#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P11226	uniprotkb:O15455	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2014)	pubmed:24530528|imex:IM-22209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9095466|imex:IM-22209-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	-	-	-	figure legend:f4a|comment:"We also examined the possibility of TLR3 interaction with exogenous MBL  after entry into the cell. Indeed, the internalized MBL was physically associated with  TLR3, as indicated by immunoprecipitation assays (Fig. 4A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/21	2014/10/16	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	intact-crc:DD57D1B329991FD8|rigid:ib9WQWzDJDJC0GZHg9kBKt2UwUo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11226	uniprotkb:O15455	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Liu et al. (2014)	pubmed:24530528|imex:IM-22209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9095512|imex:IM-22209-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	-	-	-	figure legend:f4b|comment:"In addition, confocal  microscopy showed that MBL could partially colocalize with TLR3 after entering into  either monocytes or DCs (Fig. 4B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/21	2014/10/16	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	intact-crc:0D5094A2440DBD2B|rigid:ib9WQWzDJDJC0GZHg9kBKt2UwUo	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0422"(immunostaining)