#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15259	uniprotkb:Q8N157	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9661010|imex:IM-23004-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	-	-	comment:AHI1 val443asp also interacted	figure legend:3A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/15	2014/10/16	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	intact-crc:ADFD7343384CF643|rigid:dtzSopoeQ4gREgNdCKpydMfQdBg	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P54257	uniprotkb:Q8N157	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9662973|imex:IM-23004-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	-	-	comment:AHI1 val443asp also interacted	figure legend:13C and D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/15	2014/10/16	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	intact-crc:8BAA6C4FD9F64F15|rigid:anEmD7uuXaIVTjBsyQrQDFEjGes	false	myc tag:?-?	ha tag:?-?|sufficient binding region:121-580	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N157	uniprotkb:Q8N157	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9662993|imex:IM-23004-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	-	-	comment:AHI1 val443asp also interacted	figure legend:14|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/15	2014/10/16	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	intact-crc:2033F2E55C3F4149|rigid:QiDYJYSgrK3MbptddQDGLwHF610	false	green fluorescent protein tag:c-c	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N157	uniprotkb:O15259	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9662903|imex:IM-23004-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912	omim:608629(see-also)	-	-	figure legend:3B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/15	2014/10/16	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	intact-crc:68F9DC2BD654DD49|rigid:dtzSopoeQ4gREgNdCKpydMfQdBg	false	myc tag:?-?|mutation disrupting interaction:443-443	ha tag:?-?	2	2	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15259	uniprotkb:Q8N157	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9662916|imex:IM-23004-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	omim:608629(see-also)	-	-	figure legend:3B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/15	2014/10/16	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	intact-crc:D8C01B58C8C83F75|rigid:dtzSopoeQ4gREgNdCKpydMfQdBg	false	ha tag:?-?	myc tag:?-?|mutation:443-443	1	1	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N157	uniprotkb:Q8N157	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9680668|imex:IM-23004-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	-	-	-	figure legend:13E|comment:The molecular weight of the  peak is smaller than the expected weight of the homodimer but self-association has also been shown by CoIP.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/15	2014/10/16	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	intact-crc:2892FE4F6717D0F3|rigid:FADdYhJXaAfAdIzSJ6lPdRxDIZ4	false	myc tag:?-?	myc tag:?-?	2	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P54257	uniprotkb:Q8N157	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9662984|imex:IM-23004-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	-	-	-	figure legend:13E and F|comment:"Transfection of AHI1 val443asp lead to a HAP1 hexamer next to the AHI1:HAP1 tetramer indicative that the association of HAP1 and AHI1 is disturbed."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/15	2014/10/16	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	intact-crc:242EDFE5B1EFFA85|rigid:anEmD7uuXaIVTjBsyQrQDFEjGes	false	ha tag:?-?	myc tag:?-?	2	2	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N157	uniprotkb:O15259	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9662962|imex:IM-23004-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912	-	comment:AHI1 val443asp also interacted	-	figure legend:7E-G|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/15	2014/10/16	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	intact-crc:88B6358CF522928E|rigid:dtzSopoeQ4gREgNdCKpydMfQdBg	false	myc tag:?-?|sufficient binding region:141-434	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35668	uniprotkb:Q8K3E5	intact:EBI-473704|uniprotkb:O35636|ensembl:ENSMUSP00000133356	intact:EBI-4280729|uniprotkb:Q7TNV2|uniprotkb:Q9CVY1	psi-mi:hap1_mouse(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:ahi1_mouse(display_long)|uniprotkb:Ahi1(gene name)|psi-mi:Ahi1(display_short)|uniprotkb:Abelson helper integration site 1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9662934|imex:IM-23004-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034534.1|refseq:NP_817090.1|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000138603(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|mint:O35668|go:"GO:0030425"(dendrite)|dip:DIP-32510N	interpro:IPR036028|interpro:IPR036322|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|go:"GO:0120206"(photoreceptor distal connecting cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR035832|reactome:R-MMU-5620912	-	-	-	figure legend:6|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2014/07/15	2014/10/16	rogid:mrrVufzrFAAiuT8yarD5JfWlRbc10090	rogid:J5ppuQu5jQr/lNEM9r9gIWikLVA10090	intact-crc:99C7FE38776641F4|rigid:pqiTncgnn7EFRskwEKNehOKVSBk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N157	uniprotkb:P54257	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tuz et al. (2013)	imex:IM-23004|pubmed:23532844	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9662945|imex:IM-23004-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	omim:608629(see-also)	-	-	figure legend:7C and D, 13B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/15	2014/10/16	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	intact-crc:E4AB207F297C76AB|rigid:anEmD7uuXaIVTjBsyQrQDFEjGes	false	sufficient binding region:121-580|mutation decreasing interaction:443-443	sufficient binding region:1-320	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)