#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O70594	uniprotkb:O76082	intact:EBI-9846085|uniprotkb:Q9QWL0|ensembl:ENSRNOP00000011340	intact:EBI-9846338|uniprotkb:Q6ZQZ8|uniprotkb:Q96EH6|uniprotkb:A2Q0V1|uniprotkb:B2R844|uniprotkb:D3DQ87|ensembl:ENSP00000245407	psi-mi:s22a5_rat(display_long)|uniprotkb:Slc22a5(gene name)|psi-mi:Slc22a5(display_short)|uniprotkb:Octn2(gene name synonym)|uniprotkb:CT1(gene name synonym)|uniprotkb:High-affinity sodium-dependent carnitine cotransporter(gene name synonym)|uniprotkb:Organic cation/carnitine transporter 2(gene name synonym)|uniprotkb:UST2r(gene name synonym)	psi-mi:s22a5_human(display_long)|uniprotkb:SLC22A5(gene name)|psi-mi:SLC22A5(display_short)|uniprotkb:OCTN2(gene name synonym)|uniprotkb:High-affinity sodium-dependent carnitine cotransporter(gene name synonym)|uniprotkb:Organic cation/carnitine transporter 2(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Czeredys et al. (2013)	pubmed:24349196|imex:IM-23211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846328|imex:IM-23211-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3702|refseq:NP_062142.1|ensembl:ENSRNOG00000008432(gene)|ensembl:ENSRNOT00000011340(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007512"(adult heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0015226"(carnitine transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015879"(carnitine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0048608"(reproductive structure development)|go:"GO:0060731"(positive regulation of intestinal epithelial structure maintenance)|go:"GO:0070715"(sodium-dependent organic cation transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901235"("(R)-carnitine transmembrane transporter activity")|go:"GO:1902270"("(R)-carnitine transmembrane transport")|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-200425|reactome:R-RNO-549127	refseq:NP_001295051.1|refseq:NP_003051.1|ensembl:ENSG00000197375(gene)|ensembl:ENST00000245407(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0015226"(carnitine transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015879"(carnitine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0060731"(positive regulation of intestinal epithelial structure maintenance)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070715"(sodium-dependent organic cation transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902270"("(R)-carnitine transmembrane transport")|go:"GO:1902603"(carnitine transmembrane transport)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-HSA-200425|reactome:R-HSA-549127|reactome:R-HSA-5619053|go:"GO:1901235"("(R)-carnitine transmembrane transporter activity")	-	-	-	figure legend:6|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/14	2014/11/17	rogid:fJ9Tf2oQ3Hmg9ETFkn2AZ9x6nqM10116	rogid:NyUJfbxblUhBIlQftKxtkS8w49k9606	intact-crc:A53F62119423046F|rigid:udSFWWGL5DWnXuS45/H4ibSR9aA	false	flag tag:c-c	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P41350	uniprotkb:O70594	intact:EBI-1161014|uniprotkb:Q8VIK8|uniprotkb:Q8VIK9	intact:EBI-9846085|uniprotkb:Q9QWL0|ensembl:ENSRNOP00000011340	psi-mi:cav1_rat(display_long)|uniprotkb:Cav1(gene name)|psi-mi:Cav1(display_short)|uniprotkb:Cav(gene name synonym)	psi-mi:s22a5_rat(display_long)|uniprotkb:Slc22a5(gene name)|psi-mi:Slc22a5(display_short)|uniprotkb:Octn2(gene name synonym)|uniprotkb:CT1(gene name synonym)|uniprotkb:High-affinity sodium-dependent carnitine cotransporter(gene name synonym)|uniprotkb:Organic cation/carnitine transporter 2(gene name synonym)|uniprotkb:UST2r(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Czeredys et al. (2013)	pubmed:24349196|imex:IM-23211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846396|imex:IM-23211-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042060"(wound healing)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070836"(caveola assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|rgd:2280|interpro:IPR001612(Caveolin)|interpro:IPR018361|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-9035034|reactome:R-RNO-9696264|reactome:R-RNO-9696270|reactome:R-RNO-9696273|interpro:IPR015504(Caveolin-1)|reactome:R-RNO-203615|reactome:R-RNO-203641|reactome:R-RNO-210991|reactome:R-RNO-4641262|reactome:R-RNO-5218920|reactome:R-RNO-9009391	rgd:3702|refseq:NP_062142.1|ensembl:ENSRNOG00000008432(gene)|ensembl:ENSRNOT00000011340(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007512"(adult heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0015226"(carnitine transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015879"(carnitine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0048608"(reproductive structure development)|go:"GO:0060731"(positive regulation of intestinal epithelial structure maintenance)|go:"GO:0070715"(sodium-dependent organic cation transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901235"("(R)-carnitine transmembrane transporter activity")|go:"GO:1902270"("(R)-carnitine transmembrane transport")|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-200425|reactome:R-RNO-549127	-	-	-	figure legend:7|agonist:"Phorbol 12-myristate 13-acetate (CHEBI:37537)"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-astrocyte)|taxid:10116(Rattus norvegicus astrocyte)	-	2014/10/14	2014/11/19	rogid:mbjmYKIhc9HfcQKZx/CE/YKNrps10116	rogid:fJ9Tf2oQ3Hmg9ETFkn2AZ9x6nqM10116	intact-crc:146C973A22C432B5|rigid:J2XJHZdWCtMyfQNv9jlviGCPBjs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O70594	uniprotkb:P41350	intact:EBI-9846085|uniprotkb:Q9QWL0|ensembl:ENSRNOP00000011340	intact:EBI-1161014|uniprotkb:Q8VIK8|uniprotkb:Q8VIK9	psi-mi:s22a5_rat(display_long)|uniprotkb:Slc22a5(gene name)|psi-mi:Slc22a5(display_short)|uniprotkb:Octn2(gene name synonym)|uniprotkb:CT1(gene name synonym)|uniprotkb:High-affinity sodium-dependent carnitine cotransporter(gene name synonym)|uniprotkb:Organic cation/carnitine transporter 2(gene name synonym)|uniprotkb:UST2r(gene name synonym)	psi-mi:cav1_rat(display_long)|uniprotkb:Cav1(gene name)|psi-mi:Cav1(display_short)|uniprotkb:Cav(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Czeredys et al. (2013)	pubmed:24349196|imex:IM-23211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846123|imex:IM-23211-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3702|refseq:NP_062142.1|ensembl:ENSRNOG00000008432(gene)|ensembl:ENSRNOT00000011340(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007512"(adult heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0015226"(carnitine transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015879"(carnitine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0048608"(reproductive structure development)|go:"GO:0060731"(positive regulation of intestinal epithelial structure maintenance)|go:"GO:0070715"(sodium-dependent organic cation transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901235"("(R)-carnitine transmembrane transporter activity")|go:"GO:1902270"("(R)-carnitine transmembrane transport")|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-200425|reactome:R-RNO-549127	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042060"(wound healing)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070836"(caveola assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|rgd:2280|interpro:IPR001612(Caveolin)|interpro:IPR018361|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-9035034|reactome:R-RNO-9696264|reactome:R-RNO-9696270|reactome:R-RNO-9696273|interpro:IPR015504(Caveolin-1)|reactome:R-RNO-203615|reactome:R-RNO-203641|reactome:R-RNO-210991|reactome:R-RNO-4641262|reactome:R-RNO-5218920|reactome:R-RNO-9009391	-	-	-	figure legend:4A|agonist:"PMA- (phorbol 12-myristate 13-acetate) used here as a PKC activator."|comment:"Flotillin-1 can be readily detected after PMA treatment,  but this effect  is reversed by Bisindolylmaleimide II (Bis II) -a  protein kinase C (PKC) inhibitor-  addition."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-astrocyte)|taxid:10116(Rattus norvegicus astrocyte)	-	2014/10/14	2014/10/23	rogid:fJ9Tf2oQ3Hmg9ETFkn2AZ9x6nqM10116	rogid:mbjmYKIhc9HfcQKZx/CE/YKNrps10116	intact-crc:AB50CF59F340CCA0|rigid:P2X+PBTkEiRgUb0wwmemsYGKyDc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70594	uniprotkb:Q9Z1E1	intact:EBI-9846085|uniprotkb:Q9QWL0|ensembl:ENSRNOP00000011340	intact:EBI-920268|uniprotkb:Q9Z1E2|ensembl:ENSRNOP00000001098|ensembl:ENSRNOP00000071275	psi-mi:s22a5_rat(display_long)|uniprotkb:Slc22a5(gene name)|psi-mi:Slc22a5(display_short)|uniprotkb:Octn2(gene name synonym)|uniprotkb:CT1(gene name synonym)|uniprotkb:High-affinity sodium-dependent carnitine cotransporter(gene name synonym)|uniprotkb:Organic cation/carnitine transporter 2(gene name synonym)|uniprotkb:UST2r(gene name synonym)	psi-mi:flot1_rat(display_long)|uniprotkb:Flot1(gene name)|psi-mi:Flot1(display_short)|uniprotkb:Reg2(gene name synonym)|uniprotkb:Reggie-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Czeredys et al. (2013)	pubmed:24349196|imex:IM-23211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846123|imex:IM-23211-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3702|refseq:NP_062142.1|ensembl:ENSRNOG00000008432(gene)|ensembl:ENSRNOT00000011340(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007512"(adult heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0015226"(carnitine transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015879"(carnitine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0048608"(reproductive structure development)|go:"GO:0060731"(positive regulation of intestinal epithelial structure maintenance)|go:"GO:0070715"(sodium-dependent organic cation transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901235"("(R)-carnitine transmembrane transporter activity")|go:"GO:1902270"("(R)-carnitine transmembrane transport")|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-200425|reactome:R-RNO-549127	rgd:70991|refseq:NP_073192.2|refseq:XP_006256086.1|ensembl:ENSRNOG00000000826(gene)|ensembl:ENSRNOT00000001098(transcript)|ensembl:ENSRNOT00000090039(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q9Z1E1|reactome:R-RNO-5213460|reactome:R-RNO-5675482|reactome:R-RNO-8849932|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106	-	-	-	figure legend:4A|agonist:"PMA- (phorbol 12-myristate 13-acetate) used here as a PKC activator."|comment:"Flotillin-1 can be readily detected after PMA treatment,  but this effect  is reversed by Bisindolylmaleimide II (Bis II) -a  protein kinase C (PKC) inhibitor-  addition."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-astrocyte)|taxid:10116(Rattus norvegicus astrocyte)	-	2014/10/14	2014/10/23	rogid:fJ9Tf2oQ3Hmg9ETFkn2AZ9x6nqM10116	rogid:zQd1GziJRcfE7u4/b/800Dotg8A10116	intact-crc:AB50CF59F340CCA0|rigid:P2X+PBTkEiRgUb0wwmemsYGKyDc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70594	uniprotkb:Q03135	intact:EBI-9846085|uniprotkb:Q9QWL0|ensembl:ENSRNOP00000011340	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	psi-mi:s22a5_rat(display_long)|uniprotkb:Slc22a5(gene name)|psi-mi:Slc22a5(display_short)|uniprotkb:Octn2(gene name synonym)|uniprotkb:CT1(gene name synonym)|uniprotkb:High-affinity sodium-dependent carnitine cotransporter(gene name synonym)|uniprotkb:Organic cation/carnitine transporter 2(gene name synonym)|uniprotkb:UST2r(gene name synonym)	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Czeredys et al. (2013)	pubmed:24349196|imex:IM-23211	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846256|imex:IM-23211-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3702|refseq:NP_062142.1|ensembl:ENSRNOG00000008432(gene)|ensembl:ENSRNOT00000011340(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007512"(adult heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0015226"(carnitine transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015651"(quaternary ammonium group transmembrane transporter activity)|go:"GO:0015697"(quaternary ammonium group transport)|go:"GO:0015879"(carnitine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0048608"(reproductive structure development)|go:"GO:0060731"(positive regulation of intestinal epithelial structure maintenance)|go:"GO:0070715"(sodium-dependent organic cation transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901235"("(R)-carnitine transmembrane transporter activity")|go:"GO:1902270"("(R)-carnitine transmembrane transport")|interpro:IPR004749(Organic cation transport protein)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-200425|reactome:R-RNO-549127	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	-	-	-	figure legend:5D/E|comment:Both  the 14-22 and 447-454 Octn2  fragments can bind caveolin-1; a simultaneous removal of both fragments leads to a further decrease of co-precipitating caveolin-1. However, the double deletion did not eliminate completely co-precipitation of mutated Octn2 with caveolin-1.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/14	2014/10/23	rogid:fJ9Tf2oQ3Hmg9ETFkn2AZ9x6nqM10116	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	intact-crc:ABF94964E9C7645E|rigid:btWxCKvgQyRQMzXhKEV+keJddeQ	false	flag tag:c-c|binding-associated region:447-454,14-22	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)