#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03060	ensembl:ENSG00000172116	intact:EBI-3907794|uniprotkb:Q9NZ98|uniprotkb:Q5W1A9|uniprotkb:Q16114|uniprotkb:Q14505|uniprotkb:Q5W1A6|uniprotkb:Q9NZ99|uniprotkb:Q15731|uniprotkb:Q14506|uniprotkb:Q5W1A8|uniprotkb:Q8IVD4|uniprotkb:Q5T9H7|uniprotkb:B4DXC1|uniprotkb:O75519|uniprotkb:Q16116|uniprotkb:Q14503|uniprotkb:Q9NZB9|uniprotkb:Q7Z2Q6|uniprotkb:Q14504|uniprotkb:A8MPQ2|uniprotkb:C9J785|uniprotkb:C9JZ10|uniprotkb:E9PAR4|uniprotkb:E9PHM1|uniprotkb:Q5W1A7|uniprotkb:A8K014|uniprotkb:A8K6A1|uniprotkb:Q5W1B2|uniprotkb:A8K3J7|uniprotkb:Q96AG7|uniprotkb:Q14501|uniprotkb:Q5W1B0|ensembl:ENSP00000393538	intact:EBI-10048162	psi-mi:crem_human(display_long)|uniprotkb:CREM(gene name)|psi-mi:CREM(display_short)|uniprotkb:Inducible cAMP early repressor(gene name synonym)	psi-mi:cd8b_human_gene(display_short)|psi-mi:ENSG00000172116(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Hedrich et al. (2013)	pubmed:24047902|imex:IM-23620	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10048177|efo:"EFO:0002690"|imex:IM-23620-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:XP_011517626.1|refseq:XP_011517627.1|refseq:XP_006717441.1|refseq:XP_006717442.1|refseq:XP_006717445.1|refseq:XP_006717446.1|refseq:NP_001872.3|refseq:NP_877572.1|refseq:NP_874389.1|refseq:NP_853549.1|refseq:NP_874387.1|refseq:NP_877570.1|refseq:NP_877571.1|refseq:NP_877573.1|refseq:NP_874386.1|refseq:NP_874390.1|refseq:NP_874392.1|refseq:NP_874393.1|refseq:NP_001254491.1|refseq:NP_001254493.1|refseq:NP_001254499.1|refseq:NP_874388.1|refseq:NP_898829.1|refseq:NP_898830.1|refseq:NP_898831.1|refseq:NP_001254496.1|refseq:NP_898883.1|ensembl:ENSG00000095794(gene)|ensembl:ENST00000429130(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0048511"(rhythmic process)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|reactome:R-HSA-400253|refseq:XP_016871211.1	-	-	-	-	figure legend:Fig. 5c, 5d|causality statement:Q03060 decreases expression at RNA level of ENSG00000172116|agonist:anti-CD3 and anti-CD28 antibodies|comment:Stimulation of CD8+ T cells from healthy donors with anti-CD3 and anti-CD28 antibodies resulted in increased binding of CREM and decreased binding of phospho-CREB to the CD8B gene promoter. Stimulated CD8+ T cells from SLE patients showed increased binding of CREM and decreased binding of phospho-CREB to the CD8B gene promoter compared to stimulated CD8+ T cells from healthy donors.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2014/12/19	2019/01/30	rogid:qZeS07Fyrw2lTZ6t5kgxUy11kpA9606	-	intact-crc:D68E7A50E865A0AF	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)