#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q13263 uniprotkb:Q9BQF6 intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1 intact:EBI-766251|uniprotkb:Q7Z3F4|uniprotkb:Q96PS5|uniprotkb:Q9C0F6|uniprotkb:Q9HBT5|uniprotkb:A1L3A5|uniprotkb:A8MW39|uniprotkb:B7WNW8|ensembl:ENSP00000377655 psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym) psi-mi:senp7_human(display_long)|uniprotkb:SUMO-1-specific protease 2(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP7(gene name synonym)|uniprotkb:SENP7(gene name)|psi-mi:SENP7(display_short)|uniprotkb:KIAA1707(gene name synonym)|uniprotkb:SSP2(gene name synonym)|uniprotkb:SUSP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Garvin et al. (2013) pubmed:24018422|imex:IM-22197 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9118280|imex:IM-22197-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N refseq:NP_001070671.1|refseq:NP_001269730.1|refseq:NP_001269731.1|refseq:NP_001269732.1|refseq:NP_001269733.1|refseq:NP_065705.3|refseq:XP_016862414.1|ensembl:ENSG00000138468(gene)|ensembl:ENST00000394095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016926"(protein desumoylation)|go:"GO:0070139"(SUMO-specific endopeptidase activity)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|rcsb pdb:3EAY|interpro:IPR038765 - - - figure legend:f3a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/02/04 2014/10/16 rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606 rogid:dLL7YHqSkqW17N+IHtiDf0yC07Q9606 intact-crc:41358CBEB06E01FF|rigid:kzUGgi1Zfof+m6pNcPvKY4/obcQ false - mutation increasing interaction:992-992|flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q13263 uniprotkb:Q9BQF6 intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1 intact:EBI-766251|uniprotkb:Q7Z3F4|uniprotkb:Q96PS5|uniprotkb:Q9C0F6|uniprotkb:Q9HBT5|uniprotkb:A1L3A5|uniprotkb:A8MW39|uniprotkb:B7WNW8|ensembl:ENSP00000377655 psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym) psi-mi:senp7_human(display_long)|uniprotkb:SUMO-1-specific protease 2(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP7(gene name synonym)|uniprotkb:SENP7(gene name)|psi-mi:SENP7(display_short)|uniprotkb:KIAA1707(gene name synonym)|uniprotkb:SSP2(gene name synonym)|uniprotkb:SUSP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Garvin et al. (2013) pubmed:24018422|imex:IM-22197 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9118267|imex:IM-22197-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N refseq:NP_001070671.1|refseq:NP_001269730.1|refseq:NP_001269731.1|refseq:NP_001269732.1|refseq:NP_001269733.1|refseq:NP_065705.3|refseq:XP_016862414.1|ensembl:ENSG00000138468(gene)|ensembl:ENST00000394095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016926"(protein desumoylation)|go:"GO:0070139"(SUMO-specific endopeptidase activity)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|rcsb pdb:3EAY|interpro:IPR038765 - - - figure legend:f3a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/02/04 2014/10/16 rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606 rogid:dLL7YHqSkqW17N+IHtiDf0yC07Q9606 intact-crc:3B38C4225160646C|rigid:kzUGgi1Zfof+m6pNcPvKY4/obcQ false - flag tag:?-?|mutation disrupting interaction:156-156,158-158,152-152,163-163,165-165,149-149 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BQF6 uniprotkb:P45973 intact:EBI-766251|uniprotkb:Q7Z3F4|uniprotkb:Q96PS5|uniprotkb:Q9C0F6|uniprotkb:Q9HBT5|uniprotkb:A1L3A5|uniprotkb:A8MW39|uniprotkb:B7WNW8|ensembl:ENSP00000377655 intact:EBI-78219|ensembl:ENSP00000209875|ensembl:ENSP00000401009|ensembl:ENSP00000449207|uniprotkb:B2R8T9 psi-mi:senp7_human(display_long)|uniprotkb:SUMO-1-specific protease 2(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP7(gene name synonym)|uniprotkb:SENP7(gene name)|psi-mi:SENP7(display_short)|uniprotkb:KIAA1707(gene name synonym)|uniprotkb:SSP2(gene name synonym)|uniprotkb:SUSP2(gene name synonym) psi-mi:cbx5_human(display_long)|uniprotkb:CBX5(gene name)|psi-mi:CBX5(display_short)|uniprotkb:Heterochromatin protein 1 homolog alpha(gene name synonym)|uniprotkb:Antigen p25(gene name synonym)|uniprotkb:HP1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Garvin et al. (2013) pubmed:24018422|imex:IM-22197 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9117109|imex:IM-22197-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001070671.1|refseq:NP_001269730.1|refseq:NP_001269731.1|refseq:NP_001269732.1|refseq:NP_001269733.1|refseq:NP_065705.3|refseq:XP_016862414.1|ensembl:ENSG00000138468(gene)|ensembl:ENST00000394095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016926"(protein desumoylation)|go:"GO:0070139"(SUMO-specific endopeptidase activity)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|rcsb pdb:3EAY|interpro:IPR038765 go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|go:"GO:0030674"(protein-macromolecule adaptor activity)|mint:P45973|rcsb pdb:3FDT|rcsb pdb:3I3C|reactome:R-HSA-4551638|reactome:R-HSA-8953750|reactome:R-HSA-983231|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000094916(gene)|ensembl:ENST00000209875(transcript)|ensembl:ENST00000439541(transcript)|ensembl:ENST00000550411(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|refseq:NP_001120793.1|refseq:NP_001120794.1|refseq:NP_036249.1|dip:DIP-5986N - - - figure legend:f2g f3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/02/04 2014/10/16 rogid:dLL7YHqSkqW17N+IHtiDf0yC07Q9606 rogid:yNQ+OVYYyR0Ls2cp6/xzBld1hyE9606 intact-crc:07BD4AFE482062E1|rigid:nEREO1tnTb37Ab6IJ//ext7RJPM false mutation disrupting interaction:152-152,156-156,158-158,163-163,165-165,149-149|flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot)