#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03495	uniprotkb:O43521	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116794|imex:IM-22064-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	intact-crc:9FF85516F9D0997B|rigid:Ken2JuDUfla3hdsxi5RmLQ0iGq0	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07812	uniprotkb:P03495	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116910|imex:IM-22064-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:27D07DFE81C77740|rigid:ZlaKhE1qZr73eIJ0uMvUAbg+3Gw	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03495	uniprotkb:P55916	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-9116865|uniprotkb:O60475|uniprotkb:Q96HL3|ensembl:ENSP00000323740	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:ucp3_human(display_long)|uniprotkb:UCP3(gene name)|psi-mi:UCP3(display_short)|uniprotkb:SLC25A9(gene name synonym)|uniprotkb:Solute carrier family 25 member 9(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116901|imex:IM-22064-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_003347.1|refseq:NP_073714.1|ensembl:ENSG00000175564(gene)|ensembl:ENST00000314032(transcript)|go:"GO:0000303"(response to superoxide)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005215"(transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0009409"(response to cold)|go:"GO:0014823"(response to activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990542"(mitochondrial transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002030(Mitochondrial brown fat uncoupling protein)|interpro:IPR018108|interpro:IPR023395|reactome:R-HSA-167826|reactome:R-HSA-167827	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:8fXzbXjSGsFIPVyLnuZ2aQFblkw9606	intact-crc:2F93E14C59295221|rigid:jgS2bwkcXOlDEwf2lel9Pc1s3lY	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60869	uniprotkb:P03495	intact:EBI-781301|uniprotkb:Q5T5T2|uniprotkb:Q9UIM1|ensembl:ENSP00000224073	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:edf1_human(display_long)|uniprotkb:Multiprotein-bridging factor 1(gene name synonym)|uniprotkb:EDF1(gene name)|psi-mi:EDF1(display_short)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116802|imex:IM-22064-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003783.1|refseq:NP_694880.1|refseq:NP_001268227.1|refseq:NP_001268228.1|refseq:NP_001268226.1|ensembl:ENSG00000107223(gene)|ensembl:ENST00000224073(transcript)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007275"(multicellular organism development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001387(Helix-turn-helix type 3)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013729(Multiprotein bridging factor 1, N-terminal)|rcsb pdb:1X57|rcsb pdb:6ZVH	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:FxYP3Kzsj2EOpKQY9cidx3a0FJc9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:35EE08F40C0051BE|rigid:6ONX8yYQXL6+ktr9CKSFv98KYAg	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35568	uniprotkb:P03495	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116823|imex:IM-22064-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:E363558F8E5E87BD|rigid:43bajJiNMRuhw8IIfKk1w2Q26EU	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92934	uniprotkb:P03495	intact:EBI-700771|uniprotkb:O14803|uniprotkb:Q6FH21|ensembl:ENSP00000309103|ensembl:ENSP00000378040	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:bad_human(display_long)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-2-like protein 8(gene name synonym)|uniprotkb:BAD(gene name)|psi-mi:BAD(display_short)|uniprotkb:BBC6(gene name synonym)|uniprotkb:BCL2L8(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116786|imex:IM-22064-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004313.1|refseq:NP_116784.1|dip:DIP-29184N|ensembl:ENSG00000002330(gene)|ensembl:ENST00000309032(transcript)|ensembl:ENST00000394532(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|mint:Q92934|rcsb pdb:1G5J|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-198323|reactome:R-HSA-5674400	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:2c2kSu+3ZHnx458SDbvIcdGV4PA9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:8E226805B90E1E31|rigid:wenplxqiUFK1XpDOY8+I+ttr27M	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29353	uniprotkb:P03495	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116848|imex:IM-22064-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:98B0A7008A95E2B0|rigid:oWT6K5xTNtr1bl4PSHPxoXMcb+U	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03495	uniprotkb:Q92844	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116857|imex:IM-22064-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	intact-crc:47B30357F212648A|rigid:Wg8dszF6VcpKXZ/eOvXFfekKPNk	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04049	uniprotkb:P03495	intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116839|imex:IM-22064-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:554BCCD73E20A78E|rigid:y7/99clbv23KMMK9XeHpCBa77G4	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03495	uniprotkb:Q13651	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-1031656|uniprotkb:B0YJ27|uniprotkb:A8K6I0|ensembl:ENSP00000227752	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:i10r1_human(display_long)|uniprotkb:IL10RA(gene name)|psi-mi:IL10RA(display_short)|uniprotkb:IL10R(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 1(gene name synonym)|uniprotkb:CDw210a(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116815|imex:IM-22064-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_001549.2|go:"GO:0004920"(interleukin-10 receptor activity)|ensembl:ENSG00000110324(gene)|ensembl:ENST00000227752(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019969"(interleukin-10 binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:1J7V|rcsb pdb:1LQS|rcsb pdb:1Y6K|rcsb pdb:1Y6M|rcsb pdb:1Y6N|rcsb pdb:5IXI|rcsb pdb:6X93|reactome:R-HSA-6783783|dip:DIP-3512N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:sMAPIcNDOtzRHrmx79PMcP9jDRA9606	intact-crc:E70C7A31004E64A3|rigid:SfBFsmZU3H6+4iNcD84+ir+JB/M	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBF8	uniprotkb:P03495	intact:EBI-1053214|uniprotkb:B4DGI2|uniprotkb:O15096|uniprotkb:P78405|uniprotkb:Q5VWC1|uniprotkb:Q9BWR6|uniprotkb:Q5VWB9|uniprotkb:Q5VWC0|ensembl:ENSP00000357867	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:pi4kb_human(display_long)|uniprotkb:NPIK(gene name synonym)|uniprotkb:PI4K92(gene name synonym)|uniprotkb:PI4KIII(gene name synonym)|uniprotkb:PI4KB(gene name)|psi-mi:PI4KB(display_short)|uniprotkb:PIK4CB(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116831|imex:IM-22064-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185702.1|refseq:NP_001185703.1|refseq:NP_001185704.1|refseq:NP_002642.1|ensembl:ENSG00000143393(gene)|ensembl:ENST00000368873(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR018936|interpro:IPR036940|mint:Q9UBF8|rcsb pdb:2N73|rcsb pdb:4D0L|rcsb pdb:4D0M|rcsb pdb:4WAE|rcsb pdb:4WAG|rcsb pdb:5C46|rcsb pdb:5C4G|rcsb pdb:5EUQ|rcsb pdb:5FBL|rcsb pdb:5FBQ|rcsb pdb:5FBR|rcsb pdb:5FBV|rcsb pdb:5FBW|rcsb pdb:5LX2|rcsb pdb:5NAS|rcsb pdb:6GL3|reactome:R-HSA-1660514|refseq:NP_001317650.1|refseq:XP_016856979.1|refseq:XP_016856980.1|refseq:XP_016856981.1|dip:DIP-42267N	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:EeU4q6eJ1Kji9EaWCT+xYv2Y8eA9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:A3C1C51A3A92C32E|rigid:6k6f7VHjkgSh3ml438/bnVDkE84	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2T1	uniprotkb:P03495	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116774|imex:IM-22064-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/01/28	2014/10/16	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:E6668EFB969BB739|rigid:r8Rak8Di/i2NUEhrzJehtZXBLu0	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03495	uniprotkb:P29353	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116970|imex:IM-22064-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:AA3700C64592626D|rigid:oWT6K5xTNtr1bl4PSHPxoXMcb+U	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03495	uniprotkb:P55916	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-9116865|uniprotkb:O60475|uniprotkb:Q96HL3|ensembl:ENSP00000323740	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:ucp3_human(display_long)|uniprotkb:UCP3(gene name)|psi-mi:UCP3(display_short)|uniprotkb:SLC25A9(gene name synonym)|uniprotkb:Solute carrier family 25 member 9(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116954|imex:IM-22064-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_003347.1|refseq:NP_073714.1|ensembl:ENSG00000175564(gene)|ensembl:ENST00000314032(transcript)|go:"GO:0000303"(response to superoxide)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005215"(transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0009409"(response to cold)|go:"GO:0014823"(response to activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990542"(mitochondrial transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002030(Mitochondrial brown fat uncoupling protein)|interpro:IPR018108|interpro:IPR023395|reactome:R-HSA-167826|reactome:R-HSA-167827	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:8fXzbXjSGsFIPVyLnuZ2aQFblkw9606	intact-crc:9A0E805E8B40A509|rigid:jgS2bwkcXOlDEwf2lel9Pc1s3lY	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03495	uniprotkb:Q96F86	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-997311|uniprotkb:Q9H797|uniprotkb:B3KPH0|uniprotkb:D3DW61|ensembl:ENSP00000497737|ensembl:ENSP00000320503|ensembl:ENSP00000401343|ensembl:ENSP00000455580	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:edc3_human(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:LSM16 homolog(gene name synonym)|uniprotkb:EDC3(gene name)|psi-mi:EDC3(display_short)|uniprotkb:PP844(orf name)|uniprotkb:LSM16(gene name synonym)|uniprotkb:YJDC(gene name synonym)|uniprotkb:YJEFN2(gene name synonym)|uniprotkb:YjeF N-terminal domain-containing protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116946|imex:IM-22064-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_001135915.1|refseq:NP_001135916.1|refseq:NP_079359.2|ensembl:ENST00000315127(transcript)|ensembl:ENST00000426797(transcript)|ensembl:ENST00000568176(transcript)|ensembl:ENST00000647659(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q96F86|rcsb pdb:2VC8|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:3D3J|rcsb pdb:3D3K|rcsb pdb:6S8S|reactome:R-HSA-430039|ensembl:ENSG00000179151(gene)|dip:DIP-35516N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:AFS114ghTqHNid3eOFB7iQsfwAg9606	intact-crc:5D2243CE9C0D8363|rigid:lBKQsBlQiIl0c31AW2Po5AGaVJ8	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03495	uniprotkb:P35568	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116994|imex:IM-22064-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:39A514B0ABC8DD5A|rigid:43bajJiNMRuhw8IIfKk1w2Q26EU	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03495	uniprotkb:O60869	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-781301|uniprotkb:Q5T5T2|uniprotkb:Q9UIM1|ensembl:ENSP00000224073	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:edf1_human(display_long)|uniprotkb:Multiprotein-bridging factor 1(gene name synonym)|uniprotkb:EDF1(gene name)|psi-mi:EDF1(display_short)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117013|imex:IM-22064-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_003783.1|refseq:NP_694880.1|refseq:NP_001268227.1|refseq:NP_001268228.1|refseq:NP_001268226.1|ensembl:ENSG00000107223(gene)|ensembl:ENST00000224073(transcript)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007275"(multicellular organism development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001387(Helix-turn-helix type 3)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013729(Multiprotein bridging factor 1, N-terminal)|rcsb pdb:1X57|rcsb pdb:6ZVH	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:FxYP3Kzsj2EOpKQY9cidx3a0FJc9606	intact-crc:6C5F13EFA23E57A8|rigid:6ONX8yYQXL6+ktr9CKSFv98KYAg	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92934	uniprotkb:P03495	intact:EBI-700771|uniprotkb:O14803|uniprotkb:Q6FH21|ensembl:ENSP00000309103|ensembl:ENSP00000378040	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:bad_human(display_long)|uniprotkb:Bcl-2-binding component 6(gene name synonym)|uniprotkb:Bcl-2-like protein 8(gene name synonym)|uniprotkb:BAD(gene name)|psi-mi:BAD(display_short)|uniprotkb:BBC6(gene name synonym)|uniprotkb:BCL2L8(gene name synonym)|uniprotkb:Bcl-xL/Bcl-2-associated death promoter(gene name synonym)|uniprotkb:Bcl2 antagonist of cell death(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116930|imex:IM-22064-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004313.1|refseq:NP_116784.1|dip:DIP-29184N|ensembl:ENSG00000002330(gene)|ensembl:ENST00000309032(transcript)|ensembl:ENST00000394532(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033574"(response to testosterone)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046031"(ADP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0071247"(cellular response to chromate)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901423"(response to benzene)|go:"GO:1902220"(positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1904710"(positive regulation of granulosa cell apoptotic process)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR018868|mint:Q92934|rcsb pdb:1G5J|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-198323|reactome:R-HSA-5674400	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:2c2kSu+3ZHnx458SDbvIcdGV4PA9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:316ACAA1A5C2A518|rigid:wenplxqiUFK1XpDOY8+I+ttr27M	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P55957	uniprotkb:P03495	intact:EBI-519672|uniprotkb:Q549M7|uniprotkb:Q71T04|uniprotkb:Q7Z4M9|ensembl:ENSP00000449236|ensembl:ENSP00000480414|uniprotkb:Q8IY86	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:bid_human(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:BID(gene name)|psi-mi:BID(display_short)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116938|imex:IM-22064-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000015475(gene)|ensembl:ENST00000551952(transcript)|ensembl:ENST00000622694(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|mint:P55957|rcsb pdb:1ZY3|rcsb pdb:2BID|rcsb pdb:2KBW|rcsb pdb:2M5B|rcsb pdb:2M5I|rcsb pdb:4BD2|rcsb pdb:4QVE|rcsb pdb:4ZEQ|rcsb pdb:4ZIG|rcsb pdb:4ZII|rcsb pdb:5AJJ|rcsb pdb:5C3F|reactome:R-HSA-111447|reactome:R-HSA-111452|reactome:R-HSA-111453|reactome:R-HSA-114294|reactome:R-HSA-6803204|reactome:R-HSA-75108|go:"GO:0005123"(death receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|refseq:NP_001187.1|refseq:NP_932070.1|refseq:NP_001231498.1|refseq:NP_001231499.1|refseq:NP_001231501.1|refseq:NP_932071.1|refseq:NP_001231496.1|dip:DIP-34937N	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:K7148hFL21ctiVuJRKEsddUE3tc9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:8FCE800FDED1F061|rigid:A1tzwVF4ZGkFwq541YTWUM9+6wk	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03495	uniprotkb:Q9UBF8	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-1053214|uniprotkb:B4DGI2|uniprotkb:O15096|uniprotkb:P78405|uniprotkb:Q5VWC1|uniprotkb:Q9BWR6|uniprotkb:Q5VWB9|uniprotkb:Q5VWC0|ensembl:ENSP00000357867	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:pi4kb_human(display_long)|uniprotkb:NPIK(gene name synonym)|uniprotkb:PI4K92(gene name synonym)|uniprotkb:PI4KIII(gene name synonym)|uniprotkb:PI4KB(gene name)|psi-mi:PI4KB(display_short)|uniprotkb:PIK4CB(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116986|imex:IM-22064-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_001185702.1|refseq:NP_001185703.1|refseq:NP_001185704.1|refseq:NP_002642.1|ensembl:ENSG00000143393(gene)|ensembl:ENST00000368873(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR018936|interpro:IPR036940|mint:Q9UBF8|rcsb pdb:2N73|rcsb pdb:4D0L|rcsb pdb:4D0M|rcsb pdb:4WAE|rcsb pdb:4WAG|rcsb pdb:5C46|rcsb pdb:5C4G|rcsb pdb:5EUQ|rcsb pdb:5FBL|rcsb pdb:5FBQ|rcsb pdb:5FBR|rcsb pdb:5FBV|rcsb pdb:5FBW|rcsb pdb:5LX2|rcsb pdb:5NAS|rcsb pdb:6GL3|reactome:R-HSA-1660514|refseq:NP_001317650.1|refseq:XP_016856979.1|refseq:XP_016856980.1|refseq:XP_016856981.1|dip:DIP-42267N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:EeU4q6eJ1Kji9EaWCT+xYv2Y8eA9606	intact-crc:B1B976AA33603C29|rigid:6k6f7VHjkgSh3ml438/bnVDkE84	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43521	uniprotkb:P03495	intact:EBI-526406|uniprotkb:Q0MSE7|uniprotkb:Q0MSE8|uniprotkb:Q0MSE9|uniprotkb:Q53R28|uniprotkb:Q6JTU6|uniprotkb:Q6T851|uniprotkb:Q6TE14|uniprotkb:Q6TE15|uniprotkb:Q6TE16|uniprotkb:Q6V402|uniprotkb:A8K2W2|uniprotkb:Q8WYL6|uniprotkb:Q8WYL7|uniprotkb:Q8WYL8|uniprotkb:Q8WYL9|uniprotkb:Q8WYM0|uniprotkb:Q8WYM1|uniprotkb:O43522|intact:EBI-1002160|ensembl:ENSP00000376943	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:b2l11_human(display_long)|uniprotkb:BCL2L11(gene name)|psi-mi:BCL2L11(display_short)|uniprotkb:BIM(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117021|imex:IM-22064-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191035.1|refseq:NP_001191036.1|refseq:NP_001191037.1|refseq:NP_001191038.1|refseq:NP_001191039.1|refseq:NP_001191040.1|refseq:NP_001191041.1|refseq:NP_001191042.1|refseq:NP_006529.1|refseq:NP_619527.1|refseq:NP_619528.1|refseq:NP_619529.1|refseq:NP_619530.1|refseq:NP_619531.1|refseq:NP_619532.1|refseq:NP_619533.1|refseq:NP_996885.1|refseq:NP_996886.1|ensembl:ENSG00000153094(gene)|ensembl:ENST00000393256(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012505"(endomembrane system)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|reactome:R-HSA-111453|reactome:R-HSA-193648|reactome:R-HSA-6802952|reactome:R-HSA-8862803|reactome:R-HSA-8952158|reactome:R-HSA-9607240|reactome:R-HSA-9614657|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|mint:O43521|rcsb pdb:1F95|rcsb pdb:2K7W|rcsb pdb:2NL9|rcsb pdb:2V6Q|rcsb pdb:2VM6|rcsb pdb:2WH6|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:3D7V|rcsb pdb:3FDL|rcsb pdb:3IO8|rcsb pdb:3IO9|rcsb pdb:3KJ0|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4B4S|rcsb pdb:4D2M|rcsb pdb:4QVF|rcsb pdb:4UF3|rcsb pdb:4YJ4|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIH|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5C3G|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX2|rcsb pdb:5VX3|rcsb pdb:5WOS|rcsb pdb:6QFI|rcsb pdb:6RJP|rcsb pdb:6TQQ|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6VBX|rcsb pdb:6X8O|reactome:R-HSA-111446|dip:DIP-29185N	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:YvDxFP1kVEoSiz67PVpE4ZM5wWI9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:B1A9313F83BBE789|rigid:Ken2JuDUfla3hdsxi5RmLQ0iGq0	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13651	uniprotkb:P03495	intact:EBI-1031656|uniprotkb:B0YJ27|uniprotkb:A8K6I0|ensembl:ENSP00000227752	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:i10r1_human(display_long)|uniprotkb:IL10RA(gene name)|psi-mi:IL10RA(display_short)|uniprotkb:IL10R(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 1(gene name synonym)|uniprotkb:CDw210a(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9117002|imex:IM-22064-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001549.2|go:"GO:0004920"(interleukin-10 receptor activity)|ensembl:ENSG00000110324(gene)|ensembl:ENST00000227752(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019969"(interleukin-10 binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:1J7V|rcsb pdb:1LQS|rcsb pdb:1Y6K|rcsb pdb:1Y6M|rcsb pdb:1Y6N|rcsb pdb:5IXI|rcsb pdb:6X93|reactome:R-HSA-6783783|dip:DIP-3512N	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:sMAPIcNDOtzRHrmx79PMcP9jDRA9606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:F892D4D989406BBA|rigid:SfBFsmZU3H6+4iNcD84+ir+JB/M	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P04049	uniprotkb:P03495	intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3	intact:EBI-2548993|uniprotkb:Q1K9D5	psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116978|imex:IM-22064-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	intact-crc:F590E616BBE64295|rigid:y7/99clbv23KMMK9XeHpCBa77G4	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03495	uniprotkb:Q92844	intact:EBI-2548993|uniprotkb:Q1K9D5	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2013)	pubmed:24008843|imex:IM-22064	taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9116962|imex:IM-22064-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	-	-	figure legend:st1 f2a sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/28	2014/10/16	rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	intact-crc:6A77776A796C4899|rigid:Wg8dszF6VcpKXZ/eOvXFfekKPNk	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)