#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08709	uniprotkb:O70145	intact:EBI-444895|uniprotkb:Q91WT2|uniprotkb:Q9QWP4|uniprotkb:Q9QWW0	intact:EBI-9550667|uniprotkb:Q3TC92|uniprotkb:Q3U5S4|ensembl:ENSMUSP00000027754|ensembl:ENSMUSP00000140404	psi-mi:prdx6_mouse(display_long)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:Prdx6(gene name)|psi-mi:Prdx6(display_short)|uniprotkb:Aop2(gene name synonym)|uniprotkb:Ltw4(gene name synonym)|uniprotkb:Prdx5(gene name synonym)	psi-mi:ncf2_mouse(display_long)|uniprotkb:Ncf2(gene name)|psi-mi:Ncf2(display_short)|uniprotkb:Noxa2(gene name synonym)|uniprotkb:P67phox(gene name synonym)|uniprotkb:p67-phox(gene name synonym)|uniprotkb:67 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:NADPH oxidase activator 2(gene name synonym)|uniprotkb:Neutrophil NADPH oxidase factor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krishnaiah et al. (2013)	pubmed:23401562|imex:IM-22649	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9550665|imex:IM-22649-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031479.1|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032060"(bleb assembly)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|reactome:R-MMU-3299685|reactome:R-MMU-6798695|interpro:IPR013766(Thioredoxin domain)|mint:O08709|interpro:IPR036249	refseq:NP_035007.1|refseq:XP_006529299.1|ensembl:ENSMUSG00000026480(gene)|ensembl:ENSMUST00000027754(transcript)|ensembl:ENSMUST00000186568(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006742"(NADP catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034885|interpro:IPR034889|interpro:IPR035546|interpro:IPR036028|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:1B|agonist:Angiotensin  2|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2014/06/11	2014/10/16	rogid:3Hnse2vkowtSGEobI2LJX6WrNl410090	rogid:rKcEfbaXq+SiAvrGMy+FbcKqn6I10090	intact-crc:BC52CA03BF97BB6F|rigid:qDV1Muyc2JCf45SXm6mv244FS6w	false	phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O08709	uniprotkb:O70145	intact:EBI-444895|uniprotkb:Q91WT2|uniprotkb:Q9QWP4|uniprotkb:Q9QWW0	intact:EBI-9550667|uniprotkb:Q3TC92|uniprotkb:Q3U5S4|ensembl:ENSMUSP00000027754|ensembl:ENSMUSP00000140404	psi-mi:prdx6_mouse(display_long)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:Prdx6(gene name)|psi-mi:Prdx6(display_short)|uniprotkb:Aop2(gene name synonym)|uniprotkb:Ltw4(gene name synonym)|uniprotkb:Prdx5(gene name synonym)	psi-mi:ncf2_mouse(display_long)|uniprotkb:Ncf2(gene name)|psi-mi:Ncf2(display_short)|uniprotkb:Noxa2(gene name synonym)|uniprotkb:P67phox(gene name synonym)|uniprotkb:p67-phox(gene name synonym)|uniprotkb:67 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:NADPH oxidase activator 2(gene name synonym)|uniprotkb:Neutrophil NADPH oxidase factor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krishnaiah et al. (2013)	pubmed:23401562|imex:IM-22649	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9550674|imex:IM-22649-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031479.1|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032060"(bleb assembly)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|reactome:R-MMU-3299685|reactome:R-MMU-6798695|interpro:IPR013766(Thioredoxin domain)|mint:O08709|interpro:IPR036249	refseq:NP_035007.1|refseq:XP_006529299.1|ensembl:ENSMUSG00000026480(gene)|ensembl:ENSMUST00000027754(transcript)|ensembl:ENSMUST00000186568(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006742"(NADP catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034885|interpro:IPR034889|interpro:IPR035546|interpro:IPR036028|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:1C|agonist:Angiotensin  2|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2014/06/11	2014/10/16	rogid:3Hnse2vkowtSGEobI2LJX6WrNl410090	rogid:rKcEfbaXq+SiAvrGMy+FbcKqn6I10090	intact-crc:8EA6E79D40E86395|rigid:qDV1Muyc2JCf45SXm6mv244FS6w	false	phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O08709	uniprotkb:O70145	intact:EBI-444895|uniprotkb:Q91WT2|uniprotkb:Q9QWP4|uniprotkb:Q9QWW0	intact:EBI-9550667|uniprotkb:Q3TC92|uniprotkb:Q3U5S4|ensembl:ENSMUSP00000027754|ensembl:ENSMUSP00000140404	psi-mi:prdx6_mouse(display_long)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:Prdx6(gene name)|psi-mi:Prdx6(display_short)|uniprotkb:Aop2(gene name synonym)|uniprotkb:Ltw4(gene name synonym)|uniprotkb:Prdx5(gene name synonym)	psi-mi:ncf2_mouse(display_long)|uniprotkb:Ncf2(gene name)|psi-mi:Ncf2(display_short)|uniprotkb:Noxa2(gene name synonym)|uniprotkb:P67phox(gene name synonym)|uniprotkb:p67-phox(gene name synonym)|uniprotkb:67 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:NADPH oxidase activator 2(gene name synonym)|uniprotkb:Neutrophil NADPH oxidase factor 2(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Krishnaiah et al. (2013)	pubmed:23401562|imex:IM-22649	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9550702|imex:IM-22649-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031479.1|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032060"(bleb assembly)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|reactome:R-MMU-3299685|reactome:R-MMU-6798695|interpro:IPR013766(Thioredoxin domain)|mint:O08709|interpro:IPR036249	refseq:NP_035007.1|refseq:XP_006529299.1|ensembl:ENSMUSG00000026480(gene)|ensembl:ENSMUST00000027754(transcript)|ensembl:ENSMUST00000186568(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006742"(NADP catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034885|interpro:IPR034889|interpro:IPR035546|interpro:IPR036028|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:Figure 2|agonist:Angiotensin  2|antagonist:U0126 - a MAP kinase inhibitor|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2014/06/11	2014/10/16	rogid:3Hnse2vkowtSGEobI2LJX6WrNl410090	rogid:rKcEfbaXq+SiAvrGMy+FbcKqn6I10090	intact-crc:2A153D86CFCE6CDB|rigid:qDV1Muyc2JCf45SXm6mv244FS6w	false	phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30041	uniprotkb:O70145	intact:EBI-2255129|uniprotkb:A8JZY7|uniprotkb:P32077|uniprotkb:Q5TAH4|uniprotkb:Q5ZEZ8|ensembl:ENSP00000342026	intact:EBI-9550667|uniprotkb:Q3TC92|uniprotkb:Q3U5S4|ensembl:ENSMUSP00000027754|ensembl:ENSMUSP00000140404	psi-mi:prdx6_human(display_long)|uniprotkb:PRDX6(gene name)|psi-mi:PRDX6(display_short)|uniprotkb:AOP2(gene name synonym)|uniprotkb:KIAA0106(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:24 kDa protein(gene name synonym)|uniprotkb:Liver 2D page spot 40(gene name synonym)|uniprotkb:Red blood cells page spot 12(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:ncf2_mouse(display_long)|uniprotkb:Ncf2(gene name)|psi-mi:Ncf2(display_short)|uniprotkb:Noxa2(gene name synonym)|uniprotkb:P67phox(gene name synonym)|uniprotkb:p67-phox(gene name synonym)|uniprotkb:67 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:NADPH oxidase activator 2(gene name synonym)|uniprotkb:Neutrophil NADPH oxidase factor 2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Krishnaiah et al. (2013)	pubmed:23401562|imex:IM-22649	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9550741|imex:IM-22649-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004896.1|ensembl:ENSG00000117592(gene)|ensembl:ENST00000340385(transcript)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:1PRX|rcsb pdb:5B6M|rcsb pdb:5B6N|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0042744"(hydrogen peroxide catabolic process)	refseq:NP_035007.1|refseq:XP_006529299.1|ensembl:ENSMUSG00000026480(gene)|ensembl:ENSMUST00000027754(transcript)|ensembl:ENSMUST00000186568(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006742"(NADP catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034885|interpro:IPR034889|interpro:IPR035546|interpro:IPR036028|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	-	-	-	figure legend:Figure 3|comment:p67phox primarily binds to phosphoPrdx6, and this interaction is abolished by p67phox phosphorylation.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.14x10^-6(molar)	2014/06/11	2014/10/16	rogid:ZMsHgrAJf0VJiCELzo+zSi8Ji+49606	rogid:rKcEfbaXq+SiAvrGMy+FbcKqn6I10090	intact-crc:79A1ED0F1482B64F|rigid:o+tX0UXzJFoiji6gHIrUMoWUDZU	false	phosphorylated residue:?-?|his tag:c-c	O-phospho-L-threonine:233-233|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:40265"	uniprotkb:P30041	intact:EBI-9550797	intact:EBI-2255129|uniprotkb:A8JZY7|uniprotkb:P32077|uniprotkb:Q5TAH4|uniprotkb:Q5ZEZ8|ensembl:ENSP00000342026	psi-mi:1,2-di-o-palmitoyl-sn-glycero-3-phosphocholine(display_short)|psi-mi:"CHEBI:40265"(display_long)|intact:1,2-di-O-hexadecanoyl-sn-glycero-3-phosphocholine(synonym)|intact:1,2-Dipalmitoyl-3-sn-phosphatidylcholine(synonym)|intact:1,2-Dipalmitoyl-L-lecithin(synonym)|intact:1,2-dipalmitoyl-sn-glycero-3-phosphocholine(synonym)|intact:Dipalmitoyl phosphatidylcholine(synonym)|intact:DPPC(synonym)|intact:"PC(16:0/16:0)"(synonym)|intact:"(7R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-(hexadecanoyloxy)-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide"(iupac name)	psi-mi:prdx6_human(display_long)|uniprotkb:PRDX6(gene name)|psi-mi:PRDX6(display_short)|uniprotkb:AOP2(gene name synonym)|uniprotkb:KIAA0106(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:24 kDa protein(gene name synonym)|uniprotkb:Liver 2D page spot 40(gene name synonym)|uniprotkb:Red blood cells page spot 12(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:"MI:1145"(phospholipase assay)	Krishnaiah et al. (2013)	pubmed:23401562|imex:IM-22649	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:1146"(phospholipase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9678559|imex:IM-22649-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004896.1|ensembl:ENSG00000117592(gene)|ensembl:ENST00000340385(transcript)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:1PRX|rcsb pdb:5B6M|rcsb pdb:5B6N|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0042744"(hydrogen peroxide catabolic process)	go:"GO:0004620"(phospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)	inchi key:KILNVBDSWZSGLL-KXQOOQHDSA-O	-	figure legend:Figure 4-2|comment:The addition of p67phox inhibited the PLA2 activity of both native and phosphoPrdx6, while phosphorylated p67phox had no effect.|kinetics:p67-phox inhibits   non-competitively.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2014/10/16	-	rogid:ZMsHgrAJf0VJiCELzo+zSi8Ji+49606	intact-crc:F25409A6EBF6060B	false	3h radiolabel:9-10	phosphorylated residue:?-?|his tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:40265"	uniprotkb:O70145	intact:EBI-9550797	intact:EBI-9550667|uniprotkb:Q3TC92|uniprotkb:Q3U5S4|ensembl:ENSMUSP00000027754|ensembl:ENSMUSP00000140404	psi-mi:1,2-di-o-palmitoyl-sn-glycero-3-phosphocholine(display_short)|psi-mi:"CHEBI:40265"(display_long)|intact:1,2-di-O-hexadecanoyl-sn-glycero-3-phosphocholine(synonym)|intact:1,2-Dipalmitoyl-3-sn-phosphatidylcholine(synonym)|intact:1,2-Dipalmitoyl-L-lecithin(synonym)|intact:1,2-dipalmitoyl-sn-glycero-3-phosphocholine(synonym)|intact:Dipalmitoyl phosphatidylcholine(synonym)|intact:DPPC(synonym)|intact:"PC(16:0/16:0)"(synonym)|intact:"(7R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-(hexadecanoyloxy)-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide"(iupac name)	psi-mi:ncf2_mouse(display_long)|uniprotkb:Ncf2(gene name)|psi-mi:Ncf2(display_short)|uniprotkb:Noxa2(gene name synonym)|uniprotkb:P67phox(gene name synonym)|uniprotkb:p67-phox(gene name synonym)|uniprotkb:67 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:NADPH oxidase activator 2(gene name synonym)|uniprotkb:Neutrophil NADPH oxidase factor 2(gene name synonym)	psi-mi:"MI:1145"(phospholipase assay)	Krishnaiah et al. (2013)	pubmed:23401562|imex:IM-22649	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:1146"(phospholipase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9550778|imex:IM-22649-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035007.1|refseq:XP_006529299.1|ensembl:ENSMUSG00000026480(gene)|ensembl:ENSMUST00000027754(transcript)|ensembl:ENSMUST00000186568(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006742"(NADP catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034885|interpro:IPR034889|interpro:IPR035546|interpro:IPR036028|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	go:"GO:0004623"(phospholipase A2 activity)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:0004620"(phospholipase activity)	inchi key:KILNVBDSWZSGLL-KXQOOQHDSA-O	-	figure legend:Figure 4|comment:The addition of p67phox inhibited the PLA2 activity of both native and phosphoPrdx6, while phosphorylated p67phox had no effect.|kinetics:p67-phox inhibits   non-competitively.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2014/10/16	-	rogid:rKcEfbaXq+SiAvrGMy+FbcKqn6I10090	intact-crc:75E2E224D598478D	false	3h radiolabel:9-10	O-phospho-L-threonine:233-233|his tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:40265"	uniprotkb:P30041	intact:EBI-9550797	intact:EBI-2255129|uniprotkb:A8JZY7|uniprotkb:P32077|uniprotkb:Q5TAH4|uniprotkb:Q5ZEZ8|ensembl:ENSP00000342026	psi-mi:1,2-di-o-palmitoyl-sn-glycero-3-phosphocholine(display_short)|psi-mi:"CHEBI:40265"(display_long)|intact:1,2-di-O-hexadecanoyl-sn-glycero-3-phosphocholine(synonym)|intact:1,2-Dipalmitoyl-3-sn-phosphatidylcholine(synonym)|intact:1,2-Dipalmitoyl-L-lecithin(synonym)|intact:1,2-dipalmitoyl-sn-glycero-3-phosphocholine(synonym)|intact:Dipalmitoyl phosphatidylcholine(synonym)|intact:DPPC(synonym)|intact:"PC(16:0/16:0)"(synonym)|intact:"(7R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-(hexadecanoyloxy)-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide"(iupac name)	psi-mi:prdx6_human(display_long)|uniprotkb:PRDX6(gene name)|psi-mi:PRDX6(display_short)|uniprotkb:AOP2(gene name synonym)|uniprotkb:KIAA0106(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:24 kDa protein(gene name synonym)|uniprotkb:Liver 2D page spot 40(gene name synonym)|uniprotkb:Red blood cells page spot 12(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:"MI:1145"(phospholipase assay)	Krishnaiah et al. (2013)	pubmed:23401562|imex:IM-22649	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:1146"(phospholipase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9550778|imex:IM-22649-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004896.1|ensembl:ENSG00000117592(gene)|ensembl:ENST00000340385(transcript)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:1PRX|rcsb pdb:5B6M|rcsb pdb:5B6N|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0042744"(hydrogen peroxide catabolic process)	go:"GO:0004623"(phospholipase A2 activity)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:0004620"(phospholipase activity)	inchi key:KILNVBDSWZSGLL-KXQOOQHDSA-O	-	figure legend:Figure 4|comment:The addition of p67phox inhibited the PLA2 activity of both native and phosphoPrdx6, while phosphorylated p67phox had no effect.|kinetics:p67-phox inhibits   non-competitively.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/11	2014/10/16	-	rogid:ZMsHgrAJf0VJiCELzo+zSi8Ji+49606	intact-crc:75E2E224D598478D	false	3h radiolabel:9-10	his tag:c-c|phosphorylated residue:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)