#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05877	uniprotkb:P05877	intact:EBI-9255299	intact:EBI-9255299	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Tan et al. (2014)	pubmed:24657436|imex:IM-22551	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9255340|imex:IM-22551-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	-	-	-	figure legend:f2a f2b f5a f5b|comment:"It was found that the solutions of EPs were turbid. Thus, we speculated that EPs might form amyloid   fibrils that were water insoluble. As shown in Figure 2, EPs could bind to the amyloid-specific dyes   Congo red and ThT in a dose-dependent manner (Fig. 2A and 2B). Notably, unlike SEVI, which fibril   formation requires specific conditions, including agitation, a suitable salt concentration and pH of the   solution [19], EPs could spontaneously form amyloid fibrils."|comment:"We incubated freshly dissolved EP2 with EGCG, and the formation of the β-sheet   structures was monitored. The freshly dissolved peptide could readily bind to ThT, implying a   spontaneous process of fibril formation (Fig. 5A). During the incubation period of EP2 and EGCG, the   ThT fluorescence intensity decreased in time- and dose-dependent manners, while the signals slightly   increased during incubation of EP2 alone (Fig. 5A). Next, we exposed preformed EP2 fibrils to various   concentrations of EGCG and monitored the degradation of the fibrillar structures over time via ThT   staining. The preformed EP2 amyloid fibrils (550 µM) were highly stable in PBS for a period of 72 h.   In contrast, the preformed amyloid fibrils were clearly degraded in the presence of EGCG (Fig. 5B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/10	2014/10/16	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	intact-crc:44B0F5DAC92B1360|rigid:oQ+aXwtHvJ9QRTpqItJfWN+CH2o	false	binding-associated region:417-431	binding-associated region:417-431	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P05877	uniprotkb:P05877	intact:EBI-9255299	intact:EBI-9255299	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Tan et al. (2014)	pubmed:24657436|imex:IM-22551	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9255283|imex:IM-22551-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	-	-	-	figure legend:f2a f2b|comment:"It was found that the solutions of EPs were turbid. Thus, we speculated that EPs might form amyloid   fibrils that were water insoluble. As shown in Figure 2, EPs could bind to the amyloid-specific dyes   Congo red and ThT in a dose-dependent manner (Fig. 2A and 2B). Notably, unlike SEVI, which fibril   formation requires specific conditions, including agitation, a suitable salt concentration and pH of the   solution [19], EPs could spontaneously form amyloid fibrils."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/10	2014/10/16	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	intact-crc:8CD4F399C9440B7B|rigid:oQ+aXwtHvJ9QRTpqItJfWN+CH2o	false	binding-associated region:413-427	binding-associated region:413-427	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P05877	uniprotkb:P05877	intact:EBI-9255299	intact:EBI-9255299	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Tan et al. (2014)	pubmed:24657436|imex:IM-22551	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9255363|imex:IM-22551-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	-	-	-	figure legend:f2a f2b|comment:"It was found that the solutions of EPs were turbid. Thus, we speculated that EPs might form amyloid   fibrils that were water insoluble. As shown in Figure 2, EPs could bind to the amyloid-specific dyes   Congo red and ThT in a dose-dependent manner (Fig. 2A and 2B). Notably, unlike SEVI, which fibril   formation requires specific conditions, including agitation, a suitable salt concentration and pH of the   solution [19], EPs could spontaneously form amyloid fibrils."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/10	2014/10/16	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	intact-crc:24EF80F09BD9AED8|rigid:oQ+aXwtHvJ9QRTpqItJfWN+CH2o	false	binding-associated region:413-431	binding-associated region:413-431	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P15309	uniprotkb:P15309	intact:EBI-1222012|uniprotkb:Q96KY0|uniprotkb:Q96QK9|uniprotkb:Q96QM0|uniprotkb:D3DNC6|uniprotkb:Q5FBY0|ensembl:ENSP00000337471	intact:EBI-1222012|uniprotkb:Q96KY0|uniprotkb:Q96QK9|uniprotkb:Q96QM0|uniprotkb:D3DNC6|uniprotkb:Q5FBY0|ensembl:ENSP00000337471	psi-mi:ppap_human(display_long)|uniprotkb:ACP3(gene name)|psi-mi:ACP3(display_short)|uniprotkb:5'-nucleotidase(gene name synonym)|uniprotkb:ACPP(gene name synonym)|uniprotkb:Acid phosphatase 3(gene name synonym)|uniprotkb:Ecto-5'-nucleotidase(gene name synonym)|uniprotkb:Thiamine monophosphatase(gene name synonym)|uniprotkb:Protein tyrosine phosphatase ACP3(gene name synonym)	psi-mi:ppap_human(display_long)|uniprotkb:ACP3(gene name)|psi-mi:ACP3(display_short)|uniprotkb:5'-nucleotidase(gene name synonym)|uniprotkb:ACPP(gene name synonym)|uniprotkb:Acid phosphatase 3(gene name synonym)|uniprotkb:Ecto-5'-nucleotidase(gene name synonym)|uniprotkb:Thiamine monophosphatase(gene name synonym)|uniprotkb:Protein tyrosine phosphatase ACP3(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Tan et al. (2014)	pubmed:24657436|imex:IM-22551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9255378|imex:IM-22551-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001090.2|refseq:NP_001127666.1|refseq:NP_001278966.1|ensembl:ENSG00000014257(gene)|ensembl:ENST00000336375(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0006772"(thiamine metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030175"(filopodium)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042131"(thiamine phosphate phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046085"(adenosine metabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0052642"(lysophosphatidic acid phosphatase activity)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000560(Histidine acid phosphatase)|interpro:IPR029033|interpro:IPR033379|mint:P15309|rcsb pdb:1CVI|rcsb pdb:1ND5|rcsb pdb:1ND6|rcsb pdb:2HPA|rcsb pdb:2L3H|rcsb pdb:2L77|rcsb pdb:2L79|rcsb pdb:2MG0|rcsb pdb:3PPD|reactome:R-HSA-6798695	refseq:NP_001090.2|refseq:NP_001127666.1|refseq:NP_001278966.1|ensembl:ENSG00000014257(gene)|ensembl:ENST00000336375(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0006772"(thiamine metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030175"(filopodium)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042131"(thiamine phosphate phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046085"(adenosine metabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0052642"(lysophosphatidic acid phosphatase activity)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000560(Histidine acid phosphatase)|interpro:IPR029033|interpro:IPR033379|mint:P15309|rcsb pdb:1CVI|rcsb pdb:1ND5|rcsb pdb:1ND6|rcsb pdb:2HPA|rcsb pdb:2L3H|rcsb pdb:2L77|rcsb pdb:2L79|rcsb pdb:2MG0|rcsb pdb:3PPD|reactome:R-HSA-6798695	-	-	-	figure legend:f2a f2b|comment:"Peptides derived from prostatic acidic phosphatase (PAP, predominant component   PAP248-286) in semen, designated as semen-derived enhancer of viral infection (SEVI), significantly   enhanced HIV-1 infection via the formation of amyloid fibrils"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/10	2014/10/16	rogid:FLbVR5/u8MLUphen4TZZaKOPY7U9606	rogid:FLbVR5/u8MLUphen4TZZaKOPY7U9606	intact-crc:7A49DA4B3E16492D|rigid:lYsW0H5A/o1Y/5kHyhDYe5Eacts	false	binding-associated region:248-286	binding-associated region:248-286	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P05877	uniprotkb:P05877	intact:EBI-9255299	intact:EBI-9255299	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Tan et al. (2014)	pubmed:24657436|imex:IM-22551	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9255417|imex:IM-22551-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	-	-	-	figure legend:f2c|comment:"Next, we performed transmission  microscopy to examine the morphology of amyloid fibrils composed of EPs. Interestingly, the amyloid  fibril structures of EPs are different from that of SEVI (Fig. 2C). EPs form short and soft amyloid-like  fibrils, while SEVI forms long and rigid amyloid fibrils."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/10	2014/10/16	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	intact-crc:8AE5A140235F8C69|rigid:oQ+aXwtHvJ9QRTpqItJfWN+CH2o	false	binding-associated region:413-431	binding-associated region:413-431	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P05877	uniprotkb:P05877	intact:EBI-9255299	intact:EBI-9255299	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Tan et al. (2014)	pubmed:24657436|imex:IM-22551	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9255406|imex:IM-22551-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	-	-	-	figure legend:f2c|comment:"Next, we performed transmission  microscopy to examine the morphology of amyloid fibrils composed of EPs. Interestingly, the amyloid  fibril structures of EPs are different from that of SEVI (Fig. 2C). EPs form short and soft amyloid-like  fibrils, while SEVI forms long and rigid amyloid fibrils."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/10	2014/10/16	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	intact-crc:6EA21C3CB37ED40B|rigid:oQ+aXwtHvJ9QRTpqItJfWN+CH2o	false	binding-associated region:417-431	binding-associated region:417-431	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P05877	uniprotkb:P05877	intact:EBI-9255299	intact:EBI-9255299	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:env_hv1mn(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Tan et al. (2014)	pubmed:24657436|imex:IM-22551	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	taxid:11696(hv1mn)|taxid:11696("Human immunodeficiency virus type 1 group M subtype B (isolate MN)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9255395|imex:IM-22551-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	rcsb pdb:3E6H|reactome:R-HSA-5621480|rcsb pdb:4XMK|rcsb pdb:1AI1|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR000328(Envelope Polyprotein GP41)|rcsb pdb:1ACY|rcsb pdb:1F58|rcsb pdb:1NAK|rcsb pdb:1NIZ|rcsb pdb:1NJ0|rcsb pdb:2B0S|rcsb pdb:2QSC|rcsb pdb:3GO1|rcsb pdb:3MLW|rcsb pdb:3MLX|rcsb pdb:3UJI|rcsb pdb:4M1D|rcsb pdb:4XAW|rcsb pdb:4XBE|rcsb pdb:4XC1|rcsb pdb:4XC3|rcsb pdb:4XCF|rcsb pdb:1GGI|rcsb pdb:1K5M|rcsb pdb:1Q1J|rcsb pdb:6DB7|interpro:IPR036377|interpro:IPR037527|rcsb pdb:5KD4|rcsb pdb:5KD7|rcsb pdb:5T7G|rcsb pdb:6DB6|rcsb pdb:6SH9|rcsb pdb:6MNS|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:0019062"(virion attachment to host cell)	-	-	-	figure legend:f2c|comment:"Next, we performed transmission  microscopy to examine the morphology of amyloid fibrils composed of EPs. Interestingly, the amyloid  fibril structures of EPs are different from that of SEVI (Fig. 2C). EPs form short and soft amyloid-like  fibrils, while SEVI forms long and rigid amyloid fibrils."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/10	2014/10/16	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	rogid:z7eYcHc9Uh49mZQkXImOhZSBTnE11696	intact-crc:CF5E784C37BB14F4|rigid:oQ+aXwtHvJ9QRTpqItJfWN+CH2o	false	binding-associated region:413-427	binding-associated region:413-427	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P15309	uniprotkb:P15309	intact:EBI-1222012|uniprotkb:Q96KY0|uniprotkb:Q96QK9|uniprotkb:Q96QM0|uniprotkb:D3DNC6|uniprotkb:Q5FBY0|ensembl:ENSP00000337471	intact:EBI-1222012|uniprotkb:Q96KY0|uniprotkb:Q96QK9|uniprotkb:Q96QM0|uniprotkb:D3DNC6|uniprotkb:Q5FBY0|ensembl:ENSP00000337471	psi-mi:ppap_human(display_long)|uniprotkb:ACP3(gene name)|psi-mi:ACP3(display_short)|uniprotkb:5'-nucleotidase(gene name synonym)|uniprotkb:ACPP(gene name synonym)|uniprotkb:Acid phosphatase 3(gene name synonym)|uniprotkb:Ecto-5'-nucleotidase(gene name synonym)|uniprotkb:Thiamine monophosphatase(gene name synonym)|uniprotkb:Protein tyrosine phosphatase ACP3(gene name synonym)	psi-mi:ppap_human(display_long)|uniprotkb:ACP3(gene name)|psi-mi:ACP3(display_short)|uniprotkb:5'-nucleotidase(gene name synonym)|uniprotkb:ACPP(gene name synonym)|uniprotkb:Acid phosphatase 3(gene name synonym)|uniprotkb:Ecto-5'-nucleotidase(gene name synonym)|uniprotkb:Thiamine monophosphatase(gene name synonym)|uniprotkb:Protein tyrosine phosphatase ACP3(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Tan et al. (2014)	pubmed:24657436|imex:IM-22551	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9255428|imex:IM-22551-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001090.2|refseq:NP_001127666.1|refseq:NP_001278966.1|ensembl:ENSG00000014257(gene)|ensembl:ENST00000336375(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0006772"(thiamine metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030175"(filopodium)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042131"(thiamine phosphate phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046085"(adenosine metabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0052642"(lysophosphatidic acid phosphatase activity)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000560(Histidine acid phosphatase)|interpro:IPR029033|interpro:IPR033379|mint:P15309|rcsb pdb:1CVI|rcsb pdb:1ND5|rcsb pdb:1ND6|rcsb pdb:2HPA|rcsb pdb:2L3H|rcsb pdb:2L77|rcsb pdb:2L79|rcsb pdb:2MG0|rcsb pdb:3PPD|reactome:R-HSA-6798695	refseq:NP_001090.2|refseq:NP_001127666.1|refseq:NP_001278966.1|ensembl:ENSG00000014257(gene)|ensembl:ENST00000336375(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0006772"(thiamine metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030175"(filopodium)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042131"(thiamine phosphate phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046085"(adenosine metabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0052642"(lysophosphatidic acid phosphatase activity)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000560(Histidine acid phosphatase)|interpro:IPR029033|interpro:IPR033379|mint:P15309|rcsb pdb:1CVI|rcsb pdb:1ND5|rcsb pdb:1ND6|rcsb pdb:2HPA|rcsb pdb:2L3H|rcsb pdb:2L77|rcsb pdb:2L79|rcsb pdb:2MG0|rcsb pdb:3PPD|reactome:R-HSA-6798695	-	-	-	figure legend:f2c|comment:"Next, we performed transmission  microscopy to examine the morphology of amyloid fibrils composed of EPs. Interestingly, the amyloid  fibril structures of EPs are different from that of SEVI (Fig. 2C). EPs form short and soft amyloid-like  fibrils, while SEVI forms long and rigid amyloid fibrils."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/10	2014/10/16	rogid:FLbVR5/u8MLUphen4TZZaKOPY7U9606	rogid:FLbVR5/u8MLUphen4TZZaKOPY7U9606	intact-crc:CD49B9B0F16D9B7F|rigid:lYsW0H5A/o1Y/5kHyhDYe5Eacts	false	binding-associated region:248-286	binding-associated region:248-286	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0083"(peptide synthesis)