#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14780	uniprotkb:P01033	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Thorsen et al. (2013)	imex:IM-23202|pubmed:24330623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845933|efo:"EFO:0000305"|imex:IM-23202-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	-	-	-	figure legend:"4A,  Additional File 2 (fig 2)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-plasma)|taxid:9606(homo sapiens blood plasma)	-	2014/10/14	2014/10/20	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:D0F888FD43306C00|rigid:yE77LPLwsnyVsYclorYMOkTfriQ	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P14780	uniprotkb:P01033	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Thorsen et al. (2013)	imex:IM-23202|pubmed:24330623	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845948|efo:"EFO:0000305"|imex:IM-23202-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	-	-	-	figure legend:Fig 3, 4B, Add. file 2|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-plasma)|taxid:9606(homo sapiens blood plasma)	-	2014/10/14	2014/10/20	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:2D5521BA78BF08CA|rigid:yE77LPLwsnyVsYclorYMOkTfriQ	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)