#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10997	uniprotkb:P10997	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Wang et al. (2014)	imex:IM-22231|pubmed:24561193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9119352|imex:IM-22231-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	"mimix:comment":not sure about the protein origin|comment:mint	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:f1a f3a|comment:"Firstly, we examined the inhibitory effect of the all-D-amino-acid inhibitor on the assembly  of hIAPP in bulk solution. Similarly to the results of previous studies [30], an aggregation  process from unstructured monomers to β-sheeted fibrils was observed for hIAPP alone in  bulk solution, as indicated by the time-dependence of Thioflavin-T (ThT) fluorescence,  transmission electron microscopy (TEM) image and circular dichroism (CD) spectra (Figure  1A-C). The addition of equimolar peptide inhibitor in bulk solution of hIAPP resulted in a  complete suppression of ThT fluorescence intensity (Figure 1A) and disappearance of fibrils  in TEM image where only small pieces with length around 200-300 nm were left (Figure 1D)."|comment:"We next examined the inhibitory effect of the all-D-amino-acid inhibitor under  phospholipid membrane condition. Before addition of the inhibitor, the ThT fluorescence  intensity of hIAPP in lipid vesicle solution displayed a rapid increase after ca. 5 min delay  (Figure 3A), which is much less than that of hIAPP in bulk solution (corresponding time  needed in bulk solution was ca. 2 h). The decrease in the lag time was attributed to the  accelerating role of lipid membrane for fibril formation of the amyloid peptide which has  been well established [41]."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2014/10/16	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	intact-crc:7CAAC09838104B62|rigid:BBjpAdBwRFIGXy/POxEfN3wMtAs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10997	uniprotkb:P10997	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Wang et al. (2014)	imex:IM-22231|pubmed:24561193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9119376|imex:IM-22231-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	"mimix:comment":not sure about the protein origin|comment:mint	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:f1b f1d|comment:"Firstly, we examined the inhibitory effect of the all-D-amino-acid inhibitor on the assembly  of hIAPP in bulk solution. Similarly to the results of previous studies [30], an aggregation  process from unstructured monomers to β-sheeted fibrils was observed for hIAPP alone in  bulk solution, as indicated by the time-dependence of Thioflavin-T (ThT) fluorescence,  transmission electron microscopy (TEM) image and circular dichroism (CD) spectra (Figure  1A-C). The addition of equimolar peptide inhibitor in bulk solution of hIAPP resulted in a  complete suppression of ThT fluorescence intensity (Figure 1A) and disappearance of fibrils  in TEM image where only small pieces with length around 200-300 nm were left (Figure 1D)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2014/10/16	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	intact-crc:5C47D18B1B50B39D|rigid:BBjpAdBwRFIGXy/POxEfN3wMtAs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10997	uniprotkb:P10997	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Wang et al. (2014)	imex:IM-22231|pubmed:24561193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9119389|imex:IM-22231-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	"mimix:comment":not sure about the protein origin|comment:mint	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:f2|comment:"In order to confirm the difference in the dimensions of the aggregate species of hIAPP in  bulk solution with and without inhibitor, we measured the size population in the process of  hIAPP aggregation by the dynamic light scattering (DLS) experiments in both cases (Figure  2). In the absence of inhibitor, the growth of hIAPP particles from hydrodynamic diameter (d)  of several nanometers (monomers) to several micrometers via intermediates with d smaller  than 400 nm was clearly observed, along with the broadening of size distribution. In  comparison with the case of hIAPP alone in bulk solution, the growth of the peptide in the  presence of equimolar inhibitor stopped at ~2 h with a narrower population of d around  200-350 nm."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2014/10/16	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	intact-crc:2D1857DBE0D779E0|rigid:BBjpAdBwRFIGXy/POxEfN3wMtAs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10997	uniprotkb:P10997	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Wang et al. (2014)	imex:IM-22231|pubmed:24561193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9119414|imex:IM-22231-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	"mimix:comment":not sure about the protein origin|comment:mint	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:f3b f3c f3d|comment:"As show in Figure 3B-D, whereas abundant fibrils were formed at lipid  membrane in the absence of the inhibitor, the amyloid fibrils were remarkably decreased  when hIAPP was incubated with equimolar inhibitor. The fibrillation was even completely  inhibited and a large amount of oligomers were present when threefold inhibitor was added. It  was noted that very thin and elongated fibers are clearly present in AFM image at a molar  ratio of hIAPP:inhibitor = 1:1 but there is no observable increase in the fluorescence intensity  at the same hIAPP:inhibitor ratio. This was because the fluorescence experiments were  performed at a molar ratio of lipid:hIAPP = 150:1, while the ratio used in AFM experiments  was 25:1. Lower lipid:hIAPP ratio (or higher concentration of hIAPP at membrane surface)  used in the AFM experiments caused more rapid aggregation of hIAPP and thus less effective  inhibition for fibril formation. We also measured the AFM image of the inhibitor alone in the  presence of phospholipids after the same incubation time (see Figure S1 in the Supporting  Information). No any apparent aggregates were observed on the AFM image, confirming that  the oligomers appearing in the AFM image of hIAPP in the presence of inhibitor result from  the amyloid peptides but not the inhibitor."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2014/10/16	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	intact-crc:DA53EFF4B8989428|rigid:BBjpAdBwRFIGXy/POxEfN3wMtAs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)