#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62136	uniprotkb:Q5S007	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:1019"(protein phosphatase assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9690775|imex:IM-23014-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0006470"(protein dephosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)	-	-	figure legend:Figure 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/11	2014/10/16	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:4985F4182461BF06|rigid:eGUIL+/r1ETS42g8WpgLkUxIprc	false	-	flag tag:n-n|32p radiolabel:?-?|O-phospho-L-serine:910-910|O-phospho-L-serine:935-935|O-phospho-L-serine:955-955|O-phospho-L-serine:973-973	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5S007	uniprotkb:P00634	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-552958|uniprotkb:P77801|uniprotkb:P78051|uniprotkb:Q2MC42|uniprotkb:Q47041|ensemblbacteria:AAC73486|ensemblbacteria:BAE76164	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:ppb_ecoli(display_long)|uniprotkb:phoA(gene name)|psi-mi:phoA(display_short)|uniprotkb:b0383(locus name)|uniprotkb:JW0374(locus name)	psi-mi:"MI:1019"(protein phosphatase assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9690852|imex:IM-23014-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_414917.2|refseq:WP_000814403.1|dip:DIP-10496N|ensemblbacteria:AAC73486(transcript)|ensemblbacteria:b0383(gene)|ensemblbacteria:BAE76164(gene)|ensemblbacteria:BAE76164(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030613"(oxidoreductase activity, acting on phosphorus or arsenic in donors)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0042597"(periplasmic space)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|rcsb pdb:1AJA|rcsb pdb:1AJB|rcsb pdb:1AJC|rcsb pdb:1AJD|rcsb pdb:1ALH|rcsb pdb:1ALI|rcsb pdb:1ALJ|rcsb pdb:1ALK|rcsb pdb:1ANI|rcsb pdb:1ANJ|rcsb pdb:1B8J|rcsb pdb:1ED8|rcsb pdb:1ED9|rcsb pdb:1ELX|rcsb pdb:1ELY|rcsb pdb:1ELZ|rcsb pdb:1EW8|rcsb pdb:1EW9|rcsb pdb:1HJK|rcsb pdb:1HQA|rcsb pdb:1KH4|rcsb pdb:1KH5|rcsb pdb:1KH7|rcsb pdb:1KH9|rcsb pdb:1KHJ|rcsb pdb:1KHK|rcsb pdb:1KHL|rcsb pdb:1KHN|rcsb pdb:1URA|rcsb pdb:1URB|rcsb pdb:1Y6V|rcsb pdb:1Y7A|rcsb pdb:2ANH|rcsb pdb:2G9Y|rcsb pdb:2GA3|rcsb pdb:2MLX|rcsb pdb:2MLY|rcsb pdb:2MLZ|rcsb pdb:3BDF|rcsb pdb:3BDG|rcsb pdb:3BDH|rcsb pdb:3CMR|rcsb pdb:3DPC|rcsb pdb:3DYC|rcsb pdb:3TG0|rcsb pdb:4KM4|rcsb pdb:4YR1|rcsb pdb:5C66|rcsb pdb:5GAD|rcsb pdb:5GAF|rcsb pdb:5GAG|rcsb pdb:5JTL|rcsb pdb:5JTM|rcsb pdb:5JTN|rcsb pdb:5JTO|rcsb pdb:5JTP|rcsb pdb:5TPQ|rcsb pdb:6PPT|rcsb pdb:6PQ2|rcsb pdb:6PQE|rcsb pdb:6PQM|rcsb pdb:6PRI|rcsb pdb:6PRJ|rcsb pdb:6PRQ|rcsb pdb:6PSI|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:5GAH	go:"GO:0006470"(protein dephosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)	-	-	figure legend:Figure 1|comment:positive control|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/11	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:RWPdGs8xyEdVg8pMi5LMyyqX0ZA83333	intact-crc:11314A565CD8BB46|rigid:i1c9hPeBerYrdo7YPUoVF+DRSFE	false	O-phospho-L-serine:973-973|O-phospho-L-serine:935-935|O-phospho-L-serine:910-910|O-phospho-L-serine:955-955|flag tag:n-n|32p radiolabel:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5S007	uniprotkb:P62136	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:1019"(protein phosphatase assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9690804|imex:IM-23014-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	go:"GO:0006470"(protein dephosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)	-	-	figure legend:Figure 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/11	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:4A90DED5D00A0914|rigid:eGUIL+/r1ETS42g8WpgLkUxIprc	false	flag tag:n-n|phosphorylated residue:?-?|32p radiolabel:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5S007	uniprotkb:P00634	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-552958|uniprotkb:P77801|uniprotkb:P78051|uniprotkb:Q2MC42|uniprotkb:Q47041|ensemblbacteria:AAC73486|ensemblbacteria:BAE76164	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:ppb_ecoli(display_long)|uniprotkb:phoA(gene name)|psi-mi:phoA(display_short)|uniprotkb:b0383(locus name)|uniprotkb:JW0374(locus name)	psi-mi:"MI:1019"(protein phosphatase assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9690874|imex:IM-23014-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_414917.2|refseq:WP_000814403.1|dip:DIP-10496N|ensemblbacteria:AAC73486(transcript)|ensemblbacteria:b0383(gene)|ensemblbacteria:BAE76164(gene)|ensemblbacteria:BAE76164(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030613"(oxidoreductase activity, acting on phosphorus or arsenic in donors)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0042597"(periplasmic space)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|rcsb pdb:1AJA|rcsb pdb:1AJB|rcsb pdb:1AJC|rcsb pdb:1AJD|rcsb pdb:1ALH|rcsb pdb:1ALI|rcsb pdb:1ALJ|rcsb pdb:1ALK|rcsb pdb:1ANI|rcsb pdb:1ANJ|rcsb pdb:1B8J|rcsb pdb:1ED8|rcsb pdb:1ED9|rcsb pdb:1ELX|rcsb pdb:1ELY|rcsb pdb:1ELZ|rcsb pdb:1EW8|rcsb pdb:1EW9|rcsb pdb:1HJK|rcsb pdb:1HQA|rcsb pdb:1KH4|rcsb pdb:1KH5|rcsb pdb:1KH7|rcsb pdb:1KH9|rcsb pdb:1KHJ|rcsb pdb:1KHK|rcsb pdb:1KHL|rcsb pdb:1KHN|rcsb pdb:1URA|rcsb pdb:1URB|rcsb pdb:1Y6V|rcsb pdb:1Y7A|rcsb pdb:2ANH|rcsb pdb:2G9Y|rcsb pdb:2GA3|rcsb pdb:2MLX|rcsb pdb:2MLY|rcsb pdb:2MLZ|rcsb pdb:3BDF|rcsb pdb:3BDG|rcsb pdb:3BDH|rcsb pdb:3CMR|rcsb pdb:3DPC|rcsb pdb:3DYC|rcsb pdb:3TG0|rcsb pdb:4KM4|rcsb pdb:4YR1|rcsb pdb:5C66|rcsb pdb:5GAD|rcsb pdb:5GAF|rcsb pdb:5GAG|rcsb pdb:5JTL|rcsb pdb:5JTM|rcsb pdb:5JTN|rcsb pdb:5JTO|rcsb pdb:5JTP|rcsb pdb:5TPQ|rcsb pdb:6PPT|rcsb pdb:6PQ2|rcsb pdb:6PQE|rcsb pdb:6PQM|rcsb pdb:6PRI|rcsb pdb:6PRJ|rcsb pdb:6PRQ|rcsb pdb:6PSI|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:5GAH	go:"GO:0006470"(protein dephosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)	-	-	figure legend:Figure 1|comment:positive control|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/11	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:RWPdGs8xyEdVg8pMi5LMyyqX0ZA83333	intact-crc:7E81B41F2E5A080B|rigid:i1c9hPeBerYrdo7YPUoVF+DRSFE	false	flag tag:n-n|32p radiolabel:?-?|phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P62136	uniprotkb:Q5S007	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9690901|imex:IM-23014-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figure 2A/C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/08/11	2014/10/16	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:8101FE2EC545D73B|rigid:eGUIL+/r1ETS42g8WpgLkUxIprc	false	flag tag:n-n	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q5S007	uniprotkb:P62140	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9690926|imex:IM-23014-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figure 2A-2|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/08/11	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606	intact-crc:AB882385AD349056|rigid:QVECMuyGGA788Qmuu8CS4W2/Qyc	false	enhanced green fluorescent protein tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P36873	uniprotkb:Q5S007	intact:EBI-356283|ensembl:ENSP00000335084	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:pp1g_human(display_long)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9690938|imex:IM-23014-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0004721"(phosphoprotein phosphatase activity)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000335007(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0043197"(dendritic spine)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P36873|rcsb pdb:1IT6|rcsb pdb:1JK7|rcsb pdb:1U32|rcsb pdb:2BCD|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|rcsb pdb:2BDX|rcsb pdb:4UT2|rcsb pdb:4UT3|go:"GO:0046872"(metal ion binding)|rcsb pdb:5INB|go:"GO:0047485"(protein N-terminus binding)|rcsb pdb:5J28|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|reactome:R-HSA-141444|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-9648025|reactome:R-HSA-9660537|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-400253|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-68877|refseq:NP_001231903.1|refseq:NP_002701.1|dip:DIP-749N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figure 2A-3|comment:"LRRK2 co-localized with the (small) fraction of PP1-gamma present in the cytoplasm"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/08/11	2014/10/16	rogid:SyjV/4d9V8lV/BXub2KESPKvupA9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:109B4181B76A1F5F|rigid:/wPo5TmOdQ1cAuNyNYueZE1zv6g	false	flag tag:n-n	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q5S007	uniprotkb:P62136	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9690964|imex:IM-23014-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:Figure 2B/D|agonist:LRRK2-IN1 - a selective LRRK2  inhibitor. [it induces dose-dependent inhibition of Ser910 and Ser935 phosphorylation accompanied by loss of 14-3-3 binding to both wild-type LRRK2 and LRRK2[G2019S] ]|antagonist:Calyculin A -an inhibitor of PP1 and PP2A|comment:"Addition of LRRK2-IN1 to (WT LRRK2) resulted in ser935 dephosphorylation of LRRK2 and loss of 14-3-3 binding.    LRRK2 mutants (which have reduced basal phosphorylation levels) showed enhanced binding to PP1A.    A HSP90   interaction with LRRK2  was observed  that was also enhanced with LRRK2 (aggregation-prone) mutations."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/08/11	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:3884CCE26A0E385B|rigid:eGUIL+/r1ETS42g8WpgLkUxIprc	false	enhanced green fluorescent protein tag:n-n|O-phospho-L-serine:935-935|mutation increasing interaction strength:1437-1437|mutation increasing interaction strength:1441-1441|mutation increasing interaction strength:1699-1699|mutation increasing interaction strength:910-910,935-935,955-955,973-973	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5S007	uniprotkb:P62136	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691027|imex:IM-23014-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:Figure 2C|agonist:LRRK2-IN1 - a selective LRRK2  inhibitor. [it induces dose-dependent inhibition of Ser910 and Ser935 phosphorylation accompanied by loss of 14-3-3 binding to both wild-type LRRK2 and LRRK2[G2019S] ]|antagonist:Calyculin A -an inhibitor of PP1 and PP2A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/08/11	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:6DB4FCE0A9B11A93|rigid:eGUIL+/r1ETS42g8WpgLkUxIprc	false	enhanced green fluorescent protein tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P62136	uniprotkb:Q5S007	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691062|imex:IM-23014-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:Figure 2E|agonist:LRRK2-IN1 - a selective LRRK2  inhibitor. [it induces dose-dependent inhibition of Ser910 and Ser935 phosphorylation accompanied by loss of 14-3-3 binding to both wild-type LRRK2 and LRRK2[G2019S] ]|antagonist:Calyculin A -an inhibitor of PP1 and PP2A|comment:"Addition of LRRK2-IN1 to (WT LRRK2) resulted in ser935 dephosphorylation of LRRK2."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2014/08/11	2014/10/16	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:EFD7725326F35C93|rigid:eGUIL+/r1ETS42g8WpgLkUxIprc	false	-	O-phospho-L-serine:935-935	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:17440"	uniprotkb:P19111	intact:EBI-1263351	intact:EBI-5259603|uniprotkb:Q28124	psi-mi:4-nitrophenyl dihydrogen phosphate(display_short)|psi-mi:"CHEBI:17440"(display_long)	psi-mi:ppbi_bovin(display_long)|uniprotkb:ALPI(gene name)|psi-mi:ALPI(display_short)	psi-mi:"MI:0434"(phosphatase assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691115|imex:IM-23014-12	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001952(Alkaline phosphatase)|interpro:IPR018299|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0031225"(anchored component of membrane)	go:"GO:0016311"(dephosphorylation)	-	-	figure legend:Supp fig 3B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/11	2014/10/16	-	rogid:qDMux+MP4cNIp2aqtjJYPgV+Gnw9913	intact-crc:E87BAF9E02AD092D	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17440"	uniprotkb:P35813	intact:EBI-1263351	intact:EBI-989143|uniprotkb:O75551|uniprotkb:B5BU11|uniprotkb:J3KNM0|ensembl:ENSP00000378514	psi-mi:4-nitrophenyl dihydrogen phosphate(display_short)|psi-mi:"CHEBI:17440"(display_long)	psi-mi:ppm1a_human(display_long)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:PPM1A(gene name)|psi-mi:PPM1A(display_short)|uniprotkb:PPPM1A(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691125|imex:IM-23014-14	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011535181.1|refseq:XP_011535180.1|refseq:NP_066283.1|refseq:NP_808820.1|refseq:NP_808821.2|refseq:XP_011535182.1|refseq:XP_011535183.1|refseq:XP_011535184.1|refseq:XP_011535185.1|refseq:XP_011535186.1|refseq:XP_005267836.1|refseq:XP_005267838.1|refseq:XP_016876873.1|refseq:XP_016876874.1|refseq:XP_016876875.1|refseq:XP_016876876.1|ensembl:ENSG00000100614(gene)|ensembl:ENST00000395076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:P35813|rcsb pdb:1A6Q|rcsb pdb:3FXJ|rcsb pdb:3FXK|rcsb pdb:3FXM|rcsb pdb:3FXO|rcsb pdb:4RA2|rcsb pdb:4RAF|rcsb pdb:4RAG|rcsb pdb:6B67|rcsb pdb:3FXL|reactome:R-HSA-2173795|reactome:R-HSA-380972	go:"GO:0016311"(dephosphorylation)	-	-	figure legend:Supp fig 3B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/11	2014/10/16	-	rogid:6Bhsr96yCyS7GN3SgN64RrNJTWk9606	intact-crc:605A21D17E5140B8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17440"	uniprotkb:P00634	intact:EBI-1263351	intact:EBI-552958|uniprotkb:P77801|uniprotkb:P78051|uniprotkb:Q2MC42|uniprotkb:Q47041|ensemblbacteria:AAC73486|ensemblbacteria:BAE76164	psi-mi:4-nitrophenyl dihydrogen phosphate(display_short)|psi-mi:"CHEBI:17440"(display_long)	psi-mi:ppb_ecoli(display_long)|uniprotkb:phoA(gene name)|psi-mi:phoA(display_short)|uniprotkb:b0383(locus name)|uniprotkb:JW0374(locus name)	psi-mi:"MI:0434"(phosphatase assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691110|imex:IM-23014-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414917.2|refseq:WP_000814403.1|dip:DIP-10496N|ensemblbacteria:AAC73486(transcript)|ensemblbacteria:b0383(gene)|ensemblbacteria:BAE76164(gene)|ensemblbacteria:BAE76164(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030613"(oxidoreductase activity, acting on phosphorus or arsenic in donors)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0042597"(periplasmic space)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|rcsb pdb:1AJA|rcsb pdb:1AJB|rcsb pdb:1AJC|rcsb pdb:1AJD|rcsb pdb:1ALH|rcsb pdb:1ALI|rcsb pdb:1ALJ|rcsb pdb:1ALK|rcsb pdb:1ANI|rcsb pdb:1ANJ|rcsb pdb:1B8J|rcsb pdb:1ED8|rcsb pdb:1ED9|rcsb pdb:1ELX|rcsb pdb:1ELY|rcsb pdb:1ELZ|rcsb pdb:1EW8|rcsb pdb:1EW9|rcsb pdb:1HJK|rcsb pdb:1HQA|rcsb pdb:1KH4|rcsb pdb:1KH5|rcsb pdb:1KH7|rcsb pdb:1KH9|rcsb pdb:1KHJ|rcsb pdb:1KHK|rcsb pdb:1KHL|rcsb pdb:1KHN|rcsb pdb:1URA|rcsb pdb:1URB|rcsb pdb:1Y6V|rcsb pdb:1Y7A|rcsb pdb:2ANH|rcsb pdb:2G9Y|rcsb pdb:2GA3|rcsb pdb:2MLX|rcsb pdb:2MLY|rcsb pdb:2MLZ|rcsb pdb:3BDF|rcsb pdb:3BDG|rcsb pdb:3BDH|rcsb pdb:3CMR|rcsb pdb:3DPC|rcsb pdb:3DYC|rcsb pdb:3TG0|rcsb pdb:4KM4|rcsb pdb:4YR1|rcsb pdb:5C66|rcsb pdb:5GAD|rcsb pdb:5GAF|rcsb pdb:5GAG|rcsb pdb:5JTL|rcsb pdb:5JTM|rcsb pdb:5JTN|rcsb pdb:5JTO|rcsb pdb:5JTP|rcsb pdb:5TPQ|rcsb pdb:6PPT|rcsb pdb:6PQ2|rcsb pdb:6PQE|rcsb pdb:6PQM|rcsb pdb:6PRI|rcsb pdb:6PRJ|rcsb pdb:6PRQ|rcsb pdb:6PSI|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:5GAH	go:"GO:0016311"(dephosphorylation)	-	-	figure legend:Supp fig 3B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/11	2014/10/16	-	rogid:RWPdGs8xyEdVg8pMi5LMyyqX0ZA83333	intact-crc:4D6E39CE34A48D16	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17440"	uniprotkb:P62136	intact:EBI-1263351	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:4-nitrophenyl dihydrogen phosphate(display_short)|psi-mi:"CHEBI:17440"(display_long)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Lobbestael et al. (2013)	pubmed:23937259|imex:IM-23014	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691120|imex:IM-23014-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	go:"GO:0016311"(dephosphorylation)	-	-	figure legend:Supp fig 3B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/11	2014/10/16	-	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	intact-crc:A2FBE2D7EA796572	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)