#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P16871 uniprotkb:P31785 intact:EBI-80490|uniprotkb:Q6NSP4|ensembl:ENSP00000306157|uniprotkb:Q6SV45|uniprotkb:Q9UPC1|uniprotkb:B2RCS6|uniprotkb:Q6NWM0|uniprotkb:B4DVT1|uniprotkb:Q05CU8|uniprotkb:Q6NWM1|uniprotkb:Q6NWM2|uniprotkb:Q6NWM3 intact:EBI-80475|ensembl:ENSP00000363318|uniprotkb:Q5FC12 psi-mi:il7ra_human(display_long)|uniprotkb:IL7R(gene name)|psi-mi:IL7R(display_short)|uniprotkb:CDw127(gene name synonym) psi-mi:il2rg_human(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Andersen et al. (2013) pubmed:23726671|imex:IM-23197 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9700679|imex:IM-23197-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168685(gene)|ensembl:ENST00000303115(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0003823"(antigen binding)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004917"(interleukin-7 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042100"(B cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040997|mint:P16871|rcsb pdb:3DI2|rcsb pdb:3DI3|go:"GO:0005886"(plasma membrane)|rcsb pdb:5J11|rcsb pdb:6P50|rcsb pdb:6P67|reactome:R-HSA-1266695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:3UP1|refseq:NP_002176.2|dip:DIP-3045N ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0038111"(interleukin-7-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|rcsb pdb:1ILL|rcsb pdb:1ILM|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1ILN|rcsb pdb:1ITE|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3BPL|rcsb pdb:3QAZ|rcsb pdb:3QB7|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6OEL|reactome:R-HSA-1266695|reactome:R-HSA-5673001|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|reactome:R-HSA-6785807|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-912526|refseq:NP_000197.1|dip:DIP-173N - - - figure legend:1,2|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/09/10 2018/09/18 rogid:8tfp5J+GYGrnzfuyfJhj8T+IMt89606 rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606 intact-crc:37F46BC390FC7DC0|rigid:iuZx34pRLNv0bnwNEOCVDbyiGWY false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)