#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H832	uniprotkb:O15205	intact:EBI-720977|uniprotkb:A6N8M6|uniprotkb:Q7L354|uniprotkb:Q8TCM4|uniprotkb:Q9H893|uniprotkb:A6NC60|ensembl:ENSP00000354201	intact:EBI-6657186|ensembl:ENSP00000366249|ensembl:ENSP00000373039|ensembl:ENSP00000396152|ensembl:ENSP00000410416|uniprotkb:Q96EC7|uniprotkb:Q5STL2|uniprotkb:B0UZT6|uniprotkb:Q5SUK2	psi-mi:ube2z_human(display_long)|uniprotkb:Ubiquitin-protein ligase Z(gene name synonym)|uniprotkb:Ubiquitin carrier protein Z(gene name synonym)|uniprotkb:Uba6-specific E2 conjugating enzyme 1(gene name synonym)|uniprotkb:UBE2Z(gene name)|psi-mi:UBE2Z(display_short)|uniprotkb:HOYS7(orf name)|uniprotkb:E2 ubiquitin-conjugating enzyme Z(gene name synonym)	psi-mi:ubd_human(display_long)|uniprotkb:UBD(gene name)|psi-mi:UBD(display_short)|uniprotkb:Diubiquitin(gene name synonym)|uniprotkb:FAT10(gene name synonym)|uniprotkb:Ubiquitin-like protein FAT10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Aichem et al. (2014)	imex:IM-22232|pubmed:24528925	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9119507|imex:IM-22232-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075567.2|ensembl:ENSG00000159202(gene)|ensembl:ENST00000360943(transcript)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:5A4P|reactome:R-HSA-8866652|reactome:R-HSA-983168	ensembl:ENSG00000231968(gene)|ensembl:ENST00000377050(transcript)|ensembl:ENST00000383547(transcript)|ensembl:ENST00000421519(transcript)|ensembl:ENST00000432676(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSG00000206468(gene)|ensembl:ENSG00000213886(gene)|ensembl:ENSG00000228913(gene)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070628"(proteasome binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|interpro:IPR042969|rcsb pdb:2MBE|rcsb pdb:6GF1|rcsb pdb:6GF2|reactome:R-HSA-8951664|refseq:NP_006389.2	-	-	-	figure legend:f2a f2c sf1 sf2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/06	2014/10/16	rogid:ha+cN8Y8XYZFrRnAQC9BRiMaUL89606	rogid:ySUgohBHmcPaAaD/l21zkQ3+MPI9606	intact-crc:CA22F394A2050AF1|rigid:rI/tv9+DewYdKWrIb18g1Jx9j2k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H832	uniprotkb:O15205	intact:EBI-720977|uniprotkb:A6N8M6|uniprotkb:Q7L354|uniprotkb:Q8TCM4|uniprotkb:Q9H893|uniprotkb:A6NC60|ensembl:ENSP00000354201	intact:EBI-6657186|ensembl:ENSP00000366249|ensembl:ENSP00000373039|ensembl:ENSP00000396152|ensembl:ENSP00000410416|uniprotkb:Q96EC7|uniprotkb:Q5STL2|uniprotkb:B0UZT6|uniprotkb:Q5SUK2	psi-mi:ube2z_human(display_long)|uniprotkb:Ubiquitin-protein ligase Z(gene name synonym)|uniprotkb:Ubiquitin carrier protein Z(gene name synonym)|uniprotkb:Uba6-specific E2 conjugating enzyme 1(gene name synonym)|uniprotkb:UBE2Z(gene name)|psi-mi:UBE2Z(display_short)|uniprotkb:HOYS7(orf name)|uniprotkb:E2 ubiquitin-conjugating enzyme Z(gene name synonym)	psi-mi:ubd_human(display_long)|uniprotkb:UBD(gene name)|psi-mi:UBD(display_short)|uniprotkb:Diubiquitin(gene name synonym)|uniprotkb:FAT10(gene name synonym)|uniprotkb:Ubiquitin-like protein FAT10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Aichem et al. (2014)	imex:IM-22232|pubmed:24528925	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9119842|imex:IM-22232-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075567.2|ensembl:ENSG00000159202(gene)|ensembl:ENST00000360943(transcript)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:5A4P|reactome:R-HSA-8866652|reactome:R-HSA-983168	ensembl:ENSG00000231968(gene)|ensembl:ENST00000377050(transcript)|ensembl:ENST00000383547(transcript)|ensembl:ENST00000421519(transcript)|ensembl:ENST00000432676(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSG00000206468(gene)|ensembl:ENSG00000213886(gene)|ensembl:ENSG00000228913(gene)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070628"(proteasome binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|interpro:IPR042969|rcsb pdb:2MBE|rcsb pdb:6GF1|rcsb pdb:6GF2|reactome:R-HSA-8951664|refseq:NP_006389.2	-	-	-	figure legend:f3|comment:"As shown in Fig. 3B, each mutant was still able to  form a stable conjugate with FAT10. To compare the amounts of the mutant USE1-FAT10  conjugates, the ECL signals of the USE1-FAT10 conjugates were quantified and normalized  to the respective USE1 variants in the lysate (load) (Fig. 3B, C). A statistical analysis revealed  significantly lower amounts of USE1-K323R-FAT10 (p-value 0.0156) while all other mutant  USE1-FAT10 conjugates did not significantly differ in quantity from wildtype USE1-FAT10"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/06	2014/10/16	rogid:ha+cN8Y8XYZFrRnAQC9BRiMaUL89606	rogid:ySUgohBHmcPaAaD/l21zkQ3+MPI9606	intact-crc:07255A6A665D16A7|rigid:rI/tv9+DewYdKWrIb18g1Jx9j2k	false	ha tag:?-?|mutation decreasing interaction:323-323	tandem tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)