#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q05655 uniprotkb:P24001-2 intact:EBI-704279|uniprotkb:B2R834|uniprotkb:Q86XJ6|uniprotkb:Q15144|uniprotkb:B0KZ81|ensembl:ENSP00000331602|ensembl:ENSP00000378217|ensembl:ENSP00000498400|ensembl:ENSP00000498623|ensembl:ENSP00000499558 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 psi-mi:kpcd_human(display_long)|uniprotkb:nPKC-delta(gene name synonym)|uniprotkb:PRKCD(gene name)|psi-mi:PRKCD(display_short)|uniprotkb:Tyrosine-protein kinase PRKCD(gene name synonym)|uniprotkb:PKCD(gene name synonym) psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975232|imex:IM-23281-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006245.2|refseq:NP_997704.1|refseq:NP_001303256.1|refseq:XP_016862344.1|refseq:XP_016862345.1|refseq:XP_006713322.1|dip:DIP-29954N|ensembl:ENSG00000163932(gene)|ensembl:ENST00000330452(transcript)|ensembl:ENST00000394729(transcript)|ensembl:ENST00000650739(transcript)|ensembl:ENST00000652449(transcript)|ensembl:ENST00000654719(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036019"(endolysosome)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900163"(positive regulation of phospholipid scramblase activity)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:2000303"(regulation of ceramide biosynthetic process)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000753"(positive regulation of glucosylceramide catabolic process)|go:"GO:2000755"(positive regulation of sphingomyelin catabolic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027436|interpro:IPR034667|interpro:IPR035892|mint:Q05655|rcsb pdb:1YRK|reactome:R-HSA-111465|reactome:R-HSA-111933|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597|reactome:R-HSA-450520|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8932339|rcsb pdb:2YUU intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) - - - figure legend:Fig. 3a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/13 2014/11/13 rogid:BR/lNGg6f55rGP91akTf8BLkX449606 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 intact-crc:6A77F15892AA144E|rigid:GNq9xoKPz9xhtukiQGswYvRV64o false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P24001-2 uniprotkb:P49715 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975676|imex:IM-23281-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N - - - figure legend:Fig. 7a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/13 2014/11/13 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 intact-crc:9D78074099E5A61D|rigid:Egqe4hT3oF8jD64/pZrRnsS1fmQ false flag tag:?-? sufficient binding region:250-358(IPR004827)|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49715 uniprotkb:P24001-2 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975687|imex:IM-23281-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) - - - figure legend:Fig. 7b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/13 2014/11/13 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 intact-crc:B80502B4850957A3|rigid:Egqe4hT3oF8jD64/pZrRnsS1fmQ false flag tag:?-? myc tag:?-?|sufficient binding region:1-67 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P24001-2 uniprotkb:Q05655 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 intact:EBI-704279|uniprotkb:B2R834|uniprotkb:Q86XJ6|uniprotkb:Q15144|uniprotkb:B0KZ81|ensembl:ENSP00000331602|ensembl:ENSP00000378217|ensembl:ENSP00000498400|ensembl:ENSP00000498623|ensembl:ENSP00000499558 psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:kpcd_human(display_long)|uniprotkb:nPKC-delta(gene name synonym)|uniprotkb:PRKCD(gene name)|psi-mi:PRKCD(display_short)|uniprotkb:Tyrosine-protein kinase PRKCD(gene name synonym)|uniprotkb:PKCD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975252|imex:IM-23281-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) refseq:NP_006245.2|refseq:NP_997704.1|refseq:NP_001303256.1|refseq:XP_016862344.1|refseq:XP_016862345.1|refseq:XP_006713322.1|dip:DIP-29954N|ensembl:ENSG00000163932(gene)|ensembl:ENST00000330452(transcript)|ensembl:ENST00000394729(transcript)|ensembl:ENST00000650739(transcript)|ensembl:ENST00000652449(transcript)|ensembl:ENST00000654719(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036019"(endolysosome)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900163"(positive regulation of phospholipid scramblase activity)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:2000303"(regulation of ceramide biosynthetic process)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000753"(positive regulation of glucosylceramide catabolic process)|go:"GO:2000755"(positive regulation of sphingomyelin catabolic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027436|interpro:IPR034667|interpro:IPR035892|mint:Q05655|rcsb pdb:1YRK|reactome:R-HSA-111465|reactome:R-HSA-111933|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597|reactome:R-HSA-450520|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8932339|rcsb pdb:2YUU - - - figure legend:Fig. 3b|agonist:"phorbol 13-acetate 12-myristate (PMA) (CHEBI:37537)"|antagonist:"rottlerin (CHEBI:8899), a PKC delta inhibitor"|comment:"No IL-32 beta co-precipitated with anti-PKC delta antibody from cells not treated with PMA (CHEBI:37537)."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/13 2014/11/13 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 rogid:BR/lNGg6f55rGP91akTf8BLkX449606 intact-crc:0EEED7F2351B149F|rigid:GNq9xoKPz9xhtukiQGswYvRV64o false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P24001-2 uniprotkb:Q05655 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 intact:EBI-704279|uniprotkb:B2R834|uniprotkb:Q86XJ6|uniprotkb:Q15144|uniprotkb:B0KZ81|ensembl:ENSP00000331602|ensembl:ENSP00000378217|ensembl:ENSP00000498400|ensembl:ENSP00000498623|ensembl:ENSP00000499558 psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:kpcd_human(display_long)|uniprotkb:nPKC-delta(gene name synonym)|uniprotkb:PRKCD(gene name)|psi-mi:PRKCD(display_short)|uniprotkb:Tyrosine-protein kinase PRKCD(gene name synonym)|uniprotkb:PKCD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975354|imex:IM-23281-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) refseq:NP_006245.2|refseq:NP_997704.1|refseq:NP_001303256.1|refseq:XP_016862344.1|refseq:XP_016862345.1|refseq:XP_006713322.1|dip:DIP-29954N|ensembl:ENSG00000163932(gene)|ensembl:ENST00000330452(transcript)|ensembl:ENST00000394729(transcript)|ensembl:ENST00000650739(transcript)|ensembl:ENST00000652449(transcript)|ensembl:ENST00000654719(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036019"(endolysosome)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900163"(positive regulation of phospholipid scramblase activity)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:2000303"(regulation of ceramide biosynthetic process)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000753"(positive regulation of glucosylceramide catabolic process)|go:"GO:2000755"(positive regulation of sphingomyelin catabolic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027436|interpro:IPR034667|interpro:IPR035892|mint:Q05655|rcsb pdb:1YRK|reactome:R-HSA-111465|reactome:R-HSA-111933|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597|reactome:R-HSA-450520|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8932339|rcsb pdb:2YUU - - - figure legend:Fig. 6a, 6f|agonist:"phorbol 13-acetate 12-myristate (PMA) (CHEBI:37537)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/13 2014/11/13 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 rogid:BR/lNGg6f55rGP91akTf8BLkX449606 intact-crc:4890F2D27FBDAB23|rigid:0ruLNE6C8PmSpkmzCG0cZdRJPMs false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P24001-2 uniprotkb:P49715 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975354|imex:IM-23281-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N - - - figure legend:Fig. 6a, 6f|agonist:"phorbol 13-acetate 12-myristate (PMA) (CHEBI:37537)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/13 2014/11/13 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 intact-crc:4890F2D27FBDAB23|rigid:0ruLNE6C8PmSpkmzCG0cZdRJPMs false myc tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P24001-2 uniprotkb:P49715 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975366|imex:IM-23281-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N - - - figure legend:Fig. 6a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/13 2014/11/13 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 intact-crc:BB06C3BBDA971779|rigid:Egqe4hT3oF8jD64/pZrRnsS1fmQ false myc tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49715 uniprotkb:P24001-2 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975398|imex:IM-23281-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) - - - figure legend:Fig. 6b|agonist:"phorbol 13-acetate 12-myristate (PMA) (CHEBI:37537)"|antagonist:"rottlerin (CHEBI:8899), a PKC delta inhibitor"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/13 2014/11/13 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 intact-crc:CC6418C393E3D318|rigid:Egqe4hT3oF8jD64/pZrRnsS1fmQ false myc tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49715 ensembl:ENSG00000136634 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 intact:EBI-9975278 psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:il10_human_gene(display_short)|psi-mi:ENSG00000136634(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975283|imex:IM-23281-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N - - - - figure legend:Fig. 5|agonist:IL-32 beta knockdown|causality statement:P24001-2 decreases binding of P49715 to ENSG00000136634|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells) - 2014/11/13 2014/11/24 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 - intact-crc:C61688D5742BA079 false - binding-associated region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P49715 ensembl:ENSG00000012223 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 intact:EBI-9975264 psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:trfl_human_gene(display_short)|psi-mi:ENSG00000012223(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975305|imex:IM-23281-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N - - - - figure legend:Fig. 5|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells) - 2014/11/13 2014/11/13 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 - intact-crc:DB83DE7C613BED0E false - binding-associated region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) ensembl:ENSG00000171791 uniprotkb:P49715 intact:EBI-8772209 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)|ensembl:bcl2_human_gene(shortlabel)|psi-mi:ENSG00000171791(display_long) psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975327|imex:IM-23281-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N - - - figure legend:Fig. 5|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells) - 2014/11/13 2014/11/13 - rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 intact-crc:6F98D89B8909C6C8 false binding-associated region:?-? - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P24001-2 uniprotkb:P49715 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975419|imex:IM-23281-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N - - - figure legend:Fig. 6c|agonist:"phorbol 13-acetate 12-myristate (PMA) (CHEBI:37537)"|antagonist:"rottlerin (CHEBI:8899), a PKC delta inhibitor"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells) - 2014/11/13 2014/11/13 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 intact-crc:5E5930D4D1F0BBC5|rigid:Egqe4hT3oF8jD64/pZrRnsS1fmQ false myc tag:?-? myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P24001-2 uniprotkb:P49715 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 intact:EBI-1172054|uniprotkb:A7LNP2|uniprotkb:Q05CA4|uniprotkb:P78319|ensembl:ENSP00000427514 psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:cebpa_human(display_long)|uniprotkb:CEBPA(gene name)|psi-mi:CEBPA(display_short)|uniprotkb:CEBP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975462|imex:IM-23281-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) ensembl:ENSG00000245848(gene)|ensembl:ENST00000498907(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001163"(RNA polymerase I transcription regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048469"(cell maturation)|go:"GO:0048839"(inner ear development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P49715|rcsb pdb:6DC0|reactome:R-HSA-381340|reactome:R-HSA-9616222|refseq:NP_004355.2|refseq:NP_001272758.1|refseq:NP_001274353.1|refseq:NP_001274364.1|dip:DIP-37882N - - - figure legend:Fig. 6g|agonist:"phorbol 13-acetate 12-myristate (PMA) (CHEBI:37537)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line) - 2014/11/13 2014/11/13 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 rogid:uo2VMV1hbdAvsRxr6yU2EVW11nY9606 intact-crc:AE7518E1146C3CC7|rigid:0ruLNE6C8PmSpkmzCG0cZdRJPMs false myc tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P24001-2 uniprotkb:Q05655 intact:EBI-8800907|ensembl:ENSP00000324742|ensembl:ENSP00000405063|ensembl:ENSP00000411958|ensembl:ENSP00000432218|ensembl:ENSP00000432850|ensembl:ENSP00000432917|ensembl:ENSP00000436929|ensembl:ENSP00000437020|ensembl:ENSP00000448683|ensembl:ENSP00000450364 intact:EBI-704279|uniprotkb:B2R834|uniprotkb:Q86XJ6|uniprotkb:Q15144|uniprotkb:B0KZ81|ensembl:ENSP00000331602|ensembl:ENSP00000378217|ensembl:ENSP00000498400|ensembl:ENSP00000498623|ensembl:ENSP00000499558 psi-mi:p24001-2(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:kpcd_human(display_long)|uniprotkb:nPKC-delta(gene name synonym)|uniprotkb:PRKCD(gene name)|psi-mi:PRKCD(display_short)|uniprotkb:Tyrosine-protein kinase PRKCD(gene name synonym)|uniprotkb:PKCD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2013) pubmed:23814099|imex:IM-23281 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9975462|imex:IM-23281-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2866752(isoform-parent)|ensembl:ENSG00000008517(gene)|ensembl:ENST00000325568(transcript)|ensembl:ENST00000440815(transcript)|ensembl:ENST00000444393(transcript)|ensembl:ENST00000525643(transcript)|ensembl:ENST00000526464(transcript)|ensembl:ENST00000528163(transcript)|ensembl:ENST00000529550(transcript)|ensembl:ENST00000530538(transcript)|ensembl:ENST00000533097(transcript)|ensembl:ENST00000552664(transcript) refseq:NP_006245.2|refseq:NP_997704.1|refseq:NP_001303256.1|refseq:XP_016862344.1|refseq:XP_016862345.1|refseq:XP_006713322.1|dip:DIP-29954N|ensembl:ENSG00000163932(gene)|ensembl:ENST00000330452(transcript)|ensembl:ENST00000394729(transcript)|ensembl:ENST00000650739(transcript)|ensembl:ENST00000652449(transcript)|ensembl:ENST00000654719(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036019"(endolysosome)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900163"(positive regulation of phospholipid scramblase activity)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:2000303"(regulation of ceramide biosynthetic process)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000753"(positive regulation of glucosylceramide catabolic process)|go:"GO:2000755"(positive regulation of sphingomyelin catabolic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027436|interpro:IPR034667|interpro:IPR035892|mint:Q05655|rcsb pdb:1YRK|reactome:R-HSA-111465|reactome:R-HSA-111933|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597|reactome:R-HSA-450520|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8932339|rcsb pdb:2YUU - - - figure legend:Fig. 6g|agonist:"phorbol 13-acetate 12-myristate (PMA) (CHEBI:37537)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line) - 2014/11/13 2014/11/13 rogid:/KPLOnspBKwDAHKw1fWZIce+sA49606 rogid:BR/lNGg6f55rGP91akTf8BLkX449606 intact-crc:AE7518E1146C3CC7|rigid:0ruLNE6C8PmSpkmzCG0cZdRJPMs false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)