#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y337	uniprotkb:P20930	intact:EBI-9057524|uniprotkb:A0A024R4G4|uniprotkb:Q9HBG8|uniprotkb:Q53ZR3|ensembl:ENSP00000337733|ensembl:ENSP00000375685|ensembl:ENSP00000471966	intact:EBI-1058782|ensembl:ENSP00000357789|uniprotkb:Q01720|uniprotkb:Q5T583|uniprotkb:Q9UC71	psi-mi:klk5_human(display_long)|uniprotkb:KLK5(gene name)|psi-mi:KLK5(display_short)|uniprotkb:Kallikrein-like protein 2(gene name synonym)|uniprotkb:SCTE(gene name synonym)|uniprotkb:Stratum corneum tryptic enzyme(gene name synonym)|uniprotkb:UNQ570/PRO1132(orf name)	psi-mi:fila_human(display_long)|uniprotkb:FLG(gene name)|psi-mi:FLG(display_short)	psi-mi:"MI:0435"(protease assay)	Sakabe et al. (2013)	pubmed:23629652|imex:IM-22657	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9567318|imex:IM-22657-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070959.1|refseq:NP_001070960.1|refseq:NP_036559.1|refseq:XP_011525004.1|refseq:XP_011525005.1|ensembl:ENSG00000167754(gene)|ensembl:ENST00000336334(transcript)|ensembl:ENST00000391809(transcript)|ensembl:ENST00000593428(transcript)|go:"GO:0002803"(positive regulation of antibacterial peptide production)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008544"(epidermis development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0070268"(cornification)|go:"GO:0097186"(amelogenesis)|go:"GO:0097209"(epidermal lamellar body)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:2PSX|rcsb pdb:2PSY|rcsb pdb:6QFE|reactome:R-HSA-6809371	ensembl:ENST00000368799(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007275"(multicellular organism development)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0036457"(keratohyalin granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0061436"(establishment of skin barrier)|ensembl:ENSG00000143631(gene)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003303(Filaggrin)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034325|rcsb pdb:4PCW|reactome:R-HSA-6809371|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_002007.1	go:"GO:0008236"(serine-type peptidase activity)	-	-	figure legend:2C, Figure 3.|antagonist:AEBSF, a kallikrein inhibitor.|comment:Mutating the linker sequence from SFLYQVST  to  HFLHHVHH  stopped the cleavage.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/18	2017/10/30	rogid:VszORPhPkG67B/61EmZtVoWeFHo9606	rogid:RXgRbd4W6ydxD/M1cEUUzUFGuJ09606	intact-crc:613E9ED516C8B2B4|rigid:KrPmBk2b0D9yM1zd4uUmTBdLYUs	false	sufficient binding region:67-293|his tag:c-c	mutation disrupting interaction:3391-3392,3385-3385,3388-3389|his tag:c-c|sufficient binding region:3616..3616-4061..4061	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y337	uniprotkb:P20930	intact:EBI-9057524|uniprotkb:A0A024R4G4|uniprotkb:Q9HBG8|uniprotkb:Q53ZR3|ensembl:ENSP00000337733|ensembl:ENSP00000375685|ensembl:ENSP00000471966	intact:EBI-1058782|ensembl:ENSP00000357789|uniprotkb:Q01720|uniprotkb:Q5T583|uniprotkb:Q9UC71	psi-mi:klk5_human(display_long)|uniprotkb:KLK5(gene name)|psi-mi:KLK5(display_short)|uniprotkb:Kallikrein-like protein 2(gene name synonym)|uniprotkb:SCTE(gene name synonym)|uniprotkb:Stratum corneum tryptic enzyme(gene name synonym)|uniprotkb:UNQ570/PRO1132(orf name)	psi-mi:fila_human(display_long)|uniprotkb:FLG(gene name)|psi-mi:FLG(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Sakabe et al. (2013)	pubmed:23629652|imex:IM-22657	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9632001|imex:IM-22657-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070959.1|refseq:NP_001070960.1|refseq:NP_036559.1|refseq:XP_011525004.1|refseq:XP_011525005.1|ensembl:ENSG00000167754(gene)|ensembl:ENST00000336334(transcript)|ensembl:ENST00000391809(transcript)|ensembl:ENST00000593428(transcript)|go:"GO:0002803"(positive regulation of antibacterial peptide production)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008544"(epidermis development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0070268"(cornification)|go:"GO:0097186"(amelogenesis)|go:"GO:0097209"(epidermal lamellar body)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:2PSX|rcsb pdb:2PSY|rcsb pdb:6QFE|reactome:R-HSA-6809371	ensembl:ENST00000368799(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007275"(multicellular organism development)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0036457"(keratohyalin granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0061436"(establishment of skin barrier)|ensembl:ENSG00000143631(gene)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003303(Filaggrin)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034325|rcsb pdb:4PCW|reactome:R-HSA-6809371|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_002007.1	-	-	-	figure legend:4 D-F|comment:Both proteins are expressed and localize in the granular layer.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-epidermis)|taxid:9606(HUMAN EPDERMIS)	-	2014/06/18	2017/10/30	rogid:VszORPhPkG67B/61EmZtVoWeFHo9606	rogid:RXgRbd4W6ydxD/M1cEUUzUFGuJ09606	intact-crc:89FC7A59822398D5|rigid:KrPmBk2b0D9yM1zd4uUmTBdLYUs	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q9Y337	uniprotkb:P20930	intact:EBI-9057524|uniprotkb:A0A024R4G4|uniprotkb:Q9HBG8|uniprotkb:Q53ZR3|ensembl:ENSP00000337733|ensembl:ENSP00000375685|ensembl:ENSP00000471966	intact:EBI-1058782|ensembl:ENSP00000357789|uniprotkb:Q01720|uniprotkb:Q5T583|uniprotkb:Q9UC71	psi-mi:klk5_human(display_long)|uniprotkb:KLK5(gene name)|psi-mi:KLK5(display_short)|uniprotkb:Kallikrein-like protein 2(gene name synonym)|uniprotkb:SCTE(gene name synonym)|uniprotkb:Stratum corneum tryptic enzyme(gene name synonym)|uniprotkb:UNQ570/PRO1132(orf name)	psi-mi:fila_human(display_long)|uniprotkb:FLG(gene name)|psi-mi:FLG(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sakabe et al. (2013)	pubmed:23629652|imex:IM-22657	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9632016|imex:IM-22657-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070959.1|refseq:NP_001070960.1|refseq:NP_036559.1|refseq:XP_011525004.1|refseq:XP_011525005.1|ensembl:ENSG00000167754(gene)|ensembl:ENST00000336334(transcript)|ensembl:ENST00000391809(transcript)|ensembl:ENST00000593428(transcript)|go:"GO:0002803"(positive regulation of antibacterial peptide production)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008544"(epidermis development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0070268"(cornification)|go:"GO:0097186"(amelogenesis)|go:"GO:0097209"(epidermal lamellar body)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:2PSX|rcsb pdb:2PSY|rcsb pdb:6QFE|reactome:R-HSA-6809371	ensembl:ENST00000368799(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007275"(multicellular organism development)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0036457"(keratohyalin granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0061436"(establishment of skin barrier)|ensembl:ENSG00000143631(gene)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003303(Filaggrin)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034325|rcsb pdb:4PCW|reactome:R-HSA-6809371|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_002007.1	-	-	-	figure legend:4 G-H|comment:There is an association of profilaggrin and KLK5 at the boundary of the granular and cornified layers of human epidermis.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-epidermis)|taxid:9606(HUMAN EPDERMIS)	-	2014/06/18	2017/10/30	rogid:VszORPhPkG67B/61EmZtVoWeFHo9606	rogid:RXgRbd4W6ydxD/M1cEUUzUFGuJ09606	intact-crc:D79B8A69EFE0822D|rigid:KrPmBk2b0D9yM1zd4uUmTBdLYUs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y337	uniprotkb:P20930	intact:EBI-9057524|uniprotkb:A0A024R4G4|uniprotkb:Q9HBG8|uniprotkb:Q53ZR3|ensembl:ENSP00000337733|ensembl:ENSP00000375685|ensembl:ENSP00000471966	intact:EBI-1058782|ensembl:ENSP00000357789|uniprotkb:Q01720|uniprotkb:Q5T583|uniprotkb:Q9UC71	psi-mi:klk5_human(display_long)|uniprotkb:KLK5(gene name)|psi-mi:KLK5(display_short)|uniprotkb:Kallikrein-like protein 2(gene name synonym)|uniprotkb:SCTE(gene name synonym)|uniprotkb:Stratum corneum tryptic enzyme(gene name synonym)|uniprotkb:UNQ570/PRO1132(orf name)	psi-mi:fila_human(display_long)|uniprotkb:FLG(gene name)|psi-mi:FLG(display_short)	psi-mi:"MI:0040"(electron microscopy)	Sakabe et al. (2013)	pubmed:23629652|imex:IM-22657	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9632031|imex:IM-22657-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070959.1|refseq:NP_001070960.1|refseq:NP_036559.1|refseq:XP_011525004.1|refseq:XP_011525005.1|ensembl:ENSG00000167754(gene)|ensembl:ENST00000336334(transcript)|ensembl:ENST00000391809(transcript)|ensembl:ENST00000593428(transcript)|go:"GO:0002803"(positive regulation of antibacterial peptide production)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008544"(epidermis development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0070268"(cornification)|go:"GO:0097186"(amelogenesis)|go:"GO:0097209"(epidermal lamellar body)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:2PSX|rcsb pdb:2PSY|rcsb pdb:6QFE|reactome:R-HSA-6809371	ensembl:ENST00000368799(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007275"(multicellular organism development)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0036457"(keratohyalin granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0061436"(establishment of skin barrier)|ensembl:ENSG00000143631(gene)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003303(Filaggrin)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034325|rcsb pdb:4PCW|reactome:R-HSA-6809371|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_002007.1	-	-	-	figure legend:5 D-F|comment:"Profilaggrin and KLK5 were co-localized in the vicinity of keratohyalin granules. (Keratohyalin is a protein structure found in granules in the stratum granulosum of the epidermis)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-epidermis)|taxid:9606(HUMAN EPDERMIS)	-	2014/06/18	2017/10/30	rogid:VszORPhPkG67B/61EmZtVoWeFHo9606	rogid:RXgRbd4W6ydxD/M1cEUUzUFGuJ09606	intact-crc:2FEC78F5613C36DB|rigid:KrPmBk2b0D9yM1zd4uUmTBdLYUs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)