#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95786	uniprotkb:O75569	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-713955|ensembl:ENSP00000318176|uniprotkb:Q53G24|uniprotkb:Q6X7T5|uniprotkb:Q8NDK4|uniprotkb:A8K3I6	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:prkra_human(display_long)|uniprotkb:Protein activator of the interferon-induced protein kinase(gene name synonym)|uniprotkb:PKR-associated protein X(gene name synonym)|uniprotkb:PKR-associating protein X(gene name synonym)|uniprotkb:HSD-14(orf name)|uniprotkb:PRKRA(gene name)|psi-mi:PRKRA(display_short)|uniprotkb:RAX(gene name synonym)|uniprotkb:PACT(gene name synonym)|uniprotkb:HSD14(orf name)|uniprotkb:Protein kinase, interferon-inducible double-stranded RNA-dependent activator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Luthra et al. (2013)	imex:IM-23190|pubmed:23870315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9819981|imex:IM-23190-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008047"(enzyme activator activity)|ensembl:ENSG00000180228(gene)|ensembl:ENST00000325748(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR033363|interpro:IPR044465|interpro:IPR044466|interpro:IPR044467|mint:O75569|rcsb pdb:2DIX|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_001132989.1|refseq:NP_001132990.1|refseq:NP_003681.1|dip:DIP-41809N	-	-	-	figure legend:3B and E|antagonist:"Association is disrupted by coexpression of EBOV wildtype VP35 (UniProt AC O95786)."|comment:"Expression of EBOV VP35 mutants unable to associate with human HA-tagged PRKRA/PACT (R312A, F239A and K319A/R322A) has no effect."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/18	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:tZfziopZlC+1d3De97G3kDY+Tog9606	intact-crc:57294395D100BD46|rigid:oBVZ36lq62mJSKKSdtKq/KTzu4g	false	flag tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75569	uniprotkb:Q05127	intact:EBI-713955|ensembl:ENSP00000318176|uniprotkb:Q53G24|uniprotkb:Q6X7T5|uniprotkb:Q8NDK4|uniprotkb:A8K3I6	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	psi-mi:prkra_human(display_long)|uniprotkb:Protein activator of the interferon-induced protein kinase(gene name synonym)|uniprotkb:PKR-associated protein X(gene name synonym)|uniprotkb:PKR-associating protein X(gene name synonym)|uniprotkb:HSD-14(orf name)|uniprotkb:PRKRA(gene name)|psi-mi:PRKRA(display_short)|uniprotkb:RAX(gene name synonym)|uniprotkb:PACT(gene name synonym)|uniprotkb:HSD14(orf name)|uniprotkb:Protein kinase, interferon-inducible double-stranded RNA-dependent activator(gene name synonym)	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Luthra et al. (2013)	imex:IM-23190|pubmed:23870315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9821212|imex:IM-23190-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008047"(enzyme activator activity)|ensembl:ENSG00000180228(gene)|ensembl:ENST00000325748(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR033363|interpro:IPR044465|interpro:IPR044466|interpro:IPR044467|mint:O75569|rcsb pdb:2DIX|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_001132989.1|refseq:NP_001132990.1|refseq:NP_003681.1|dip:DIP-41809N	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	-	-	-	figure legend:S1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/18	2014/10/16	rogid:tZfziopZlC+1d3De97G3kDY+Tog9606	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	intact-crc:B106665ED17BE0F0|rigid:ON41AcBfFcqjGzutZnZ1D878kw8	false	ha tag:n-n	flag tag:n-n|sufficient binding region:219-340	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75569	uniprotkb:Q05127	intact:EBI-713955|ensembl:ENSP00000318176|uniprotkb:Q53G24|uniprotkb:Q6X7T5|uniprotkb:Q8NDK4|uniprotkb:A8K3I6	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	psi-mi:prkra_human(display_long)|uniprotkb:Protein activator of the interferon-induced protein kinase(gene name synonym)|uniprotkb:PKR-associated protein X(gene name synonym)|uniprotkb:PKR-associating protein X(gene name synonym)|uniprotkb:HSD-14(orf name)|uniprotkb:PRKRA(gene name)|psi-mi:PRKRA(display_short)|uniprotkb:RAX(gene name synonym)|uniprotkb:PACT(gene name synonym)|uniprotkb:HSD14(orf name)|uniprotkb:Protein kinase, interferon-inducible double-stranded RNA-dependent activator(gene name synonym)	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Luthra et al. (2013)	imex:IM-23190|pubmed:23870315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9819967|imex:IM-23190-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008047"(enzyme activator activity)|ensembl:ENSG00000180228(gene)|ensembl:ENST00000325748(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR033363|interpro:IPR044465|interpro:IPR044466|interpro:IPR044467|mint:O75569|rcsb pdb:2DIX|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_001132989.1|refseq:NP_001132990.1|refseq:NP_003681.1|dip:DIP-41809N	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	-	-	-	figure legend:3A and D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/18	2014/10/16	rogid:tZfziopZlC+1d3De97G3kDY+Tog9606	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	intact-crc:3BE7B48DFE5F9E52|rigid:ON41AcBfFcqjGzutZnZ1D878kw8	false	ha tag:n-n	mutation disrupting interaction:312-312|mutation disrupting interaction:319-319,322-322|mutation disrupting interaction:239-239	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05318	uniprotkb:Q05127	intact:EBI-9820256|uniprotkb:O39794|uniprotkb:Q773N0|uniprotkb:Q8JS59|uniprotkb:Q9DQD1	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	psi-mi:l_ebozm(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym)	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Luthra et al. (2013)	imex:IM-23190|pubmed:23870315	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9820245|imex:IM-23190-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066251.1|interpro:IPR026890|interpro:IPR014023(RNA-directed RNA polymerase catalytic)|interpro:IPR017235(RNA-directed RNA polymerase, filovirus)|interpro:IPR025786|interpro:IPR039736|go:"GO:0003924"(GTPase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039697"(negative stranded viral RNA transcription)|go:"GO:0005524"(ATP binding)	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	-	-	-	figure legend:5D and S3|antagonist:Coexpression of  HA-tagged wildtype PRKRA/PACT decreases the interaction;this effect  is not seen when using mutant EBOV VP35 K319A/R322A which is unable to associate with  PRKRA/PACT.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/18	2014/10/16	rogid:uyd0Z4S5xMSSceIULxtJ21i3mfk128952	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	intact-crc:BA19411290187603|rigid:XLuQ77mOkmxdb+1FROBgB8bbKvM	false	sufficient binding region:1-505|flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95786	uniprotkb:O75569	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-713955|ensembl:ENSP00000318176|uniprotkb:Q53G24|uniprotkb:Q6X7T5|uniprotkb:Q8NDK4|uniprotkb:A8K3I6	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:prkra_human(display_long)|uniprotkb:Protein activator of the interferon-induced protein kinase(gene name synonym)|uniprotkb:PKR-associated protein X(gene name synonym)|uniprotkb:PKR-associating protein X(gene name synonym)|uniprotkb:HSD-14(orf name)|uniprotkb:PRKRA(gene name)|psi-mi:PRKRA(display_short)|uniprotkb:RAX(gene name synonym)|uniprotkb:PACT(gene name synonym)|uniprotkb:HSD14(orf name)|uniprotkb:Protein kinase, interferon-inducible double-stranded RNA-dependent activator(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Luthra et al. (2013)	imex:IM-23190|pubmed:23870315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9820067|imex:IM-23190-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008047"(enzyme activator activity)|ensembl:ENSG00000180228(gene)|ensembl:ENST00000325748(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR033363|interpro:IPR044465|interpro:IPR044466|interpro:IPR044467|mint:O75569|rcsb pdb:2DIX|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_001132989.1|refseq:NP_001132990.1|refseq:NP_003681.1|dip:DIP-41809N	-	-	-	figure legend:3C|comment:Association detected in Sendai virus and mock infected cells.|antagonist:"Association is disrupted by stable expression of  EBOV VP35 (UniProt AC Q05127)"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/18	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:tZfziopZlC+1d3De97G3kDY+Tog9606	intact-crc:2EFEC96C329646FF|rigid:oBVZ36lq62mJSKKSdtKq/KTzu4g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05127	uniprotkb:P18272	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	intact:EBI-9820219|uniprotkb:Q773N6|uniprotkb:Q8JS64|uniprotkb:Q9DQD3|uniprotkb:Q9YMG4	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:ncap_ebozm(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)|uniprotkb:Ebola NP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Luthra et al. (2013)	imex:IM-23190|pubmed:23870315	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9820236|imex:IM-23190-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	rcsb pdb:4QAZ|rcsb pdb:4QB0|interpro:IPR008609(Ebola nucleoprotein)|refseq:NP_066243.1|rcsb pdb:4YPI|rcsb pdb:4Z9P|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:5T3T|rcsb pdb:5Z9W|rcsb pdb:6NUT|rcsb pdb:6EHL|rcsb pdb:6EHM|rcsb pdb:6C54|go:"GO:0003723"(RNA binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0030430"(host cell cytoplasm)	-	-	-	figure legend:5C|comment:Coexpression of HA-tagged PRKRA/PACT does not change the association.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/18	2014/10/16	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	rogid:3gzyp+qys0/sPa2AahEeyMFElIo128952	intact-crc:D8F32EA5C159F292|rigid:CTz1puQJPNv9osqk0n+nEjV+964	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)