym)|uniprotkb:Protein-tyrosine kinase 8(gene name synonym)|uniprotkb:CDw136(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	refseq:NP_001231866.1|refseq:NP_002438.2|ensembl:ENSG00000164078(gene)|ensembl:ENST00000296474(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036352|interpro:IPR039413|mint:Q04912|rcsb pdb:3PLS|rcsb pdb:4FWW|rcsb pdb:4QT8|reactome:R-HSA-8852405|dip:DIP-6029N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:qwF0CoIEkkzk0ETJxoUnwwKDHho9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:64310"	uniprotkb:Q96GD4	intact:EBI-9250491|chebi:"CHEBI:702271"	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	psi-mi:crizotinib(display_short)|psi-mi:"CHEBI:64310"(display_long)|intact:crizotinib(synonym)|intact:PF 2341066(synonym)|intact:PF-2341066(synonym)|intact:"3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250501	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:877399-52-5(identity)	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	-	inchi key:KTEIFNKAUNYNJU-GFCCVEGCSA-N	-	figure legend:3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2018/09/18	-	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	intact-crc:7B97DA570553A291	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77555"	uniprotkb:P36639	intact:EBI-9250442|cas registry number:1374356-45-2	intact:EBI-1048967|uniprotkb:Q6P0Y6|uniprotkb:Q9UBM0|uniprotkb:Q9UBM9|ensembl:ENSP00000343439|uniprotkb:Q8IV95|ensembl:ENSP00000380239|ensembl:ENSP00000349148|uniprotkb:A4D205|ensembl:ENSP00000380242|uniprotkb:Q6LES7|uniprotkb:Q7Z7N6	psi-mi:s-crizotinib(display_short)|psi-mi:"CHEBI:77555"(display_long)	psi-mi:8odp_human(display_long)|uniprotkb:8-oxo-dGTPase(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 1(gene name synonym)|uniprotkb:NUDT1(gene name)|psi-mi:NUDT1(display_short)|uniprotkb:MTH1(gene name synonym)|uniprotkb:2-hydroxy-dATP diphosphatase(gene name synonym)|uniprotkb:7,8-dihydro-8-oxoguanine triphosphatase(gene name synonym)|uniprotkb:Methylated purine nucleoside triphosphate hydrolase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250549	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:1374356-45-2(identity)	ensembl:ENSG00000106268(gene)|refseq:NP_002443.3|refseq:NP_945186.1|refseq:NP_945187.1|refseq:NP_945188.1|refseq:NP_945190.1|refseq:NP_945191.1|refseq:NP_945192.1|ensembl:ENST00000339737(transcript)|ensembl:ENST00000397046(transcript)|ensembl:ENST00000356714(transcript)|ensembl:ENST00000397049(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006152"(purine nucleoside catabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008413"(8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0008828"(dATP pyrophosphohydrolase activity)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035539"(8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity)|go:"GO:0042262"(DNA protection)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047693"(ATP diphosphatase activity)|go:"GO:0106377"(2-hydroxy-ATP hydrolase activity)|go:"GO:0106378"(2-hydroxy-dATP hydrolase activity)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR003563(7,8-dihydro-8-oxoguanine triphosphatase)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR020476|rcsb pdb:1IRY|rcsb pdb:3Q93|rcsb pdb:3WHW|rcsb pdb:3ZR0|rcsb pdb:3ZR1|rcsb pdb:4C9W|rcsb pdb:4C9X|rcsb pdb:4N1T|rcsb pdb:4N1U|rcsb pdb:5ANS|rcsb pdb:5ANT|rcsb pdb:5ANU|rcsb pdb:5ANV|rcsb pdb:5ANW|rcsb pdb:5FSI|rcsb pdb:5FSK|rcsb pdb:5FSL|rcsb pdb:5FSM|rcsb pdb:5FSN|rcsb pdb:5FSO|rcsb pdb:5GHI|rcsb pdb:5GHJ|rcsb pdb:5GHM|rcsb pdb:5GHN|rcsb pdb:5GHO|rcsb pdb:5GHP|rcsb pdb:5GHQ|rcsb pdb:5NGR|rcsb pdb:5NGS|rcsb pdb:5NGT|rcsb pdb:5NHY|rcsb pdb:5OTM|rcsb pdb:5WS7|rcsb pdb:6AA3|rcsb pdb:6AA4|rcsb pdb:6AA5|rcsb pdb:6EQ2|rcsb pdb:6EQ3|rcsb pdb:6EQ4|rcsb pdb:6EQ5|rcsb pdb:6EQ6|rcsb pdb:6EQ7|rcsb pdb:6F1X|rcsb pdb:6F20|rcsb pdb:6F22|rcsb pdb:6F23|rcsb pdb:6GLE|rcsb pdb:6GLF|rcsb pdb:6GLG|rcsb pdb:6GLH|rcsb pdb:6GLI|rcsb pdb:6GLJ|rcsb pdb:6GLK|rcsb pdb:6GLL|rcsb pdb:6GLM|rcsb pdb:6GLN|rcsb pdb:6GLO|rcsb pdb:6GLP|rcsb pdb:6GLQ|rcsb pdb:6GLR|rcsb pdb:6GLS|rcsb pdb:6GLT|rcsb pdb:6GLU|rcsb pdb:6GLV|rcsb pdb:6IJY|rcsb pdb:6ILI|rcsb pdb:6IMZ|rcsb pdb:6JVF|rcsb pdb:6JVG|rcsb pdb:6JVH|rcsb pdb:6JVI|rcsb pdb:6JVJ|rcsb pdb:6JVK|rcsb pdb:6JVL|rcsb pdb:6JVM|rcsb pdb:6JVN|rcsb pdb:6JVO|rcsb pdb:6JVP|rcsb pdb:6JVQ|rcsb pdb:6JVR|rcsb pdb:6JVS|rcsb pdb:6JVT|rcsb pdb:6QVO|rcsb pdb:6US2|rcsb pdb:6US3|rcsb pdb:6US4|rcsb pdb:7ESF|reactome:R-HSA-2393930	-	-	-	figure legend:3A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:erF2lD2RVURwEzFcyHqrIpWkO8U9606	intact-crc:888A08D5C7E93898	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:Q13557	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-351018|intact:EBI-1642546|uniprotkb:Q52PK4|uniprotkb:Q59G21|uniprotkb:Q8N553|uniprotkb:Q9UGH6|uniprotkb:Q9UQE9|uniprotkb:A8MVS8|ensembl:ENSP00000339740|ensembl:ENSP00000507073	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:kcc2d_human(display_long)|uniprotkb:CAMK2D(gene name)|psi-mi:CAMK2D(display_short)|uniprotkb:CAMKD(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	refseq:NP_001212.2|refseq:NP_742112.1|refseq:NP_742113.1|refseq:NP_742125.1|refseq:NP_742126.1|refseq:NP_742127.1|refseq:NP_001308495.1|refseq:NP_001308502.1|refseq:NP_001308509.1|refseq:NP_001308518.1|ensembl:ENSG00000145349(gene)|ensembl:ENST00000342666(transcript)|ensembl:ENST00000683023(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031432"(titin binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901725"(regulation of histone deacetylase activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13557|rcsb pdb:2VN9|rcsb pdb:2W2C|rcsb pdb:2WEL|rcsb pdb:3GP2|rcsb pdb:5VLO|rcsb pdb:6AYW|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR032710|refseq:XP_011530591.1|refseq:XP_011530593.1|dip:DIP-33129N	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:z2mz73Kq9gwpKgo2Todn0IxQpSI9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:Q8NC51	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-523558|uniprotkb:Q8WUH0|uniprotkb:Q96SE2|uniprotkb:Q9BTY3|uniprotkb:Q9BUM4|uniprotkb:Q9Y367|uniprotkb:Q9Y4S3|uniprotkb:Q5VU19|intact:EBI-1058614|ensembl:ENSP00000360034|uniprotkb:Q5VU20|uniprotkb:Q5VU22	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:pairb_human(display_long)|uniprotkb:PAI1 RNA-binding protein 1(gene name synonym)|uniprotkb:SERPINE1 mRNA-binding protein 1(gene name synonym)|uniprotkb:CGI-55(orf name)|uniprotkb:SERBP1(gene name)|psi-mi:SERBP1(display_short)|uniprotkb:PAIRBP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	ensembl:ENSG00000142864(gene)|ensembl:ENST00000370995(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030578"(PML body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR027205|interpro:IPR032381|interpro:IPR039764|mint:Q8NC51|rcsb pdb:4V6X|rcsb pdb:6Z6M|rcsb pdb:6Z6N|refseq:NP_001018077.1|refseq:NP_001018078.1|refseq:NP_001018079.1|refseq:NP_056455.3|dip:DIP-33819N	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:lVkIPRkoXs3B4Qop1pA2zG/RKlo9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:P09417	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-1220237|uniprotkb:Q53F52|uniprotkb:Q9H3M5|uniprotkb:B3KW71|uniprotkb:A8K158|ensembl:ENSP00000281243	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:dhpr_human(display_long)|uniprotkb:QDPR(gene name)|psi-mi:QDPR(display_short)|uniprotkb:DHPR(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 33C member 1(gene name synonym)|uniprotkb:SDR33C1(gene name synonym)|uniprotkb:HDHPR(gene name synonym)|uniprotkb:Quinoid dihydropteridine reductase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	refseq:NP_000311.2|refseq:NP_001293069.1|ensembl:ENSG00000151552(gene)|ensembl:ENST00000281243(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004155"(6,7-dihydropteridine reductase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0006559"(L-phenylalanine catabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010288"(response to lead ion)|go:"GO:0033762"(response to glucagon)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0051066"(dihydrobiopterin metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070402"(NADPH binding)|go:"GO:0070404"(NADH binding)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|rcsb pdb:1HDR|reactome:R-HSA-8964208	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:RqJtqqhZKq5A8usbPddeDp3440c9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:Q00610	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:P32320	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-9250559|ensembl:ENSP00000364212	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:cdd_human(display_long)|uniprotkb:CDA(gene name)|psi-mi:CDA(display_short)|uniprotkb:CDD(gene name synonym)|uniprotkb:Cytidine aminohydrolase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	refseq:NP_001776.1|ensembl:ENSG00000158825(gene)|ensembl:ENST00000375071(transcript)|go:"GO:0001882"(nucleoside binding)|go:"GO:0004126"(cytidine deaminase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008655"(pyrimidine-containing compound salvage)|go:"GO:0009972"(cytidine deamination)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045980"(negative regulation of nucleotide metabolic process)|go:"GO:0047844"(deoxycytidine deaminase activity)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002125(CMP/dCMP deaminase, zinc-binding)|interpro:IPR006262(Cytidine deaminase, homotetrameric)|interpro:IPR016192(APOBEC/CMP deaminase, zinc-binding)|interpro:IPR016193(Cytidine deaminase-like)|rcsb pdb:1MQ0|reactome:R-HSA-6798695|reactome:R-HSA-73614	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:DpRhSQmMab4lqQ5XjR+kiUALOAs9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:P16083	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-358466|uniprotkb:B2R492|ensembl:ENSP00000337773|ensembl:ENSP00000369795|ensembl:ENSP00000369822|uniprotkb:Q5TD04	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:nqo2_human(display_long)|uniprotkb:NQO2(gene name)|psi-mi:NQO2(display_short)|uniprotkb:NMOR2(gene name synonym)|uniprotkb:NRH dehydrogenase [quinone] 2(gene name synonym)|uniprotkb:"NRH:quinone oxidoreductase 2"(gene name synonym)|uniprotkb:Quinone reductase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	rcsb pdb:1QR2|rcsb pdb:1SG0|go:"GO:0031404"(chloride ion binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071949"(FAD binding)|go:"GO:1901662"(quinone catabolic process)|go:"GO:1904408"(melatonin binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905594"(resveratrol binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|refseq:NP_000895.2|ensembl:ENSG00000124588(gene)|ensembl:ENST00000338130(transcript)|ensembl:ENST00000380430(transcript)|ensembl:ENST00000380455(transcript)|go:"GO:0001512"(dihydronicotinamide riboside quinone reductase activity)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|refseq:NP_001305869.1|refseq:NP_001277150.1|rcsb pdb:1XI2|rcsb pdb:1ZX1|rcsb pdb:2BZS|rcsb pdb:2QMY|rcsb pdb:2QMZ|rcsb pdb:2QR2|rcsb pdb:2QWX|rcsb pdb:2QX4|rcsb pdb:2QX6|rcsb pdb:2QX8|rcsb pdb:2QX9|rcsb pdb:3FW1|rcsb pdb:3G5M|rcsb pdb:3GAM|rcsb pdb:3NFR|rcsb pdb:3NHF|rcsb pdb:3NHJ|rcsb pdb:3NHK|rcsb pdb:3NHL|rcsb pdb:3NHP|rcsb pdb:3NHR|rcsb pdb:3NHS|rcsb pdb:3NHW|rcsb pdb:3NHY|rcsb pdb:3O2N|rcsb pdb:3O73|rcsb pdb:3OVM|rcsb pdb:3OWH|rcsb pdb:3OWX|rcsb pdb:3OX1|rcsb pdb:3OX2|rcsb pdb:3OX3|rcsb pdb:3TE7|rcsb pdb:3TEM|rcsb pdb:3TZB|rcsb pdb:3UXE|rcsb pdb:3UXH|rcsb pdb:4FGJ|rcsb pdb:4FGK|rcsb pdb:4FGL|rcsb pdb:4GQI|rcsb pdb:4GR9|rcsb pdb:4QOD|rcsb pdb:4QOE|rcsb pdb:4QOF|rcsb pdb:4QOG|rcsb pdb:4QOH|rcsb pdb:4QOI|rcsb pdb:4QOJ|rcsb pdb:4U7F|rcsb pdb:4U7G|rcsb pdb:4U7H|rcsb pdb:4XDG|rcsb pdb:4XDH|rcsb pdb:4ZVK|rcsb pdb:4ZVL|rcsb pdb:4ZVM|rcsb pdb:4ZVN|rcsb pdb:5BUC|rcsb pdb:5LBT|rcsb pdb:5LBU|rcsb pdb:5LBW|rcsb pdb:5LBY|rcsb pdb:5LBZ|reactome:R-HSA-211945|rcsb pdb:3NHU|dip:DIP-39704N	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:e23niMWdj6fUH4WR3K6sUCTM0KE9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:P62269	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-352451|ensembl:ENSP00000211372|ensembl:ENSP00000393241|ensembl:ENSP00000403175|ensembl:ENSP00000412583|ensembl:ENSP00000416110|uniprotkb:P25232|uniprotkb:Q6IPF8|uniprotkb:Q5SUJ3	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:rs18_human(display_long)|uniprotkb:RPS18(gene name)|psi-mi:RPS18(display_short)|uniprotkb:D6S218E(gene name synonym)|uniprotkb:Ke-3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS13(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	refseq:NP_072045.1|ensembl:ENSG00000096150(gene)|ensembl:ENSG00000223367(gene)|ensembl:ENSG00000226225(gene)|ensembl:ENSG00000231500(gene)|ensembl:ENSG00000235650(gene)|ensembl:ENST00000211372(transcript)|ensembl:ENST00000434122(transcript)|ensembl:ENST00000439602(transcript)|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENST00000454021(transcript)|ensembl:ENST00000457341(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62269|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|dip:DIP-32892N	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:yOHgKM/BuvgGdqp1OEVPeuiABg89606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:P55263	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-1384340|uniprotkb:B7Z800|uniprotkb:O00741|uniprotkb:O00742|uniprotkb:Q16710|uniprotkb:Q9BTN2|uniprotkb:Q5JQ11|uniprotkb:B7Z783|uniprotkb:Q5JQ10|ensembl:ENSP00000443965	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:adk_human(display_long)|uniprotkb:Adenosine 5'-phosphotransferase(gene name synonym)|uniprotkb:ADK(gene name)|psi-mi:ADK(display_short)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	refseq:NP_001114.2|refseq:NP_001189378.1|refseq:NP_006712.2|refseq:NP_001189379.1|ensembl:ENSG00000156110(gene)|ensembl:ENST00000539909(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004001"(adenosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006175"(dATP biosynthetic process)|go:"GO:0009156"(ribonucleoside monophosphate biosynthetic process)|go:"GO:0044209"(AMP salvage)|go:"GO:0046872"(metal ion binding)|interpro:IPR001805(Adenosine kinase)|interpro:IPR002173(Carbohydrate/puine kinase, PfkB, conserved site)|interpro:IPR011611(Carbohydrate/purine kinase)|interpro:IPR029056|rcsb pdb:1BX4|rcsb pdb:2I6A|rcsb pdb:2I6B|rcsb pdb:4O1L|reactome:R-HSA-74217|go:"GO:0006166"(purine ribonucleoside salvage)	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:YiapVEW3Fq83fwNLkIwwnJxFYzE9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:P36639	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-1048967|uniprotkb:Q6P0Y6|uniprotkb:Q9UBM0|uniprotkb:Q9UBM9|ensembl:ENSP00000343439|uniprotkb:Q8IV95|ensembl:ENSP00000380239|ensembl:ENSP00000349148|uniprotkb:A4D205|ensembl:ENSP00000380242|uniprotkb:Q6LES7|uniprotkb:Q7Z7N6	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:8odp_human(display_long)|uniprotkb:8-oxo-dGTPase(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 1(gene name synonym)|uniprotkb:NUDT1(gene name)|psi-mi:NUDT1(display_short)|uniprotkb:MTH1(gene name synonym)|uniprotkb:2-hydroxy-dATP diphosphatase(gene name synonym)|uniprotkb:7,8-dihydro-8-oxoguanine triphosphatase(gene name synonym)|uniprotkb:Methylated purine nucleoside triphosphate hydrolase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	ensembl:ENSG00000106268(gene)|refseq:NP_002443.3|refseq:NP_945186.1|refseq:NP_945187.1|refseq:NP_945188.1|refseq:NP_945190.1|refseq:NP_945191.1|refseq:NP_945192.1|ensembl:ENST00000339737(transcript)|ensembl:ENST00000397046(transcript)|ensembl:ENST00000356714(transcript)|ensembl:ENST00000397049(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006152"(purine nucleoside catabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008413"(8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0008828"(dATP pyrophosphohydrolase activity)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035539"(8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity)|go:"GO:0042262"(DNA protection)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047693"(ATP diphosphatase activity)|go:"GO:0106377"(2-hydroxy-ATP hydrolase activity)|go:"GO:0106378"(2-hydroxy-dATP hydrolase activity)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR003563(7,8-dihydro-8-oxoguanine triphosphatase)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR020476|rcsb pdb:1IRY|rcsb pdb:3Q93|rcsb pdb:3WHW|rcsb pdb:3ZR0|rcsb pdb:3ZR1|rcsb pdb:4C9W|rcsb pdb:4C9X|rcsb pdb:4N1T|rcsb pdb:4N1U|rcsb pdb:5ANS|rcsb pdb:5ANT|rcsb pdb:5ANU|rcsb pdb:5ANV|rcsb pdb:5ANW|rcsb pdb:5FSI|rcsb pdb:5FSK|rcsb pdb:5FSL|rcsb pdb:5FSM|rcsb pdb:5FSN|rcsb pdb:5FSO|rcsb pdb:5GHI|rcsb pdb:5GHJ|rcsb pdb:5GHM|rcsb pdb:5GHN|rcsb pdb:5GHO|rcsb pdb:5GHP|rcsb pdb:5GHQ|rcsb pdb:5NGR|rcsb pdb:5NGS|rcsb pdb:5NGT|rcsb pdb:5NHY|rcsb pdb:5OTM|rcsb pdb:5WS7|rcsb pdb:6AA3|rcsb pdb:6AA4|rcsb pdb:6AA5|rcsb pdb:6EQ2|rcsb pdb:6EQ3|rcsb pdb:6EQ4|rcsb pdb:6EQ5|rcsb pdb:6EQ6|rcsb pdb:6EQ7|rcsb pdb:6F1X|rcsb pdb:6F20|rcsb pdb:6F22|rcsb pdb:6F23|rcsb pdb:6GLE|rcsb pdb:6GLF|rcsb pdb:6GLG|rcsb pdb:6GLH|rcsb pdb:6GLI|rcsb pdb:6GLJ|rcsb pdb:6GLK|rcsb pdb:6GLL|rcsb pdb:6GLM|rcsb pdb:6GLN|rcsb pdb:6GLO|rcsb pdb:6GLP|rcsb pdb:6GLQ|rcsb pdb:6GLR|rcsb pdb:6GLS|rcsb pdb:6GLT|rcsb pdb:6GLU|rcsb pdb:6GLV|rcsb pdb:6IJY|rcsb pdb:6ILI|rcsb pdb:6IMZ|rcsb pdb:6JVF|rcsb pdb:6JVG|rcsb pdb:6JVH|rcsb pdb:6JVI|rcsb pdb:6JVJ|rcsb pdb:6JVK|rcsb pdb:6JVL|rcsb pdb:6JVM|rcsb pdb:6JVN|rcsb pdb:6JVO|rcsb pdb:6JVP|rcsb pdb:6JVQ|rcsb pdb:6JVR|rcsb pdb:6JVS|rcsb pdb:6JVT|rcsb pdb:6QVO|rcsb pdb:6US2|rcsb pdb:6US3|rcsb pdb:6US4|rcsb pdb:7ESF|reactome:R-HSA-2393930	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:erF2lD2RVURwEzFcyHqrIpWkO8U9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77556"	uniprotkb:P61247	intact:EBI-9250455|cas registry number:171927-40-5	intact:EBI-352378|uniprotkb:P33443|uniprotkb:P49241|uniprotkb:B2R4D4|intact:EBI-3440915|uniprotkb:D3DP05|ensembl:ENSP00000346050	psi-mi:sch51344(display_short)|psi-mi:"CHEBI:77556"(display_long)	psi-mi:rs3a_human(display_long)|uniprotkb:RPS3A(gene name)|psi-mi:RPS3A(display_short)|uniprotkb:MFTL(gene name synonym)|uniprotkb:FTE1(gene name synonym)|uniprotkb:v-fos transformation effector protein(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huber et al. (2014)	pubmed:24695225|intact:EBI-9232460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9250555	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	cas registry number:171927-40-5(identity)	refseq:NP_000997.1|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:4V6X|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000145425(gene)|ensembl:ENST00000274065(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|mint:P61247|rcsb pdb:4UG0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6OM7|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-29408N	-	-	-	figure legend:1A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/25	2021/11/30	-	rogid:g1TMzz8OFWEuhrRCoecj7KW0qTQ9606	intact-crc:E325C51E2CE40859	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)