#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08151	uniprotkb:Q9UMX1	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2013)	imex:IM-22237|pubmed:24217340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9315213|imex:IM-22237-1|wwpdb:4KMD	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	-	-	-	figure legend:Table 1|3d-r-factors:working 19.46%, free 22.21%|3d-resolution:1.70A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/04	2014/10/16	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	intact-crc:CE8560190C9C3B90|rigid:JOx0hhBN9wqKAGpAFIWK1s6MlbE	false	sufficient binding region:112-128(LIG_SUFU_1)	his tag:n-n|sufficient binding region:1-285,346-484	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08151	uniprotkb:Q9UMX1	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zhang et al. (2013)	imex:IM-22237|pubmed:24217340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9315323|imex:IM-22237-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	-	-	-	figure legend:Fig. 3b, Fig. 3c, Fig. 5b, Fig. 5e, Fig. 5i, Fig. 5j, Table 2.  Suppl. Figs. 8, 9, 11.|kinetic_conditions:Temp = 25C|kinetics:"Full length Sufu binds Gli1 (residues 97-143) with Kd = 95.2 +/- 29.1 10e-9 molar. A shorter Sufu construct (residues 1-285 + 346-484) binds Gli1 (residues 97-143) with Kd = 61.3 +/- 31.9 10e-9 molar.     The tyr147arg-phe155ala mutation in Sufu (residues 1-285 + 346-484) lowers the affinity for Gli1 (residues 97-143) to Kd = 5.38 +/- 1.78 10e-6 molar.     The gly122ala-his123ala-leu124asp mutation in Gli1 (residues 97-143) lowers the affinity to Kd = 19.9 +/- 10.4 10e-6 molar for full length Sufu and to Kd = 10.7 +/- 4.6 10e-6 molar for Sufu (residues 1-285 + 346-484). A shorter Gli1 peptide (residues 112-128) binds full length Sufu with Kd = 1.96 +/- 0.37 10e-6 molar and Sufu (residues 1-285 + 346-484) with Kd = 3.86 +/- 0.62 10e-6 molar. The peptides Gli1(residues 107-133) and Gli1(residues 102-138) bind Sufu (residues 1-285 + 346-484) with Kd = 0.602 +/- 0.078 10e-6 molar and Kd = 93.5 +/- 31.7 10e-9 molar, respectively."|comment:Both the N- and C-terminal domain of Sufu need to be present for binding with Gli1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:95.2x10^-9 ~29.1(molar)	2014/03/04	2014/10/16	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	intact-crc:246B00F9FFD9FD46|rigid:JOx0hhBN9wqKAGpAFIWK1s6MlbE	false	sufficient binding region:112-128(LIG_SUFU_1)|mutation decreasing interaction:122-124	his tag:n-n|mutation disrupting interaction:147-147,159-159|mutation decreasing interaction:147-147,155-155|mutation disrupting interaction:147-147,159-159,380-380|mutation disrupting interaction:147-147,155-155,159-159,380-380|mutation disrupting interaction:147-147,155-155,159-159,380-380|sufficient binding region:1-285,346-484	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19538	uniprotkb:Q9VG38	intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245	intact:EBI-110605|ensemblmetazoa:FBpp0082134	psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym)	psi-mi:q9vg38_drome(display_long)|uniprotkb:"Su(fu)"(gene name)|psi-mi:"Su(fu)"(display_short)|uniprotkb:CG6054(orf name)|uniprotkb:Dmel\CG6054(gene name synonym)|uniprotkb:"SU(FU)"(gene name synonym)|uniprotkb:SUFU(gene name synonym)|uniprotkb:"Su(Fu)"(gene name synonym)|uniprotkb:SuFu(gene name synonym)|uniprotkb:Sufu(gene name synonym)|uniprotkb:dSufu(gene name synonym)|uniprotkb:"su(fu)"(gene name synonym)|uniprotkb:sufu(gene name synonym)|uniprotkb:Dmel_CG6054(orf name)|uniprotkb:d Sufu(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zhang et al. (2013)	imex:IM-22237|pubmed:24217340	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9316150|imex:IM-22237-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N	refseq:NP_536750.2|flybase:FBgn0005355|dip:DIP-60773N|ensemblmetazoa:FBgn0005355(gene)|ensemblmetazoa:FBtr0082665(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046823"(negative regulation of nucleocytoplasmic transport)|go:"GO:0140311"(protein sequestering activity)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR024314|interpro:IPR037181|interpro:IPR038489|rcsb pdb:4KMA|rcsb pdb:6LPH|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684	-	-	-	figure legend:Fig. 5f, Fig. 5g, Table 2|kinetic_conditions:Temp = 25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.41x10^-6 ~2.91(molar)	2014/03/04	2014/10/16	rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227	rogid:bgRdXcd2LSsl7sfv4ArpqgWFzeU7227	intact-crc:8ADFD3341B35859D|rigid:+RKQDOLoQHupscqcPxD6ROorEe0	false	sufficient binding region:230-272(LIG_SUFU_1)|mutation disrupting interaction:257-259	his tag:n-n	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UMX1	uniprotkb:P08151	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2013)	imex:IM-22237|pubmed:24217340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9344173|imex:IM-22237-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N	-	-	-	figure legend:Fig. 3a, Fig. 5a, Fig. 5h|comment:Both the N- and C-terminal domain of Sufu need to be present for binding with Gli1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/04	2014/10/16	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606	intact-crc:FE294267A0EC89F4|rigid:JOx0hhBN9wqKAGpAFIWK1s6MlbE	false	mutation disrupting interaction:147-147,155-155|sufficient binding region:1-285,346-484|his tag:n-n|mutation disrupting interaction:159-159|mutation disrupting interaction:147-147,159-159|mutation disrupting interaction:159-159|mutation disrupting interaction:147-147,155-155,159-159|mutation disrupting interaction:147-147,159-159,380-380|mutation disrupting interaction:147-147,155-155,159-159,380-380	sufficient binding region:97-143(LIG_SUFU_1)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q0VGT2	uniprotkb:Q9UMX1	intact:EBI-9344284|uniprotkb:E9PYJ4|ensembl:ENSMUSP00000054837	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	psi-mi:gli2_mouse(display_long)|uniprotkb:Gli2(gene name)|psi-mi:Gli2(display_short)|uniprotkb:Thp(gene name synonym)|uniprotkb:Tax helper protein(gene name synonym)	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2013)	imex:IM-22237|pubmed:24217340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9344345|imex:IM-22237-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074594.1|dip:DIP-60772N|ensembl:ENSMUSG00000048402(gene)|ensembl:ENSMUST00000062483(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007389"(pattern specification process)|go:"GO:0007411"(axon guidance)|go:"GO:0007418"(ventral midline development)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0021508"(floor plate formation)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021915"(neural tube development)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030879"(mammary gland development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031514"(motile cilium)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0035295"(tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060032"(notochord regression)|go:"GO:0060322"(head development)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|reactome:R-MMU-5610787|reactome:R-MMU-5632684	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	-	-	-	figure legend:Fig. 5c, Fig. 5d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/03/04	2014/10/16	rogid:4rTCAbaXgbOsAHrJ9fhiPKh5ORQ10090	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	intact-crc:0123DAEA65E2E81D|rigid:poI9LVMfMLvFXJ8Yt4b6wsdJw+M	false	sufficient binding region:1-633|mutation disrupting interaction:270-272|myc tag:n-n|mutation disrupting interaction:270-272	yellow fluorescent protein tag:n-n|cyan fluorescent protein tag:c-c|mutation decreasing interaction:159-159|mutation decreasing interaction:380-380|mutation disrupting interaction:147-147,159-159,380-380	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UMX1	uniprotkb:Q0VGT2	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	intact:EBI-9344284|uniprotkb:E9PYJ4|ensembl:ENSMUSP00000054837	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:gli2_mouse(display_long)|uniprotkb:Gli2(gene name)|psi-mi:Gli2(display_short)|uniprotkb:Thp(gene name synonym)|uniprotkb:Tax helper protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2013)	imex:IM-22237|pubmed:24217340	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9344382|imex:IM-22237-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	refseq:NP_001074594.1|dip:DIP-60772N|ensembl:ENSMUSG00000048402(gene)|ensembl:ENSMUST00000062483(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007389"(pattern specification process)|go:"GO:0007411"(axon guidance)|go:"GO:0007418"(ventral midline development)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0021508"(floor plate formation)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021915"(neural tube development)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030879"(mammary gland development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031514"(motile cilium)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0035295"(tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060032"(notochord regression)|go:"GO:0060322"(head development)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|reactome:R-MMU-5610787|reactome:R-MMU-5632684	-	-	-	figure legend:Fig. 5c, Fig. 5d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/03/04	2014/10/16	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	rogid:4rTCAbaXgbOsAHrJ9fhiPKh5ORQ10090	intact-crc:0E93368E8D4ADECB|rigid:poI9LVMfMLvFXJ8Yt4b6wsdJw+M	false	yellow fluorescent protein tag:n-n|cyan fluorescent protein tag:c-c|mutation disrupting interaction:159-159|mutation disrupting interaction:380-380|mutation disrupting interaction:147-147,159-159,380-380	sufficient binding region:1-633|myc tag:n-n|mutation disrupting interaction:270-272|mutation disrupting interaction:270-272	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q0VGT2	uniprotkb:Q9UMX1	intact:EBI-9344284|uniprotkb:E9PYJ4|ensembl:ENSMUSP00000054837	intact:EBI-740595|uniprotkb:Q7LCP7|uniprotkb:Q9NT90|uniprotkb:Q9NZ07|uniprotkb:Q9UHK2|uniprotkb:Q9UHM8|uniprotkb:Q9UMY0|intact:EBI-28969623|ensembl:ENSP00000358918	psi-mi:gli2_mouse(display_long)|uniprotkb:Gli2(gene name)|psi-mi:Gli2(display_short)|uniprotkb:Thp(gene name synonym)|uniprotkb:Tax helper protein(gene name synonym)	psi-mi:sufu_human(display_long)|uniprotkb:SUFU(gene name)|psi-mi:SUFU(display_short)|uniprotkb:UNQ650/PRO1280(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2013)	imex:IM-22237|pubmed:24217340	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9344468|imex:IM-22237-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074594.1|dip:DIP-60772N|ensembl:ENSMUSG00000048402(gene)|ensembl:ENSMUST00000062483(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007389"(pattern specification process)|go:"GO:0007411"(axon guidance)|go:"GO:0007418"(ventral midline development)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0021508"(floor plate formation)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021915"(neural tube development)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030879"(mammary gland development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031514"(motile cilium)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0035295"(tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060032"(notochord regression)|go:"GO:0060322"(head development)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|reactome:R-MMU-5610787|reactome:R-MMU-5632684	refseq:NP_001171604.1|refseq:NP_057253.2|ensembl:ENST00000369899|ensembl:ENSP00000358915|ensembl:ENSP00000358918|ensembl:ENSP00000411597|ensembl:ENST00000423559|ensembl:ENSG00000107882(gene)|ensembl:ENST00000369902(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0035904"(aorta development)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043588"(skin development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR007768(Suppressor of fused)|interpro:IPR016591(Suppressor of fused protein)|interpro:IPR020941|interpro:IPR037181|interpro:IPR024314|interpro:IPR038489|rcsb pdb:1M1L|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4KM8|rcsb pdb:4KM9|rcsb pdb:4KMD|rcsb pdb:4KMH|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2014/03/04	2014/10/16	rogid:4rTCAbaXgbOsAHrJ9fhiPKh5ORQ10090	rogid:fY3B2k7IsBmMcCaDhHXbPsxjzYc9606	intact-crc:7C8C8B9DF09095A2|rigid:poI9LVMfMLvFXJ8Yt4b6wsdJw+M	false	myc tag:n-n	mutation disrupting interaction:380-380|yellow fluorescent protein tag:n-n|cyan fluorescent protein tag:c-c|mutation disrupting interaction:159-159|mutation disrupting interaction:147-147,159-159,380-380|sufficient binding region:1-285,346-484	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)