#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O00499 uniprotkb:Q13496 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9106365|imex:IM-22063-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:f1b sf7|comment:"GFP-tagged BARþPI, BAR, SH3 and BIN1 FL co-immunoprecipitated with B10-MTM1 (Fig 1B). Similar results were obtained when the co-immunoprecipitation was performed in the reverse direction (supplementary Fig S1 online). Moreover, GST-tagged BIN1 full length, BAR and SH3, produced in bacteria, were able to pull down in vitro-translated B10-MTM1 (Fig 1C), suggesting that MTM1 interacts directly with BIN1.The stronger interaction observed after co-immunoprecipitation and pull-down with BAR and SH3 domains compared with BIN1 FL (Fig 1B,C; supplementary Fig S1 online) suggested MTM1 interaction depends on BIN1 conformation"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cv-1)|taxid:9534(Monkey African Green kidney fibroblast) - 2014/01/28 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:26CE02E688F3F1A3|rigid:4jRmlwCrmhIWlGA9nYW94eAHbsU false green fluorescent protein tag:?-?|mutation increasing interaction:575-575 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q13496 uniprotkb:O00499 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9104825|imex:IM-22063-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - - - figure legend:f5a sf1 sf7|comment:"GFP-tagged BARþPI, BAR, SH3 and BIN1 FL co-immunoprecipitated with B10-MTM1 (Fig 1B). Similar results were obtained when the co-immunoprecipitation was performed in the reverse direction (supplementary Fig S1 online). Moreover, GST-tagged BIN1 full length, BAR and SH3, produced in bacteria, were able to pull down in vitro-translated B10-MTM1 (Fig 1C), suggesting that MTM1 interacts directly with BIN1.The stronger interaction observed after co-immunoprecipitation and pull-down with BAR and SH3 domains compared with BIN1 FL (Fig 1B,C; supplementary Fig S1 online) suggested MTM1 interaction depends on BIN1 conformation"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cv-1)|taxid:9534(Monkey African Green kidney fibroblast) - 2014/01/28 2014/10/16 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:C76BA0CF7076208A|rigid:4jRmlwCrmhIWlGA9nYW94eAHbsU false tag:?-? mutation increasing interaction:573-573|green fluorescent protein tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O00499 uniprotkb:Q13496 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9106351|imex:IM-22063-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:f5a sf1 sf7|comment:"GFP-tagged BARþPI, BAR, SH3 and BIN1 FL co-immunoprecipitated with B10-MTM1 (Fig 1B). Similar results were obtained when the co-immunoprecipitation was performed in the reverse direction (supplementary Fig S1 online). Moreover, GST-tagged BIN1 full length, BAR and SH3, produced in bacteria, were able to pull down in vitro-translated B10-MTM1 (Fig 1C), suggesting that MTM1 interacts directly with BIN1.The stronger interaction observed after co-immunoprecipitation and pull-down with BAR and SH3 domains compared with BIN1 FL (Fig 1B,C; supplementary Fig S1 online) suggested MTM1 interaction depends on BIN1 conformation"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cv-1)|taxid:9534(Monkey African Green kidney fibroblast) - 2014/01/28 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:4B8E460B5848087C|rigid:4jRmlwCrmhIWlGA9nYW94eAHbsU false mutation increasing interaction:575-575|green fluorescent protein tag:?-? tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O00499 uniprotkb:Q13496 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9104768|imex:IM-22063-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:f1b sf7|comment:"GFP-tagged BARþPI, BAR, SH3 and BIN1 FL co-immunoprecipitated with B10-MTM1 (Fig 1B). Similar results were obtained when the co-immunoprecipitation was performed in the reverse direction (supplementary Fig S1 online). Moreover, GST-tagged BIN1 full length, BAR and SH3, produced in bacteria, were able to pull down in vitro-translated B10-MTM1 (Fig 1C), suggesting that MTM1 interacts directly with BIN1.The stronger interaction observed after co-immunoprecipitation and pull-down with BAR and SH3 domains compared with BIN1 FL (Fig 1B,C; supplementary Fig S1 online) suggested MTM1 interaction depends on BIN1 conformation"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cv-1)|taxid:9534(Monkey African Green kidney fibroblast) - 2014/01/28 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:36FC07FE26BB8A4A|rigid:4jRmlwCrmhIWlGA9nYW94eAHbsU false green fluorescent protein tag:?-?|mutation increasing interaction:573-573 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O00499 uniprotkb:Q13496 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0096"(pull down) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-9104906|imex:IM-22063-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:f1c|comment:"GFP-tagged BARþPI, BAR, SH3 and BIN1 FL co-immunoprecipitated with B10-MTM1 (Fig 1B). Similar results were obtained when the co-immunoprecipitation was performed in the reverse direction (supplementary Fig S1 online). Moreover, GST-tagged BIN1 full length, BAR and SH3, produced in bacteria, were able to pull down in vitro-translated B10-MTM1 (Fig 1C), suggesting that MTM1 interacts directly with BIN1.The stronger interaction observed after co-immunoprecipitation and pull-down with BAR and SH3 domains compared with BIN1 FL (Fig 1B,C; supplementary Fig S1 online) suggested MTM1 interaction depends on BIN1 conformation"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/28 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:6908D3FA4166DA2D|rigid:4jRmlwCrmhIWlGA9nYW94eAHbsU false glutathione s tranferase tag:?-?|binding-associated region:1-255,380-454 tag:?-? - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O00499 uniprotkb:O00499 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0096"(pull down) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-9106419|imex:IM-22063-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - - - figure legend:f5c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/28 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:267E6B6455A9D110|rigid:DIJGepXmPLJXKfVEiIu6kkVwcbk false green fluorescent protein tag:?-?|mutation increasing interaction:575-575 glutathione s tranferase tag:?-?|binding-associated region:380-454 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O00499 uniprotkb:O00499 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0096"(pull down) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-9106405|imex:IM-22063-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - - - figure legend:f5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/28 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:3B986DC4C2131725|rigid:DIJGepXmPLJXKfVEiIu6kkVwcbk false green fluorescent protein tag:?-?|binding-associated region:1-281 glutathione s tranferase tag:?-?|binding-associated region:380-454 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O00499 uniprotkb:Q13496 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0096"(pull down) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9106729|imex:IM-22063-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:sf3c|comment:"The p.C375S MTM1 mutant was not able to pull down with GST-BIN1 BAR, contrary to other inactive MTM1 mutants tested (supplementary Fig S3C online)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/28 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:F748347F76F0ECE0|rigid:4jRmlwCrmhIWlGA9nYW94eAHbsU false glutathione s tranferase tag:?-?|binding-associated region:1-255 tag:?-?|mutation disrupting interaction:375-375 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O08539 uniprotkb:Q9Z2C5 intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9106221|imex:IM-22063-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828 ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 - - - figure legend:f1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2014/01/28 2014/10/16 rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 intact-crc:DA2D4C1B1E65FD8A|rigid:d9SsmjmyhV7QasjvtsoURKOKNTE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O08539 uniprotkb:Q9Z2C5 intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9105112|imex:IM-22063-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828 ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 - - - figure legend:f1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2014/01/28 2014/10/16 rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 intact-crc:299FE178AE9DF447|rigid:d9SsmjmyhV7QasjvtsoURKOKNTE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04191 uniprotkb:G1T894 intact:EBI-79241|uniprotkb:P11719 intact:EBI-9106282|ensembl:ENSOCUP00000012777 psi-mi:at2a1_rabit(display_long)|uniprotkb:ATP2A1(gene name)|psi-mi:ATP2A1(display_short)|uniprotkb:Calcium pump 1(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:g1t894_rabit(display_long)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106233|imex:IM-22063-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0106134"(positive regulation of cardiac muscle cell contraction)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:1902082"(positive regulation of calcium ion import into sarcoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031448"(positive regulation of fast-twitch skeletal muscle fiber contraction)|go:"GO:0031673"(H zone)|go:"GO:0031674"(I band)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|refseq:NP_001082787.1|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR023299|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023214|rcsb pdb:1FQU|rcsb pdb:1IWO|rcsb pdb:1KJU|rcsb pdb:1SU4|rcsb pdb:1T5S|rcsb pdb:1T5T|rcsb pdb:1VFP|rcsb pdb:1WPG|rcsb pdb:1XP5|rcsb pdb:2AGV|rcsb pdb:2BY4|rcsb pdb:2C88|rcsb pdb:2C8K|rcsb pdb:2C8L|rcsb pdb:2C9M|rcsb pdb:2DQS|rcsb pdb:2EAR|rcsb pdb:2EAT|rcsb pdb:2EAU|rcsb pdb:2O9J|rcsb pdb:2OA0|rcsb pdb:2YFY|rcsb pdb:2ZBD|rcsb pdb:2ZBE|rcsb pdb:2ZBF|rcsb pdb:2ZBG|rcsb pdb:3AR2|rcsb pdb:3AR3|rcsb pdb:3AR4|rcsb pdb:3AR5|rcsb pdb:3AR6|rcsb pdb:3AR7|rcsb pdb:3AR8|rcsb pdb:3AR9|rcsb pdb:3B9B|rcsb pdb:3B9R|rcsb pdb:3BA6|rcsb pdb:3FGO|rcsb pdb:3FPB|rcsb pdb:3FPS|rcsb pdb:3N5K|rcsb pdb:3N8G|rcsb pdb:2VOY|rcsb pdb:4NAB|interpro:IPR044492|rcsb pdb:5XA7|rcsb pdb:5XA8|rcsb pdb:4XOU|rcsb pdb:5A3Q|rcsb pdb:5A3R|rcsb pdb:5A3S|rcsb pdb:5ZMV|rcsb pdb:3J7T|rcsb pdb:4Y3U|rcsb pdb:4YCL|rcsb pdb:5ZMW|rcsb pdb:4UU0|rcsb pdb:4UU1|rcsb pdb:4YCM|rcsb pdb:4YCN|rcsb pdb:3W5A|rcsb pdb:3W5B|rcsb pdb:3W5C|rcsb pdb:3W5D|rcsb pdb:4H1W|rcsb pdb:4J2T|rcsb pdb:4KYT|rcsb pdb:4BEW|rcsb pdb:6RB2|rcsb pdb:6YSO|rcsb pdb:5NCQ|rcsb pdb:5XA9|rcsb pdb:5XAA|rcsb pdb:5XAB|interpro:IPR036412|rcsb pdb:6HEF|rcsb pdb:6YAA ensembl:ENSOCUG00000014862(gene)|ensembl:ENSOCUT00000014864(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006997"(nucleus organization)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031982"(vesicle)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028 go:"GO:0030315"(T-tubule) - - figure legend:f1f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") - 2014/01/28 2020/01/08 rogid:I0RNY0A95dY7WP5KaUrE144M2ks9986 rogid:hj0ommjoeRs3YAzdRmbhXDtZuK89986 intact-crc:FD3B0E6751BF0D59|rigid:4B+lylCW046LrzXNLZbYHq8tfbs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04191 uniprotkb:G1TC60 intact:EBI-79241|uniprotkb:P11719 intact:EBI-9106254|ensembl:ENSOCUP00000014348 psi-mi:at2a1_rabit(display_long)|uniprotkb:ATP2A1(gene name)|psi-mi:ATP2A1(display_short)|uniprotkb:Calcium pump 1(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:g1tc60_rabit(display_long)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106233|imex:IM-22063-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0106134"(positive regulation of cardiac muscle cell contraction)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:1902082"(positive regulation of calcium ion import into sarcoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031448"(positive regulation of fast-twitch skeletal muscle fiber contraction)|go:"GO:0031673"(H zone)|go:"GO:0031674"(I band)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|refseq:NP_001082787.1|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR023299|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023214|rcsb pdb:1FQU|rcsb pdb:1IWO|rcsb pdb:1KJU|rcsb pdb:1SU4|rcsb pdb:1T5S|rcsb pdb:1T5T|rcsb pdb:1VFP|rcsb pdb:1WPG|rcsb pdb:1XP5|rcsb pdb:2AGV|rcsb pdb:2BY4|rcsb pdb:2C88|rcsb pdb:2C8K|rcsb pdb:2C8L|rcsb pdb:2C9M|rcsb pdb:2DQS|rcsb pdb:2EAR|rcsb pdb:2EAT|rcsb pdb:2EAU|rcsb pdb:2O9J|rcsb pdb:2OA0|rcsb pdb:2YFY|rcsb pdb:2ZBD|rcsb pdb:2ZBE|rcsb pdb:2ZBF|rcsb pdb:2ZBG|rcsb pdb:3AR2|rcsb pdb:3AR3|rcsb pdb:3AR4|rcsb pdb:3AR5|rcsb pdb:3AR6|rcsb pdb:3AR7|rcsb pdb:3AR8|rcsb pdb:3AR9|rcsb pdb:3B9B|rcsb pdb:3B9R|rcsb pdb:3BA6|rcsb pdb:3FGO|rcsb pdb:3FPB|rcsb pdb:3FPS|rcsb pdb:3N5K|rcsb pdb:3N8G|rcsb pdb:2VOY|rcsb pdb:4NAB|interpro:IPR044492|rcsb pdb:5XA7|rcsb pdb:5XA8|rcsb pdb:4XOU|rcsb pdb:5A3Q|rcsb pdb:5A3R|rcsb pdb:5A3S|rcsb pdb:5ZMV|rcsb pdb:3J7T|rcsb pdb:4Y3U|rcsb pdb:4YCL|rcsb pdb:5ZMW|rcsb pdb:4UU0|rcsb pdb:4UU1|rcsb pdb:4YCM|rcsb pdb:4YCN|rcsb pdb:3W5A|rcsb pdb:3W5B|rcsb pdb:3W5C|rcsb pdb:3W5D|rcsb pdb:4H1W|rcsb pdb:4J2T|rcsb pdb:4KYT|rcsb pdb:4BEW|rcsb pdb:6RB2|rcsb pdb:6YSO|rcsb pdb:5NCQ|rcsb pdb:5XA9|rcsb pdb:5XAA|rcsb pdb:5XAB|interpro:IPR036412|rcsb pdb:6HEF|rcsb pdb:6YAA ensembl:ENSOCUG00000016688(gene)|ensembl:ENSOCUT00000016688(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR030561|interpro:IPR030564|interpro:IPR029021 go:"GO:0030315"(T-tubule) - - figure legend:f1f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") - 2014/01/28 2020/01/08 rogid:I0RNY0A95dY7WP5KaUrE144M2ks9986 rogid:maGRMb6shXPl7qyRu1fChvji6tg9986 intact-crc:FD3B0E6751BF0D59|rigid:4B+lylCW046LrzXNLZbYHq8tfbs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04191 intact:EBI-9106245 intact:EBI-79241|uniprotkb:P11719 - psi-mi:at2a1_rabit(display_long)|uniprotkb:ATP2A1(gene name)|psi-mi:ATP2A1(display_short)|uniprotkb:Calcium pump 1(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:g1tzq2_rabit(display_short)|psi-mi:EBI-9106245(display_long)|uniprotkb:CAV3(gene name)|psi-mi:CAV3(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106233|imex:IM-22063-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0106134"(positive regulation of cardiac muscle cell contraction)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:1902082"(positive regulation of calcium ion import into sarcoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031448"(positive regulation of fast-twitch skeletal muscle fiber contraction)|go:"GO:0031673"(H zone)|go:"GO:0031674"(I band)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|refseq:NP_001082787.1|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR023299|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023214|rcsb pdb:1FQU|rcsb pdb:1IWO|rcsb pdb:1KJU|rcsb pdb:1SU4|rcsb pdb:1T5S|rcsb pdb:1T5T|rcsb pdb:1VFP|rcsb pdb:1WPG|rcsb pdb:1XP5|rcsb pdb:2AGV|rcsb pdb:2BY4|rcsb pdb:2C88|rcsb pdb:2C8K|rcsb pdb:2C8L|rcsb pdb:2C9M|rcsb pdb:2DQS|rcsb pdb:2EAR|rcsb pdb:2EAT|rcsb pdb:2EAU|rcsb pdb:2O9J|rcsb pdb:2OA0|rcsb pdb:2YFY|rcsb pdb:2ZBD|rcsb pdb:2ZBE|rcsb pdb:2ZBF|rcsb pdb:2ZBG|rcsb pdb:3AR2|rcsb pdb:3AR3|rcsb pdb:3AR4|rcsb pdb:3AR5|rcsb pdb:3AR6|rcsb pdb:3AR7|rcsb pdb:3AR8|rcsb pdb:3AR9|rcsb pdb:3B9B|rcsb pdb:3B9R|rcsb pdb:3BA6|rcsb pdb:3FGO|rcsb pdb:3FPB|rcsb pdb:3FPS|rcsb pdb:3N5K|rcsb pdb:3N8G|rcsb pdb:2VOY|rcsb pdb:4NAB|interpro:IPR044492|rcsb pdb:5XA7|rcsb pdb:5XA8|rcsb pdb:4XOU|rcsb pdb:5A3Q|rcsb pdb:5A3R|rcsb pdb:5A3S|rcsb pdb:5ZMV|rcsb pdb:3J7T|rcsb pdb:4Y3U|rcsb pdb:4YCL|rcsb pdb:5ZMW|rcsb pdb:4UU0|rcsb pdb:4UU1|rcsb pdb:4YCM|rcsb pdb:4YCN|rcsb pdb:3W5A|rcsb pdb:3W5B|rcsb pdb:3W5C|rcsb pdb:3W5D|rcsb pdb:4H1W|rcsb pdb:4J2T|rcsb pdb:4KYT|rcsb pdb:4BEW|rcsb pdb:6RB2|rcsb pdb:6YSO|rcsb pdb:5NCQ|rcsb pdb:5XA9|rcsb pdb:5XAA|rcsb pdb:5XAB|interpro:IPR036412|rcsb pdb:6HEF|rcsb pdb:6YAA mint:G1TZQ2|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0070836"(caveola assembly)|ensembl:ENSOCUG00000005950|ensembl:ENSOCUP00000022576|go:"GO:0000139"(Golgi membrane)|go:"GO:0005623"(obsolete cell)|interpro:IPR031091|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0005901"(caveola)|interpro:IPR001612(Caveolin)|interpro:IPR018361|ensembl:ENSOCUT00000005946|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0030315"(T-tubule)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0071253"(connexin binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity) go:"GO:0030315"(T-tubule) - no-uniprot-update:no candidate replacement found. figure legend:f1f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") - 2014/01/28 2020/01/08 rogid:I0RNY0A95dY7WP5KaUrE144M2ks9986 rogid:bI66xSGke0+3uUO9E2IthRQH2Wg9986 intact-crc:FD3B0E6751BF0D59|rigid:4B+lylCW046LrzXNLZbYHq8tfbs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04191 uniprotkb:P11716 intact:EBI-79241|uniprotkb:P11719 intact:EBI-6477441 psi-mi:at2a1_rabit(display_long)|uniprotkb:ATP2A1(gene name)|psi-mi:ATP2A1(display_short)|uniprotkb:Calcium pump 1(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:ryr1_rabit(display_long)|uniprotkb:RYR1(gene name)|psi-mi:RYR1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106233|imex:IM-22063-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0106134"(positive regulation of cardiac muscle cell contraction)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:1902082"(positive regulation of calcium ion import into sarcoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031448"(positive regulation of fast-twitch skeletal muscle fiber contraction)|go:"GO:0031673"(H zone)|go:"GO:0031674"(I band)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|refseq:NP_001082787.1|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR023299|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023214|rcsb pdb:1FQU|rcsb pdb:1IWO|rcsb pdb:1KJU|rcsb pdb:1SU4|rcsb pdb:1T5S|rcsb pdb:1T5T|rcsb pdb:1VFP|rcsb pdb:1WPG|rcsb pdb:1XP5|rcsb pdb:2AGV|rcsb pdb:2BY4|rcsb pdb:2C88|rcsb pdb:2C8K|rcsb pdb:2C8L|rcsb pdb:2C9M|rcsb pdb:2DQS|rcsb pdb:2EAR|rcsb pdb:2EAT|rcsb pdb:2EAU|rcsb pdb:2O9J|rcsb pdb:2OA0|rcsb pdb:2YFY|rcsb pdb:2ZBD|rcsb pdb:2ZBE|rcsb pdb:2ZBF|rcsb pdb:2ZBG|rcsb pdb:3AR2|rcsb pdb:3AR3|rcsb pdb:3AR4|rcsb pdb:3AR5|rcsb pdb:3AR6|rcsb pdb:3AR7|rcsb pdb:3AR8|rcsb pdb:3AR9|rcsb pdb:3B9B|rcsb pdb:3B9R|rcsb pdb:3BA6|rcsb pdb:3FGO|rcsb pdb:3FPB|rcsb pdb:3FPS|rcsb pdb:3N5K|rcsb pdb:3N8G|rcsb pdb:2VOY|rcsb pdb:4NAB|interpro:IPR044492|rcsb pdb:5XA7|rcsb pdb:5XA8|rcsb pdb:4XOU|rcsb pdb:5A3Q|rcsb pdb:5A3R|rcsb pdb:5A3S|rcsb pdb:5ZMV|rcsb pdb:3J7T|rcsb pdb:4Y3U|rcsb pdb:4YCL|rcsb pdb:5ZMW|rcsb pdb:4UU0|rcsb pdb:4UU1|rcsb pdb:4YCM|rcsb pdb:4YCN|rcsb pdb:3W5A|rcsb pdb:3W5B|rcsb pdb:3W5C|rcsb pdb:3W5D|rcsb pdb:4H1W|rcsb pdb:4J2T|rcsb pdb:4KYT|rcsb pdb:4BEW|rcsb pdb:6RB2|rcsb pdb:6YSO|rcsb pdb:5NCQ|rcsb pdb:5XA9|rcsb pdb:5XAA|rcsb pdb:5XAB|interpro:IPR036412|rcsb pdb:6HEF|rcsb pdb:6YAA go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:2BCX|rcsb pdb:2XOA|rcsb pdb:3HSM|rcsb pdb:3ILA|rcsb pdb:3J8H|rcsb pdb:3RQR|rcsb pdb:4ERT|rcsb pdb:4ESU|rcsb pdb:4ETT|go:"GO:0035381"(ATP-gated ion channel activity)|rcsb pdb:4ETU|rcsb pdb:4I0Y|rcsb pdb:4I1E|go:"GO:0042802"(identical protein binding)|rcsb pdb:4I2S|rcsb pdb:4I37|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|rcsb pdb:4I3N|rcsb pdb:4I6I|rcsb pdb:4I7I|rcsb pdb:4I8M|rcsb pdb:4I96|rcsb pdb:4P9J|rcsb pdb:4UWA|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:4UWE|rcsb pdb:5C30|rcsb pdb:5GKY|rcsb pdb:5GKZ|rcsb pdb:5GL0|rcsb pdb:5GL1|rcsb pdb:5J8V|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6FG3|rcsb pdb:6FOO|rcsb pdb:6M2W|rcsb pdb:6WOT|rcsb pdb:7CF9|refseq:NP_001095188.1|dip:DIP-41872N go:"GO:0030315"(T-tubule) - - figure legend:f1f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") - 2014/01/28 2020/01/08 rogid:I0RNY0A95dY7WP5KaUrE144M2ks9986 rogid:QUlch7kTlopwGM10g+OXd4rODXo9986 intact-crc:FD3B0E6751BF0D59|rigid:4B+lylCW046LrzXNLZbYHq8tfbs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Z2C5 uniprotkb:Q8R3Z5 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 intact:EBI-644833|uniprotkb:O88517|uniprotkb:Q7TPF2|uniprotkb:Q8R3Z6|uniprotkb:Q9EPT9|uniprotkb:A2A544 psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:cacb1_mouse(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:Cacnb1(gene name)|psi-mi:Cacnb1(display_short)|uniprotkb:Cacnlb1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106724|imex:IM-22063-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 refseq:NP_001152791.1|refseq:NP_112450.1|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR027417|rcsb pdb:4ZW2|go:"GO:0030315"(T-tubule)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0098793"(presynapse)|reactome:R-MMU-5576892|reactome:R-MMU-5576893|reactome:R-MMU-112308|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|interpro:IPR036028 go:"GO:0030315"(T-tubule) - - figure legend:sf2a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2014/01/28 2014/10/16 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 rogid:e7XKbBMDfWDxQMlMoCmj8zyECCI10090 intact-crc:7A4D77C817DB2829|rigid:+xZSEMDIpkpWyC0IZM8MLnmfBhU false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:E9PZQ0 uniprotkb:O08539 intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123 intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239 psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym) psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106677|imex:IM-22063-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828 go:"GO:0030315"(T-tubule) caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573 - figure legend:sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2014/01/28 2014/10/16 rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090 rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090 intact-crc:307F6EF58A095694|rigid:wqYTGtIdX7W+0hW3GpmQlYhgFPg false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q9Z2C5 uniprotkb:O08539 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239 psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106603|imex:IM-22063-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828 go:"GO:0031674"(I band) - - figure legend:f1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2014/01/28 2014/10/16 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090 intact-crc:9D050747F27CDA23|rigid:d9SsmjmyhV7QasjvtsoURKOKNTE false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:E9PZQ0 uniprotkb:Q9Z2C5 intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym) psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106682|imex:IM-22063-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 go:"GO:0030315"(T-tubule) caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573 - figure legend:sf2a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2014/01/28 2014/10/16 rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 intact-crc:F9A91357C6F99124|rigid:12LEXpK7zLefli/vMYDkWIWFzVk false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:O08539 uniprotkb:Q8R3Z5 intact:EBI-775152|uniprotkb:Q62434|ensembl:ENSMUSP00000025239 intact:EBI-644833|uniprotkb:O88517|uniprotkb:Q7TPF2|uniprotkb:Q8R3Z6|uniprotkb:Q9EPT9|uniprotkb:A2A544 psi-mi:bin1_mouse(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:SH3 domain-containing protein 9(gene name synonym)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Sh3p9(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:cacb1_mouse(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:Cacnb1(gene name)|psi-mi:Cacnb1(display_short)|uniprotkb:Cacnlb1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Royer et al. (2013) pubmed:23917616|imex:IM-22063 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-9106672|imex:IM-22063-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033798.1|refseq:XP_006526056.1|ensembl:ENSMUSG00000024381(gene)|ensembl:ENSMUST00000025239(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O08539|reactome:R-MMU-8856828 refseq:NP_001152791.1|refseq:NP_112450.1|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR027417|rcsb pdb:4ZW2|go:"GO:0030315"(T-tubule)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0098793"(presynapse)|reactome:R-MMU-5576892|reactome:R-MMU-5576893|reactome:R-MMU-112308|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|interpro:IPR036028 go:"GO:0030315"(T-tubule) - - figure legend:sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2014/01/28 2014/10/16 rogid:VdFcKXTcbayNaahmrT13Dju7kLo10090 rogid:e7XKbBMDfWDxQMlMoCmj8zyECCI10090 intact-crc:87822C6071409104|rigid:trAS+wbROD+E+WVgeuyrAHRSy4A false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)