#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13255	uniprotkb:Q13255	intact:EBI-8527352|uniprotkb:Q14757|uniprotkb:Q9NU10|uniprotkb:Q5VTF8|uniprotkb:Q14758|uniprotkb:Q13256|uniprotkb:Q9UGS9|uniprotkb:Q9UGT0|intact:MINT-2806316|uniprotkb:Q5VTF7|uniprotkb:B9EG79|uniprotkb:F8W805|ensembl:ENSP00000282753|ensembl:ENSP00000354896	intact:EBI-8527352|uniprotkb:Q14757|uniprotkb:Q9NU10|uniprotkb:Q5VTF8|uniprotkb:Q14758|uniprotkb:Q13256|uniprotkb:Q9UGS9|uniprotkb:Q9UGT0|intact:MINT-2806316|uniprotkb:Q5VTF7|uniprotkb:B9EG79|uniprotkb:F8W805|ensembl:ENSP00000282753|ensembl:ENSP00000354896	psi-mi:grm1_human(display_long)|uniprotkb:MGLUR1(gene name synonym)|uniprotkb:GRM1(gene name)|psi-mi:GRM1(display_short)|uniprotkb:GPRC1A(gene name synonym)	psi-mi:grm1_human(display_long)|uniprotkb:MGLUR1(gene name synonym)|uniprotkb:GRM1(gene name)|psi-mi:GRM1(display_short)|uniprotkb:GPRC1A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wu et al. (2014)	pubmed:24603153	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636453|pdbe:4or2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534084.1|ensembl:ENSP00000282753|ensembl:ENST00000355289|ensembl:ENSP00000347437|ensembl:ENSP00000354896|ensembl:ENST00000492807|ensembl:ENSP00000424095|ensembl:ENST00000507907|ensembl:ENSP00000425599|refseq:NP_001264993.1|refseq:NP_001264994.1|refseq:NP_001264995.1|refseq:NP_001264996.1|refseq:XP_016866272.1|refseq:XP_016866273.1|refseq:XP_016866274.1|refseq:XP_016866275.1|refseq:XP_016866276.1|dip:DIP-57522N|ensembl:ENSG00000152822(gene)|ensembl:ENST00000282753(transcript)|ensembl:ENST00000361719(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|mint:Q13255|rcsb pdb:3KS9|rcsb pdb:4OR2|reactome:R-HSA-416476|reactome:R-HSA-420499|reactome:R-HSA-6794361	refseq:XP_011534084.1|ensembl:ENSP00000282753|ensembl:ENST00000355289|ensembl:ENSP00000347437|ensembl:ENSP00000354896|ensembl:ENST00000492807|ensembl:ENSP00000424095|ensembl:ENST00000507907|ensembl:ENSP00000425599|refseq:NP_001264993.1|refseq:NP_001264994.1|refseq:NP_001264995.1|refseq:NP_001264996.1|refseq:XP_016866272.1|refseq:XP_016866273.1|refseq:XP_016866274.1|refseq:XP_016866275.1|refseq:XP_016866276.1|dip:DIP-57522N|ensembl:ENSG00000152822(gene)|ensembl:ENST00000282753(transcript)|ensembl:ENST00000361719(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|mint:Q13255|rcsb pdb:3KS9|rcsb pdb:4OR2|reactome:R-HSA-416476|reactome:R-HSA-420499|reactome:R-HSA-6794361	-	comment:mint|function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum	comment:mint|function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum	figure legend:fig s5|3d-resolution:2.8 A|3d-r-factors:"R-factor: 0.229, R-free: 0.268"|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/03	2014/10/16	rogid:Ym6IL2WbnfJH4aZCVq6xJiI8Ik09606	rogid:Ym6IL2WbnfJH4aZCVq6xJiI8Ik09606	intact-crc:F1F5F28321EF5DC1|rigid:xmlqMcdlU0GaU95Oz+b1Sj+uM3g	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)