#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97348	uniprotkb:O43293	intact:EBI-7527344|uniprotkb:O09104|intact:MINT-1340205|ensembl:ENSMUSP00000036031	intact:EBI-77293|uniprotkb:A0AVN4|uniprotkb:B3KQE2|uniprotkb:Q05JY4|ensembl:ENSP00000301264|ensembl:ENSP00000442973	psi-mi:rhod_mouse(display_long)|uniprotkb:Rhod(gene name)|psi-mi:Rhod(display_short)|uniprotkb:Arhd(gene name synonym)|uniprotkb:Rhom(gene name synonym)	psi-mi:dapk3_human(display_long)|uniprotkb:DAPK3(gene name)|psi-mi:DAPK3(display_short)|uniprotkb:ZIPK(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:Zipper-interacting protein kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nehru et al. (2013)	pubmed:23454120|imex:IM-23046	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9693828|imex:IM-23046-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031511.1|ensembl:ENSMUSG00000041845(gene)|ensembl:ENSMUST00000048197(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-5663220|reactome:R-MMU-9013405	refseq:NP_001339.1|refseq:XP_005259565.1|ensembl:ENSG00000167657(gene)|ensembl:ENST00000301264(transcript)|ensembl:ENST00000545797(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870|mint:O43293|rcsb pdb:1YRP|rcsb pdb:2J90|rcsb pdb:3BHY|rcsb pdb:3BQR|rcsb pdb:5A6N|rcsb pdb:5A6O|rcsb pdb:5VJA|reactome:R-HSA-418889	-	comment:mint|function:Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton	-	figure legend:1B and C|comment:"RhoD wildtype and in GTP-bound form interacted (transfected RhoD G26V).  DAPK3/ZIPK mutant construct lacking the leucine zipper domain interacted with RhoD wildtype and RhoD GDP- and GTP-bound forms ( transfected RhoD T31N and RhoD G26V, respectively)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/08/26	2014/10/16	rogid:FRwPCPAwwUap1HahZo7SwpNvILU10090	rogid:s8wsdvHltjaM7k0sJRNSjpXVpwM9606	intact-crc:0F523EDE8BC2A795|rigid:ezEVicybBi00ng7e6sl74Q3XTaA	false	mutation disrupting interaction:31-31|myc tag:?-?	flag tag:?-?|mutation:161-161	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43293	uniprotkb:O00212	intact:EBI-77293|uniprotkb:A0AVN4|uniprotkb:B3KQE2|uniprotkb:Q05JY4|ensembl:ENSP00000301264|ensembl:ENSP00000442973	intact:EBI-3918631|ensembl:ENSP00000308576	psi-mi:dapk3_human(display_long)|uniprotkb:DAPK3(gene name)|psi-mi:DAPK3(display_short)|uniprotkb:ZIPK(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:Zipper-interacting protein kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym)	psi-mi:rhod_human(display_long)|uniprotkb:RHOD(gene name)|psi-mi:RHOD(display_short)|uniprotkb:ARHD(gene name synonym)|uniprotkb:Rho-related protein HP1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nehru et al. (2013)	pubmed:23454120|imex:IM-23046	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9693791|imex:IM-23046-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001339.1|refseq:XP_005259565.1|ensembl:ENSG00000167657(gene)|ensembl:ENST00000301264(transcript)|ensembl:ENST00000545797(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870|mint:O43293|rcsb pdb:1YRP|rcsb pdb:2J90|rcsb pdb:3BHY|rcsb pdb:3BQR|rcsb pdb:5A6N|rcsb pdb:5A6O|rcsb pdb:5VJA|reactome:R-HSA-418889	ensembl:ENSG00000173156(gene)|ensembl:ENST00000308831(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010008"(endosome membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR027417|rcsb pdb:2J1L|reactome:R-HSA-5663220|reactome:R-HSA-9013405|interpro:IPR005225(Small GTP-binding protein)|refseq:NP_055393.1	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/08/26	2014/10/16	rogid:s8wsdvHltjaM7k0sJRNSjpXVpwM9606	rogid:tfbt/6dhQwIrWhNcSRuDwIVjYbA9606	intact-crc:126AC5AE13C940F1|rigid:HXUMTAPH/0umu2CCiAVVq06UbD8	false	-	mutation:26-26	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)