#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15208	uniprotkb:Q3UJU9	intact:EBI-6999015|ensembl:ENSMUSP00000088837|uniprotkb:F8VPU4|intact:MINT-1516207	intact:EBI-2554307|uniprotkb:Q3UB61|uniprotkb:Q3U5Y8|uniprotkb:A9UN03|uniprotkb:Q7TNF2|uniprotkb:Q6P8M2|ensembl:ENSMUSP00000092283	psi-mi:insr_mouse(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:rmd3_mouse(display_long)|uniprotkb:Rmdn3(gene name)|psi-mi:Rmdn3(display_short)|uniprotkb:Fam82a2(gene name synonym)|uniprotkb:Fam82c(gene name synonym)|uniprotkb:Protein FAM82A2(gene name synonym)|uniprotkb:Protein FAM82C(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Bobrich et al. (2013)	imex:IM-24142|pubmed:23533724	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9552689|imex:IM-24142-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000005534(gene)|ensembl:ENSMUST00000091291(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0060417"(yolk)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:2000194"(regulation of female gonad development)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000494(EGF receptor, L domain)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P15208|rcsb pdb:1LK2|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-74752|reactome:R-MMU-77387|refseq:NP_034698.2|dip:DIP-41452N	refseq:NP_001028308.1|ensembl:ENSMUSG00000070730(gene)|ensembl:ENSMUST00000094695(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0044232"(organelle membrane contact site)|go:"GO:0045171"(intercellular bridge)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR011990(Tetratricopeptide-like helical)	go:"GO:0005886"(plasma membrane)	comment:mint|function:This receptor binds insulin and has a tyrosine-protein kinase activity	-	figure legend:3 A/B|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-adipocytes)|taxid:10090(Mus musculus)	-	2014/06/18	2015/05/01	rogid:DduFddui4LY0r8EIHI5S5EN485Y10090	rogid:kOVgQsGsp6neZfNc1Gq/3sDlok010090	intact-crc:20EA724E87F7C5EA|rigid:bNBMXWQq6vqZM9sH9sa//uXY/xg	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P15208	uniprotkb:Q3UJU9	intact:EBI-6999015|ensembl:ENSMUSP00000088837|uniprotkb:F8VPU4|intact:MINT-1516207	intact:EBI-2554307|uniprotkb:Q3UB61|uniprotkb:Q3U5Y8|uniprotkb:A9UN03|uniprotkb:Q7TNF2|uniprotkb:Q6P8M2|ensembl:ENSMUSP00000092283	psi-mi:insr_mouse(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:rmd3_mouse(display_long)|uniprotkb:Rmdn3(gene name)|psi-mi:Rmdn3(display_short)|uniprotkb:Fam82a2(gene name synonym)|uniprotkb:Fam82c(gene name synonym)|uniprotkb:Protein FAM82A2(gene name synonym)|uniprotkb:Protein FAM82C(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Bobrich et al. (2013)	imex:IM-24142|pubmed:23533724	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9553806|imex:IM-24142-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000005534(gene)|ensembl:ENSMUST00000091291(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0060417"(yolk)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:2000194"(regulation of female gonad development)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000494(EGF receptor, L domain)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P15208|rcsb pdb:1LK2|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-74752|reactome:R-MMU-77387|refseq:NP_034698.2|dip:DIP-41452N	refseq:NP_001028308.1|ensembl:ENSMUSG00000070730(gene)|ensembl:ENSMUST00000094695(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0044232"(organelle membrane contact site)|go:"GO:0045171"(intercellular bridge)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR011990(Tetratricopeptide-like helical)	go:"GO:0005886"(plasma membrane)	comment:mint|function:This receptor binds insulin and has a tyrosine-protein kinase activity	-	figure legend:4A,  5|comment:Animals fed a high fat diet showed the highest interaction level.|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-adipocytes)|taxid:10090(Mus musculus)	-	2014/06/18	2014/10/16	rogid:DduFddui4LY0r8EIHI5S5EN485Y10090	rogid:kOVgQsGsp6neZfNc1Gq/3sDlok010090	intact-crc:8F7C5895407AA64B|rigid:bNBMXWQq6vqZM9sH9sa//uXY/xg	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)