#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19686	uniprotkb:P04785	intact:EBI-9551592	intact:EBI-915861|uniprotkb:P13700|ensembl:ENSRNOP00000051841	psi-mi:gcya1_rat(display_long)|uniprotkb:Gucy1a1(gene name)|psi-mi:Gucy1a1(display_short)|uniprotkb:Guanylate cyclase soluble subunit alpha-3(gene name synonym)|uniprotkb:Guc1a1(gene name synonym)|uniprotkb:Gucy1a3(gene name synonym)|uniprotkb:Soluble guanylate cyclase large subunit(gene name synonym)	psi-mi:pdia1_rat(display_long)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:P4hb(gene name)|psi-mi:P4hb(display_short)|uniprotkb:Pdia1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Heckler et al. (2013)	imex:IM-22659|pubmed:23477350	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9551589|imex:IM-22659-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029787|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|rgd:68436|interpro:IPR038158|interpro:IPR042463|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009635"(response to herbicide)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0020037"(heme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043167"(ion binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0098925"(retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)	refseq:NP_037130.2|rgd:3244|ensembl:ENSRNOG00000036689(gene)|ensembl:ENSRNOT00000054958(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P04785|reactome:R-RNO-1650814|reactome:R-RNO-3299685|reactome:R-RNO-381426|reactome:R-RNO-5358346|reactome:R-RNO-8866423|reactome:R-RNO-8957275|reactome:R-RNO-8963888|reactome:R-RNO-9020591|reactome:R-RNO-9020933	-	-	-	figure legend:Figure 5|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-sv40lt-smc)|taxid:10116(Rattus norvegicus)	-	2014/06/18	2014/10/16	rogid:1u/ds87BtDmVcDRLJe3ku1vB6SQ10116	rogid:nXaUDIKzWIRQ95lFxT0hB0T9enQ10116	intact-crc:6DCDBFEFD0425DF5|rigid:lGnaBpJJhWJwtvWRNWF2QHQn1bA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P20595	uniprotkb:P04785	intact:EBI-7980539|uniprotkb:Q8CH88|intact:MINT-1782852|ensembl:ENSRNOP00000062785	intact:EBI-915861|uniprotkb:P13700|ensembl:ENSRNOP00000051841	psi-mi:gcyb1_rat(display_long)|uniprotkb:Guanylate cyclase soluble subunit beta-3(gene name synonym)|uniprotkb:Guc1b3(gene name synonym)|uniprotkb:Gucy1b3(gene name synonym)|uniprotkb:Gucy1b1(gene name)|psi-mi:Gucy1b1(display_short)|uniprotkb:Soluble guanylate cyclase small subunit(gene name synonym)	psi-mi:pdia1_rat(display_long)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:P4hb(gene name)|psi-mi:P4hb(display_short)|uniprotkb:Pdia1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Heckler et al. (2013)	imex:IM-22659|pubmed:23477350	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9551595|imex:IM-22659-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036901.2|rgd:2769|ensembl:ENSRNOG00000012060(gene)|ensembl:ENSRNOT00000064930(transcript)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020037"(heme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0043167"(ion binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099555"(trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:3HLS|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)	refseq:NP_037130.2|rgd:3244|ensembl:ENSRNOG00000036689(gene)|ensembl:ENSRNOT00000054958(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P04785|reactome:R-RNO-1650814|reactome:R-RNO-3299685|reactome:R-RNO-381426|reactome:R-RNO-5358346|reactome:R-RNO-8866423|reactome:R-RNO-8957275|reactome:R-RNO-8963888|reactome:R-RNO-9020591|reactome:R-RNO-9020933	-	comment:mint	-	figure legend:Figure 5i|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-sv40lt-smc)|taxid:10116(Rattus norvegicus)	-	2014/06/18	2014/10/16	rogid:/IurAvUOPtWzpyyVdz+othpolB410116	rogid:nXaUDIKzWIRQ95lFxT0hB0T9enQ10116	intact-crc:D441BDBFEFD0425D|rigid:REKMshMeSfcc9xOmK/4UTGBfiZ4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P20595	uniprotkb:P09103	intact:EBI-7980539|uniprotkb:Q8CH88|intact:MINT-1782852|ensembl:ENSRNOP00000062785	intact:EBI-494709|uniprotkb:Q922C8|ensembl:ENSMUSP00000026122	psi-mi:gcyb1_rat(display_long)|uniprotkb:Guanylate cyclase soluble subunit beta-3(gene name synonym)|uniprotkb:Guc1b3(gene name synonym)|uniprotkb:Gucy1b3(gene name synonym)|uniprotkb:Gucy1b1(gene name)|psi-mi:Gucy1b1(display_short)|uniprotkb:Soluble guanylate cyclase small subunit(gene name synonym)	psi-mi:pdia1_mouse(display_long)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 59(gene name synonym)|uniprotkb:P4hb(gene name)|psi-mi:P4hb(display_short)|uniprotkb:Pdia1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Heckler et al. (2013)	imex:IM-22659|pubmed:23477350	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9632427|imex:IM-22659-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036901.2|rgd:2769|ensembl:ENSRNOG00000012060(gene)|ensembl:ENSRNOT00000064930(transcript)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020037"(heme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0043167"(ion binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099555"(trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:3HLS|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)	refseq:NP_035162.1|ensembl:ENSMUSG00000025130(gene)|ensembl:ENSMUST00000026122(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P09103|reactome:R-MMU-1650814|reactome:R-MMU-3299685|reactome:R-MMU-381426|reactome:R-MMU-5358346|reactome:R-MMU-8866423|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-9020591|reactome:R-MMU-9020933	-	comment:mint	-	figure legend:Figure 3A|comment:"FLAG-tagged PDI WT and PDI CXXS pulled down sGC in COS-7 lysates, as a complex of approximately 200 kDa  and of higher molecular mass (potential multimers). Addition of reductant (2-mercaptoethanol) to the bound samples resolves the high-molecular-mass complexes to the expected sGCa and sGCb subunit size (~80 and 75 kDa),"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2014/06/18	2014/10/16	rogid:/IurAvUOPtWzpyyVdz+othpolB410116	rogid:j20LBPF1r9AYUdJAgzNS/+Uq8GY10090	intact-crc:6563FEDF089D08E8|rigid:jzWPDjhRhjBIS9EGKgUlDTjtqg4	false	-	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09103	uniprotkb:P19686	intact:EBI-494709|uniprotkb:Q922C8|ensembl:ENSMUSP00000026122	intact:EBI-9551592	psi-mi:pdia1_mouse(display_long)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 59(gene name synonym)|uniprotkb:P4hb(gene name)|psi-mi:P4hb(display_short)|uniprotkb:Pdia1(gene name synonym)	psi-mi:gcya1_rat(display_long)|uniprotkb:Gucy1a1(gene name)|psi-mi:Gucy1a1(display_short)|uniprotkb:Guanylate cyclase soluble subunit alpha-3(gene name synonym)|uniprotkb:Guc1a1(gene name synonym)|uniprotkb:Gucy1a3(gene name synonym)|uniprotkb:Soluble guanylate cyclase large subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Heckler et al. (2013)	imex:IM-22659|pubmed:23477350	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9632429|imex:IM-22659-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035162.1|ensembl:ENSMUSG00000025130(gene)|ensembl:ENSMUST00000026122(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P09103|reactome:R-MMU-1650814|reactome:R-MMU-3299685|reactome:R-MMU-381426|reactome:R-MMU-5358346|reactome:R-MMU-8866423|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-9020591|reactome:R-MMU-9020933	interpro:IPR029787|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|rgd:68436|interpro:IPR038158|interpro:IPR042463|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009635"(response to herbicide)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0020037"(heme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043167"(ion binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0098925"(retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)	-	-	-	figure legend:Figure 3A|comment:"FLAG-tagged PDI WT and PDI CXXS pulled down sGC in COS-7 lysates, as a complex of approximately 200 kDa  and of higher molecular mass (potential multimers). Addition of reductant (2-mercaptoethanol) to the bound samples resolves the high-molecular-mass complexes to the expected sGCa and sGCb subunit size (~80 and 75 kDa),"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2014/06/18	2014/10/16	rogid:j20LBPF1r9AYUdJAgzNS/+Uq8GY10090	rogid:1u/ds87BtDmVcDRLJe3ku1vB6SQ10116	intact-crc:85C115EE81634B34|rigid:Mx0Z1hatf3Rhggoap6hkkqKMlkQ	false	flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)