#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
matrixdb:MULT_81_VAR1_mouse	uniprotkb:P21810	intact:EBI-9656926	intact:EBI-762076|uniprotkb:P13247|uniprotkb:D3DWU3|ensembl:ENSP00000327336	psi-mi:vegfa_mouse-1(display_short)|psi-mi:MULT_81_VAR1_mouse(display_long)|intact:Vascular endothelial growth factor A complex(complex recommended name)|intact:Vegfa dimer(complex systematic name)|intact:VEGF-A complex(complex synonym)	psi-mi:pgs1_human(display_long)|uniprotkb:SLRR1A(gene name synonym)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)|uniprotkb:BGN(gene name)|psi-mi:BGN(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Berendsen et al. (2014)	pubmed:24373744|imex:IM-22957	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9657102|imex:IM-22957-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005544"|pubmed:24332926(see-also)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:1990150"(VEGF-A complex)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:2001214"(positive regulation of vasculogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|pubmed:19658168(see-also)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|complex portal:CPX-1977(inferred-from)|complex portal:CPX-3160(complex-primary)	refseq:NP_001702.1|refseq:XP_016885213.1|ensembl:ENSG00000182492(gene)|ensembl:ENST00000331595(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|mint:P21810|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332	-	curated-complex:"Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Can promote tumor vascularization. Ligand to vascular endothelial growth factor receptor (VGFR-1) complex. Has heparin-binding properties."|complex-properties:Homodimer, via disulfide bridges|complex-assembly:Homodimer	-	figure legend:Fig 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/15	2019/09/03	-	rogid:G7A6TRMpSIqTBpXtm67XG0GfM2w9606	intact-crc:F934257BED3C17BF	false	-	dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-?|his tag:n-n|chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0981"(tag visualisation by peroxidase activity)
uniprotkb:P21810	matrixdb:MULT_81_VAR1_mouse	intact:EBI-762076|uniprotkb:P13247|uniprotkb:D3DWU3|ensembl:ENSP00000327336	intact:EBI-9656926	psi-mi:pgs1_human(display_long)|uniprotkb:SLRR1A(gene name synonym)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)|uniprotkb:BGN(gene name)|psi-mi:BGN(display_short)	psi-mi:vegfa_mouse-1(display_short)|psi-mi:MULT_81_VAR1_mouse(display_long)|intact:Vascular endothelial growth factor A complex(complex recommended name)|intact:Vegfa dimer(complex systematic name)|intact:VEGF-A complex(complex synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Berendsen et al. (2014)	pubmed:24373744|imex:IM-22957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9657292|imex:IM-22957-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_001702.1|refseq:XP_016885213.1|ensembl:ENSG00000182492(gene)|ensembl:ENST00000331595(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|mint:P21810|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332	evidence ontology:"ECO:0005544"|pubmed:24332926(see-also)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:1990150"(VEGF-A complex)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:2001214"(positive regulation of vasculogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|pubmed:19658168(see-also)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|complex portal:CPX-1977(inferred-from)|complex portal:CPX-3160(complex-primary)	-	-	curated-complex:"Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Can promote tumor vascularization. Ligand to vascular endothelial growth factor receptor (VGFR-1) complex. Has heparin-binding properties."|complex-properties:Homodimer, via disulfide bridges|complex-assembly:Homodimer	figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/15	2019/09/03	rogid:G7A6TRMpSIqTBpXtm67XG0GfM2w9606	-	intact-crc:D63E5E69AB9E8C7E	false	his tag:n-n	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)