#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5M848	uniprotkb:P84903	intact:EBI-9700451	intact:EBI-9700551|ensembl:ENSRNOP00000027685	psi-mi:crcm1_rat(display_long)|uniprotkb:Orai1(gene name)|psi-mi:Orai1(display_short)|uniprotkb:Cracm1(gene name synonym)|uniprotkb:Tmem142a(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:stim1_rat(display_long)|uniprotkb:Stim1(gene name)|psi-mi:Stim1(display_short)|uniprotkb:Sim(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Gruszczynska-Biegala et al. (2013)	imex:IM-23077|pubmed:23711249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9700535|imex:IM-23077-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014004.1|interpro:IPR012446(Protein of unknown function DUF1650)|rgd:1311873|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)	rgd:1306831|refseq:NP_001101966.2|ensembl:ENSRNOG00000020425(gene)|ensembl:ENSRNOT00000027685(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0014902"(myotube differentiation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|reactome:R-RNO-5578775|reactome:R-RNO-983695	go:"GO:0044297"(cell body)	-	-	figure legend:6|agonist:"Thapsigargin (a  non-competitive inhibitor of    sarco/endoplasmic reticulum Ca2+ ATPases  resulting in increased cytosolic (intracellular) calcium concentration."|comment:"The addition of the SOCE (store-operated calcium entry) inhibitor   ML9 (1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride)  after addition of Thapsigargin decreased the number of complexes nearly to the state before thapsigargin stimulation."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2014/09/10	2014/10/16	rogid:7DhIGR6sq6d9A3m6/u8kotOXZZM10116	rogid:tFviWTvMIXmKSj4188GoXiMc8HM10116	intact-crc:DFAB6E2D1BFBE5EB|rigid:Pcfu+LdnxWtiglSp4DRIqUpN/qw	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:D4A5X1	uniprotkb:Q5M848	intact:EBI-9700435|ensembl:ENSRNOP00000004006	intact:EBI-9700451	psi-mi:d4a5x1_rat(display_long)|uniprotkb:Stim2(gene name)|psi-mi:Stim2(display_short)	psi-mi:crcm1_rat(display_long)|uniprotkb:Orai1(gene name)|psi-mi:Orai1(display_short)|uniprotkb:Cracm1(gene name synonym)|uniprotkb:Tmem142a(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Gruszczynska-Biegala et al. (2013)	imex:IM-23077|pubmed:23711249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9700484|imex:IM-23077-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001099220.2|rgd:1304641|ensembl:ENSRNOG00000002956(gene)|ensembl:ENSRNOT00000004006(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032393|interpro:IPR037608|interpro:IPR037610|go:"GO:0006874"(cellular calcium ion homeostasis)	refseq:NP_001014004.1|interpro:IPR012446(Protein of unknown function DUF1650)|rgd:1311873|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)	go:"GO:0044297"(cell body)	-	-	figure legend:2,3,4,5,  Supp fig 1|agonist:"EGTA containing medium (chelates/removes calcium ions)."|antagonist:high-calcium ion containing medium|comment:Results suggest that  STIM2-ORAI1 complexes formed as a result of decreased cytosolic calcium levels.|agonist:BAPTA-AM -  a calcium chelator that penetrates live cells and decreases intracellular calcium concentrations|agonist:Low extracellular calcium levels.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2014/09/10	2014/10/16	rogid:oCVJASTb9u+xMPkNteivCiEcm0w10116	rogid:7DhIGR6sq6d9A3m6/u8kotOXZZM10116	intact-crc:F1C3ADC26EBA6DC2|rigid:RPXTrrRZuypqvFcYh8np28iCRtk	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:D4A5X1	uniprotkb:Q5M848	intact:EBI-9700435|ensembl:ENSRNOP00000004006	intact:EBI-9700451	psi-mi:d4a5x1_rat(display_long)|uniprotkb:Stim2(gene name)|psi-mi:Stim2(display_short)	psi-mi:crcm1_rat(display_long)|uniprotkb:Orai1(gene name)|psi-mi:Orai1(display_short)|uniprotkb:Cracm1(gene name synonym)|uniprotkb:Tmem142a(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gruszczynska-Biegala et al. (2013)	imex:IM-23077|pubmed:23711249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9700433|imex:IM-23077-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001099220.2|rgd:1304641|ensembl:ENSRNOG00000002956(gene)|ensembl:ENSRNOT00000004006(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032393|interpro:IPR037608|interpro:IPR037610|go:"GO:0006874"(cellular calcium ion homeostasis)	refseq:NP_001014004.1|interpro:IPR012446(Protein of unknown function DUF1650)|rgd:1311873|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)	-	-	-	figure legend:1|agonist:"EGTA (removes calcium ions)"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2014/09/10	2014/10/16	rogid:oCVJASTb9u+xMPkNteivCiEcm0w10116	rogid:7DhIGR6sq6d9A3m6/u8kotOXZZM10116	intact-crc:A6CFCF5EC68A3402|rigid:RPXTrrRZuypqvFcYh8np28iCRtk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5M848	uniprotkb:D4A5X1	intact:EBI-9700451	intact:EBI-9700435|ensembl:ENSRNOP00000004006	psi-mi:crcm1_rat(display_long)|uniprotkb:Orai1(gene name)|psi-mi:Orai1(display_short)|uniprotkb:Cracm1(gene name synonym)|uniprotkb:Tmem142a(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:d4a5x1_rat(display_long)|uniprotkb:Stim2(gene name)|psi-mi:Stim2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gruszczynska-Biegala et al. (2013)	imex:IM-23077|pubmed:23711249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9700472|imex:IM-23077-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014004.1|interpro:IPR012446(Protein of unknown function DUF1650)|rgd:1311873|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030426"(growth cone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)	refseq:NP_001099220.2|rgd:1304641|ensembl:ENSRNOG00000002956(gene)|ensembl:ENSRNOT00000004006(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032393|interpro:IPR037608|interpro:IPR037610|go:"GO:0006874"(cellular calcium ion homeostasis)	-	-	-	figure legend:1|agonist:"EGTA (removes calcium ions)"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2014/09/10	2014/10/16	rogid:7DhIGR6sq6d9A3m6/u8kotOXZZM10116	rogid:oCVJASTb9u+xMPkNteivCiEcm0w10116	intact-crc:9CAC9D53934E31EE|rigid:RPXTrrRZuypqvFcYh8np28iCRtk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)