#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06213	uniprotkb:P07585	intact:EBI-475899|uniprotkb:Q17RW0|uniprotkb:Q59H98|uniprotkb:Q9UCB7|uniprotkb:Q9UCB8|uniprotkb:Q9UCB9|ensembl:ENSP00000303830	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	psi-mi:insr_human(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Morcavallo et al. (2014)	pubmed:24389353|imex:IM-22962	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9663693|imex:IM-22962-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000199.2|refseq:NP_001073285.1|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P06213|rcsb pdb:1GAG|rcsb pdb:1I44|rcsb pdb:1IR3|rcsb pdb:1IRK|rcsb pdb:1P14|rcsb pdb:1RQQ|rcsb pdb:2AUH|rcsb pdb:2B4S|rcsb pdb:2HR7|rcsb pdb:2MFR|go:"GO:0032809"(neuronal cell body membrane)|rcsb pdb:2Z8C|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|rcsb pdb:3EKK|rcsb pdb:3EKN|dip:DIP-480N|rcsb pdb:7BW8|rcsb pdb:7BWA|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:4IBM|rcsb pdb:4OGA|rcsb pdb:4XLV|rcsb pdb:4XSS|rcsb pdb:4XST|rcsb pdb:4ZXB|rcsb pdb:5E1S|rcsb pdb:5HHW|rcsb pdb:5J3H|rcsb pdb:5KQV|rcsb pdb:5U1M|rcsb pdb:6HN4|rcsb pdb:6HN5|rcsb pdb:6PXV|rcsb pdb:3ETA|rcsb pdb:6PXW|rcsb pdb:6SOF|rcsb pdb:6VEP|rcsb pdb:6VEQ|rcsb pdb:7BW7	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.8x10^-9 ~1.9(molar)	2014/07/16	2014/10/16	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	intact-crc:179A8C5D18C3DBBD|rigid:En40PJIEpu4cpvjIyDenE5IQzXU	false	his tag:c-c|sufficient binding region:1-944	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01344	uniprotkb:P07585	intact:EBI-7178764|ensembl:ENSP00000370796|ensembl:ENSP00000370802|ensembl:ENSP00000402047|ensembl:ENSP00000414497|uniprotkb:E3UN45|uniprotkb:Q14299|intact:MINT-6380943|uniprotkb:B7WP08|uniprotkb:Q9UC69|uniprotkb:Q1WM26|uniprotkb:Q9UC68|uniprotkb:B3KX48|uniprotkb:P78449|uniprotkb:C9JAF2	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	psi-mi:igf2_human(display_long)|uniprotkb:T3M-11-derived growth factor(gene name synonym)|uniprotkb:PP1446(orf name)|uniprotkb:IGF2(gene name)|psi-mi:IGF2(display_short)|uniprotkb:Somatomedin-A(gene name synonym)	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Morcavallo et al. (2014)	pubmed:24389353|imex:IM-22962	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9663701|imex:IM-22962-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278790.1|refseq:NP_001278791.1|ensembl:ENSG00000167244(gene)|ensembl:ENST00000381395(transcript)|ensembl:ENST00000416167(transcript)|ensembl:ENST00000418738(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|ensembl:ENST00000381389(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0007275"(multicellular organism development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|go:"GO:0051146"(striated muscle cell differentiation)|mint:P01344|rcsb pdb:1GF2|rcsb pdb:1IGL|rcsb pdb:2L29|rcsb pdb:2V5P|rcsb pdb:3E4Z|rcsb pdb:3KR3|rcsb pdb:5L3L|rcsb pdb:5L3M|rcsb pdb:5L3N|rcsb pdb:6UM2|rcsb pdb:6VWG|rcsb pdb:6VWI|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|refseq:NP_001007140.2|refseq:NP_001121070.1|refseq:NP_000603.1|dip:DIP-29508N	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	-	comment:mint|comment:homomint|function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.5x10^-9 ~0.2(molar)	2014/07/16	2014/10/16	rogid:1ladOE1XgM3qL9KOsKVIGhfkjrA9606	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	intact-crc:B4F5D483469921C4|rigid:388cxnJD4bUFqZmqeKUMGyUI0y4	false	sufficient binding region:25-91	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01315	uniprotkb:P07585	intact:EBI-8437944|intact:MINT-1505666|uniprotkb:Q9TSJ5|ensembl:ENSSSCP00000044635|ensembl:ENSSSCP00015002060|ensembl:ENSSSCP00025013482|ensembl:ENSSSCP00030047908|ensembl:ENSSSCP00035009642|ensembl:ENSSSCP00040009750|ensembl:ENSSSCP00045005838|ensembl:ENSSSCP00050004834|ensembl:ENSSSCP00055025559|ensembl:ENSSSCP00060020355|ensembl:ENSSSCP00065038365|ensembl:ENSSSCP00070024989	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	psi-mi:ins_pig(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Morcavallo et al. (2014)	pubmed:24389353|imex:IM-22962	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9663707|imex:IM-22962-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103242.1|ensembl:ENSSSCG00000033740(gene)|ensembl:ENSSSCG00015004005(gene)|ensembl:ENSSSCG00025023773(gene)|ensembl:ENSSSCG00030073948(gene)|ensembl:ENSSSCG00035019667(gene)|ensembl:ENSSSCG00040017207(gene)|ensembl:ENSSSCG00045005189(gene)|ensembl:ENSSSCG00050008342(gene)|ensembl:ENSSSCG00055016292(gene)|ensembl:ENSSSCG00060035069(gene)|ensembl:ENSSSCG00065063887(gene)|ensembl:ENSSSCG00070015252(gene)|ensembl:ENSSSCT00000064136(transcript)|ensembl:ENSSSCT00015005290(transcript)|ensembl:ENSSSCT00025032226(transcript)|ensembl:ENSSSCT00030103634(transcript)|ensembl:ENSSSCT00035025488(transcript)|ensembl:ENSSSCT00040023180(transcript)|ensembl:ENSSSCT00045008618(transcript)|ensembl:ENSSSCT00050011348(transcript)|ensembl:ENSSSCT00055032104(transcript)|ensembl:ENSSSCT00060047539(transcript)|ensembl:ENSSSCT00065087685(transcript)|ensembl:ENSSSCT00070029958(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903576"(response to L-arginine)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B17|rcsb pdb:1B18|rcsb pdb:1B19|rcsb pdb:1B2A|rcsb pdb:1B2B|rcsb pdb:1B2C|rcsb pdb:1B2D|rcsb pdb:1B2E|rcsb pdb:1B2F|rcsb pdb:1B2G|rcsb pdb:1DEI|rcsb pdb:1IZA|rcsb pdb:1IZB|rcsb pdb:1M5A|rcsb pdb:1MPJ|rcsb pdb:1SDB|rcsb pdb:1WAV|rcsb pdb:1ZEI|rcsb pdb:1ZNI|rcsb pdb:2EFA|rcsb pdb:2G4M|rcsb pdb:2TCI|rcsb pdb:2ZPP|rcsb pdb:3FHP|rcsb pdb:3GKY|rcsb pdb:3INS|rcsb pdb:3MTH|rcsb pdb:3RTO|rcsb pdb:3T2A|rcsb pdb:4A7E|rcsb pdb:4INS|rcsb pdb:5D52|rcsb pdb:5D53|rcsb pdb:5D54|rcsb pdb:5D5E|rcsb pdb:5FB6|rcsb pdb:5LIS|rcsb pdb:6INS|rcsb pdb:6Z7Z|rcsb pdb:7INS|rcsb pdb:9INS	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	-	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.1x10^-9 ~0.5(molar)	2014/07/16	2014/10/16	rogid:jJtfIrm2VcLfHHHuPKRkLde+nW09823	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	intact-crc:CC41C8C5206CD1CE|rigid:u0dM7A9VquwZ6Ouiagzu8C+2vQE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01308	uniprotkb:P07585	intact:EBI-7090529|ensembl:ENSP00000250971|ensembl:ENSP00000370731|ensembl:ENSP00000380432|uniprotkb:Q5EEX2|intact:MINT-106847	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	psi-mi:ins_human(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Morcavallo et al. (2014)	pubmed:24389353|imex:IM-22962	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9663711|imex:IM-22962-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278826.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050890"(cognition)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0005179"(hormone activity)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|mint:P01308|rcsb pdb:1A7F|rcsb pdb:1AI0|rcsb pdb:1AIY|rcsb pdb:1B9E|rcsb pdb:1BEN|rcsb pdb:1EFE|rcsb pdb:1EV3|rcsb pdb:1EV6|rcsb pdb:1EVR|rcsb pdb:1FU2|rcsb pdb:1FUB|rcsb pdb:1G7A|rcsb pdb:1G7B|rcsb pdb:1GUJ|rcsb pdb:1HIQ|rcsb pdb:1HIS|rcsb pdb:1HIT|rcsb pdb:1HLS|rcsb pdb:1HTV|rcsb pdb:1HUI|rcsb pdb:1IOG|rcsb pdb:1IOH|rcsb pdb:1J73|rcsb pdb:1JCA|rcsb pdb:1JCO|rcsb pdb:1JK8|rcsb pdb:1K3M|rcsb pdb:1KMF|rcsb pdb:1LKQ|rcsb pdb:1LPH|rcsb pdb:1MHI|rcsb pdb:1MHJ|rcsb pdb:1MSO|rcsb pdb:1OS3|rcsb pdb:1OS4|rcsb pdb:1Q4V|rcsb pdb:1QIY|rcsb pdb:1QIZ|rcsb pdb:1QJ0|rcsb pdb:1RWE|rcsb pdb:1SF1|rcsb pdb:1SJT|rcsb pdb:1SJU|rcsb pdb:1T0C|rcsb pdb:1T1K|rcsb pdb:1T1P|rcsb pdb:1T1Q|rcsb pdb:1TRZ|rcsb pdb:1TYL|rcsb pdb:1TYM|rcsb pdb:1UZ9|rcsb pdb:1VKT|rcsb pdb:1W8P|rcsb pdb:1XDA|rcsb pdb:1XGL|rcsb pdb:1XW7|rcsb pdb:1ZEG|rcsb pdb:1ZEH|rcsb pdb:1ZNJ|rcsb pdb:2AIY|rcsb pdb:2C8Q|rcsb pdb:2C8R|rcsb pdb:2CEU|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2H67|rcsb pdb:2HH4|rcsb pdb:2HHO|rcsb pdb:2HIU|rcsb pdb:2JMN|rcsb pdb:2JUM|rcsb pdb:2JUU|rcsb pdb:2JUV|rcsb pdb:2JZQ|rcsb pdb:2K91|rcsb pdb:2K9R|rcsb pdb:2KJJ|rcsb pdb:2KJU|rcsb pdb:2JV1|rcsb pdb:2KQP|rcsb pdb:2KQQ|rcsb pdb:2KXK|rcsb pdb:2L1Y|rcsb pdb:2L1Z|rcsb pdb:2LGB|rcsb pdb:2LWZ|rcsb pdb:2M1D|rcsb pdb:2M1E|rcsb pdb:2M2M|rcsb pdb:2M2N|rcsb pdb:2M2O|rcsb pdb:2M2P|rcsb pdb:2MLI|rcsb pdb:2MPG|rcsb pdb:2MPI|rcsb pdb:2MVC|rcsb pdb:2MVD|rcsb pdb:2N2V|rcsb pdb:2N2W|rcsb pdb:2N2X|rcsb pdb:2OLY|rcsb pdb:2OLZ|rcsb pdb:2OM0|rcsb pdb:2OM1|rcsb pdb:2OMG|rcsb pdb:2OMH|rcsb pdb:2OMI|rcsb pdb:2OMQ|rcsb pdb:2QIU|rcsb pdb:2R34|rcsb pdb:2R35|rcsb pdb:2R36|rcsb pdb:2RN5|rcsb pdb:2VJZ|rcsb pdb:2VK0|rcsb pdb:2W44|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WRU|rcsb pdb:2WRV|rcsb pdb:2WRW|rcsb pdb:2WRX|rcsb pdb:2WS0|rcsb pdb:2WS1|rcsb pdb:2WS4|rcsb pdb:2WS6|rcsb pdb:2WS7|rcsb pdb:3AIY|rcsb pdb:3BXQ|rcsb pdb:3E7Y|rcsb pdb:3E7Z|rcsb pdb:3EXX|rcsb pdb:3FQ9|rcsb pdb:3HYD|rcsb pdb:3I3Z|rcsb pdb:3I40|rcsb pdb:3ILG|rcsb pdb:3INC|rcsb pdb:3IR0|rcsb pdb:3JSD|rcsb pdb:3KQ6|rcsb pdb:3P2X|rcsb pdb:3P33|rcsb pdb:3Q6E|rcsb pdb:3ROV|rcsb pdb:3TT8|rcsb pdb:3U4N|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V19|rcsb pdb:3V1G|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:3W7Y|rcsb pdb:3W7Z|rcsb pdb:3W80|rcsb pdb:3ZI3|rcsb pdb:3ZQR|rcsb pdb:3ZS2|rcsb pdb:3ZU1|rcsb pdb:4AIY|rcsb pdb:4AJX|rcsb pdb:4AJZ|rcsb pdb:4AK0|rcsb pdb:4AKJ|rcsb pdb:4CXL|rcsb pdb:4CXN|rcsb pdb:4CY7|rcsb pdb:4EFX|rcsb pdb:4EWW|rcsb pdb:4EWX|rcsb pdb:4EWZ|rcsb pdb:4EX0|rcsb pdb:4EX1|rcsb pdb:4EXX|rcsb pdb:4EY1|rcsb pdb:4EY9|rcsb pdb:4EYD|rcsb pdb:4EYN|rcsb pdb:4EYP|rcsb pdb:4F0N|rcsb pdb:4F0O|rcsb pdb:4F1A|rcsb pdb:4F1B|rcsb pdb:4F1C|rcsb pdb:4F1D|rcsb pdb:4F1F|rcsb pdb:4F1G|rcsb pdb:4F4T|rcsb pdb:4F4V|rcsb pdb:4F51|rcsb pdb:4F8F|rcsb pdb:4FG3|rcsb pdb:4FKA|rcsb pdb:4GBC|rcsb pdb:4GBI|rcsb pdb:4GBK|rcsb pdb:4GBL|rcsb pdb:4GBN|rcsb pdb:4IUZ|rcsb pdb:4IYD|rcsb pdb:4IYF|rcsb pdb:4NIB|rcsb pdb:4OGA|rcsb pdb:4P65|rcsb pdb:4RXW|rcsb pdb:4UNE|rcsb pdb:4UNG|rcsb pdb:4UNH|rcsb pdb:4WDI|rcsb pdb:4XC4|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5AIY|rcsb pdb:5BOQ|rcsb pdb:5BPO|rcsb pdb:5BQQ|rcsb pdb:5BTS|rcsb pdb:5C0D|rcsb pdb:5CJO|rcsb pdb:5CNY|rcsb pdb:5CO2|rcsb pdb:5CO6|rcsb pdb:5CO9|rcsb pdb:5E7W|rcsb pdb:5EMS|rcsb pdb:5EN9|rcsb pdb:5ENA|rcsb pdb:5HPR|rcsb pdb:5HPU|rcsb pdb:5HQI|rcsb pdb:5HRQ|rcsb pdb:5HYJ|rcsb pdb:5MAM|rcsb pdb:5MHD|rcsb pdb:5MT3|rcsb pdb:5MT9|rcsb pdb:5MWQ|rcsb pdb:5T7R|rcsb pdb:5UDP|rcsb pdb:5UOZ|rcsb pdb:5UQA|rcsb pdb:5URT|rcsb pdb:5URU|rcsb pdb:5USP|rcsb pdb:5USS|rcsb pdb:5USV|rcsb pdb:5UU2|rcsb pdb:5UU3|rcsb pdb:5UU4|rcsb pdb:5VIZ|rcsb pdb:5WBT|rcsb pdb:5WDM|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6BFC|rcsb pdb:6CE7|rcsb pdb:6CE9|rcsb pdb:6CEB|rcsb pdb:6CK2|rcsb pdb:6GNQ|rcsb pdb:6GV0|rcsb pdb:6H3M|rcsb pdb:6HN5|rcsb pdb:6JR3|rcsb pdb:6K59|rcsb pdb:6NWV|rcsb pdb:6O17|rcsb pdb:6P4Z|rcsb pdb:6S34|rcsb pdb:6S4I|rcsb pdb:6S4J|rcsb pdb:6SOF|rcsb pdb:6TC2|rcsb pdb:6TYH|rcsb pdb:6U46|rcsb pdb:6VEP|rcsb pdb:6VER|rcsb pdb:6VES|rcsb pdb:6VET|rcsb pdb:6X4X|rcsb pdb:6Z7W|rcsb pdb:6Z7Y|rcsb pdb:7BW7|rcsb pdb:7BW8|rcsb pdb:7BWA|rcsb pdb:7NHU|reactome:R-HSA-210745|reactome:R-HSA-264876|reactome:R-HSA-422085|reactome:R-HSA-422356|reactome:R-HSA-6807878|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|reactome:R-HSA-9615017|reactome:R-HSA-977225|rcsb pdb:6JK8|ensembl:ENSG00000254647(gene)|ensembl:ENST00000250971(transcript)|ensembl:ENST00000381330(transcript)|ensembl:ENST00000397262(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|refseq:NP_001172026.1|refseq:NP_000198.1|refseq:NP_001172027.1|dip:DIP-6024N	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	-	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:homomint|function:"Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]"	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.3x10^-9 ~1.8(molar)	2014/07/16	2014/10/16	rogid:RFnbvRnJ3AIA4j1Se0KPx0RFhD89606	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	intact-crc:DF75B757F7C3CE2D|rigid:9E6p0alfyZlDPpnjcJ6a0chyeYY	false	his tag:n-n|sufficient binding region:25-110	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)