#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q80UE6 uniprotkb:P69744 intact:EBI-295378|uniprotkb:Q4VAC1|uniprotkb:Q80XB5|uniprotkb:Q80XN2|uniprotkb:Q8R0N0|uniprotkb:Q8R340|uniprotkb:A2A4J7|ensembl:ENSMUSP00000099397 intact:EBI-538447|uniprotkb:Q2TB50|ensembl:ENSMUSP00000031901 psi-mi:wnk4_mouse(display_long)|uniprotkb:Wnk4(gene name)|psi-mi:Wnk4(display_short)|uniprotkb:Prkwnk4(gene name synonym)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym) psi-mi:trpv5_mouse(display_long)|uniprotkb:Osm-9-like TRP channel 3(gene name synonym)|uniprotkb:Epithelial calcium channel 1(gene name synonym)|uniprotkb:Calcium transport protein 2(gene name synonym)|uniprotkb:Trpv5(gene name)|psi-mi:Trpv5(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Andrukhova et al. (2014) pubmed:24434184|imex:IM-22219 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9214242|imex:IM-22219-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_783569.1|dip:DIP-33231N|ensembl:ENSMUSG00000035112(gene)|ensembl:ENSMUST00000103108(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|mint:Q80UE6|reactome:R-MMU-2672351 refseq:NP_001007573.1|ensembl:ENSMUSG00000036899(gene)|ensembl:ENSMUST00000031901(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035809"(regulation of urine volume)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008346(Epithelial calcium channel 2)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|reactome:R-MMU-3295583|refseq:XP_017176952.1 - - - figure legend:f5f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-kidney)|taxid:10090(Mus musculus) - 2014/02/24 2014/10/16 rogid:Djz8WcXVZvZ4fNqMjyR9lPdOL2A10090 rogid:9/W1L+WA5f93qEt56EKIKAxcjD410090 intact-crc:6EA14E153CA72FBE|rigid:EMbwTgwfVfpQ/mMkLzRTBGudNhE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q80UE6 uniprotkb:P69744 intact:EBI-295378|uniprotkb:Q4VAC1|uniprotkb:Q80XB5|uniprotkb:Q80XN2|uniprotkb:Q8R0N0|uniprotkb:Q8R340|uniprotkb:A2A4J7|ensembl:ENSMUSP00000099397 intact:EBI-538447|uniprotkb:Q2TB50|ensembl:ENSMUSP00000031901 psi-mi:wnk4_mouse(display_long)|uniprotkb:Wnk4(gene name)|psi-mi:Wnk4(display_short)|uniprotkb:Prkwnk4(gene name synonym)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym) psi-mi:trpv5_mouse(display_long)|uniprotkb:Osm-9-like TRP channel 3(gene name synonym)|uniprotkb:Epithelial calcium channel 1(gene name synonym)|uniprotkb:Calcium transport protein 2(gene name synonym)|uniprotkb:Trpv5(gene name)|psi-mi:Trpv5(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Andrukhova et al. (2014) pubmed:24434184|imex:IM-22219 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9214238|imex:IM-22219-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_783569.1|dip:DIP-33231N|ensembl:ENSMUSG00000035112(gene)|ensembl:ENSMUST00000103108(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|mint:Q80UE6|reactome:R-MMU-2672351 refseq:NP_001007573.1|ensembl:ENSMUSG00000036899(gene)|ensembl:ENSMUST00000031901(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035809"(regulation of urine volume)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098703"(calcium ion import across plasma membrane)|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008344(Epithelial calcium channel)|interpro:IPR008346(Epithelial calcium channel 2)|interpro:IPR020683|interpro:IPR024862|interpro:IPR036770|reactome:R-MMU-3295583|refseq:XP_017176952.1 - - - figure legend:f5f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-kidney)|taxid:10090(Mus musculus) - 2014/02/24 2014/10/16 rogid:Djz8WcXVZvZ4fNqMjyR9lPdOL2A10090 rogid:9/W1L+WA5f93qEt56EKIKAxcjD410090 intact-crc:BDBE34BAA1A0247C|rigid:EMbwTgwfVfpQ/mMkLzRTBGudNhE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)