#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04156-PRO_0000025675	uniprotkb:P11499	intact:EBI-8830282	intact:EBI-492813|uniprotkb:O89078|uniprotkb:Q3UIQ7|ensembl:ENSMUSP00000024739	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:hs90b_mouse(display_long)|uniprotkb:Heat shock 84 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 84 kDa antigen(gene name synonym)|uniprotkb:Hsp90ab1(gene name)|psi-mi:Hsp90ab1(display_short)|uniprotkb:Hsp84(gene name synonym)|uniprotkb:Hsp84-1(gene name synonym)|uniprotkb:Hspcb(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_032328.2|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P11499|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-399954|reactome:R-MMU-6798695|reactome:R-MMU-844456|reactome:R-MMU-8852276|reactome:R-MMU-8937144|reactome:R-MMU-8939211|reactome:R-MMU-9013418|reactome:R-MMU-9018519|ensembl:ENSMUSG00000023944(gene)|ensembl:ENSMUST00000024739(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|dip:DIP-461N	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:5/MXDESVXdwuWna0s87Ap19aLMA10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:O09131	intact:EBI-8830282	intact:EBI-8319597|uniprotkb:Q3TH87|intact:MINT-1868625|ensembl:ENSMUSP00000026050	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:gsto1_mouse(display_long)|uniprotkb:Gsto1(gene name)|psi-mi:Gsto1(display_short)|uniprotkb:Gstx(gene name synonym)|uniprotkb:Gtsttl(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:Glutathione S-transferase omega 1-1(gene name synonym)|uniprotkb:Glutathione-dependent dehydroascorbate reductase(gene name synonym)|uniprotkb:Monomethylarsonic acid reductase(gene name synonym)|uniprotkb:"S-(Phenacyl)glutathione reductase"(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_034492.1|ensembl:ENSMUSG00000025068(gene)|ensembl:ENSMUST00000026050(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005604"(basement membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019853"(L-ascorbic acid biosynthetic process)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042178"(xenobiotic catabolic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0045174"("glutathione dehydrogenase (ascorbate) activity")|go:"GO:0050610"(methylarsonate reductase activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071243"(cellular response to arsenic-containing substance)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR005442(Glutathione S-transferase, omega-class)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:O09131|reactome:R-MMU-156581|reactome:R-MMU-156590|reactome:R-MMU-196836	-	chain-seq-start:23|chain-seq-end:230	comment:mint|function:Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:yU3j41SUoCgjNAKw+kMSGvsOPLA10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P06151	intact:EBI-8830282	intact:EBI-444940|ensembl:ENSMUSP00000036386|ensembl:ENSMUSP00000103267	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:ldha_mouse(display_long)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_034829.1|ensembl:ENSMUSG00000063229(gene)|ensembl:ENSMUST00000005051(transcript)|ensembl:ENSMUST00000048209(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P06151|reactome:R-MMU-70268	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:IErFuOIWq53/XyIxWgUyVi76VnM10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P63017	intact:EBI-8830282	intact:EBI-433443|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q3U6R0|uniprotkb:Q3U764|uniprotkb:Q3U7D7|uniprotkb:Q3U7E2|uniprotkb:Q3U9B4|uniprotkb:Q3U9G0|uniprotkb:Q3UGM0|uniprotkb:Q5FWJ6|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375|uniprotkb:Q6NZD0|ensembl:ENSMUSP00000015800	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:hsp7c_mouse(display_long)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_112442.2|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0030425"(dendrite)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005681"(spliceosomal complex)|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-450408|reactome:R-MMU-6798695|reactome:R-MMU-72163|reactome:R-MMU-8856828|reactome:R-MMU-8876725|reactome:R-MMU-888590|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P63017|rcsb pdb:3CQX|reactome:R-MMU-3371453|reactome:R-MMU-3371497|ensembl:ENSMUSG00000015656(gene)|ensembl:ENSMUST00000015800(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|dip:DIP-32353N	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P48036	intact:EBI-8830282	intact:EBI-1184119|uniprotkb:Q3U5Q1|uniprotkb:Q3U5X4|uniprotkb:Q3U8K1|uniprotkb:Q3UGV0|uniprotkb:Q99LA1|ensembl:ENSMUSP00000029266	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:anxa5_mouse(display_long)|uniprotkb:Anxa5(gene name)|psi-mi:Anxa5(display_short)|uniprotkb:Anx5(gene name synonym)|uniprotkb:Annexin-5(gene name synonym)|uniprotkb:Annexin V(gene name synonym)|uniprotkb:Lipocortin V(gene name synonym)|uniprotkb:Endonexin II(gene name synonym)|uniprotkb:Calphobindin I(gene name synonym)|uniprotkb:Placental anticoagulant protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein 4(gene name synonym)|uniprotkb:Thromboplastin inhibitor(gene name synonym)|uniprotkb:Vascular anticoagulant-alpha(gene name synonym)|uniprotkb:Anchorin CII(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_033803.1|go:"GO:1901317"(regulation of flagellated sperm motility)|go:"GO:1902721"(negative regulation of prolactin secretion)|interpro:IPR001464(Annexin)|interpro:IPR002392(Annexin, type V)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P48036|reactome:R-MMU-114608|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|ensembl:ENSMUSG00000027712(gene)|ensembl:ENSMUST00000029266(transcript)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030018"(Z disc)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072563"(endothelial microparticle)	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:CJEThujZVYsg5/wpN8fAMdpY38U10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P63038	intact:EBI-8830282	intact:EBI-299343|ensembl:ENSMUSP00000027123|uniprotkb:P19226|uniprotkb:P19227|uniprotkb:P97602|uniprotkb:Q3KQP2|uniprotkb:Q3UIP0|uniprotkb:Q8C2C7|uniprotkb:Q8VEF4	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:ch60_mouse(display_long)|uniprotkb:Hspd1(gene name)|psi-mi:Hspd1(display_short)|uniprotkb:Hsp60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:HSP-65(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	ensembl:ENSMUSG00000025980(gene)|ensembl:ENSMUST00000027123(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P63038|reactome:R-MMU-1268020|refseq:XP_006495769.1|refseq:NP_034607.3|dip:DIP-31396N	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:WD1fQLh4I0ovpakE8KtM1R0XpL410090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P10126	intact:EBI-8830282	intact:EBI-773865|uniprotkb:Q61511|uniprotkb:Q6ZWN2|uniprotkb:Q8BMB8|uniprotkb:Q8BVS8|uniprotkb:Q99KU5|ensembl:ENSMUSP00000042457	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:ef1a1_mouse(display_long)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Eef1a1(gene name)|psi-mi:Eef1a1(display_short)|uniprotkb:Eef1a(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	dip:DIP-46609N|refseq:NP_034236.2|ensembl:ENSMUSG00000037742(gene)|ensembl:ENSMUST00000042235(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P10126|reactome:R-MMU-156842|reactome:R-MMU-3371511|reactome:R-MMU-6798695|reactome:R-MMU-8876725	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:85G9Uje743KzA02bB/rmKuq2HbU10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P10107	intact:EBI-8830282	intact:EBI-647848|ensembl:ENSMUSP00000025561|ensembl:ENSMUSP00000158305	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:anxa1_mouse(display_long)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Anxa1(gene name)|psi-mi:Anxa1(display_short)|uniprotkb:Anx1(gene name synonym)|uniprotkb:Lpc1(gene name synonym)|uniprotkb:Lpc-1(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_034860.2|ensembl:ENSMUSG00000024659(gene)|ensembl:ENSMUST00000025561(transcript)|ensembl:ENSMUST00000235280(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P10107|reactome:R-MMU-416476|reactome:R-MMU-418594|reactome:R-MMU-444473|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:V9sZHzXdA0iCeXidE8a0ahnWFoE10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P52480	intact:EBI-8830282	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P20152	intact:EBI-8830282	intact:EBI-299269|ensembl:ENSMUSP00000028062|uniprotkb:O08704|uniprotkb:Q8CCH1	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:vime_mouse(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	ensembl:ENSMUSG00000026728(gene)|ensembl:ENSMUST00000028062(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|interpro:IPR027699|interpro:IPR039008|mint:P20152|reactome:R-MMU-264870|reactome:R-MMU-390522|reactome:R-MMU-9013422|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|reactome:R-MMU-9646399|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|refseq:NP_035831.2|dip:DIP-188N	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid://GDvGAXOR4hUXNtVpnZefex5v410090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P58252	intact:EBI-8830282	intact:EBI-773856|uniprotkb:Q544E4|ensembl:ENSMUSP00000046101	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:ef2_mouse(display_long)|uniprotkb:Eef2(gene name)|psi-mi:Eef2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_031933.1|ensembl:ENSMUSG00000034994(gene)|ensembl:ENSMUST00000047864(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P58252|reactome:R-MMU-156902|reactome:R-MMU-5358493|reactome:R-MMU-6798695	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:910/vo3IRjcncyPD4f43dPtS83o10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P16858	intact:EBI-8830282	intact:EBI-444871|uniprotkb:Q0QEU0|uniprotkb:Q3THM2|uniprotkb:Q3TUI2|uniprotkb:Q3UMT2|uniprotkb:Q4V783|uniprotkb:Q569X2|uniprotkb:Q569X5|uniprotkb:Q5U410|uniprotkb:A6H6A8|ensembl:ENSMUSP00000073289|ensembl:ENSMUSP00000113213	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:g3p_mouse(display_long)|uniprotkb:Gapdh(gene name)|psi-mi:Gapdh(display_short)|uniprotkb:Gapd(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_032110.1|refseq:XP_001476757.1|ensembl:ENSMUSG00000057666(gene)|ensembl:ENSMUST00000073605(transcript)|ensembl:ENSMUST00000118875(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031906"(late endosome lumen)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0060359"(response to ammonium ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P16858|rcsb pdb:6LGJ|rcsb pdb:6LGK|rcsb pdb:6LGM|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001276655.1|dip:DIP-31404N	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:SkcdXZ+143DDQFioo6mNWNpCLTI10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:Q8BFZ3	intact:EBI-8830282	intact:EBI-2693747|ensembl:ENSMUSP00000052086	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:actbl_mouse(display_long)|uniprotkb:Actbl2(gene name)|psi-mi:Actbl2(display_short)|uniprotkb:Kappa-actin(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_780706.1|ensembl:ENSMUSG00000055194(gene)|ensembl:ENSMUST00000054716(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0007409"(axonogenesis)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0045202"(synapse)|go:"GO:0048870"(cell motility)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:Q8BFZ3	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:OBTnGqn28Mc9uRapk7IOxAoxbZY10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:Q8VDD5	intact:EBI-8830282	intact:EBI-400906|intact:EBI-777674|uniprotkb:Q3UHT9|uniprotkb:Q3UHU4|uniprotkb:Q6KAN6|uniprotkb:Q811I2|ensembl:ENSMUSP00000016771	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:myh9_mouse(display_long)|uniprotkb:Myh9(gene name)|psi-mi:Myh9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_071855.2|ensembl:ENSMUSG00000022443(gene)|ensembl:ENSMUST00000016771(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0097513"(myosin II filament)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q8VDD5|reactome:R-MMU-2029482|reactome:R-MMU-5627123|dip:DIP-29546N	-	chain-seq-start:23|chain-seq-end:230	caution:This sequence has been withdrawn from Uniprot.|crc64:AAAC0E83A0A4F24A	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:qYfcGuWOF9npzsKD3zXTuLeP9iE10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P63101	intact:EBI-8830282	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P05064	intact:EBI-8830282	intact:EBI-494220|ensembl:ENSMUSP00000032934|ensembl:ENSMUSP00000101955	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:aldoa_mouse(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Aldolase 1(gene name synonym)|uniprotkb:Aldoa(gene name)|psi-mi:Aldoa(display_short)|uniprotkb:Aldo1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:XP_006507273.1|refseq:XP_006507274.1|refseq:NP_001170779.1|refseq:NP_031464.1|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031430"(M band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061827"(sperm head)|go:"GO:0005886"(plasma membrane)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|ensembl:ENSMUSG00000030695(gene)|ensembl:ENSMUST00000032934(transcript)|ensembl:ENSMUST00000106348(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0002020"(protease binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|mint:P05064|reactome:R-MMU-114608|reactome:R-MMU-6798695|reactome:R-MMU-70171|reactome:R-MMU-70263|interpro:IPR029768	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:m116/AX8vWkh1JCGOnEZv9ZOU9010090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P62259	intact:EBI-8830282	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:Q9EQU5	intact:EBI-8830282	intact:EBI-1543689|uniprotkb:Q9CY82|uniprotkb:Q9D0A9|uniprotkb:Q9Z181|uniprotkb:A2BE95|ensembl:ENSMUSP00000099930	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:set_mouse(display_long)|uniprotkb:Set(gene name)|psi-mi:Set(display_short)|uniprotkb:Phosphatase 2A inhibitor I2PP2A(gene name synonym)|uniprotkb:Template-activating factor I(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_001191804.1|refseq:NP_076360.1|ensembl:ENSMUSG00000054766(gene)|ensembl:ENSMUST00000102866(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q9EQU5|reactome:R-MMU-2299718|reactome:R-MMU-450520	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:1PEoqWcGzQ6q4T2SbfswpNI2Dr810090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P07901	intact:EBI-8830282	intact:EBI-78930|ensembl:ENSMUSP00000021698|ensembl:ENSMUSP00000091921	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:hs90a_mouse(display_long)|uniprotkb:Hsp90aa1(gene name)|psi-mi:Hsp90aa1(display_short)|uniprotkb:Hsp86(gene name synonym)|uniprotkb:Hsp86-1(gene name synonym)|uniprotkb:Hspca(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 86 kDa antigen(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_034610.1|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097226"(sperm mitochondrial sheath)|go:"GO:0097524"(sperm plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07901|rcsb pdb:5H22|reactome:R-MMU-1227986|reactome:R-MMU-1474151|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-203615|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-5218920|reactome:R-MMU-5620912|reactome:R-MMU-5675482|reactome:R-MMU-6798695|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8863795|reactome:R-MMU-8939211|reactome:R-MMU-9009391|reactome:R-MMU-9013418|reactome:R-MMU-9018519|reactome:R-MMU-9652282|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032564"(dATP binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|ensembl:ENSMUSG00000021270(gene)|ensembl:ENSMUST00000021698(transcript)|ensembl:ENSMUST00000094361(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042026"(protein refolding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|dip:DIP-30975N	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:t9XAeXdXezYOtJX0wp3IY9/ZMkQ10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P17742	intact:EBI-8830282	intact:EBI-1206043|uniprotkb:Q9CWJ5|uniprotkb:Q9R137|ensembl:ENSMUSP00000117987	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:ppia_mouse(display_long)|uniprotkb:Ppia(gene name)|psi-mi:Ppia(display_short)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:SP18(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_032933.1|reactome:R-MMU-210991|reactome:R-MMU-6798695|rcsb pdb:6FK1|ensembl:ENSMUSG00000071866(gene)|ensembl:ENSMUST00000132846(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:P17742	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:VwIoW2yfdaAEwZj6MfekFYqkZjw10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:Q61753	intact:EBI-8830282	intact:EBI-1633989|uniprotkb:Q3TEE5|uniprotkb:Q75SV9|uniprotkb:Q8C603|ensembl:ENSMUSP00000064755	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:sera_mouse(display_long)|uniprotkb:Phgdh(gene name)|psi-mi:Phgdh(display_short)|uniprotkb:A10(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_058662.2|ensembl:ENSMUSG00000053398(gene)|ensembl:ENSMUST00000065793(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0031175"(neuron projection development)|go:"GO:0043209"(myelin sheath)|go:"GO:0051287"(NAD binding)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:Q61753|reactome:R-MMU-977347	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:66i2iIx5qSIN6BkqSPF14+UqDIA10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P38647	intact:EBI-8830282	intact:EBI-772469|uniprotkb:Q9CQ05|intact:EBI-4282065|uniprotkb:Q3TW93|uniprotkb:Q3UVN1|uniprotkb:Q3V015|intact:EBI-1635058|uniprotkb:Q7TSZ0|ensembl:ENSMUSP00000025217	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:grp75_mouse(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:p66 MOT(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hsp74(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_034611.2|ensembl:ENSMUSG00000024359(gene)|ensembl:ENSMUST00000025217(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P38647|reactome:R-MMU-3371453	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:HyohIe5BGD5mW3UO0OekqUKOhbU10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P60710	intact:EBI-8830282	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514612|imex:IM-22520-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3B, table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	intact-crc:D12060E341CAEA35|rigid:jPnbCJufr9efk9Wrvou9hfOqGo4	false	strep tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P52480	intact:EBI-8830282	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514651|imex:IM-22520-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	-	chain-seq-start:23|chain-seq-end:230	-	figure legend:3C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	intact-crc:9DDCFAD5CC48983B|rigid:JYNWxzLD4cRYq1OxzZ0TCe/+0cU	false	strep tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52480	uniprotkb:P04156-PRO_0000025675	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	intact:EBI-8830282	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514711|imex:IM-22520-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	intact:EBI-977302(chain-parent)	-	-	chain-seq-start:23|chain-seq-end:230	comment:"Interaction was specific of the truncated version of PrPc (p04156-pro_0000025675, aas 23-230) and could not be detected with the full-length form (aas 1-253)."|figure legend:4B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2015/03/24	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	intact-crc:5401C00672F1FF1A|rigid:JYNWxzLD4cRYq1OxzZ0TCe/+0cU	false	-	strep tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04156-PRO_0000025675	uniprotkb:P52480	intact:EBI-8830282	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514700|imex:IM-22520-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-977302(chain-parent)	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	-	chain-seq-start:23|chain-seq-end:230	-	comment:"Interaction was specific of the truncated version of PrPc (p04156-pro_0000025675, aas 23-230) and could not be detected with the full-length form (aas 1-253)."|figure legend:4A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2015/03/24	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	intact-crc:6FDFD041F243ECB0|rigid:JYNWxzLD4cRYq1OxzZ0TCe/+0cU	false	strep tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52480	uniprotkb:P04156-PRO_0000025675	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	intact:EBI-8830282	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:p04156-pro_0000025675(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514759|imex:IM-22520-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	intact:EBI-977302(chain-parent)	-	-	chain-seq-start:23|chain-seq-end:230	figure legend:6C|comment:High co-localization between PKM2 and PrPC in HpL3-4 cells expressing 23–230 PrPC was observed, without STS treatment.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	rogid:4v2pBT8AODrfbr+t6sj9TzFwvLE9606	intact-crc:4CD7CA4C88D30022|rigid:JYNWxzLD4cRYq1OxzZ0TCe/+0cU	false	-	strep tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P52480	uniprotkb:P04156-1	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	intact:EBI-9514773|ensembl:ENSP00000368752|ensembl:ENSP00000399376|ensembl:ENSP00000411599|ensembl:ENSP00000415284	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:p04156-1(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)|uniprotkb:PrP(isoform synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zafar et al. (2014)	pubmed:24390569|imex:IM-22520	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9514761|imex:IM-22520-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	ensembl:ENSG00000171867(gene)|ensembl:ENST00000379440(transcript)|ensembl:ENST00000424424(transcript)|ensembl:ENST00000430350(transcript)|ensembl:ENST00000457586(transcript)|intact:EBI-977302(isoform-parent)	-	-	-	figure legend:6C|agonist:"\"STS\" = Staurosporine mediated apoptotic stress.  (Staurosporine is an antibiotic that is  a  ATP-competitive protein kinase inhibitor.)"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hpl3-4)|taxid:10090(Mouse HpL3-4  - PrP deficient cell line)	-	2014/03/21	2014/10/16	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	rogid:O9dYBDKthE5DdgePny2xsDYzb989606	intact-crc:E640D66628B08787|rigid:TPT+N3Mz6xhQwrxWpdg8gJa4WJ4	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)