#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P48722 uniprotkb:Q9JK11-1 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 intact:EBI-919989 psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9818196|imex:IM-23092-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 intact:EBI-919972(rtn4_rat) - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase - figure legend:Fig 1D|comment:very faint band visible|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 intact-crc:EC698F79B02C50CD|rigid:IcdJ6QfCNqYml1ussYyfeZbghuo false - sufficient binding region:174-979|strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P48722 uniprotkb:Q9JK11-1 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 intact:EBI-919989 psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9818242|imex:IM-23092-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 intact:EBI-919972(rtn4_rat) - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase - figure legend:Fig 1E|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1) - 2014/09/15 2014/10/16 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 intact-crc:96A02B0C1F88DB44|rigid:IcdJ6QfCNqYml1ussYyfeZbghuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P48722 uniprotkb:Q9JK11-1 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 intact:EBI-919989 psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9818263|imex:IM-23092-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 intact:EBI-919972(rtn4_rat) - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase - figure legend:Fig 1E|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1) - 2014/09/15 2014/10/16 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 intact-crc:CC4D74A1191CBF48|rigid:IcdJ6QfCNqYml1ussYyfeZbghuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P48722 uniprotkb:Q99P72 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 intact:EBI-3869532|uniprotkb:Q8BHF5|uniprotkb:Q78NS1|uniprotkb:Q8BH78|uniprotkb:Q5DTK9|uniprotkb:Q7TNB7|uniprotkb:Q80W95|uniprotkb:Q8BGK7|uniprotkb:Q8BGM9|uniprotkb:Q8K290|uniprotkb:Q8K3G8|uniprotkb:Q9CTE3|ensembl:ENSMUSP00000099907 psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:rtn4_mouse(display_long)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Kiaa0886(gene name synonym)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9818274|imex:IM-23092-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 refseq:NP_077188.1|refseq:NP_918940.1|refseq:NP_918943.1|dip:DIP-41976N|ensembl:ENSMUSG00000020458(gene)|ensembl:ENSMUST00000102843(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q99P72|rcsb pdb:2KO2|reactome:R-MMU-193634|refseq:NP_918941.1|refseq:NP_918942.1 - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase - figure legend:Fig 2A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/09/15 2014/10/16 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 rogid:+hmGWVeJPIbs6/SavXBsKK22Nqw10090 intact-crc:17AE7500F2D20E5E|rigid:8MwjWj7X6JxO2SjcMGL+BvmOnKU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P48722 uniprotkb:Q99P72 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 intact:EBI-3869532|uniprotkb:Q8BHF5|uniprotkb:Q78NS1|uniprotkb:Q8BH78|uniprotkb:Q5DTK9|uniprotkb:Q7TNB7|uniprotkb:Q80W95|uniprotkb:Q8BGK7|uniprotkb:Q8BGM9|uniprotkb:Q8K290|uniprotkb:Q8K3G8|uniprotkb:Q9CTE3|ensembl:ENSMUSP00000099907 psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:rtn4_mouse(display_long)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Kiaa0886(gene name synonym)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9818276|imex:IM-23092-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 refseq:NP_077188.1|refseq:NP_918940.1|refseq:NP_918943.1|dip:DIP-41976N|ensembl:ENSMUSG00000020458(gene)|ensembl:ENSMUST00000102843(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q99P72|rcsb pdb:2KO2|reactome:R-MMU-193634|refseq:NP_918941.1|refseq:NP_918942.1 - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase - figure legend:Fig 2A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/09/15 2014/10/16 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 rogid:+hmGWVeJPIbs6/SavXBsKK22Nqw10090 intact-crc:BB0F88C5177DD247|rigid:8MwjWj7X6JxO2SjcMGL+BvmOnKU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P48722 uniprotkb:Q9JK11-1 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 intact:EBI-919989 psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9818503|imex:IM-23092-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 intact:EBI-919972(rtn4_rat) - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase - figure legend:Fig 4A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1) - 2014/09/15 2014/10/16 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 intact-crc:0C14F8471CCFF011|rigid:IcdJ6QfCNqYml1ussYyfeZbghuo false tag:c-c|fluorescent protein tag:c-c enhanced green fluorescent protein tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P48722 uniprotkb:Q99P72 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 intact:EBI-3869532|uniprotkb:Q8BHF5|uniprotkb:Q78NS1|uniprotkb:Q8BH78|uniprotkb:Q5DTK9|uniprotkb:Q7TNB7|uniprotkb:Q80W95|uniprotkb:Q8BGK7|uniprotkb:Q8BGM9|uniprotkb:Q8K290|uniprotkb:Q8K3G8|uniprotkb:Q9CTE3|ensembl:ENSMUSP00000099907 psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:rtn4_mouse(display_long)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Kiaa0886(gene name synonym)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9823893|imex:IM-23092-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 refseq:NP_077188.1|refseq:NP_918940.1|refseq:NP_918943.1|dip:DIP-41976N|ensembl:ENSMUSG00000020458(gene)|ensembl:ENSMUST00000102843(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q99P72|rcsb pdb:2KO2|reactome:R-MMU-193634|refseq:NP_918941.1|refseq:NP_918942.1 - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase - figure legend:Fig 4B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain_hippocampal_neuron)|taxid:10090(Mus musculus, brain, hippocampal neurons) - 2014/09/15 2014/10/16 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 rogid:+hmGWVeJPIbs6/SavXBsKK22Nqw10090 intact-crc:E9908CFFCFD091FD|rigid:8MwjWj7X6JxO2SjcMGL+BvmOnKU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9JK11-1 uniprotkb:P48722 intact:EBI-919989 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817832|imex:IM-23092-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 - - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase figure legend:Fig 1C, Supp table 1|comment:TCA precipitation was used prior to MS/MS. All proteins listed were identified in two independent MS screens.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 intact-crc:DC45B108ECB77394|rigid:7YbdXSpCcc/6BvpOvOq5Cg/dih4 false sufficient binding region:174-979|strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:P99029 intact:EBI-919989 intact:EBI-2735704|uniprotkb:Q9QX45|uniprotkb:Q9QZ75|ensembl:ENSMUSP00000025904 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:prdx5_mouse(display_long)|uniprotkb:Prdx5(gene name)|psi-mi:Prdx5(display_short)|uniprotkb:Prdx6(gene name synonym)|uniprotkb:Peroxiredoxin V(gene name synonym)|uniprotkb:Peroxisomal antioxidant enzyme(gene name synonym)|uniprotkb:PLP(gene name synonym)|uniprotkb:Thioredoxin peroxidase PMP20(gene name synonym)|uniprotkb:Antioxidant enzyme B166(gene name synonym)|uniprotkb:Liver tissue 2D-page spot 2D-0014IV(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 5(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817832|imex:IM-23092-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) refseq:NP_036151.1|ensembl:ENSMUSG00000024953(gene)|ensembl:ENSMUST00000025904(transcript)|go:"GO:0001016"(RNA polymerase III transcription regulatory region sequence-specific DNA binding)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016480"(negative regulation of transcription by RNA polymerase III)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060785"(regulation of apoptosis involved in tissue homeostasis)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0072541"(peroxynitrite reductase activity)|go:"GO:2001057"(reactive nitrogen species metabolic process)|interpro:IPR013740(Redoxin)|interpro:IPR036249|interpro:IPR037944|mint:P99029|reactome:R-MMU-3299685|reactome:R-MMU-5628897|interpro:IPR013766(Thioredoxin domain) - - - figure legend:Fig 1C, Supp table 1|comment:TCA precipitation was used prior to MS/MS. All proteins listed were identified in two independent MS screens.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:uWS2EcAdupLmsVsQ6h1AV+vRffs10090 intact-crc:DC45B108ECB77394|rigid:7YbdXSpCcc/6BvpOvOq5Cg/dih4 false sufficient binding region:174-979|strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:Q61171 intact:EBI-919989 intact:EBI-444957|uniprotkb:O88376|uniprotkb:Q60796|uniprotkb:Q9CWJ4|uniprotkb:Q9DB49|ensembl:ENSMUSP00000005292|ensembl:ENSMUSP00000105355|ensembl:ENSMUSP00000105356|ensembl:ENSMUSP00000126451 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:prdx2_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:Prdx2(gene name)|psi-mi:Prdx2(display_short)|uniprotkb:Tdpx1(gene name synonym)|uniprotkb:Tpx(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817832|imex:IM-23092-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) refseq:NP_035693.3|go:"GO:0042098"(T cell proliferation)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q61171|reactome:R-MMU-3299685|reactome:R-MMU-5628897|go:"GO:0034599"(cellular response to oxidative stress)|refseq:NP_001304314.1|ensembl:ENSMUSG00000005161(gene)|ensembl:ENSMUST00000005292(transcript)|ensembl:ENSMUST00000109733(transcript)|ensembl:ENSMUST00000109734(transcript)|ensembl:ENSMUST00000164807(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008430"(selenium binding)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide) - - - figure legend:Fig 1C, Supp table 1|comment:TCA precipitation was used prior to MS/MS. All proteins listed were identified in two independent MS screens.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:P1NxwIOnv1n4sNzQWtFjy2znSbA10090 intact-crc:DC45B108ECB77394|rigid:7YbdXSpCcc/6BvpOvOq5Cg/dih4 false sufficient binding region:174-979|strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:P35700 intact:EBI-919989 intact:EBI-444948|uniprotkb:Q3UBV4|uniprotkb:Q9CWI2|ensembl:ENSMUSP00000102078|ensembl:ENSMUSP00000114159 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:prdx1_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Osteoblast-specific factor 3(gene name synonym)|uniprotkb:Macrophage 23 kDa stress protein(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Prdx1(gene name)|psi-mi:Prdx1(display_short)|uniprotkb:Msp23(gene name synonym)|uniprotkb:Paga(gene name synonym)|uniprotkb:Tdpx2(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817832|imex:IM-23092-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) refseq:NP_035164.1|ensembl:ENSMUST00000135573(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000791"(euchromatin)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P35700|reactome:R-MMU-3299685|reactome:R-MMU-5628897|ensembl:ENSMUST00000106470(transcript)|ensembl:ENSMUSG00000028691(gene) - - - figure legend:Fig 1C, Supp table 1|comment:TCA precipitation was used prior to MS/MS. All proteins listed were identified in two independent MS screens.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:xOppWev1GtpILoJ1rY+tSPoymVU10090 intact-crc:DC45B108ECB77394|rigid:7YbdXSpCcc/6BvpOvOq5Cg/dih4 false sufficient binding region:174-979|strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:Q3UM45 intact:EBI-919989 intact:EBI-8318179|ensembl:ENSMUSP00000027494|intact:MINT-1869744|uniprotkb:Q9CV31|uniprotkb:Q9Z105|intact:MINT-3292766 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:pp1r7_mouse(display_long)|uniprotkb:Ppp1r7(gene name)|psi-mi:Ppp1r7(display_short)|uniprotkb:Sds22(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817848|imex:IM-23092-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) ensembl:ENSMUSG00000026275(gene)|ensembl:ENSMUST00000027494(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0007059"(chromosome segregation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR025875|interpro:IPR032675|mint:Q3UM45|refseq:NP_075689.1 - - comment:mint|function:Regulatory subunit of protein phosphatase 1 figure legend:1C, Supp table 1|comment:SDS/PAGE, followed by in-gel digestion was used prior to MS/MS|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:/Mhy2MmXvmdOYuIKhxmu/rNQRKc10090 intact-crc:6A7010F211C6852F|rigid:B1ei7EdW8XjaKl9VIgYGW5hI2+w false strep tag:c-c|sufficient binding region:174-979 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:P48722 intact:EBI-919989 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817848|imex:IM-23092-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 - - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase figure legend:1C, Supp table 1|comment:SDS/PAGE, followed by in-gel digestion was used prior to MS/MS|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 intact-crc:6A7010F211C6852F|rigid:B1ei7EdW8XjaKl9VIgYGW5hI2+w false strep tag:c-c|sufficient binding region:174-979 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:P47754 intact:EBI-919989 intact:EBI-299188|ensembl:ENSMUSP00000015877 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:caza2_mouse(display_long)|uniprotkb:Capza2(gene name)|psi-mi:Capza2(display_short)|uniprotkb:Cappa2(gene name synonym)|uniprotkb:CapZ alpha-2(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817848|imex:IM-23092-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) ensembl:ENSMUST00000015877(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P47754|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231|ensembl:ENSMUSG00000015733(gene)|refseq:NP_031630.1|dip:DIP-31382N - - - figure legend:1C, Supp table 1|comment:SDS/PAGE, followed by in-gel digestion was used prior to MS/MS|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:9nxfEbrpHlDtTYwSvHAJvZLLweo10090 intact-crc:6A7010F211C6852F|rigid:B1ei7EdW8XjaKl9VIgYGW5hI2+w false strep tag:c-c|sufficient binding region:174-979 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:Q68FD5 intact:EBI-919989 intact:EBI-769168|ensembl:ENSMUSP00000099475 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:clh1_mouse(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817848|imex:IM-23092-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) refseq:NP_001003908.1|dip:DIP-31947N|ensembl:ENSMUSG00000047126(gene)|ensembl:ENSMUST00000103186(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043209"(myelin sheath)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q68FD5|rcsb pdb:5ODS|reactome:R-MMU-177504|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0032051"(clathrin light chain binding) - - - figure legend:1C, Supp table 1|comment:SDS/PAGE, followed by in-gel digestion was used prior to MS/MS|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:iHg/TOG2rWePqtsEmuc/szn/chI10090 intact-crc:6A7010F211C6852F|rigid:B1ei7EdW8XjaKl9VIgYGW5hI2+w false strep tag:c-c|sufficient binding region:174-979 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:O08807 intact:EBI-919989 intact:EBI-494652|uniprotkb:Q3U8E4|uniprotkb:B1AZS7|ensembl:ENSMUSP00000026328 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:prdx4_mouse(display_long)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)|uniprotkb:Prdx4(gene name)|psi-mi:Prdx4(display_short) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817848|imex:IM-23092-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) refseq:NP_058044.1|refseq:NP_001300640.1|dip:DIP-34137N|ensembl:ENSMUSG00000025289(gene)|ensembl:ENSMUST00000026328(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:O08807|rcsb pdb:3VWU|rcsb pdb:3VWV|rcsb pdb:3W8J|rcsb pdb:3WGX|reactome:R-MMU-6798695 - - - figure legend:1C, Supp table 1|comment:SDS/PAGE, followed by in-gel digestion was used prior to MS/MS|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:86EzEedrO6v5Z2dnSB2fSPaV2hc10090 intact-crc:6A7010F211C6852F|rigid:B1ei7EdW8XjaKl9VIgYGW5hI2+w false strep tag:c-c|sufficient binding region:174-979 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:P35700 intact:EBI-919989 intact:EBI-444948|uniprotkb:Q3UBV4|uniprotkb:Q9CWI2|ensembl:ENSMUSP00000102078|ensembl:ENSMUSP00000114159 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:prdx1_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Osteoblast-specific factor 3(gene name synonym)|uniprotkb:Macrophage 23 kDa stress protein(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Prdx1(gene name)|psi-mi:Prdx1(display_short)|uniprotkb:Msp23(gene name synonym)|uniprotkb:Paga(gene name synonym)|uniprotkb:Tdpx2(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817848|imex:IM-23092-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) refseq:NP_035164.1|ensembl:ENSMUST00000135573(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000791"(euchromatin)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P35700|reactome:R-MMU-3299685|reactome:R-MMU-5628897|ensembl:ENSMUST00000106470(transcript)|ensembl:ENSMUSG00000028691(gene) - - - figure legend:1C, Supp table 1|comment:SDS/PAGE, followed by in-gel digestion was used prior to MS/MS|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:xOppWev1GtpILoJ1rY+tSPoymVU10090 intact-crc:6A7010F211C6852F|rigid:B1ei7EdW8XjaKl9VIgYGW5hI2+w false strep tag:c-c|sufficient binding region:174-979 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 intact:EBI-9817897 intact:EBI-919989 genbank identifier:EDL09793.1 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:camk2a(display_short)|psi-mi:EBI-9817897(display_long) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817848|imex:IM-23092-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) uniparc:UPI000154731F(see-also) - - - figure legend:1C, Supp table 1|comment:SDS/PAGE, followed by in-gel digestion was used prior to MS/MS|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:HyPZqGSg5urRVzGiRRTig4SuPXo10090 intact-crc:6A7010F211C6852F|rigid:B1ei7EdW8XjaKl9VIgYGW5hI2+w false strep tag:c-c|sufficient binding region:174-979 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9JK11-1 uniprotkb:Q8BZ98-2 intact:EBI-919989 intact:EBI-9817911|ensembl:ENSMUSP00000064538 psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:q8bz98-2(display_long)|uniprotkb:Dnm3(gene name)|psi-mi:Dnm3(display_short)|uniprotkb:Kiaa0820(gene name synonym) psi-mi:"MI:0096"(pull down) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9817848|imex:IM-23092-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-919972(rtn4_rat) intact:EBI-6880033(isoform-parent)|ensembl:ENSMUSG00000040265(gene)|ensembl:ENSMUST00000070330(transcript) - - isoform-comment:No experimental confirmation available. figure legend:1C, Supp table 1|comment:SDS/PAGE, followed by in-gel digestion was used prior to MS/MS|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/15 2014/10/16 rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116 rogid:sFRuzHq0+brqDinlkwEm0pBdjOw10090 intact-crc:6A7010F211C6852F|rigid:B1ei7EdW8XjaKl9VIgYGW5hI2+w false strep tag:c-c|sufficient binding region:174-979 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P48722 uniprotkb:Q99P72 intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4 intact:EBI-3869532|uniprotkb:Q8BHF5|uniprotkb:Q78NS1|uniprotkb:Q8BH78|uniprotkb:Q5DTK9|uniprotkb:Q7TNB7|uniprotkb:Q80W95|uniprotkb:Q8BGK7|uniprotkb:Q8BGM9|uniprotkb:Q8K290|uniprotkb:Q8K3G8|uniprotkb:Q9CTE3|ensembl:ENSMUSP00000099907 psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym) psi-mi:rtn4_mouse(display_long)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Kiaa0886(gene name synonym)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Kern et al. (2013) pubmed:23909438|imex:IM-23092 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-9818393|imex:IM-23092-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1 refseq:NP_077188.1|refseq:NP_918940.1|refseq:NP_918943.1|dip:DIP-41976N|ensembl:ENSMUSG00000020458(gene)|ensembl:ENSMUST00000102843(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q99P72|rcsb pdb:2KO2|reactome:R-MMU-193634|refseq:NP_918941.1|refseq:NP_918942.1 - comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase - figure legend:Supp Fig 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain_hippocampal_neuron)|taxid:10090(Mus musculus, brain, hippocampal neurons) - 2014/09/15 2014/10/16 rogid:6woBxNys6oLJnLJERYXaeuymJvw10090 rogid:+hmGWVeJPIbs6/SavXBsKK22Nqw10090 intact-crc:8BBCC54F941BEEF3|rigid:8MwjWj7X6JxO2SjcMGL+BvmOnKU false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)