#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P9WGD5	uniprotkb:P9WMR3	intact:EBI-9081374|uniprotkb:P0A610|uniprotkb:L0T5J5|uniprotkb:P71711	intact:EBI-9081402|uniprotkb:P71715|uniprotkb:L0T2G0	psi-mi:ssb_myctu(display_long)|uniprotkb:ssb(gene name)|psi-mi:ssb(display_short)|uniprotkb:MTCY21D4.17(orf name)|uniprotkb:Rv0054(locus name)	psi-mi:dnab_myctu(display_long)|uniprotkb:dnaB(gene name)|psi-mi:dnaB(display_short)|uniprotkb:MTCY21D4.21(orf name)|uniprotkb:Rv0058(locus name)	psi-mi:"MI:0018"(two hybrid)	- (2014)	pubmed:24387047|imex:IM-22036	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9081372|imex:IM-22036-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_003400534.1|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|refseq:NP_214568.1|rcsb pdb:1UE1|rcsb pdb:1UE5|rcsb pdb:1UE6|rcsb pdb:1UE7|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009295"(nucleoid)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051096"(positive regulation of helicase activity)	refseq:WP_003916208.1|interpro:IPR030934|interpro:IPR036185|interpro:IPR036844|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007692(DNA helicase, DnaB type)|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR007693(DNA helicase, DnaB-like, N-terminal)|interpro:IPR016136(DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR027434|interpro:IPR006142(Intein)|interpro:IPR004042(Intein DOD homing endonuclease)|interpro:IPR006141(Intein splicing site)|interpro:IPR027417|refseq:NP_214572.1|rcsb pdb:2R5U|interpro:IPR004860(LAGLIDADG DNA endonuclease)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005618"(cell wall)|go:"GO:0005829"(cytosol)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006314"(intron homing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990077"(primosome complex)	-	-	-	figure legend:f4a|comment:"Neither F21L nor N12S/P132L mutations affected the interaction of MtbDnaB and  MtbSSB as the co-transformants containing F21L/MtbDnaB.  (N12S/P132L)/MtbDnaB grew well on the screening medium. Furthermore, 10 amino  acid residues from the SSB C-terminal, which affect the interaction between PriA and  SSB in E. coli, were deleted from MtbSSB. Co-transformants containing  SSBΔ10/MtbDnaB also grew well on the screening medium, but no growth was found  when 20 amino acid residues were deleted from the MtbSSB C-terminal. This result  suggests that the key interaction sites in MtbSSB are within the next 10 amino acid  residues. These results also demonstrate specific interaction between MtbDnaB and  MtbSSB."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2014/01/12	2014/10/16	rogid:QegccGgxAsJfI5pHPQQ5pfN9luw83332	rogid:pyeT8wgrFMnS16YxrLRlceMqLwA83332	intact-crc:4D073F006AB296E0|rigid:FYkaZlUvWidSuv/B3UXLgsBVOT8	false	binding-associated region:144-154	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P9WGD5	uniprotkb:P9WMR3	intact:EBI-9081374|uniprotkb:P0A610|uniprotkb:L0T5J5|uniprotkb:P71711	intact:EBI-9081402|uniprotkb:P71715|uniprotkb:L0T2G0	psi-mi:ssb_myctu(display_long)|uniprotkb:ssb(gene name)|psi-mi:ssb(display_short)|uniprotkb:MTCY21D4.17(orf name)|uniprotkb:Rv0054(locus name)	psi-mi:dnab_myctu(display_long)|uniprotkb:dnaB(gene name)|psi-mi:dnaB(display_short)|uniprotkb:MTCY21D4.21(orf name)|uniprotkb:Rv0058(locus name)	psi-mi:"MI:0107"(surface plasmon resonance)	- (2014)	pubmed:24387047|imex:IM-22036	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9081455|imex:IM-22036-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_003400534.1|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|refseq:NP_214568.1|rcsb pdb:1UE1|rcsb pdb:1UE5|rcsb pdb:1UE6|rcsb pdb:1UE7|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009295"(nucleoid)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051096"(positive regulation of helicase activity)	refseq:WP_003916208.1|interpro:IPR030934|interpro:IPR036185|interpro:IPR036844|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007692(DNA helicase, DnaB type)|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR007693(DNA helicase, DnaB-like, N-terminal)|interpro:IPR016136(DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR027434|interpro:IPR006142(Intein)|interpro:IPR004042(Intein DOD homing endonuclease)|interpro:IPR006141(Intein splicing site)|interpro:IPR027417|refseq:NP_214572.1|rcsb pdb:2R5U|interpro:IPR004860(LAGLIDADG DNA endonuclease)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005618"(cell wall)|go:"GO:0005829"(cytosol)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006314"(intron homing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990077"(primosome complex)	-	-	-	figure legend:f4b|comment:"The interaction of MtbDnaB with MtbSSB was further confirmed by surface plasmon  resonance (SPR) assay. His-tagged MtbDnaB proteins were first immobilized on a  nitrilotriacetate chip. As shown in Fig. 4B, significant responses of approximately 140  and 250 response units (RU) were found when increasing amounts of 30 and 60 nM  GST-tagged MtbDnaB protein were passed over the chip, respectively (Fig. 4B, left  panel). Similar results were also observed for the interaction of F21L, N12S/P132L,  or SSBΔC10 with MtbDnaB, but a smaller response (48 RU) was observed when  SSBΔC20 was passed over the chip (Fig. 4B, right panel). No response was observed  for GST alone or GST-1505c."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/12	2014/10/16	rogid:QegccGgxAsJfI5pHPQQ5pfN9luw83332	rogid:pyeT8wgrFMnS16YxrLRlceMqLwA83332	intact-crc:10CEAB8432138096|rigid:FYkaZlUvWidSuv/B3UXLgsBVOT8	false	binding-associated region:144-154|glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P9WMR3	uniprotkb:P9WGD5	intact:EBI-9081402|uniprotkb:P71715|uniprotkb:L0T2G0	intact:EBI-9081374|uniprotkb:P0A610|uniprotkb:L0T5J5|uniprotkb:P71711	psi-mi:dnab_myctu(display_long)|uniprotkb:dnaB(gene name)|psi-mi:dnaB(display_short)|uniprotkb:MTCY21D4.21(orf name)|uniprotkb:Rv0058(locus name)	psi-mi:ssb_myctu(display_long)|uniprotkb:ssb(gene name)|psi-mi:ssb(display_short)|uniprotkb:MTCY21D4.17(orf name)|uniprotkb:Rv0054(locus name)	psi-mi:"MI:0030"(cross-linking study)	- (2014)	pubmed:24387047|imex:IM-22036	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9081474|imex:IM-22036-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_003916208.1|interpro:IPR030934|interpro:IPR036185|interpro:IPR036844|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007692(DNA helicase, DnaB type)|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR007693(DNA helicase, DnaB-like, N-terminal)|interpro:IPR016136(DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR027434|interpro:IPR006142(Intein)|interpro:IPR004042(Intein DOD homing endonuclease)|interpro:IPR006141(Intein splicing site)|interpro:IPR027417|refseq:NP_214572.1|rcsb pdb:2R5U|interpro:IPR004860(LAGLIDADG DNA endonuclease)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005618"(cell wall)|go:"GO:0005829"(cytosol)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006314"(intron homing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990077"(primosome complex)	refseq:WP_003400534.1|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|refseq:NP_214568.1|rcsb pdb:1UE1|rcsb pdb:1UE5|rcsb pdb:1UE6|rcsb pdb:1UE7|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009295"(nucleoid)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051096"(positive regulation of helicase activity)	-	-	-	figure legend:f4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:410289(mycbp)|taxid:410289(mycbp)	-	2014/01/12	2014/10/16	rogid:pyeT8wgrFMnS16YxrLRlceMqLwA83332	rogid:QegccGgxAsJfI5pHPQQ5pfN9luw83332	intact-crc:830ADE34D1FBA3A3|rigid:FYkaZlUvWidSuv/B3UXLgsBVOT8	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)