#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UEW8	uniprotkb:Q9UHW9	intact:EBI-2680974|uniprotkb:Q9UER4|uniprotkb:O14774|uniprotkb:Q53S90|uniprotkb:Q53SL7|uniprotkb:Q53SS1|ensembl:ENSP00000348278|uniprotkb:X5D9C8	intact:EBI-2823282|uniprotkb:Q2VI00|uniprotkb:Q7Z2E7|uniprotkb:Q7Z4G5|uniprotkb:Q9UFR2|uniprotkb:Q8TDD4|uniprotkb:Q9Y665|uniprotkb:Q9Y642|uniprotkb:A0AV76|ensembl:ENSP00000346112|ensembl:ENSP00000453473|ensembl:ENSP00000454168	psi-mi:stk39_human(display_long)|uniprotkb:SPAK(gene name synonym)|uniprotkb:DCHT(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:STK39(gene name)|psi-mi:STK39(display_short)	psi-mi:s12a6_human(display_long)|uniprotkb:SLC12A6(gene name)|psi-mi:SLC12A6(display_short)|uniprotkb:KCC3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chiu et al. (2014)	pubmed:24655550|imex:IM-22547	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9254964|imex:IM-22547-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037365.2|ensembl:ENSG00000198648(gene)|ensembl:ENST00000355999(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)	refseq:NP_001035959.1|refseq:NP_001035960.1|refseq:NP_001035961.1|refseq:NP_001035962.1|refseq:NP_005126.1|refseq:NP_598408.1|rcsb pdb:7D90|rcsb pdb:7NGB|reactome:R-HSA-426117|reactome:R-HSA-5619039|ensembl:ENSG00000140199(gene)|ensembl:ENST00000354181(transcript)|ensembl:ENST00000558667(transcript)|ensembl:ENST00000560611(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045202"(synapse)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0140157"(ammonium import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000076(K-Cl co-transporter)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR018491|interpro:IPR030364|rcsb pdb:6M1Y|rcsb pdb:6M22|rcsb pdb:6Y5R|rcsb pdb:6Y5V|rcsb pdb:7AIN|rcsb pdb:7AIO	-	-	-	figure legend:f2b|comment:"To establish an IPTG-inducible KCC3 cell line, HEK 293 cells were selected to be   co-transfected with pTet-on-Lac Hyg and pLacM hKCC3 using Lipofectamine 2000   (Invitrogen, Carlsbad, CA, USA) according to the manufacturer’s protocol, and stable   transfectants were selected with Hygomycin B (Invitrogen). This cell line was named   iKCC3 HEK293"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/03/10	2014/10/16	rogid:472OT0D4ddZoxjICU4UOhTOJ4Oo9606	rogid:ZNS+vbjlSeW9IjjaZoqhq/Z8IzA9606	intact-crc:13DE34D4158BDA68|rigid:8oiZP2X84YEQ07V1S3yh2Lu0TgU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)