#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95376	uniprotkb:Q93034	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117738|imex:IM-22207-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	-	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:12F6DEA807F9F394|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P68036	uniprotkb:O95376	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117698|imex:IM-22207-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	intact-crc:BA7D37741DFB0570|rigid:fxvoJldDk1ywiJg/lEXiNgn6mP8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q93034	uniprotkb:O95376	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117734|imex:IM-22207-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	-	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	intact-crc:BA7FE5A41DFB0570|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:Q93034	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117718|imex:IM-22207-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	-	-	-	figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:32B51324AF81445E|rigid:lcSlVFma3h2vEs+/NyaNEQvk5ZY	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O95376	uniprotkb:P68036	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117718|imex:IM-22207-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:32B51324AF81445E|rigid:lcSlVFma3h2vEs+/NyaNEQvk5ZY	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q93034	uniprotkb:O95376	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117830|imex:IM-22207-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	-	-	-	figure legend:f3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	intact-crc:AA50AC1A120F6D9B|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	-	mutation decreasing interaction:86-86,84-84,100-100|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P68036	uniprotkb:Q9Y4X5	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118057|imex:IM-22207-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	-	-	-	figure legend:f5b|comment:"Precipitation of GFP‐HHARI with either an N‐terminal 100‐aa deletion (GFP‐HHARI (aa 101–557)) or triple mutations in the predicted UBA‐like domain (V123A, I124A, and W140A) abolished or significantly reduced the interaction with CUL1‐NEDD8 (Figure 5B and C), whereas the RING1 H205A mutation significantly decreased UBCH7 binding without disrupting the interaction with CUL1‐NEDD8."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	intact-crc:F2AD0AE8EAD69A3A|rigid:+bLmNdB5LKDddTIODpncrLKrVRA	false	-	green fluorescent protein tag:?-?|mutation disrupting interaction:205-205	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y4X5	uniprotkb:Q13618	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118023|imex:IM-22207-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168	-	-	-	figure legend:sf4|comment:"Strikingly, GFP‐HHARI interacted with the neddylated form of CUL1, ‐2, ‐3 and ‐4A but not with CUL4B or CUL5 (Figure 5A; Supplementary Figure S4)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	intact-crc:FA0B21CCF0002D3D|rigid:yXnpRFalFEqWTTR7BxMfugpE+RY	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:Q13619	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118023|imex:IM-22207-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)	-	-	-	figure legend:sf4|comment:"Strikingly, GFP‐HHARI interacted with the neddylated form of CUL1, ‐2, ‐3 and ‐4A but not with CUL4B or CUL5 (Figure 5A; Supplementary Figure S4)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606	intact-crc:FA0B21CCF0002D3D|rigid:yXnpRFalFEqWTTR7BxMfugpE+RY	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:Q13617	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118023|imex:IM-22207-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553	-	-	-	figure legend:sf4|comment:"Strikingly, GFP‐HHARI interacted with the neddylated form of CUL1, ‐2, ‐3 and ‐4A but not with CUL4B or CUL5 (Figure 5A; Supplementary Figure S4)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	intact-crc:FA0B21CCF0002D3D|rigid:yXnpRFalFEqWTTR7BxMfugpE+RY	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:P68036	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118023|imex:IM-22207-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:sf4|comment:"Strikingly, GFP‐HHARI interacted with the neddylated form of CUL1, ‐2, ‐3 and ‐4A but not with CUL4B or CUL5 (Figure 5A; Supplementary Figure S4)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:FA0B21CCF0002D3D|rigid:yXnpRFalFEqWTTR7BxMfugpE+RY	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:Q13616	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118080|imex:IM-22207-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	-	-	-	figure legend:f5c f5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	intact-crc:227366CBFED5855E|rigid:AWs0MPMmtC2U5bkOkcVbb7yN4Ko	false	mutation decreasing interaction:123-123|green fluorescent protein tag:?-?|binding-associated region:1-100	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:Q13616	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118068|imex:IM-22207-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	-	-	-	figure legend:f5c f5b|comment:"Precipitation of GFP‐HHARI with either an N‐terminal 100‐aa deletion (GFP‐HHARI (aa 101–557)) or triple mutations in the predicted UBA‐like domain (V123A, I124A, and W140A) abolished or significantly reduced the interaction with CUL1‐NEDD8 (Figure 5B and C), whereas the RING1 H205A mutation significantly decreased UBCH7 binding without disrupting the interaction with CUL1‐NEDD8."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	intact-crc:559A08EA4E25D015|rigid:AWs0MPMmtC2U5bkOkcVbb7yN4Ko	false	green fluorescent protein tag:?-?|binding-associated region:1-100|mutation disrupting interaction:123-123,124-124,140-140	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:P68036	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117710|imex:IM-22207-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:160BC3D24F8C6D31|rigid:fxvoJldDk1ywiJg/lEXiNgn6mP8	false	mutation disrupting interaction:158-158|green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q93034	uniprotkb:O95376	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118147|imex:IM-22207-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	-	-	-	figure legend:f7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	intact-crc:03EF97DBC61FDE3D|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	-	mutation increasing interaction:310-310|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y4X5	uniprotkb:Q13616	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118093|imex:IM-22207-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	-	-	-	figure legend:sf5f|comment:"We next tested the effects of mutations in the HHARI Ariadne domain, which were recently shown to relieve auto‐inhibition and result in enhanced HHARI auto‐ubiquitylation in vitro (Duda et al, 2013) (Figure 7H). We observed less GFP‐HHARI overall, potentially reflecting effects of auto‐ubiquitylation, and a concomitant increase in CUL1‐NEDD8 levels. Inactivation of E3 ligase activity by means of an additional catalytic C357S mutation restored accumulation of these Ariadne domain variants, as did treatment with the proteasomal inhibitor MG132 (Supplementary Figure S5F)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	intact-crc:5FAD89812C0AC334|rigid:c0MmStjY9+9M1RXyuXL1a0V3LPU	false	mutation disrupting interaction:430-430,431-431,503-503|green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:P68036	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118093|imex:IM-22207-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:sf5f|comment:"We next tested the effects of mutations in the HHARI Ariadne domain, which were recently shown to relieve auto‐inhibition and result in enhanced HHARI auto‐ubiquitylation in vitro (Duda et al, 2013) (Figure 7H). We observed less GFP‐HHARI overall, potentially reflecting effects of auto‐ubiquitylation, and a concomitant increase in CUL1‐NEDD8 levels. Inactivation of E3 ligase activity by means of an additional catalytic C357S mutation restored accumulation of these Ariadne domain variants, as did treatment with the proteasomal inhibitor MG132 (Supplementary Figure S5F)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:5FAD89812C0AC334|rigid:c0MmStjY9+9M1RXyuXL1a0V3LPU	false	mutation disrupting interaction:430-430,431-431,503-503|green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:Q13616	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118014|imex:IM-22207-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	-	-	-	figure legend:f5a f5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	intact-crc:23B87462672228B5|rigid:c0MmStjY9+9M1RXyuXL1a0V3LPU	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:P68036	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118014|imex:IM-22207-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:f5a f5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:23B87462672228B5|rigid:c0MmStjY9+9M1RXyuXL1a0V3LPU	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:Q15370	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117813|imex:IM-22207-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	-	-	-	figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:2998C277928FA865|rigid:t2rrCG8RFJ2y3pk4+Ok9c/Ihr2E	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:Q15369	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117813|imex:IM-22207-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N	-	-	-	figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:2998C277928FA865|rigid:t2rrCG8RFJ2y3pk4+Ok9c/Ihr2E	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:P68036	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117813|imex:IM-22207-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:2998C277928FA865|rigid:t2rrCG8RFJ2y3pk4+Ok9c/Ihr2E	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:Q93034	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117813|imex:IM-22207-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	-	-	-	figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:2998C277928FA865|rigid:t2rrCG8RFJ2y3pk4+Ok9c/Ihr2E	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:P68036	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117742|imex:IM-22207-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:f2d sf2b f7a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:691780B786D33687|rigid:lcSlVFma3h2vEs+/NyaNEQvk5ZY	false	green fluorescent protein tag:?-?|sufficient binding region:1-290	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:Q93034	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117742|imex:IM-22207-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	-	-	-	figure legend:f2d sf2b f7a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:691780B786D33687|rigid:lcSlVFma3h2vEs+/NyaNEQvk5ZY	false	green fluorescent protein tag:?-?|sufficient binding region:1-290	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13616	uniprotkb:Q9Y4X5	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118163|imex:IM-22207-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	-	-	-	figure legend:f7d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	intact-crc:E291963E4758D2E4|rigid:AWs0MPMmtC2U5bkOkcVbb7yN4Ko	false	-	green fluorescent protein tag:?-?|mutation increasing interaction:375-375	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95376	uniprotkb:Q93034	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118155|imex:IM-22207-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	-	-	-	figure legend:f7b f7a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:FBA9AE482FAF97DB|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	green fluorescent protein tag:?-?|mutation increasing interaction:300-300	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:P24864	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-519526|uniprotkb:Q14091|uniprotkb:Q8NFG1|uniprotkb:Q92501|ensembl:ENSP00000262643|uniprotkb:A8K684|uniprotkb:Q9UD21	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:ccne1_human(display_long)|uniprotkb:CCNE1(gene name)|psi-mi:CCNE1(display_short)|uniprotkb:CCNE(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118177|imex:IM-22207-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	ensembl:ENSG00000105173(gene)|ensembl:ENST00000262643(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|mint:P24864|rcsb pdb:1W98|rcsb pdb:5L2W|rcsb pdb:7KJS|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-8849470|reactome:R-HSA-9661069|reactome:R-HSA-9706019|refseq:NP_001229.1|refseq:NP_001309191.1|dip:DIP-149N	-	-	-	figure legend:f7h|comment:"We next tested the effects of mutations in the HHARI Ariadne domain, which were recently shown to relieve auto‐inhibition and result in enhanced HHARI auto‐ubiquitylation in vitro (Duda et al, 2013) (Figure 7H). We observed less GFP‐HHARI overall, potentially reflecting effects of auto‐ubiquitylation, and a concomitant increase in CUL1‐NEDD8 levels."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:IAmpLalK9y8siqmQgbDtQAgsxC09606	intact-crc:33149B9D63E032FA|rigid:9421H+nXqhh3AiL8XET07FVI7V8	false	green fluorescent protein tag:?-?|mutation increasing interaction:357-357	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:P46527	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118177|imex:IM-22207-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	-	-	-	figure legend:f7h|comment:"We next tested the effects of mutations in the HHARI Ariadne domain, which were recently shown to relieve auto‐inhibition and result in enhanced HHARI auto‐ubiquitylation in vitro (Duda et al, 2013) (Figure 7H). We observed less GFP‐HHARI overall, potentially reflecting effects of auto‐ubiquitylation, and a concomitant increase in CUL1‐NEDD8 levels."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	intact-crc:33149B9D63E032FA|rigid:9421H+nXqhh3AiL8XET07FVI7V8	false	green fluorescent protein tag:?-?|mutation increasing interaction:357-357	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:Q13616	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118177|imex:IM-22207-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	-	-	-	figure legend:f7h|comment:"We next tested the effects of mutations in the HHARI Ariadne domain, which were recently shown to relieve auto‐inhibition and result in enhanced HHARI auto‐ubiquitylation in vitro (Duda et al, 2013) (Figure 7H). We observed less GFP‐HHARI overall, potentially reflecting effects of auto‐ubiquitylation, and a concomitant increase in CUL1‐NEDD8 levels."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	intact-crc:33149B9D63E032FA|rigid:9421H+nXqhh3AiL8XET07FVI7V8	false	green fluorescent protein tag:?-?|mutation increasing interaction:357-357	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4X5	uniprotkb:P68036	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118177|imex:IM-22207-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:f7h|comment:"We next tested the effects of mutations in the HHARI Ariadne domain, which were recently shown to relieve auto‐inhibition and result in enhanced HHARI auto‐ubiquitylation in vitro (Duda et al, 2013) (Figure 7H). We observed less GFP‐HHARI overall, potentially reflecting effects of auto‐ubiquitylation, and a concomitant increase in CUL1‐NEDD8 levels."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:33149B9D63E032FA|rigid:9421H+nXqhh3AiL8XET07FVI7V8	false	green fluorescent protein tag:?-?|mutation increasing interaction:357-357	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:Q93034	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118123|imex:IM-22207-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	-	-	-	figure legend:f7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:997BB46A23901273|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	green fluorescent protein tag:?-?|mutation increasing interaction:310-310	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q93034	uniprotkb:O95376	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118131|imex:IM-22207-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	-	-	-	figure legend:f7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	intact-crc:D2F218F7B87DA9A8|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	-	green fluorescent protein tag:?-?|mutation increasing interaction:318-318	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95376	uniprotkb:Q93034	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117763|imex:IM-22207-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	-	-	-	figure legend:f2d sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:CDA9F06281CC8BB0|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	sufficient binding region:1-60|green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95376	uniprotkb:Q93034	intact:EBI-711158|uniprotkb:Q9HBZ6|uniprotkb:Q9UEM9|ensembl:ENSP00000348769|ensembl:ENSP00000403222	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ari2_human(display_long)|uniprotkb:Triad1 protein(gene name synonym)|uniprotkb:ARIH2(gene name)|psi-mi:ARIH2(display_short)|uniprotkb:ARI2(gene name synonym)|uniprotkb:TRIAD1(gene name synonym)|uniprotkb:HT005(orf name)|uniprotkb:RING-type E3 ubiquitin transferase ARIH2(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kelsall et al. (2013)	imex:IM-22207|pubmed:24076655	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9118004|imex:IM-22207-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304262.1|refseq:NP_001304263.1|refseq:NP_006312.1|ensembl:ENSG00000177479(gene)|ensembl:ENST00000356401(transcript)|ensembl:ENST00000449376(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048588"(developmental cell growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR031126|interpro:IPR031127|interpro:IPR044066|reactome:R-HSA-983168|refseq:XP_016861020.1|refseq:XP_016861021.1	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	-	-	-	figure legend:f3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/02/04	2014/10/16	rogid:536Qu2bpbptYcIhxoeLJNTErLTM9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:ADBD1FEA6D95B9A5|rigid:ftc0f/RkCOjrHaUBO2BAZ1eG3lo	false	mutation decreasing interaction:100-100|green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)