#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05928	uniprotkb:Q96AY2	intact:EBI-9210238	intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q8IY92	intact:EBI-9210238	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:P07992	intact:EBI-9210238	intact:EBI-750962|ensembl:ENSP00000300853|ensembl:ENSP00000468035|uniprotkb:B2RC01|uniprotkb:B3KRR0|uniprotkb:Q7Z7F5|uniprotkb:Q96S40	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:ercc1_human(display_long)|uniprotkb:ERCC1(gene name)|psi-mi:ERCC1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001974.1|ensembl:ENSG00000012061(gene)|ensembl:ENST00000300853(transcript)|ensembl:ENST00000589165(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|refseq:XP_011524912.1|refseq:NP_001159521.1|refseq:NP_973730.1|refseq:XP_005258691.1|refseq:XP_005258692.1|refseq:XP_005258693.1|refseq:XP_016881948.1|refseq:XP_016881949.1|refseq:XP_016881950.1|refseq:XP_016881951.1|refseq:XP_016881952.1|refseq:XP_016881953.1|refseq:XP_016881954.1|refseq:XP_016881955.1|dip:DIP-24235N|reactome:R-HSA-6783310|reactome:R-HSA-6782135|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006949"(syncytium formation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009650"(UV protection)|go:"GO:0009744"(response to sucrose)|go:"GO:0010165"(response to X-ray)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0045190"(isotype switching)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048477"(oogenesis)|go:"GO:0048568"(embryonic organ development)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0090399"(replicative senescence)|go:"GO:0090656"(t-circle formation)|go:"GO:1904431"(positive regulation of t-circle formation)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR004579(DNA repair protein rad10)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|rcsb pdb:1Z00|rcsb pdb:2A1I|rcsb pdb:2A1J|rcsb pdb:2JNW|rcsb pdb:2JPD|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:wgacfBH+F2NRhpzRsTChE4zSPho9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q9BW61	intact:EBI-9210238	intact:EBI-2510241|ensembl:ENSP00000352928|ensembl:ENSP00000472171|ensembl:ENSP00000473086	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:dda1_human(display_long)|uniprotkb:DDA1(gene name)|psi-mi:DDA1(display_short)|uniprotkb:C19orf58(gene name synonym)|uniprotkb:PCIA1(gene name synonym)|uniprotkb:Placenta cross-immune reaction antigen 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	ensembl:ENSG00000130311(gene)|ensembl:ENST00000359866(transcript)|ensembl:ENST00000593466(transcript)|ensembl:ENST00000596582(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR018276|interpro:IPR033575|mint:Q9BW61|rcsb pdb:6DSZ|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|reactome:R-HSA-8951664|refseq:NP_076955.1|dip:DIP-53527N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:yD3tRVKVhirdHUj58DCTphW7ZYs9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q13619	intact:EBI-9210238	intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q16531	intact:EBI-9210238	intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q92889	intact:EBI-9210238	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q5VYV7	intact:EBI-9210238	intact:EBI-2370881|uniprotkb:Q05CG2|uniprotkb:Q05CT9|intact:EBI-28986158|ensembl:ENSP00000335557	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:slx4i_human(display_long)|uniprotkb:SLX4IP(gene name)|psi-mi:SLX4IP(display_short)|uniprotkb:C20orf94(gene name synonym)|uniprotkb:SLX4-interacting protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001009608.1|ensembl:ENSP00000335557|ensembl:ENSG00000149346(gene)|ensembl:ENST00000334534(transcript)|interpro:IPR031479	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:hWZ4TnAZJs6aYg3dykhSQfCdWHU9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q9H0U9	intact:EBI-9210238	intact:EBI-2371049|uniprotkb:O75885|uniprotkb:Q5TFE6|ensembl:ENSP00000357597|ensembl:ENSP00000498597	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:tsyl1_human(display_long)|uniprotkb:TSPYL1(gene name)|psi-mi:TSPYL1(display_short)|uniprotkb:TSPYL(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_003300.1|ensembl:ENSG00000189241(gene)|ensembl:ENST00000368608(transcript)|ensembl:ENST00000652202(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q9H0U9	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:wo2DsKIGA3gDmomoBajtGRpQpTQ9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q9Y4B6	intact:EBI-9210238	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q96NY9	intact:EBI-9210238	intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097570|imex:IM-22043-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606	intact-crc:0D171CBF4498E03D|rigid:r9A0C1oYE/WlcahQxBL0qYHFNHY	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P05928	uniprotkb:Q9Y4B6	intact:EBI-9210238	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210200|imex:IM-22043-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	-	-	-	figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	intact-crc:45616499E5B06E9A|rigid:SKAjvP765IAfIRjZpmOTlwjVrFM	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:P53350	intact:EBI-9210238	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210200|imex:IM-22043-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	-	-	-	figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	intact-crc:45616499E5B06E9A|rigid:SKAjvP765IAfIRjZpmOTlwjVrFM	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q8IY92	intact:EBI-9210238	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210200|imex:IM-22043-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:45616499E5B06E9A|rigid:SKAjvP765IAfIRjZpmOTlwjVrFM	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q96NY9	intact:EBI-9210238	intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210200|imex:IM-22043-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606	intact-crc:45616499E5B06E9A|rigid:SKAjvP765IAfIRjZpmOTlwjVrFM	false	flag tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q16531	intact:EBI-9210238	intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097677|imex:IM-22043-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N	-	-	-	figure legend:Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606	intact-crc:F5F82D93C06DC800|rigid:/vyAvz/BzdSuZniaD+s5KsEPHjQ	false	ha tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q92889	intact:EBI-9210238	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097677|imex:IM-22043-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:F5F82D93C06DC800|rigid:/vyAvz/BzdSuZniaD+s5KsEPHjQ	false	ha tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q8IY92	intact:EBI-9210238	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097677|imex:IM-22043-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:F5F82D93C06DC800|rigid:/vyAvz/BzdSuZniaD+s5KsEPHjQ	false	ha tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q96NY9	intact:EBI-9210238	intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9097677|imex:IM-22043-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606	intact-crc:F5F82D93C06DC800|rigid:/vyAvz/BzdSuZniaD+s5KsEPHjQ	false	ha tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q9Y4B6	intact:EBI-9210238	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210224|imex:IM-22043-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	-	-	-	figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	intact-crc:89F119075ED7007C|rigid:v9IvZIDY7HJopi6T7kb2VTXh9vA	false	ha tag:n-n|flag tag:n-n|mutation:80-80	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q8IY92	intact:EBI-9210238	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210224|imex:IM-22043-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:89F119075ED7007C|rigid:v9IvZIDY7HJopi6T7kb2VTXh9vA	false	ha tag:n-n|flag tag:n-n|mutation:80-80	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:P53350	intact:EBI-9210238	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210469|imex:IM-22043-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	-	-	-	figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	intact-crc:D1CBBFCB3BCE113E|rigid:0NqzcPsvADpbKP+1GkQquWj2Enw	false	mutation:65-65|ha tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q92889	intact:EBI-9210238	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210276|imex:IM-22043-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	-	-	-	figure legend:Supp. Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:DC49E9EF6E606FA8|rigid:rSgGBgV3YdQfa6q3myPxMKShFk0	false	ha tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q9Y4B6	intact:EBI-9210238	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210276|imex:IM-22043-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	-	-	-	figure legend:Supp. Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	intact-crc:DC49E9EF6E606FA8|rigid:rSgGBgV3YdQfa6q3myPxMKShFk0	false	ha tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q96NY9	intact:EBI-9210238	intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210276|imex:IM-22043-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310	-	-	-	figure legend:Supp. Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606	intact-crc:DC49E9EF6E606FA8|rigid:rSgGBgV3YdQfa6q3myPxMKShFk0	false	ha tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q92889	intact:EBI-9210238	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210289|imex:IM-22043-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	-	-	-	figure legend:Supp. Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:F2D8A2E166479D62|rigid:f2MlOBe25bEsklkw/86HODriLtA	false	flag tag:n-n|ha tag:n-n|mutation:80-80	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05928	uniprotkb:Q9Y4B6	intact:EBI-9210238	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210289|imex:IM-22043-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	-	-	-	figure legend:Supp. Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/01/23	2014/10/16	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	intact-crc:F2D8A2E166479D62|rigid:f2MlOBe25bEsklkw/86HODriLtA	false	flag tag:n-n|ha tag:n-n|mutation:80-80	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4B6	uniprotkb:Q16531	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210010|imex:IM-22043-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N	-	-	-	figure legend:Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2015/02/12	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606	intact-crc:CD00C32EF7619CEE|rigid:0S4LgiaLN83AjVvQY4BfU9kWAsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4B6	uniprotkb:Q96AY2	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210010|imex:IM-22043-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N	-	-	-	figure legend:Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2015/02/12	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606	intact-crc:CD00C32EF7619CEE|rigid:0S4LgiaLN83AjVvQY4BfU9kWAsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4B6	uniprotkb:P07992	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	intact:EBI-750962|ensembl:ENSP00000300853|ensembl:ENSP00000468035|uniprotkb:B2RC01|uniprotkb:B3KRR0|uniprotkb:Q7Z7F5|uniprotkb:Q96S40	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:ercc1_human(display_long)|uniprotkb:ERCC1(gene name)|psi-mi:ERCC1(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210010|imex:IM-22043-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	refseq:NP_001974.1|ensembl:ENSG00000012061(gene)|ensembl:ENST00000300853(transcript)|ensembl:ENST00000589165(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|refseq:XP_011524912.1|refseq:NP_001159521.1|refseq:NP_973730.1|refseq:XP_005258691.1|refseq:XP_005258692.1|refseq:XP_005258693.1|refseq:XP_016881948.1|refseq:XP_016881949.1|refseq:XP_016881950.1|refseq:XP_016881951.1|refseq:XP_016881952.1|refseq:XP_016881953.1|refseq:XP_016881954.1|refseq:XP_016881955.1|dip:DIP-24235N|reactome:R-HSA-6783310|reactome:R-HSA-6782135|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006949"(syncytium formation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009650"(UV protection)|go:"GO:0009744"(response to sucrose)|go:"GO:0010165"(response to X-ray)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0045190"(isotype switching)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048477"(oogenesis)|go:"GO:0048568"(embryonic organ development)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0090399"(replicative senescence)|go:"GO:0090656"(t-circle formation)|go:"GO:1904431"(positive regulation of t-circle formation)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR004579(DNA repair protein rad10)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|rcsb pdb:1Z00|rcsb pdb:2A1I|rcsb pdb:2A1J|rcsb pdb:2JNW|rcsb pdb:2JPD|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400	-	-	-	figure legend:Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2015/02/12	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	rogid:wgacfBH+F2NRhpzRsTChE4zSPho9606	intact-crc:CD00C32EF7619CEE|rigid:0S4LgiaLN83AjVvQY4BfU9kWAsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4B6	uniprotkb:Q96NY9	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210010|imex:IM-22043-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2015/02/12	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606	intact-crc:CD00C32EF7619CEE|rigid:0S4LgiaLN83AjVvQY4BfU9kWAsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4B6	uniprotkb:Q8IY92	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210010|imex:IM-22043-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2015/02/12	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:CD00C32EF7619CEE|rigid:0S4LgiaLN83AjVvQY4BfU9kWAsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4B6	uniprotkb:P69726	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	intact:EBI-9097571|uniprotkb:P05926|uniprotkb:Q85577	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:vpr_hv1h2(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210010|imex:IM-22043-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:4U1S|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180897|reactome:R-HSA-180910|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0044423"(virion component)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0075732"(viral penetration into host nucleus)	-	-	-	figure legend:Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2015/02/12	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	rogid:KbuLGrH+zNV14uCZ1mVwEPoZQJU11706	intact-crc:CD00C32EF7619CEE|rigid:0S4LgiaLN83AjVvQY4BfU9kWAsk	false	-	ha tag:n-n|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4B6	uniprotkb:Q92889	intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Laguette et al. (2014)	pubmed:24412650|imex:IM-22043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210010|imex:IM-22043-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	-	-	-	figure legend:Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2014/01/23	2015/02/12	rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:CD00C32EF7619CEE|rigid:0S4LgiaLN83AjVvQY4BfU9kWAsk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)