#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99707	uniprotkb:Q9Y4U1	intact:EBI-1045782|uniprotkb:Q99713|uniprotkb:Q99723|uniprotkb:A9Z1W4|uniprotkb:B9EGF7|uniprotkb:A1L4N8|uniprotkb:B7ZLW7|ensembl:ENSP00000355536	intact:EBI-9775184|uniprotkb:Q5T157|uniprotkb:Q9BRQ7|ensembl:ENSP00000383840	psi-mi:meth_human(display_long)|uniprotkb:5-methyltetrahydrofolate--homocysteine methyltransferase(gene name synonym)|uniprotkb:Vitamin-B12 dependent methionine synthase(gene name synonym)|uniprotkb:MTR(gene name)|psi-mi:MTR(display_short)|uniprotkb:Cobalamin-dependent methionine synthase(gene name synonym)	psi-mi:mmac_human(display_long)|uniprotkb:MMACHC(gene name)|psi-mi:MMACHC(display_short)|uniprotkb:CblC(gene name synonym)|uniprotkb:"Cyanocobalamin reductase (cyanide-eliminating)"(gene name synonym)|uniprotkb:"Alkylcobalamin:glutathione S-alkyltransferase"(gene name synonym)|uniprotkb:Methylmalonic aciduria and homocystinuria type C protein(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Fofou-Caillierez et al. (2013)	pubmed:23825108|imex:IM-23087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9778040|imex:IM-23087-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278869.1|refseq:NP_000245.2|ensembl:ENSG00000116984(gene)|ensembl:ENST00000366577(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008705"(methionine synthase activity)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0031103"(axon regeneration)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032259"(methylation)|go:"GO:0042558"(pteridine-containing compound metabolic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR000489(Dihydropteroate synthase, DHPS)|interpro:IPR003726(Homocysteine S-methyltransferase)|interpro:IPR003759("Methionine synthase, cobalamin (vitamin B12)-binding module, cap")|interpro:IPR004223(Vitamin B12 dependent methionine synthase, activation region)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR011005(Dihydropteroate synthase-like)|interpro:IPR011822(5-methyltetrahydrofolate--homocysteine methyltransferase)|interpro:IPR033706|interpro:IPR036589|interpro:IPR036594|interpro:IPR036724|interpro:IPR037010|rcsb pdb:2O2K|rcsb pdb:4CCZ|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-196741|reactome:R-HSA-3359467|reactome:R-HSA-3359469|reactome:R-HSA-9013407|refseq:NP_001278868.1|dip:DIP-40306N	refseq:NP_056321.2|refseq:NP_001317469.1|ensembl:ENSG00000132763(gene)|ensembl:ENST00000401061(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016740"(transferase activity)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0033787"("cyanocobalamin reductase (cyanide-eliminating) activity")|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0070988"(demethylation)|go:"GO:0071949"(FAD binding)|interpro:IPR032037|rcsb pdb:3SBY|rcsb pdb:3SBZ|rcsb pdb:3SC0|rcsb pdb:3SOM|rcsb pdb:5UOS|reactome:R-HSA-196741|reactome:R-HSA-3359473|reactome:R-HSA-3359474	-	-	-	figure legend:4B|comment:"Fibroblasts from two patients with the \"cblC\"  inborn error of cobalamin  metabolism (SA and WG4130 cell lines) showed reduced interaction.  Fibroblast from a patient with the \"cblG\" disorder (KF cell line) showed increased interaction.      [SA was a cblC case with compound heterozygosity for c.271dupA, p.R91 > GNsX14 and c.616C > T, p.R206W of MMACHC. WG4130 was a cblC case with compound heterozygosity for c.328delAACC, p.N110EfsX13 and 482G > A, p.R161Q of MMACHC. KF has a MTR homozygous mutation c.3518C > T, p.P1173L.]"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2014/09/12	2014/10/16	rogid:wfY9f5C2d1neO4MQeVdVrVGzrrs9606	rogid:HLpV70pJ6XpjFsQ6SehGTXMRuDQ9606	intact-crc:0A0D16B1D28BB382|rigid:jszmPPaR2lznMNNg4Kgr3xQL8J8	false	mutation increasing interaction strength:1173-1173	mutation decreasing interaction strength:161-161|mutation decreasing interaction strength:206-206	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y4U1	uniprotkb:Q99707	intact:EBI-9775184|uniprotkb:Q5T157|uniprotkb:Q9BRQ7|ensembl:ENSP00000383840	intact:EBI-1045782|uniprotkb:Q99713|uniprotkb:Q99723|uniprotkb:A9Z1W4|uniprotkb:B9EGF7|uniprotkb:A1L4N8|uniprotkb:B7ZLW7|ensembl:ENSP00000355536	psi-mi:mmac_human(display_long)|uniprotkb:MMACHC(gene name)|psi-mi:MMACHC(display_short)|uniprotkb:CblC(gene name synonym)|uniprotkb:"Cyanocobalamin reductase (cyanide-eliminating)"(gene name synonym)|uniprotkb:"Alkylcobalamin:glutathione S-alkyltransferase"(gene name synonym)|uniprotkb:Methylmalonic aciduria and homocystinuria type C protein(gene name synonym)	psi-mi:meth_human(display_long)|uniprotkb:5-methyltetrahydrofolate--homocysteine methyltransferase(gene name synonym)|uniprotkb:Vitamin-B12 dependent methionine synthase(gene name synonym)|uniprotkb:MTR(gene name)|psi-mi:MTR(display_short)|uniprotkb:Cobalamin-dependent methionine synthase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fofou-Caillierez et al. (2013)	pubmed:23825108|imex:IM-23087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9774889|efo:"EFO:0004272"|efo:"EFO:0000734"|imex:IM-23087-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056321.2|refseq:NP_001317469.1|ensembl:ENSG00000132763(gene)|ensembl:ENST00000401061(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016740"(transferase activity)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0033787"("cyanocobalamin reductase (cyanide-eliminating) activity")|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0070988"(demethylation)|go:"GO:0071949"(FAD binding)|interpro:IPR032037|rcsb pdb:3SBY|rcsb pdb:3SBZ|rcsb pdb:3SC0|rcsb pdb:3SOM|rcsb pdb:5UOS|reactome:R-HSA-196741|reactome:R-HSA-3359473|reactome:R-HSA-3359474	refseq:NP_001278869.1|refseq:NP_000245.2|ensembl:ENSG00000116984(gene)|ensembl:ENST00000366577(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008705"(methionine synthase activity)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0031103"(axon regeneration)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032259"(methylation)|go:"GO:0042558"(pteridine-containing compound metabolic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR000489(Dihydropteroate synthase, DHPS)|interpro:IPR003726(Homocysteine S-methyltransferase)|interpro:IPR003759("Methionine synthase, cobalamin (vitamin B12)-binding module, cap")|interpro:IPR004223(Vitamin B12 dependent methionine synthase, activation region)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR011005(Dihydropteroate synthase-like)|interpro:IPR011822(5-methyltetrahydrofolate--homocysteine methyltransferase)|interpro:IPR033706|interpro:IPR036589|interpro:IPR036594|interpro:IPR036724|interpro:IPR037010|rcsb pdb:2O2K|rcsb pdb:4CCZ|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-196741|reactome:R-HSA-3359467|reactome:R-HSA-3359469|reactome:R-HSA-9013407|refseq:NP_001278868.1|dip:DIP-40306N	-	-	-	figure legend:4A|comment:"Fibroblasts from two patients with the \"cblC\"  inborn error of cobalamin  metabolism (SA and WG4130 cell lines) showed reduced binding.  [SA was a cblC case with compound heterozygosity for c.271dupA, p.R91 > GNsX14 and c.616C > T, p.R206W of MMACHC. WG4130 was a cblC case with compound heterozygosity for c.328delAACC, p.N110EfsX13 and 482G > A, p.R161Q of MMACHC. ]"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2014/09/12	2014/10/16	rogid:HLpV70pJ6XpjFsQ6SehGTXMRuDQ9606	rogid:wfY9f5C2d1neO4MQeVdVrVGzrrs9606	intact-crc:D96F662A00CF8169|rigid:jszmPPaR2lznMNNg4Kgr3xQL8J8	false	mutation decreasing interaction strength:206-206|mutation decreasing interaction strength:161-161|disease causing amino-acid variant:206-206|disease causing amino-acid variant:161-161	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99707	uniprotkb:Q9Y4U1	intact:EBI-1045782|uniprotkb:Q99713|uniprotkb:Q99723|uniprotkb:A9Z1W4|uniprotkb:B9EGF7|uniprotkb:A1L4N8|uniprotkb:B7ZLW7|ensembl:ENSP00000355536	intact:EBI-9775184|uniprotkb:Q5T157|uniprotkb:Q9BRQ7|ensembl:ENSP00000383840	psi-mi:meth_human(display_long)|uniprotkb:5-methyltetrahydrofolate--homocysteine methyltransferase(gene name synonym)|uniprotkb:Vitamin-B12 dependent methionine synthase(gene name synonym)|uniprotkb:MTR(gene name)|psi-mi:MTR(display_short)|uniprotkb:Cobalamin-dependent methionine synthase(gene name synonym)	psi-mi:mmac_human(display_long)|uniprotkb:MMACHC(gene name)|psi-mi:MMACHC(display_short)|uniprotkb:CblC(gene name synonym)|uniprotkb:"Cyanocobalamin reductase (cyanide-eliminating)"(gene name synonym)|uniprotkb:"Alkylcobalamin:glutathione S-alkyltransferase"(gene name synonym)|uniprotkb:Methylmalonic aciduria and homocystinuria type C protein(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Fofou-Caillierez et al. (2013)	pubmed:23825108|imex:IM-23087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9781034|imex:IM-23087-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278869.1|refseq:NP_000245.2|ensembl:ENSG00000116984(gene)|ensembl:ENST00000366577(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008705"(methionine synthase activity)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0031103"(axon regeneration)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032259"(methylation)|go:"GO:0042558"(pteridine-containing compound metabolic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR000489(Dihydropteroate synthase, DHPS)|interpro:IPR003726(Homocysteine S-methyltransferase)|interpro:IPR003759("Methionine synthase, cobalamin (vitamin B12)-binding module, cap")|interpro:IPR004223(Vitamin B12 dependent methionine synthase, activation region)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR011005(Dihydropteroate synthase-like)|interpro:IPR011822(5-methyltetrahydrofolate--homocysteine methyltransferase)|interpro:IPR033706|interpro:IPR036589|interpro:IPR036594|interpro:IPR036724|interpro:IPR037010|rcsb pdb:2O2K|rcsb pdb:4CCZ|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-196741|reactome:R-HSA-3359467|reactome:R-HSA-3359469|reactome:R-HSA-9013407|refseq:NP_001278868.1|dip:DIP-40306N	refseq:NP_056321.2|refseq:NP_001317469.1|ensembl:ENSG00000132763(gene)|ensembl:ENST00000401061(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016740"(transferase activity)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0033787"("cyanocobalamin reductase (cyanide-eliminating) activity")|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0070988"(demethylation)|go:"GO:0071949"(FAD binding)|interpro:IPR032037|rcsb pdb:3SBY|rcsb pdb:3SBZ|rcsb pdb:3SC0|rcsb pdb:3SOM|rcsb pdb:5UOS|reactome:R-HSA-196741|reactome:R-HSA-3359473|reactome:R-HSA-3359474	-	-	-	figure legend:4B|antagonist:"siRNA #24 (targeting the end of exon 24)  siRNA #16 (targeting exon 16)  siRNA #6 (targeting exon 6)"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/09/12	2014/10/16	rogid:wfY9f5C2d1neO4MQeVdVrVGzrrs9606	rogid:HLpV70pJ6XpjFsQ6SehGTXMRuDQ9606	intact-crc:7E6032591CF7745F|rigid:jszmPPaR2lznMNNg4Kgr3xQL8J8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)