#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35002	uniprotkb:O35002	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0071"(molecular sieving)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076442|imex:IM-21969-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:8C899A7EABE46E4F|rigid:laaEbdC0B5KvpsDi/MnRxk6MFoc	false	his tag:?-?|necessary binding region:1-86	his tag:?-?|necessary binding region:1-86	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
intact:EBI-9076680	uniprotkb:O35002	-	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:poly alanine peptide(display_short)|psi-mi:EBI-9076680(display_long)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076577|imex:IM-21969-6|wwpdb:4c2d	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Supp. Fig. 3 Supp. Table 1|3d-resolution:2.6A|3d-r-factors:Rworking = 0.23, Rfree = 0.24|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	-	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:52A7774842654000	false	sufficient binding region:?-?	his tag:c-c|sufficient binding region:44-480|direct binding region:309-309	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35002	uniprotkb:O35002	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076704|wwpdb:4c2e|imex:IM-21969-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Supp. Table 1.|3d-resolution:1.95A|3d-r-factors:Rworking = 0.2, Rfree = 0.24|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:4613756CA8327F80|rigid:laaEbdC0B5KvpsDi/MnRxk6MFoc	false	his tag:c-c|mutation:118-118|sufficient binding region:44-480	his tag:c-c|mutation:118-118|sufficient binding region:44-480	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35002	uniprotkb:O35002	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076529|imex:IM-21969-5|wwpdb:4c2c	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Supp. Table 1|3d-resolution:1.9A|3d-r-factors:Rworking = 0.2, Rfree = 0.22|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:B33CA1F824877866|rigid:laaEbdC0B5KvpsDi/MnRxk6MFoc	false	his tag:c-c|sufficient binding region:44-480	his tag:c-c|sufficient binding region:44-480	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35002	uniprotkb:O35002	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076633|imex:IM-21969-7|wwpdb:4c2e	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Supp. Table 1|3d-resolution:1.8A|3d-r-factors:Rworking = 0.18, Rfree = 0.19|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:72C11815FCEB99F1|rigid:laaEbdC0B5KvpsDi/MnRxk6MFoc	false	sufficient binding region:44-480|his tag:c-c|mutation:209-209	sufficient binding region:44-480|his tag:c-c|mutation:209-209	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-9076680	uniprotkb:O35002	-	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:poly alanine peptide(display_short)|psi-mi:EBI-9076680(display_long)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076650|imex:IM-21969-8|wwpdb:4c2f	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Supp. Table 1|3d-resolution:2.4A|3d-r-factors:Rworking = 0.22, Rfree = 0.26|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	-	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:4E098595EFA3CFC0	false	-	mutation:168-168|his tag:c-c|sufficient binding region:44-480	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35002	uniprotkb:O35002	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076665|imex:IM-21969-9|wwpdb:4c2g	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Supp. Table 1|3d-resolution:1.9A|3d-r-factors:Rworking = 0.2, Rfree = 0.23|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:C90648F9322BB479|rigid:y3hsICRQjHHwWck5D13pQamjmTg	false	sufficient binding region:29-40	his tag:c-c|sufficient binding region:44-480	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26936	uniprotkb:O35002	intact:EBI-5254757|ensemblbacteria:CAB14758	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:sp4fa_bacsu(display_long)|uniprotkb:spoIVFA(gene name)|psi-mi:spoIVFA(display_short)|uniprotkb:bofB(gene name synonym)|uniprotkb:BSU27980(locus name)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0435"(protease assay)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076200|imex:IM-21969-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_004398684.1|interpro:IPR011055(Duplicated hybrid motif)|interpro:IPR016047(Peptidase M23)|refseq:NP_390676.1|ensemblbacteria:BSU_27980(gene)|ensemblbacteria:CAB14758(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)	go:"GO:0006508"(proteolysis)|go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Fig. 1B, Supp. Fig. 1B, 1D|causality statement:O35002 increases degradation at protein level of P26936|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:/1mR8hka35ScvTXT0u85z25OXEc224308	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:7FF21FB3150CB911|rigid:J6XgLLp+mi5ZE7xP6h/XjbjrPKk	false	his tag:?-?|sufficient binding region:91..91-264	necessary binding region:43-85|his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O35002	-	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	-	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	-	psi-mi:"MI:0435"(protease assay)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	-	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076408|imex:IM-21969-3	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)	-	go:"GO:0006508"(proteolysis)|go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	-	intact-crc:0037DC4C5830B364	false	his tag:?-?|mutation disrupting interaction rate:309-309|necessary binding region:1-42	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	-
uniprotkb:P17896	uniprotkb:P26936	intact:EBI-9076980|ensemblbacteria:CAB14354	intact:EBI-5254757|ensemblbacteria:CAB14758	psi-mi:sp4b_bacsu(display_long)|uniprotkb:spoIVB(gene name)|psi-mi:spoIVB(display_short)|uniprotkb:Sporulation factor IV B protease(gene name synonym)|uniprotkb:Stage IV sporulation protein B(gene name synonym)|uniprotkb:BSU24230(locus name)	psi-mi:sp4fa_bacsu(display_long)|uniprotkb:spoIVFA(gene name)|psi-mi:spoIVFA(display_short)|uniprotkb:bofB(gene name synonym)|uniprotkb:BSU27980(locus name)	psi-mi:"MI:0435"(protease assay)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076305|imex:IM-21969-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR041489|interpro:IPR036034|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR014219(Peptidase S55, sporulation stage IV, protein B)|interpro:IPR008763(Peptidase S55, SpoIVB)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|refseq:NP_390303.2|refseq:WP_004398697.1|refseq:WP_009967699.1|ensemblbacteria:BSU_24230(gene)|ensemblbacteria:CAB14354(transcript)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)	refseq:WP_004398684.1|interpro:IPR011055(Duplicated hybrid motif)|interpro:IPR016047(Peptidase M23)|refseq:NP_390676.1|ensemblbacteria:BSU_27980(gene)|ensemblbacteria:CAB14758(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)	go:"GO:0006508"(proteolysis)|go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Fig. 1B|causality statement:P26937 increases degradation at protein level of P26936|comment:In vitro reconstituted cleavage reactions demonstrate that 4B-dependent cleavage of 4FA generates a substrate that can be further digested by CtpB.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:syI6UhlH3FF8rI6dmwi68P96CgE224308	rogid:/1mR8hka35ScvTXT0u85z25OXEc224308	intact-crc:224E4A5F676C4674|rigid:34NhtCQO3BE7uMKsIof+x8jdX8w	false	his tag:?-?	sufficient binding region:91..91-264|his tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P26936	uniprotkb:O35002	intact:EBI-5254757|ensemblbacteria:CAB14758	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:sp4fa_bacsu(display_long)|uniprotkb:spoIVFA(gene name)|psi-mi:spoIVFA(display_short)|uniprotkb:bofB(gene name synonym)|uniprotkb:BSU27980(locus name)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0435"(protease assay)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076920|imex:IM-21969-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_004398684.1|interpro:IPR011055(Duplicated hybrid motif)|interpro:IPR016047(Peptidase M23)|refseq:NP_390676.1|ensemblbacteria:BSU_27980(gene)|ensemblbacteria:CAB14758(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Fig. 5C,|comment:Sequence length of spoIVFA inferred from information in Fig. 1C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:/1mR8hka35ScvTXT0u85z25OXEc224308	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:22043AAE92D65DFD|rigid:J6XgLLp+mi5ZE7xP6h/XjbjrPKk	false	his tag:?-?|sufficient binding region:91..91-154..154	necessary binding region:155..155-480,43-89..89|his tag:c-c|mutation decreasing interaction rate:168-168|mutation disrupting interaction rate:118-118,168-168|mutation disrupting interaction rate:338-338|mutation disrupting interaction rate:118-118,168-168|mutation decreasing interaction rate:118-118|mutation decreasing interaction rate:168-168	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
intact:EBI-9076809	uniprotkb:O35002	-	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:pdz binder(display_short)|psi-mi:EBI-9076809(display_long)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0081"(peptide array)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076815|imex:IM-21969-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Fig. 4C, Supp. Fig. 4A, 4B|comment:Amino acid subsitutions demonstrated that the PDZ domain of CtpB preferentially binds peptides carrying Tyr/Phe/Trp-Ala/Val combinations at their C terminus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/07	2014/10/16	rogid:s0zxNUPaw5P8Wm20xE66muAEf7E-2	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:2E999758648DDDE1|rigid:O2XZ5GKS5T5UzCaIkblotwHCHEA	false	-	necessary binding region:43-85|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-9076853	uniprotkb:O35002	-	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	psi-mi:fmllrrkaya(display_short)|psi-mi:EBI-9076853(display_long)	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9076862|imex:IM-21969-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	figure legend:Supp. Fig. 4C, 5B|comment:"The derived dissociation constants (KD) for the full-length CtpB protein were about 3-fold higher than for the isolated PDZ domain"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.5x10^-6(molar)	2014/01/07	2014/10/16	rogid:UYHlmDVwwyoigRUm7XaqctCucAY-2	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	intact-crc:68DF969FBF6D54DF|rigid:66lqkxuIv+uwnb99uSuDBPTPFcg	false	mutation increasing interaction strength:10-10	mutation:309-309|mutation decreasing interaction strength:168-168|mutation disrupting interaction strength:118-118|his tag:c-c|mutation decreasing interaction strength:168-168	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35002	intact:EBI-9076853	intact:EBI-5246793|uniprotkb:Q795D7|ensemblbacteria:CAB15541	-	psi-mi:ctpb_bacsu(display_long)|uniprotkb:ctpB(gene name)|psi-mi:ctpB(display_short)|uniprotkb:yvjB(gene name synonym)|uniprotkb:BSU35240(locus name)	psi-mi:fmllrrkaya(display_short)|psi-mi:EBI-9076853(display_long)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mastny et al. (2013)	pubmed:24243021|imex:IM-21969	taxid:224308(bacsu)|taxid:224308(Bacillus subtilis)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9207654|imex:IM-21969-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	rcsb pdb:4C2C|rcsb pdb:4C2D|rcsb pdb:4C2E|rcsb pdb:4C2F|rcsb pdb:4C2G|rcsb pdb:4C2H|interpro:IPR041489|refseq:NP_391404.1|interpro:IPR005151(Peptidase S41)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004447(Peptidase S41A, C-terminal protease)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR036034|interpro:IPR036365|interpro:IPR036366|interpro:IPR029045|refseq:WP_003228041.1|ensemblbacteria:BSU_35240(gene)|ensemblbacteria:CAB15541(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008233"(peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)	-	-	-	-	figure legend:Supp. Fig. 4C|comment:"The derived dissociation constants (KD) for the full-length CtpB protein were about 3-fold higher than for the isolated PDZ domain"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.3x10^-6(molar)	2014/01/07	2014/10/16	rogid:Nnv+l6evj0dv4BSFg0N9Ql2U9vA224308	rogid:UYHlmDVwwyoigRUm7XaqctCucAY-2	intact-crc:E67EDDF3127CD83A|rigid:66lqkxuIv+uwnb99uSuDBPTPFcg	false	sufficient binding region:43-85|his tag:c-c	mutation increasing interaction strength:10-10	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)