#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13043	uniprotkb:Q06830	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846520|imex:IM-23209-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/10/16	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:C3EDAF57A8294590|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13043	uniprotkb:Q9H8S9	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-748229|uniprotkb:Q53S34|uniprotkb:Q9H3T5|uniprotkb:Q9HAI0|uniprotkb:Q9NVE2|ensembl:ENSP00000379364	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mob1a_human(display_long)|uniprotkb:MOB1A(gene name)|psi-mi:MOB1A(display_short)|uniprotkb:C2orf6(gene name synonym)|uniprotkb:MOB4B(gene name synonym)|uniprotkb:MOBK1B(gene name synonym)|uniprotkb:MOBKL1B(gene name synonym)|uniprotkb:Mob1 alpha(gene name synonym)|uniprotkb:Mob1 homolog 1B(gene name synonym)|uniprotkb:Mps one binder kinase activator-like 1B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974023|imex:IM-23209-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001304039.1|refseq:NP_001304040.1|refseq:NP_001304041.1|refseq:NP_060691.2|ensembl:ENSG00000114978(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0035329"(hippo signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005301(Mob1/phocein)|interpro:IPR036703|mint:Q9H8S9|rcsb pdb:1PI1|rcsb pdb:4J1V|rcsb pdb:4JIZ|rcsb pdb:5BRK|rcsb pdb:5BRM|rcsb pdb:5TWF|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:5XQZ|rcsb pdb:6MCP|rcsb pdb:6MCQ|reactome:R-HSA-2028269|ensembl:ENST00000396049(transcript)|dip:DIP-36594N	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:Gup4pRYJH3cfC6+XkgI27yiF7g89606	intact-crc:36141B680C37482D|rigid:aq+oNzI4T2ea2/bg9xSPlraWWW8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NWS0	uniprotkb:Q13043	intact:EBI-357318|intact:EBI-748162|uniprotkb:B4DGN7|uniprotkb:B4E2X7|uniprotkb:Q9BVL0|ensembl:ENSP00000262265|ensembl:ENSP00000470445	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:pihd1_human(display_long)|uniprotkb:PIH1D1(gene name)|psi-mi:PIH1D1(display_short)|uniprotkb:NOP17(gene name synonym)|uniprotkb:Nucleolar protein 17 homolog(gene name synonym)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974027|imex:IM-23209-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060386.1|ensembl:ENSG00000104872(gene)|ensembl:ENST00000262265(transcript)|ensembl:ENST00000596049(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042393"(histone binding)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0097255"(R2TP complex)|go:"GO:1900110"(negative regulation of histone H3-K9 dimethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR012981(Nop17p)|interpro:IPR041442|mint:Q9NWS0|rcsb pdb:4PSF|rcsb pdb:4PSI|rcsb pdb:6GXZ|rcsb pdb:7AVC	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:lugKS0BlzZYpMZn/7LFHODnFk0Q9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:0F0991B4221A07FB|rigid:nxSWGFajfVp2XJBIhDs8hzudrAo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13043	uniprotkb:Q13043	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974031|imex:IM-23209-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:C3B79AEBEFF798EE|rigid:mEgdkPao5cIqbWyph+uYwIbiWQQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13043	uniprotkb:Q9H4B6	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1017775|uniprotkb:Q6IA58|uniprotkb:Q9H949|uniprotkb:Q9HAK9|uniprotkb:A8K4B8|uniprotkb:D3DSB6|ensembl:ENSP00000324729	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:sav1_human(display_long)|uniprotkb:SAV1(gene name)|psi-mi:SAV1(display_short)|uniprotkb:WW45(gene name synonym)|uniprotkb:45 kDa WW domain protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974035|imex:IM-23209-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_068590.1|ensembl:ENSG00000151748(gene)|ensembl:ENST00000324679(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0035329"(hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR011524(SARAH)|interpro:IPR030030|interpro:IPR036020|mint:Q9H4B6|rcsb pdb:6AO5|reactome:R-HSA-2028269|dip:DIP-36127N	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:djvNX49LV19MDK/wNLfLkX2JMxM9606	intact-crc:EF4EE415CF82D8C6|rigid:JG/xKMgecUgY3WhgBiCzwBJ6WM8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13043	uniprotkb:Q9HBI1	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1047679|uniprotkb:Q5TGJ5|uniprotkb:Q86X93|uniprotkb:Q9NSP7|uniprotkb:Q9UGT3|uniprotkb:Q9Y368|uniprotkb:Q9Y3L6|uniprotkb:Q9Y3L7|uniprotkb:B0QYM8|uniprotkb:B2R9X6|uniprotkb:B0QYN1|uniprotkb:Q96PN1|ensembl:ENSP00000342492	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:parvb_human(display_long)|uniprotkb:Affixin(gene name synonym)|uniprotkb:PARVB(gene name)|psi-mi:PARVB(display_short)|uniprotkb:CGI-56(orf name)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974039|imex:IM-23209-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001003828.1|refseq:NP_037459.2|refseq:NP_001230315.1|refseq:NP_001230314.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR028433|interpro:IPR036872|mint:Q9HBI1|rcsb pdb:4EDL|rcsb pdb:4EDM|rcsb pdb:4EDN|reactome:R-HSA-446353|reactome:R-HSA-446388|ensembl:ENSG00000188677(gene)|ensembl:ENST00000338758(transcript)|go:"GO:0003779"(actin binding)	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:TgzllMJYQ4Ex1Mgc7Kuk1SdrrR89606	intact-crc:1471710C0AC36F4C|rigid:+nSOq6n8AFq03H/ZL4b4UZJIoTM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0CG47	uniprotkb:Q13043	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974043|imex:IM-23209-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:EF4F45630877FD4E|rigid:W7jsELgFlVpXTcwLvl9OuEzfwPI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13043	uniprotkb:Q16527	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2959737|ensembl:ENSP00000310901|ensembl:ENSP00000450056|uniprotkb:Q93030	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:csrp2_human(display_long)|uniprotkb:CSRP2(gene name)|psi-mi:CSRP2(display_short)|uniprotkb:LMO5(gene name synonym)|uniprotkb:SMLIM(gene name synonym)|uniprotkb:Cysteine-rich protein 2(gene name synonym)|uniprotkb:LIM domain only protein 5(gene name synonym)|uniprotkb:Smooth muscle cell LIM protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974047|imex:IM-23209-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001312.1|ensembl:ENSG00000175183(gene)|ensembl:ENST00000311083(transcript)|ensembl:ENST00000546966(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0060537"(muscle tissue development)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001287894.1	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:nyQ01E4UJb21IE/mZhZjXakJoyo9606	intact-crc:C3518A65A16A85EB|rigid:u5JetQd9ri1Rzhq662WNhvO11C0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BVQ7	uniprotkb:Q13043	intact:EBI-7950854|uniprotkb:Q9HA41|intact:MINT-4718214|uniprotkb:Q9H8W7|uniprotkb:C9JHR5|ensembl:ENSP00000305494	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:spa5l_human(display_long)|uniprotkb:SPATA5L1(gene name)|psi-mi:SPATA5L1(display_short)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974051|imex:IM-23209-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076968.2|refseq:NP_001310569.1|ensembl:ENSG00000171763(gene)|ensembl:ENST00000305560(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|mint:Q9BVQ7	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	comment:mint|comment:homomint	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:8FTQdkGYS4xx3pmJDk9xNtPy3Ao9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:F67E94AC4B9CF4D9|rigid:MZAGb92h7pdILbploBSoAsDTfTk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13043	uniprotkb:Q14BN4	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1043216|ensembl:ENSP00000499241|uniprotkb:Q14C95|uniprotkb:Q6AI54|uniprotkb:Q6UXC9|uniprotkb:Q6ZVQ8|uniprotkb:Q8NCW9|uniprotkb:Q9H297|uniprotkb:Q9HCH1|uniprotkb:Q9Y681	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:slmap_human(display_long)|uniprotkb:SLMAP(gene name)|psi-mi:SLMAP(display_short)|uniprotkb:KIAA1601(gene name synonym)|uniprotkb:SLAP(gene name synonym)|uniprotkb:UNQ1847/PRO3577(orf name)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974055|imex:IM-23209-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000163681(gene)|ensembl:ENST00000659705(transcript)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1905150"(regulation of voltage-gated sodium channel activity)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR030498|rcsb pdb:6AKM|rcsb pdb:6AR0|rcsb pdb:6AR2|refseq:XP_016862659.1|refseq:NP_009090.2|refseq:NP_001298107.1|refseq:NP_001298108.1|refseq:NP_001291349.1|refseq:NP_001291350.1|refseq:XP_005265518.1|refseq:XP_005265523.1|refseq:XP_005265528.1	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/11/07	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:K73SyLNTT+WZ/eE6gcjXw6yiOXQ9606	intact-crc:D11FE4119984662C|rigid:m8xH5jwbsHIeAsNinCuHvaueDNo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04179	uniprotkb:Q13043	intact:EBI-716989|intact:EBI-1058533|uniprotkb:P78434|uniprotkb:Q16792|uniprotkb:Q5TCM1|uniprotkb:Q96EE6|uniprotkb:Q9P2Z3|uniprotkb:B2R7R1|uniprotkb:E1P5A9|uniprotkb:B3KUK2|uniprotkb:B4E3K9|intact:EBI-11528264|uniprotkb:B4DL20|ensembl:ENSP00000356022|ensembl:ENSP00000446252	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:sodm_human(display_long)|uniprotkb:SOD2(gene name)|psi-mi:SOD2(display_short)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974061|imex:IM-23209-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019637.1|refseq:NP_000627.2|refseq:NP_001019636.1|refseq:NP_001309743.1|refseq:NP_001309744.1|refseq:NP_001309746.1|refseq:NP_001309748.1|refseq:NP_001309749.1|ensembl:ENSG00000112096(gene)|ensembl:ENST00000367055(transcript)|ensembl:ENST00000538183(transcript)|go:"GO:0000303"(response to superoxide)|go:"GO:0001315"(age-dependent response to reactive oxygen species)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003069"(acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003677"(DNA binding)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009409"(response to cold)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014823"(response to activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034021"(response to silicon dioxide)|go:"GO:0035900"(response to isolation stress)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071000"(response to magnetism)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902631"(negative regulation of membrane hyperpolarization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905932"(positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|interpro:IPR001189(Manganese and iron superoxide dismutase)|interpro:IPR019831|interpro:IPR019832|interpro:IPR019833|interpro:IPR036314|interpro:IPR036324|mint:P04179|rcsb pdb:1AP5|rcsb pdb:1AP6|rcsb pdb:1EM1|rcsb pdb:1JA8|rcsb pdb:1LUV|rcsb pdb:1LUW|rcsb pdb:1MSD|rcsb pdb:1N0J|rcsb pdb:1N0N|rcsb pdb:1PL4|rcsb pdb:1PM9|rcsb pdb:1QNM|rcsb pdb:1SZX|rcsb pdb:1VAR|rcsb pdb:1XDC|rcsb pdb:1XIL|rcsb pdb:1ZTE|rcsb pdb:1ZUQ|rcsb pdb:2ADP|rcsb pdb:2ADQ|rcsb pdb:2GDS|rcsb pdb:2P4K|rcsb pdb:2QKA|rcsb pdb:2QKC|rcsb pdb:3C3S|rcsb pdb:3C3T|rcsb pdb:5GXO|rcsb pdb:5T30|rcsb pdb:5VF9|rcsb pdb:7KKS|rcsb pdb:7KKU|rcsb pdb:7KKW|rcsb pdb:7KLB|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-8862803|reactome:R-HSA-8950505|rcsb pdb:1ZSP|reactome:R-HSA-9615017	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	-	-	figure legend:Suppl. Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2018/01/16	rogid:W5bvoLylgk4nEcm5peimceKIBbE9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:B6936F164D2A8B29|rigid:c8EtFeFuEgapnO3POTM6A0AQBqQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06830	uniprotkb:Q13043	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974817|imex:IM-23209-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	-	-	figure legend:Fig. 1a|agonist:"hydrogen peroxide (H2O2) (CHEBI:16240)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/14	2014/11/12	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:6BEC81A6E01C9E9E|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	ha tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q06830	uniprotkb:Q13043	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974835|imex:IM-23209-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	-	-	figure legend:Fig. 1b|agonist:"hydrogen peroxide (H2O2) (CHEBI:16240)"|comment:"No endogenous Mst1 co-precipitated with streptavidin beads from cells not treated with hydrogen peroxide (H2O2) (CHEBI:16240)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/14	2014/11/12	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:FDC101D66E4BD071|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	sbp:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13043	uniprotkb:Q06830	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974841|imex:IM-23209-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:Fig. 1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/14	2014/11/12	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:82B99EEC4D7E9A4F|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	sbp:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13043	uniprotkb:Q06830	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974869|imex:IM-23209-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:Fig. 1f, 1g|agonist:"hydrogen peroxide (H2O2) (CHEBI:16240)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/14	2014/11/12	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:9751F907A2E05A48|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	myc tag:n-n|mutation increasing interaction:59-59	ha tag:n-n|mutation decreasing interaction:52-52,173-173	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13188	uniprotkb:Q06830	intact:EBI-992580|uniprotkb:Q15445|uniprotkb:Q15801|uniprotkb:Q96FM6|uniprotkb:A8K722|ensembl:ENSP00000390500|uniprotkb:B3KYA7	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:stk3_human(display_long)|uniprotkb:STE20-like kinase MST2(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-1(gene name synonym)|uniprotkb:STK3(gene name)|psi-mi:STK3(display_short)|uniprotkb:MST2(gene name synonym)|uniprotkb:KRS1(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974883|imex:IM-23209-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243241.1|refseq:NP_006272.2|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR036674|mint:Q13188|rcsb pdb:3WWS|rcsb pdb:4HKD|rcsb pdb:4L0N|rcsb pdb:4LG4|rcsb pdb:4LGD|rcsb pdb:4OH9|rcsb pdb:5BRM|rcsb pdb:5DH3|rcsb pdb:6AO5|rcsb pdb:6AR2|reactome:R-HSA-2028269|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0106311"|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000104375(gene)|ensembl:ENST00000419617(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001841"(neural tube formation)|go:"GO:0003157"(endocardium development)|dip:DIP-36128N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:Fig. 1h|agonist:"hydrogen peroxide (H2O2) (CHEBI:16240)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/14	2014/11/12	rogid:slrC4Ax6263chBC1DJygdoExuCc9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:58529F1CDB18A873|rigid:zXouzJTxzNna9c06pQExqfxnUEM	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06830	uniprotkb:Q13043	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9974860|imex:IM-23209-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	-	-	figure legend:Fig. 1e|agonist:"hydrogen peroxide (H2O2) (CHEBI:16240)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/11/12	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:DB2746BE398098C0|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	-	ha tag:n-n|sbp:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06830	uniprotkb:Q13043	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049373|imex:IM-23209-18	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 3a, 3d, 3e, 3f|causality statement:Q13043 is required for phosphorylation of Q06830|causality statement:Q13043 decreases activity of Q06830|causality statement:"CHEBI:16240 increases binding of Q13043 to Q06830"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/14	2014/12/23	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:5B07C04722B9F2FE|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	mutation decreasing interaction rate:90-90|mutation decreasing interaction rate:111-111|mutation decreasing interaction rate:18-18|mutation decreasing interaction rate:156-156|mutation decreasing interaction rate:183-183|mutation decreasing interaction rate:18-18,90-90|mutation decreasing interaction rate:18-18,90-90,183-183|mutation decreasing interaction rate:18-18,90-90,156-156,183-183|mutation decreasing interaction rate:18-18,90-90,111-111,183-183	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q13043	uniprotkb:Q06830	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049445|imex:IM-23209-19	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 3b|resulting-ptm:Q06830 thr-18 O-phospho-L-threonine, thr-90 O-phospho-L-threonine, thr-111 O-phospho-L-threonine, thr-156 O-phospho-L-threonine, thr-183 O-phospho-L-threonine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:F8FF71B6EBC54E97|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16240"	uniprotkb:Q06830	intact:EBI-6927689|chebi:"CHEBI:13354"|chebi:"CHEBI:13355"|chebi:"CHEBI:295106"|chebi:"CHEBI:24637"|chebi:"CHEBI:44812"|chebi:"CHEBI:5586"	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:hydrogen peroxide(display_short)|psi-mi:"CHEBI:16240"(display_long)|intact:"[OH(OH)]"(synonym)|intact:dihydrogen dioxide(synonym)|intact:H2O2(synonym)|intact:HOOH(synonym)|intact:Hydrogen peroxide(synonym)|intact:HYDROGEN PEROXIDE(synonym)|intact:Oxydol(synonym)|intact:"bis(hydridooxygen)(O--O)"(iupac name)|intact:dihydrogen peroxide(iupac name)|intact:"dihydrogen(peroxide)"(iupac name)|intact:dioxidane(iupac name)|intact:hydrogen peroxide(iupac name)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0979"(oxidoreductase assay)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049463|imex:IM-23209-24	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0051920"(peroxiredoxin activity)	inchi key:MHAJPDPJQMAIIY-UHFFFAOYSA-N	-	figure legend:Fig. 4b, 4c, 5|comment:Prdx1 peroxidase activity was higher in the Prdx1 fraction compared to the phosphorylated Prdx1 fraction.|causality statement:"Q06830 is required for reduction of CHEBI:16240"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/14	2015/01/08	-	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:9F4B536431787D11	false	-	mutation disrupting interaction rate:90-90|mutation disrupting interaction rate:90-90|mutation decreasing interaction rate:183-183	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13043	uniprotkb:Q06830	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049490|imex:IM-23209-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:Suppl. Fig. S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:B2A5FEAB761F1B7C|rigid:HqE1PrPIsek7kAKtf6k1IyflQts	false	glutathione s tranferase tag:n-n	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13043	uniprotkb:P50749	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-960081|uniprotkb:Q17S06|uniprotkb:Q53HD0|uniprotkb:Q6AHZ2|uniprotkb:A6NIX9|uniprotkb:A8K5Z3|uniprotkb:Q8IZA5|ensembl:ENSP00000368684|ensembl:ENSP00000368710	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rasf2_human(display_long)|uniprotkb:RASSF2(gene name)|psi-mi:RASSF2(display_short)|uniprotkb:KIAA0168(gene name synonym)|uniprotkb:CENP-34(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_055552.1|refseq:NP_739580.1|refseq:XP_005260952.1|refseq:XP_016883639.1|refseq:XP_016883640.1|refseq:XP_016883641.1|refseq:XP_016883642.1|ensembl:ENSG00000101265(gene)|ensembl:ENST00000379376(transcript)|ensembl:ENST00000379400(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0038168"(epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046849"(bone remodeling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050821"(protein stabilization)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000159(Ras-association)|interpro:IPR011524(SARAH)|interpro:IPR029071|interpro:IPR033614|interpro:IPR033618|mint:P50749	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:rHOuV9DDbLYoQvm4W6RNF3V2fUo9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9BUF5	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9HCC0	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2211296|uniprotkb:A6NIY9|uniprotkb:Q96C27|uniprotkb:Q9Y4L7|ensembl:ENSP00000343657	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mccb_human(display_long)|uniprotkb:MCCC2(gene name)|psi-mi:MCCC2(display_short)|uniprotkb:MCCB(gene name synonym)|uniprotkb:"3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta"(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase 2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_071415.1|refseq:XP_005248624.1|ensembl:ENSG00000131844(gene)|ensembl:ENST00000340941(transcript)|go:"GO:0002169"(3-methylcrotonyl-CoA carboxylase complex, mitochondrial)|go:"GO:0004485"(methylcrotonoyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:1905202"(methylcrotonoyl-CoA carboxylase complex)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR029045|interpro:IPR034733|mint:Q9HCC0|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70895	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:5NkqDKqdX1wHsbqXW7v5+/Gld109606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P01876	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-727651|ensembl:ENSP00000374989|ensembl:ENSP00000488021	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:igha1_human(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short)|uniprotkb:Ig alpha-1 chain C region(gene name synonym)|uniprotkb:Ig alpha-1 chain C region BUR(gene name synonym)|uniprotkb:Ig alpha-1 chain C region TRO(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000211895(gene)|ensembl:ENSG00000282633(gene)|ensembl:ENST00000390547(transcript)|ensembl:ENST00000633714(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IGA|rcsb pdb:1OW0|rcsb pdb:2ESG|rcsb pdb:2QEJ|rcsb pdb:3CHN|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6XJA|reactome:R-HSA-202733|reactome:R-HSA-2168880|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:Mystbtg9uttxFXl//LGdoM32po09606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P02788	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1058602|ensembl:ENSP00000231751|uniprotkb:O00756|uniprotkb:Q16780|uniprotkb:Q16785|uniprotkb:Q16786|uniprotkb:Q16789|uniprotkb:Q8IU92|uniprotkb:Q8IZH6|uniprotkb:Q8TCD2|uniprotkb:Q96KZ4|uniprotkb:Q96KZ5|uniprotkb:Q9H1Z3|uniprotkb:Q9UCY5|uniprotkb:B7Z4X2|uniprotkb:E7EQH5|uniprotkb:B2MV13|uniprotkb:Q5DSM0|uniprotkb:A8K9U8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:trfl_human(display_long)|uniprotkb:LTF(gene name)|psi-mi:LTF(display_short)|uniprotkb:LF(gene name synonym)|uniprotkb:Talalactoferrin(gene name synonym)|uniprotkb:GIG12(gene name synonym)|uniprotkb:Growth-inhibiting protein 12(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001308050.1|ensembl:ENST00000231751(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0006959"(humoral immune response)|go:"GO:0008201"(heparin binding)|ensembl:ENSG00000012223(gene)|refseq:NP_001186078.1|refseq:NP_002334.2|go:"GO:0009986"(cell surface)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0030141"(secretory granule)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1900159"(positive regulation of bone mineralization involved in bone maturation)|go:"GO:1900229"(negative regulation of single-species biofilm formation in or on host organism)|go:"GO:0042581"(specific granule)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000308"("negative regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:2001205"(negative regulation of osteoclast development)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0048525"(negative regulation of viral process)|interpro:IPR016357(Transferrin)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051673"(membrane disruption in another organism)|interpro:IPR018195|interpro:IPR030684|mint:P02788|rcsb pdb:1B0L|rcsb pdb:1BKA|rcsb pdb:1CB6|rcsb pdb:1DSN|rcsb pdb:1EH3|rcsb pdb:1FCK|rcsb pdb:1H43|rcsb pdb:1H44|rcsb pdb:1H45|rcsb pdb:1HSE|rcsb pdb:1L5T|rcsb pdb:1LCF|rcsb pdb:1LCT|rcsb pdb:1LFG|rcsb pdb:1LFH|rcsb pdb:1LFI|rcsb pdb:1LGB|rcsb pdb:1N76|rcsb pdb:1SQY|rcsb pdb:1VFD|rcsb pdb:1VFE|rcsb pdb:1XV4|rcsb pdb:1XV7|rcsb pdb:1Z6V|rcsb pdb:1Z6W|rcsb pdb:2BJJ|rcsb pdb:2DP4|rcsb pdb:2GMC|rcsb pdb:2GMD|rcsb pdb:2HD4|rcsb pdb:2PMS|reactome:R-HSA-1222449|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-6803157|reactome:R-HSA-977225|rcsb pdb:1U62|refseq:NP_001308051.1|dip:DIP-41354N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:OLhbdYXPaD10eAg3HyhCA5Akw8o9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q15696	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-6657923|ensembl:ENSP00000303015|uniprotkb:Q14D69	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:u2afm_human(display_long)|uniprotkb:ZRSR2(gene name)|psi-mi:ZRSR2(display_short)|uniprotkb:CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-20(gene name synonym)|uniprotkb:"U2(RNU2) small nuclear RNA auxiliary factor 1-like 2"(gene name synonym)|uniprotkb:U2AF1-RS2(gene name synonym)|uniprotkb:U2AF1L2(gene name synonym)|uniprotkb:U2AF1RS2(gene name synonym)|uniprotkb:U2AF35-related protein(gene name synonym)|uniprotkb:URP(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000169249(gene)|ensembl:ENST00000307771(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR009145(U2 auxiliary factor small subunit)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|reactome:R-HSA-72165|go:"GO:0042802"(identical protein binding)|dip:DIP-62117N|refseq:NP_005080.1	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:F/pwj2ZqRutuCgfyKmvoVLWwHzo9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9H4B6	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1017775|uniprotkb:Q6IA58|uniprotkb:Q9H949|uniprotkb:Q9HAK9|uniprotkb:A8K4B8|uniprotkb:D3DSB6|ensembl:ENSP00000324729	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:sav1_human(display_long)|uniprotkb:SAV1(gene name)|psi-mi:SAV1(display_short)|uniprotkb:WW45(gene name synonym)|uniprotkb:45 kDa WW domain protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_068590.1|ensembl:ENSG00000151748(gene)|ensembl:ENST00000324679(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0035329"(hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR011524(SARAH)|interpro:IPR030030|interpro:IPR036020|mint:Q9H4B6|rcsb pdb:6AO5|reactome:R-HSA-2028269|dip:DIP-36127N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:djvNX49LV19MDK/wNLfLkX2JMxM9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q59FY4	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-10049509|ensembl:ENSP00000483969|ensembl:ENSP00000488846	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:q59fy4_human(display_long)|uniprotkb:ACACA(gene name)|psi-mi:ACACA(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000275176(gene)|ensembl:ENSG00000278540(gene)|ensembl:ENST00000619546(transcript)|ensembl:ENST00000632453(transcript)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006633"(fatty acid biosynthetic process)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR029045|interpro:IPR034733	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:+mtBPqrwam54pjT8gYaHCkzqUOk9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P02768	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P20930	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1058782|ensembl:ENSP00000357789|uniprotkb:Q01720|uniprotkb:Q5T583|uniprotkb:Q9UC71	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:fila_human(display_long)|uniprotkb:FLG(gene name)|psi-mi:FLG(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENST00000368799(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007275"(multicellular organism development)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0036457"(keratohyalin granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0061436"(establishment of skin barrier)|ensembl:ENSG00000143631(gene)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003303(Filaggrin)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034325|rcsb pdb:4PCW|reactome:R-HSA-6809371|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_002007.1	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:RXgRbd4W6ydxD/M1cEUUzUFGuJ09606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P08107	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P07900	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9BQE3	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1103245|ensembl:ENSP00000301072	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tba1c_human(display_long)|uniprotkb:TUBA1C(gene name)|psi-mi:TUBA1C(display_short)|uniprotkb:TUBA6(gene name synonym)|uniprotkb:Tubulin alpha-6 chain(gene name synonym)|uniprotkb:Alpha-tubulin 6(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|ensembl:ENSG00000167553(gene)|ensembl:ENST00000301072(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031982"(vesicle)|go:"GO:0051301"(cell division)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BQE3|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_116093.1	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:53r1CNUJNgCreVCw4riUsTPh+yw9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9GZY4	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P38646	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P25311	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2513837|ensembl:ENSP00000292401|uniprotkb:Q5XKQ4|uniprotkb:O60386|uniprotkb:Q8N4N0|uniprotkb:D6W5T8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:za2g_human(display_long)|uniprotkb:AZGP1(gene name)|psi-mi:AZGP1(display_short)|uniprotkb:ZAG(gene name synonym)|uniprotkb:ZNGP1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000160862(gene)|ensembl:ENST00000292401(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|interpro:IPR036179|interpro:IPR037055|mint:P25311|rcsb pdb:1T7V|rcsb pdb:1T7W|rcsb pdb:1T7X|rcsb pdb:1T7Y|rcsb pdb:1T7Z|rcsb pdb:1T80|rcsb pdb:1ZAG|rcsb pdb:3ES6|rcsb pdb:6R2U|reactome:R-HSA-5223345|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_001176.1	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:3Fp6qALNiZRqsI8Kh2lTQ9IMYek9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q6LC01	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-9201722	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:q6lc01_human(display_long)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	interpro:IPR002453(Beta tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR023123|go:"GO:0003924"(GTPase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|interpro:IPR036525|interpro:IPR037103	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:/WGeYWB5j/CRWcvsU2CL4CdOLcY9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P11021	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q13748	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-355068|uniprotkb:A6NJQ0|uniprotkb:Q5W099|uniprotkb:Q6PEY3|uniprotkb:Q96F18|uniprotkb:P0DPH8|uniprotkb:P0DPH7	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tba3c_human(display_long)|uniprotkb:TUBA3C(gene name)|psi-mi:TUBA3C(display_short)|uniprotkb:TUBA3D(gene name)|psi-mi:TUBA3D(display_short)|uniprotkb:TUBA2(gene name synonym)|uniprotkb:Alpha-tubulin 3C/D(gene name synonym)|uniprotkb:Tubulin alpha-2 chain(gene name synonym)|uniprotkb:Alpha-tubulin 2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	go:"GO:0005200"(structural constituent of cytoskeleton)|ensembl:ENSG00000075886|ensembl:ENSG00000198033|ensembl:ENSP00000326042|ensembl:ENSP00000382982|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005525"(GTP binding)|go:"GO:0003924"(GTPase activity)|refseq:NP_005992.1|refseq:NP_525125.2|interpro:IPR002452(Alpha tubulin)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|ensembl:ENSP00000482878|ensembl:ENST00000618094|reactome:R-HSA-6807878|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-983189|go:"GO:0007017"(microtubule-based process)|go:"GO:0005634"(nucleus)|ensembl:ENST00000321253|ensembl:ENST00000400113|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-8852276|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR023123|mint:Q13748|dip:DIP-34513N|reactome:R-HSA-3371497|reactome:R-HSA-8955332|interpro:IPR036525|interpro:IPR037103|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0036064"(ciliary basal body)	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:mE1Hcdc9AAMMxfxzKB6TfM6RrHE9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P54652	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9NS23	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-367363|uniprotkb:B7ZLL1|uniprotkb:Q0VGC6|uniprotkb:O14571|uniprotkb:O60539|uniprotkb:O60710|uniprotkb:Q9HB04|uniprotkb:Q9HB18|uniprotkb:Q9NS22|uniprotkb:Q9UND4|uniprotkb:Q9UND5|intact:EBI-2556435|uniprotkb:Q5TZT2|ensembl:ENSP00000349547	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rasf1_human(display_long)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:XP_011531617.1|refseq:XP_011531618.1|refseq:NP_001193886.1|refseq:NP_009113.3|refseq:NP_733830.1|refseq:NP_733831.1|refseq:NP_733832.1|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|interpro:IPR000159(Ras-association)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011524(SARAH)|interpro:IPR029071|interpro:IPR033600|interpro:IPR033614|mint:Q9NS23|rcsb pdb:2KZU|ensembl:ENSG00000068028(gene)|ensembl:ENST00000357043(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|dip:DIP-31270N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:kMwpeQ92/ax7NZwtEVal0/XilaI9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P17066	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-355106|uniprotkb:Q8IYK7|uniprotkb:Q9BT95|uniprotkb:Q1HBA8|ensembl:ENSP00000310219	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hsp76_human(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_002146.2|ensembl:ENSG00000173110(gene)|ensembl:ENST00000309758(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P17066|rcsb pdb:3FE1|reactome:R-HSA-3371453|reactome:R-HSA-6798695	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:AcNwJ2S/RD3n/8iRNy5ioetVZ+U9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9H4B7	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2949748|ensembl:ENSP00000217133	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tbb1_human(display_long)|uniprotkb:TUBB1(gene name)|psi-mi:TUBB1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000101162(gene)|ensembl:ENST00000217133(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0051225"(spindle assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9H4B7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-983189|reactome:R-HSA-9668328|refseq:NP_110400.1|dip:DIP-42487N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:6bCGUsGUoUdlvvDkLH2G+2V3cdc9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q13188	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-992580|uniprotkb:Q15445|uniprotkb:Q15801|uniprotkb:Q96FM6|uniprotkb:A8K722|ensembl:ENSP00000390500|uniprotkb:B3KYA7	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:stk3_human(display_long)|uniprotkb:STE20-like kinase MST2(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-1(gene name synonym)|uniprotkb:STK3(gene name)|psi-mi:STK3(display_short)|uniprotkb:MST2(gene name synonym)|uniprotkb:KRS1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001243241.1|refseq:NP_006272.2|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR036674|mint:Q13188|rcsb pdb:3WWS|rcsb pdb:4HKD|rcsb pdb:4L0N|rcsb pdb:4LG4|rcsb pdb:4LGD|rcsb pdb:4OH9|rcsb pdb:5BRM|rcsb pdb:5DH3|rcsb pdb:6AO5|rcsb pdb:6AR2|reactome:R-HSA-2028269|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0106311"|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000104375(gene)|ensembl:ENST00000419617(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001841"(neural tube formation)|go:"GO:0003157"(endocardium development)|dip:DIP-36128N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:slrC4Ax6263chBC1DJygdoExuCc9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P11142	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049507|imex:IM-23209-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	-	-	figure legend:Suppl. Table S2|comment:Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under non-oxidative stress conditions.|caution:The participants indicated by the gene symbols HS70L, KAC and KV2A in table S2 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here. The sequence of Q65ZQ1 has been withdrawn from uniprot, hence it was not captured as a participant in the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:A11144796CE33C86|rigid:SehXoZzy7uEjrczpKdBu+Ok1G/M	false	ha tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P50749	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-960081|uniprotkb:Q17S06|uniprotkb:Q53HD0|uniprotkb:Q6AHZ2|uniprotkb:A6NIX9|uniprotkb:A8K5Z3|uniprotkb:Q8IZA5|ensembl:ENSP00000368684|ensembl:ENSP00000368710	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rasf2_human(display_long)|uniprotkb:RASSF2(gene name)|psi-mi:RASSF2(display_short)|uniprotkb:KIAA0168(gene name synonym)|uniprotkb:CENP-34(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_055552.1|refseq:NP_739580.1|refseq:XP_005260952.1|refseq:XP_016883639.1|refseq:XP_016883640.1|refseq:XP_016883641.1|refseq:XP_016883642.1|ensembl:ENSG00000101265(gene)|ensembl:ENST00000379376(transcript)|ensembl:ENST00000379400(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0038168"(epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046849"(bone remodeling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050821"(protein stabilization)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000159(Ras-association)|interpro:IPR011524(SARAH)|interpro:IPR029071|interpro:IPR033614|interpro:IPR033618|mint:P50749	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:rHOuV9DDbLYoQvm4W6RNF3V2fUo9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P04792	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P16403	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-358372|ensembl:ENSP00000339566|uniprotkb:A8K4I2	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:h12_human(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:H1F2(gene name synonym)|uniprotkb:HIST1H1C(gene name synonym)|uniprotkb:Histone H1c(gene name synonym)|uniprotkb:Histone H1d(gene name synonym)|uniprotkb:Histone H1s-1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005310.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0098532"(histone H3-K27 trimethylation)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P16403|reactome:R-HSA-140342|reactome:R-HSA-2559584|ensembl:ENSG00000187837(gene)|ensembl:ENST00000343677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0035327"|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-36359N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:eRT5bTyBJUg6nRANMRYZekT4N+g9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P25311	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2513837|ensembl:ENSP00000292401|uniprotkb:Q5XKQ4|uniprotkb:O60386|uniprotkb:Q8N4N0|uniprotkb:D6W5T8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:za2g_human(display_long)|uniprotkb:AZGP1(gene name)|psi-mi:AZGP1(display_short)|uniprotkb:ZAG(gene name synonym)|uniprotkb:ZNGP1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000160862(gene)|ensembl:ENST00000292401(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|interpro:IPR036179|interpro:IPR037055|mint:P25311|rcsb pdb:1T7V|rcsb pdb:1T7W|rcsb pdb:1T7X|rcsb pdb:1T7Y|rcsb pdb:1T7Z|rcsb pdb:1T80|rcsb pdb:1ZAG|rcsb pdb:3ES6|rcsb pdb:6R2U|reactome:R-HSA-5223345|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_001176.1	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:3Fp6qALNiZRqsI8Kh2lTQ9IMYek9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q96RQ3	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2211703|uniprotkb:Q59ES4|uniprotkb:Q9H959|uniprotkb:Q9NS97|ensembl:ENSP00000265594	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mcca_human(display_long)|uniprotkb:MCCC1(gene name)|psi-mi:MCCC1(display_short)|uniprotkb:MCCA(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase 1(gene name synonym)|uniprotkb:"3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha"(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase biotin-containing subunit(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_064551.3|refseq:NP_001280202.1|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR016185(PreATP-grasp-like fold)|mint:Q96RQ3|rcsb pdb:2EJM|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70895|ensembl:ENSG00000078070(gene)|ensembl:ENST00000265594(transcript)|go:"GO:0002169"(3-methylcrotonyl-CoA carboxylase complex, mitochondrial)|go:"GO:0004075"(biotin carboxylase activity)|go:"GO:0004485"(methylcrotonoyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006768"(biotin metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0016421"(CoA carboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:1905202"(methylcrotonoyl-CoA carboxylase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:obze7v7i2yTIIcJjd7laIriNFg89606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q13188	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-992580|uniprotkb:Q15445|uniprotkb:Q15801|uniprotkb:Q96FM6|uniprotkb:A8K722|ensembl:ENSP00000390500|uniprotkb:B3KYA7	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:stk3_human(display_long)|uniprotkb:STE20-like kinase MST2(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-1(gene name synonym)|uniprotkb:STK3(gene name)|psi-mi:STK3(display_short)|uniprotkb:MST2(gene name synonym)|uniprotkb:KRS1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001243241.1|refseq:NP_006272.2|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR036674|mint:Q13188|rcsb pdb:3WWS|rcsb pdb:4HKD|rcsb pdb:4L0N|rcsb pdb:4LG4|rcsb pdb:4LGD|rcsb pdb:4OH9|rcsb pdb:5BRM|rcsb pdb:5DH3|rcsb pdb:6AO5|rcsb pdb:6AR2|reactome:R-HSA-2028269|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0106311"|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000104375(gene)|ensembl:ENST00000419617(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001841"(neural tube formation)|go:"GO:0003157"(endocardium development)|dip:DIP-36128N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:slrC4Ax6263chBC1DJygdoExuCc9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q08188	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1050019|uniprotkb:A8K5N6|uniprotkb:Q32MM0|uniprotkb:O95933|uniprotkb:Q32ML9|uniprotkb:B2RCR6|uniprotkb:D3DVX1|ensembl:ENSP00000370867	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tgm3_human(display_long)|uniprotkb:Transglutaminase-3(gene name synonym)|uniprotkb:TGM3(gene name)|psi-mi:TGM3(display_short)|uniprotkb:Transglutaminase E(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_003236.3|ensembl:ENSG00000125780(gene)|ensembl:ENST00000381458(transcript)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0003824"(catalytic activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031424"(keratinization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043163"(cell envelope organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:Q08188|rcsb pdb:1L9M|rcsb pdb:1L9N|rcsb pdb:1NUD|rcsb pdb:1NUF|rcsb pdb:1NUG	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:5UuVUvhYOaQcLJQO2myrilPgFFw9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P0CG04	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1221063|uniprotkb:P80423|uniprotkb:A0M8Q4|uniprotkb:P01842|uniprotkb:A0A075B6K8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:iglc1_human(display_long)|uniprotkb:IGLC1(gene name)|psi-mi:IGLC1(display_short)|uniprotkb:Ig lambda chain C region MGC(gene name synonym)|uniprotkb:Ig lambda-1 chain C region(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|mint:P0CG04|interpro:IPR036179|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1ZVO|rcsb pdb:2FB4|rcsb pdb:2IG2|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|go:"GO:0045087"(innate immune response)|reactome:R-HSA-2871837|reactome:R-HSA-5690714|reactome:R-HSA-9664422|reactome:R-HSA-977606|reactome:R-HSA-983695|reactome:R-HSA-9664323	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:OOdxBXPI2Jzf9HxurFZjk3/L1DM9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:A6NMY6	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2513389	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:axa2l_human(display_long)|uniprotkb:ANXA2P2(gene name)|psi-mi:ANXA2P2(display_short)|uniprotkb:ANX2L2(gene name synonym)|uniprotkb:ANX2P2(gene name synonym)|uniprotkb:LPC2B(gene name synonym)|uniprotkb:Annexin A2 pseudogene 2(gene name synonym)|uniprotkb:Lipocortin II pseudogene(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002020"(protease binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0031982"(vesicle)|go:"GO:0042470"(melanosome)|go:"GO:0046790"(virion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR018502|interpro:IPR018252|interpro:IPR002389(Annexin, type II)|mint:A6NMY6|interpro:IPR037104	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:1dVlFkkFYmN/Yn3Kv7/sCStcX089606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P11021	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9NZT1	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1051681|uniprotkb:Q8IXU8|uniprotkb:Q5SQI3|ensembl:ENSP00000369689	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:call5_human(display_long)|uniprotkb:Calmodulin-like skin protein(gene name synonym)|uniprotkb:CALML5(gene name)|psi-mi:CALML5(display_short)|uniprotkb:CLSP(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_059118.2|ensembl:ENST00000380332(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q9NZT1|rcsb pdb:2B1U|reactome:R-HSA-6798695|ensembl:ENSG00000178372(gene)	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:uPD/avsoqpiogqHCK5TGJQwvCX89606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P42357	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-10049552|uniprotkb:B4DQC1|uniprotkb:B4E0V8|uniprotkb:F5GXF2|uniprotkb:F5H1U5|uniprotkb:Q4VB92|uniprotkb:Q4VB93|ensembl:ENSP00000261208	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:huth_human(display_long)|uniprotkb:HAL(gene name)|psi-mi:HAL(display_short)|uniprotkb:HIS(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001245262.1|refseq:NP_001245263.1|refseq:NP_002099.1|ensembl:ENSG00000084110(gene)|ensembl:ENST00000261208(transcript)|go:"GO:0004397"(histidine ammonia-lyase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006548"(histidine catabolic process)|go:"GO:0016841"(ammonia-lyase activity)|go:"GO:0019556"(histidine catabolic process to glutamate and formamide)|go:"GO:0019557"(histidine catabolic process to glutamate and formate)|interpro:IPR001106(Phenylalanine/histidine ammonia-lyase)|interpro:IPR005921(Histidine ammonia-lyase)|interpro:IPR021922|interpro:IPR022313|interpro:IPR024083|reactome:R-HSA-70921|interpro:IPR008948(L-Aspartase-like)	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:t6E3MyflSEAoJXZSBRuSdI2Sczk9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q562R1	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1773495|uniprotkb:Q562R2|uniprotkb:Q562S9|uniprotkb:Q562X8|uniprotkb:B2RPJ1|ensembl:ENSP00000416706	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:actbl_human(display_long)|uniprotkb:ACTBL2(gene name)|psi-mi:ACTBL2(display_short)|uniprotkb:Kappa-actin(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001017992.1|ensembl:ENSG00000169067(gene)|ensembl:ENST00000423391(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0007409"(axonogenesis)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0045202"(synapse)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:Q562R1	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:GTzKP5YRJGH8ocAJW0WEsdQFEdc9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P04083	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354007|ensembl:ENSP00000257497|ensembl:ENSP00000366109|uniprotkb:B5BU38	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:anxa1_human(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:LPC1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_000691.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|ensembl:ENSG00000135046(gene)|ensembl:ENST00000257497(transcript)|ensembl:ENST00000376911(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|refseq:XP_011516911.1|dip:DIP-32875N|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P04083|rcsb pdb:1AIN|rcsb pdb:1BO9|rcsb pdb:1QLS|rcsb pdb:5VFW|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-445355|reactome:R-HSA-6785807|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:QKmqz+UsAof35B/so2qKLQjn2v09606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9HCC0	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2211296|uniprotkb:A6NIY9|uniprotkb:Q96C27|uniprotkb:Q9Y4L7|ensembl:ENSP00000343657	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mccb_human(display_long)|uniprotkb:MCCC2(gene name)|psi-mi:MCCC2(display_short)|uniprotkb:MCCB(gene name synonym)|uniprotkb:"3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta"(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase 2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_071415.1|refseq:XP_005248624.1|ensembl:ENSG00000131844(gene)|ensembl:ENST00000340941(transcript)|go:"GO:0002169"(3-methylcrotonyl-CoA carboxylase complex, mitochondrial)|go:"GO:0004485"(methylcrotonoyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:1905202"(methylcrotonoyl-CoA carboxylase complex)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR029045|interpro:IPR034733|mint:Q9HCC0|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70895	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:5NkqDKqdX1wHsbqXW7v5+/Gld109606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q05639	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354943|ensembl:ENSP00000217182|uniprotkb:P54266|uniprotkb:Q0VGC7|uniprotkb:B5BUF3|uniprotkb:E1P5J1	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ef1a2_human(display_long)|uniprotkb:EEF1A2(gene name)|psi-mi:EEF1A2(display_short)|uniprotkb:EEF1AL(gene name synonym)|uniprotkb:STN(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-2(gene name synonym)|uniprotkb:Statin-S1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000101210(gene)|ensembl:ENST00000217182(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:Q05639|rcsb pdb:3C5J|reactome:R-HSA-156842|refseq:NP_001949.1|dip:DIP-40060N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:vFXfcSRokxKo5RW0tRE1qEK0NKw9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:O75223	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-6912130|ensembl:ENSP00000275428|uniprotkb:B8ZZR8|uniprotkb:Q9BS37|uniprotkb:B8ZZN4|uniprotkb:B2RDN0	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ggct_human(display_long)|uniprotkb:C7orf24(gene name synonym)|uniprotkb:CRF21(gene name synonym)|uniprotkb:Cytochrome c-releasing factor 21(gene name synonym)|uniprotkb:GGCT(gene name)|psi-mi:GGCT(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000006625(gene)|ensembl:ENST00000275428(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003839"(gamma-glutamylcyclotransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013024(Butirosin biosynthesis, BtrG-like)|interpro:IPR017939|interpro:IPR036568|mint:O75223|rcsb pdb:2I5T|rcsb pdb:2PN7|rcsb pdb:2Q53|rcsb pdb:2RBH|rcsb pdb:3CRY|reactome:R-HSA-174403|refseq:NP_001186744.1|refseq:NP_001186745.1|refseq:NP_001186746.1|refseq:NP_076956.1	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:OPoR51zHOj/GAUlzTuVvYmxaaxk9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P11142	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P02768	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P68371	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-351356|uniprotkb:P05217|uniprotkb:A2BFA2|ensembl:ENSP00000341289	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tbb4b_human(display_long)|uniprotkb:TUBB4B(gene name)|psi-mi:TUBB4B(display_short)|uniprotkb:TUBB2C(gene name synonym)|uniprotkb:Tubulin beta-2 chain(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_006079.1|ensembl:ENSG00000188229(gene)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|go:"GO:0005200"(structural constituent of cytoskeleton)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68371|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|ensembl:ENST00000340384(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:4LwMs7E7eILMjB9Z/1bstAp22CY9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P02788	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1058602|ensembl:ENSP00000231751|uniprotkb:O00756|uniprotkb:Q16780|uniprotkb:Q16785|uniprotkb:Q16786|uniprotkb:Q16789|uniprotkb:Q8IU92|uniprotkb:Q8IZH6|uniprotkb:Q8TCD2|uniprotkb:Q96KZ4|uniprotkb:Q96KZ5|uniprotkb:Q9H1Z3|uniprotkb:Q9UCY5|uniprotkb:B7Z4X2|uniprotkb:E7EQH5|uniprotkb:B2MV13|uniprotkb:Q5DSM0|uniprotkb:A8K9U8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:trfl_human(display_long)|uniprotkb:LTF(gene name)|psi-mi:LTF(display_short)|uniprotkb:LF(gene name synonym)|uniprotkb:Talalactoferrin(gene name synonym)|uniprotkb:GIG12(gene name synonym)|uniprotkb:Growth-inhibiting protein 12(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001308050.1|ensembl:ENST00000231751(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0006959"(humoral immune response)|go:"GO:0008201"(heparin binding)|ensembl:ENSG00000012223(gene)|refseq:NP_001186078.1|refseq:NP_002334.2|go:"GO:0009986"(cell surface)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0030141"(secretory granule)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1900159"(positive regulation of bone mineralization involved in bone maturation)|go:"GO:1900229"(negative regulation of single-species biofilm formation in or on host organism)|go:"GO:0042581"(specific granule)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000308"("negative regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:2001205"(negative regulation of osteoclast development)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0048525"(negative regulation of viral process)|interpro:IPR016357(Transferrin)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051673"(membrane disruption in another organism)|interpro:IPR018195|interpro:IPR030684|mint:P02788|rcsb pdb:1B0L|rcsb pdb:1BKA|rcsb pdb:1CB6|rcsb pdb:1DSN|rcsb pdb:1EH3|rcsb pdb:1FCK|rcsb pdb:1H43|rcsb pdb:1H44|rcsb pdb:1H45|rcsb pdb:1HSE|rcsb pdb:1L5T|rcsb pdb:1LCF|rcsb pdb:1LCT|rcsb pdb:1LFG|rcsb pdb:1LFH|rcsb pdb:1LFI|rcsb pdb:1LGB|rcsb pdb:1N76|rcsb pdb:1SQY|rcsb pdb:1VFD|rcsb pdb:1VFE|rcsb pdb:1XV4|rcsb pdb:1XV7|rcsb pdb:1Z6V|rcsb pdb:1Z6W|rcsb pdb:2BJJ|rcsb pdb:2DP4|rcsb pdb:2GMC|rcsb pdb:2GMD|rcsb pdb:2HD4|rcsb pdb:2PMS|reactome:R-HSA-1222449|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-6803157|reactome:R-HSA-977225|rcsb pdb:1U62|refseq:NP_001308051.1|dip:DIP-41354N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:OLhbdYXPaD10eAg3HyhCA5Akw8o9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P34931	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354912|uniprotkb:O75634|uniprotkb:Q2HXR3|uniprotkb:Q8NE72|uniprotkb:A6NNB0|uniprotkb:Q96QC9|uniprotkb:Q9UQM1|uniprotkb:B0UXW8|ensembl:ENSP00000364805|ensembl:ENSP00000372881|ensembl:ENSP00000396486|ensembl:ENSP00000408347	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hs71l_human(display_long)|uniprotkb:HSPA1L(gene name)|psi-mi:HSPA1L(display_short)|uniprotkb:Heat shock 70 kDa protein 1-Hom(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005518.3|ensembl:ENSG00000204390(gene)|ensembl:ENSG00000206383(gene)|ensembl:ENSG00000234258(gene)|ensembl:ENSG00000236251(gene)|ensembl:ENST00000375654(transcript)|ensembl:ENST00000383390(transcript)|ensembl:ENST00000417601(transcript)|ensembl:ENST00000456772(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0072562"(blood microparticle)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P34931|rcsb pdb:3GDQ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:KS02DcMpD2sxSF36hUjKiSdYi4c9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P01876	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-727651|ensembl:ENSP00000374989|ensembl:ENSP00000488021	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:igha1_human(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short)|uniprotkb:Ig alpha-1 chain C region(gene name synonym)|uniprotkb:Ig alpha-1 chain C region BUR(gene name synonym)|uniprotkb:Ig alpha-1 chain C region TRO(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000211895(gene)|ensembl:ENSG00000282633(gene)|ensembl:ENST00000390547(transcript)|ensembl:ENST00000633714(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IGA|rcsb pdb:1OW0|rcsb pdb:2ESG|rcsb pdb:2QEJ|rcsb pdb:3CHN|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6XJA|reactome:R-HSA-202733|reactome:R-HSA-2168880|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:Mystbtg9uttxFXl//LGdoM32po09606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P48741	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-877656|uniprotkb:P19790	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hsp77_human(display_long)|uniprotkb:Heat shock 70 kDa protein B(gene name synonym)|uniprotkb:HSPA7(gene name)|psi-mi:HSPA7(display_short)|uniprotkb:HSP70B(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|reactome:R-HSA-3371453|interpro:IPR043129	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZXOhfWYdKdW1ek+VsKZyF/Zo84o9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P31025	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1052433|uniprotkb:Q5T8A1|ensembl:ENSP00000263598|ensembl:ENSP00000360846	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:lcn1_human(display_long)|uniprotkb:Tear prealbumin(gene name synonym)|uniprotkb:Tear lipocalin(gene name synonym)|uniprotkb:LCN1(gene name)|psi-mi:LCN1(display_short)|uniprotkb:VEGP(gene name synonym)|uniprotkb:von Ebner gland protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_002288.1|refseq:NP_001239547.1|refseq:NP_001239548.1|refseq:NP_001239546.1|ensembl:ENSG00000160349(gene)|ensembl:ENST00000263598(transcript)|ensembl:ENST00000371781(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR002450(von Ebner's gland protein/ Bos/Can allergen)|interpro:IPR012674(Calycin)|mint:P31025|rcsb pdb:1XKI|rcsb pdb:3EYC|rcsb pdb:4QAF|rcsb pdb:5T43|reactome:R-HSA-804914	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:bpcDgVZMNuh6M1hEl3b8IncbuO49606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P02814	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-738612|uniprotkb:Q9UBN0|uniprotkb:Q9UCT0|uniprotkb:B7ZMG7|ensembl:ENSP00000302400|ensembl:ENSP00000423138	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:smr3b_human(display_long)|uniprotkb:SMR3B(gene name)|psi-mi:SMR3B(display_short)|uniprotkb:PBII(gene name synonym)|uniprotkb:PRL3(gene name synonym)|uniprotkb:Proline-rich protein 3(gene name synonym)|uniprotkb:Proline-rich peptide P-B(gene name synonym)|uniprotkb:PROL3(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_006676.1|ensembl:ENSG00000171201(gene)|ensembl:ENST00000304915(transcript)|ensembl:ENST00000504825(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070062"(extracellular exosome)|interpro:IPR026288|mint:P02814	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:WJ7Ag6lcBGK16pBo7LaEWJ1hydg9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q6ZVX7	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2877737|ensembl:ENSP00000342137|uniprotkb:Q6NVV5	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:fbx50_human(display_long)|uniprotkb:NCCRP1(gene name)|psi-mi:NCCRP1(display_short)|uniprotkb:FBXO50(gene name synonym)|uniprotkb:NCC receptor protein 1 homolog(gene name synonym)|uniprotkb:Non-specific cytotoxic cell receptor protein 1 homolog(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000188505(gene)|ensembl:ENST00000339852(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007397(F-box associated region)|interpro:IPR008979(Galactose-binding like)|interpro:IPR039752|refseq:NP_001001414.1	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:Gj02wJIGGIYTIMxQmqn5rIePVLQ9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P68366	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-351772|uniprotkb:A8MUB1|uniprotkb:P05215|ensembl:ENSP00000248437|uniprotkb:B3KNQ6|intact:EBI-11134566	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tba4a_human(display_long)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Testis-specific alpha-tubulin(gene name synonym)|uniprotkb:Tubulin H2-alpha(gene name synonym)|uniprotkb:TUBA1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005991.1|ensembl:ENSG00000127824(gene)|ensembl:ENST00000248437(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68366|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001265481.1	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P01833	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1052371|uniprotkb:Q68D81|uniprotkb:Q8IZY7|ensembl:ENSP00000348888	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:pigr_human(display_long)|uniprotkb:Hepatocellular carcinoma-associated protein TB6(gene name synonym)|uniprotkb:PIGR(gene name)|psi-mi:PIGR(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_002635.2|refseq:XP_011507931.1|ensembl:ENSG00000162896(gene)|ensembl:ENST00000356495(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001792"(polymeric immunoglobulin receptor activity)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002415"(immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0038093"(Fc receptor signaling pathway)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1XED|rcsb pdb:2OCW|rcsb pdb:3CHN|rcsb pdb:3CM9|rcsb pdb:5D4K|rcsb pdb:6KXS|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6UE8|rcsb pdb:6UE9|rcsb pdb:6UEA|rcsb pdb:7K0C|reactome:R-HSA-6798695	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:qidY3KoxSMLEzEryHDcr9OZoXo49606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q13085	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-717681|intact:EBI-3962262|uniprotkb:B2ZZ90|uniprotkb:Q6KEV6|uniprotkb:Q6XDA8|uniprotkb:Q7Z2G8|uniprotkb:Q7Z561|uniprotkb:Q7Z563|uniprotkb:Q7Z564|uniprotkb:Q86WB2|uniprotkb:Q86WB3|uniprotkb:B2RP68|ensembl:ENSP00000478547|ensembl:ENSP00000483674	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:acaca_human(display_long)|uniprotkb:ACACA(gene name)|psi-mi:ACACA(display_short)|uniprotkb:ACAC(gene name synonym)|uniprotkb:ACC1(gene name synonym)|uniprotkb:ACCA(gene name synonym)|uniprotkb:Acetyl-Coenzyme A carboxylase alpha(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_942131.1|refseq:NP_942133.1|refseq:NP_942134.1|refseq:NP_942135.1|refseq:NP_942136.1|refseq:XP_016880044.1|refseq:XP_011523005.1|ensembl:ENSG00000275176(gene)|ensembl:ENSG00000278540(gene)|ensembl:ENST00000613687(transcript)|ensembl:ENST00000614428(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019538"(protein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:2001295"(malonyl-CoA biosynthetic process)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR029045|interpro:IPR034733|mint:Q13085|rcsb pdb:2YL2|rcsb pdb:3COJ|rcsb pdb:4ASI|rcsb pdb:6G2D|rcsb pdb:6G2H|rcsb pdb:6G2I|reactome:R-HSA-163765|reactome:R-HSA-196780|reactome:R-HSA-200425|reactome:R-HSA-2426168|reactome:R-HSA-3371599|reactome:R-HSA-75105|dip:DIP-36122N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:P9d0QlkoP1zrBdF1WOrK68ueGng9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q06830	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P01591	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2866826|ensembl:ENSP00000254801|ensembl:ENSP00000426687	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:igj_human(display_long)|uniprotkb:JCHAIN(gene name)|psi-mi:JCHAIN(display_short)|uniprotkb:IGCJ(gene name synonym)|uniprotkb:IGJ(gene name synonym)|uniprotkb:Joining chain of multimeric IgA and IgM(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:XP_011530227.1|refseq:XP_011530228.1|refseq:NP_653247.1|refseq:XP_006714274.1|refseq:XP_006714275.1|ensembl:ENSG00000132465(gene)|ensembl:ENST00000254801(transcript)|ensembl:ENST00000510437(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019862"(IgA binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071750"(dimeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0071756"(pentameric IgM immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR024110|rcsb pdb:6KXS|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6UE8|rcsb pdb:6UE9|rcsb pdb:6UEA|rcsb pdb:7K0C|reactome:R-HSA-202733|reactome:R-HSA-2168880	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:0LaSqZzqBXZZZx+9zeTse0tZOdo9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P08107	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P04406	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049589|imex:IM-23209-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:Suppl. Table S3|comment:"Extracts were prepared from Mst1/Stk4 Flp-In 293 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols PC, PIP, HP and TUBB1C in table S3 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/10/14	2014/12/23	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	intact-crc:DC35AA5791232983|rigid:NfKzfo2FGotnEO+G3ibSH8yD1rQ	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q7Z6Z7	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:B5ME19	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-8456517|intact:MINT-7001747|ensembl:ENSP00000370258|ensembl:ENSP00000381917	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:eifcl_human(display_long)|uniprotkb:EIF3CL(gene name)|psi-mi:EIF3CL(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001304785.1|refseq:NP_001304786.1|refseq:NP_001093131.1|ensembl:ENSG00000205609(gene)|ensembl:ENST00000380876(transcript)|ensembl:ENST00000398944(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ulI4eNNH+NrUd9lDyHHrOmsFsDc9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:O43175	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P53621	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P43246	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P39748	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-707816|ensembl:ENSP00000305480	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:fen1_human(display_long)|uniprotkb:Flap structure-specific endonuclease 1(gene name synonym)|uniprotkb:Maturation factor 1(gene name synonym)|uniprotkb:DNase IV(gene name synonym)|uniprotkb:FEN1(gene name)|psi-mi:FEN1(display_short)|uniprotkb:RAD2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000168496(gene)|ensembl:ENST00000305885(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|refseq:NP_004102.1|dip:DIP-24216N|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007613"(memory)|go:"GO:0008309"(double-stranded DNA exodeoxyribonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0048256"(flap endonuclease activity)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR023426|interpro:IPR029060|interpro:IPR036279|mint:P39748|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:3Q8K|rcsb pdb:3Q8L|rcsb pdb:3Q8M|rcsb pdb:3UVU|rcsb pdb:5E0V|rcsb pdb:5FV7|rcsb pdb:5K97|rcsb pdb:5KSE|rcsb pdb:5UM9|rcsb pdb:5ZOD|rcsb pdb:5ZOE|rcsb pdb:5ZOF|rcsb pdb:5ZOG|rcsb pdb:6TNZ|reactome:R-HSA-110362|reactome:R-HSA-162594|reactome:R-HSA-174437|reactome:R-HSA-5651801|reactome:R-HSA-5685939|reactome:R-HSA-69166	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:l9A+/Q39cGBPac0d8USNWE+17NM9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P46060	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9Y678	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P18085	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1237085|ensembl:ENSP00000306010|uniprotkb:P21371|uniprotkb:B2R7J7	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:arf4_human(display_long)|uniprotkb:ARF4(gene name)|psi-mi:ARF4(display_short)|uniprotkb:ARF2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000168374(gene)|ensembl:ENST00000303436(transcript)|refseq:NP_001651.1|dip:DIP-38214N|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045176"(apical protein localization)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048678"(response to axon injury)|go:"GO:0060271"(cilium assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P18085|rcsb pdb:1Z6X|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:AN3aBuSStAMrmkqq1HEDQtOiCy49606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P33991	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:O00410	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P25205	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q8N392	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-372814|uniprotkb:E1P575|uniprotkb:Q58EZ3|uniprotkb:Q6P679|uniprotkb:Q6PJD7|uniprotkb:Q96S64|intact:EBI-28984395|ensembl:ENSP00000357131	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rhg18_human(display_long)|uniprotkb:Rho-type GTPase-activating protein 18(gene name synonym)|uniprotkb:MacGAP(gene name synonym)|uniprotkb:ARHGAP18(gene name)|psi-mi:ARHGAP18(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_277050.2|ensembl:ENSP00000357131|ensembl:ENSG00000146376(gene)|ensembl:ENST00000368149(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016607"(nuclear speck)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|go:"GO:2000145"(regulation of cell motility)	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:24F0Swg/Ye/UfWPt8fJcO+q0nkc9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P62269	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-352451|ensembl:ENSP00000211372|ensembl:ENSP00000393241|ensembl:ENSP00000403175|ensembl:ENSP00000412583|ensembl:ENSP00000416110|uniprotkb:P25232|uniprotkb:Q6IPF8|uniprotkb:Q5SUJ3	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rs18_human(display_long)|uniprotkb:RPS18(gene name)|psi-mi:RPS18(display_short)|uniprotkb:D6S218E(gene name synonym)|uniprotkb:Ke-3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS13(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_072045.1|ensembl:ENSG00000096150(gene)|ensembl:ENSG00000223367(gene)|ensembl:ENSG00000226225(gene)|ensembl:ENSG00000231500(gene)|ensembl:ENSG00000235650(gene)|ensembl:ENST00000211372(transcript)|ensembl:ENST00000434122(transcript)|ensembl:ENST00000439602(transcript)|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENST00000454021(transcript)|ensembl:ENST00000457341(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62269|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|dip:DIP-32892N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:yOHgKM/BuvgGdqp1OEVPeuiABg89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P26599	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-350540|ensembl:ENSP00000014112|intact:EBI-744534|uniprotkb:Q9BUQ0	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ptbp1_human(display_long)|uniprotkb:PTBP1(gene name)|psi-mi:PTBP1(display_short)|uniprotkb:PTB(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein I(gene name synonym)|uniprotkb:57 kDa RNA-binding protein PPTB-1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_002810.1|refseq:NP_114367.1|refseq:NP_114368.1|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0016020"(membrane)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034798|interpro:IPR035000|interpro:IPR035001|interpro:IPR035979|mint:P26599|rcsb pdb:1QM9|rcsb pdb:1SJQ|ensembl:ENSG00000011304(gene)|ensembl:ENST00000349038(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0008380"(RNA splicing)|rcsb pdb:2AD9|rcsb pdb:2ADB|rcsb pdb:2ADC|rcsb pdb:2EVZ|rcsb pdb:2N3O|rcsb pdb:3ZZY|rcsb pdb:3ZZZ|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|rcsb pdb:1SJR	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:fkSnYJELgHxDP0oAQEjBmSX0HIs9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q13813	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:O75643	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P50990	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-356507|uniprotkb:A6NN54|uniprotkb:Q4VBP8|uniprotkb:B4DEM7|uniprotkb:B4DQH4|ensembl:ENSP00000286788	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tcpq_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:CCTQ(gene name synonym)|uniprotkb:KIAA0002(gene name synonym)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-15(gene name synonym)|uniprotkb:C21orf112(gene name synonym)|uniprotkb:Chaperonin containing T-complex polypeptide 1 subunit 8(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001269836.1|refseq:NP_001269838.1|refseq:NP_006576.2|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50990|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|ensembl:ENSG00000156261(gene)|ensembl:ENST00000286788(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016887"(ATP hydrolysis activity)|reactome:R-HSA-6798695|reactome:R-HSA-6814122|reactome:R-HSA-5620922|dip:DIP-38124N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:/TlB7Gk2Z9GPvfV3JBE0nWUF34Y9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q06830	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P49368	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P55060	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P61011	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2854176|uniprotkb:B2R759|uniprotkb:P13624|uniprotkb:B4DUW6|ensembl:ENSP00000216774|ensembl:ENSP00000451818|ensembl:ENSP00000504518|ensembl:ENSP00000504673	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:srp54_human(display_long)|uniprotkb:SRP54(gene name)|psi-mi:SRP54(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:XP_011535408.1|refseq:NP_001139754.1|refseq:NP_003127.1|ensembl:ENSG00000100883(gene)|ensembl:ENST00000678963(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006617"(SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition)|go:"GO:0008312"(7S RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019003"(GDP binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR000897(Signal recognition particle, SRP54 subunit, GTPase)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004125(Signal recognition particle, SRP54 subunit, M-domain)|interpro:IPR006325(Signal recognition particle, SRP54 subunit)|interpro:IPR013822(Signal recognition particle, SRP54 subunit, helical bundle)|interpro:IPR022941|interpro:IPR027417|interpro:IPR036225|interpro:IPR036891|interpro:IPR042101|mint:P61011|rcsb pdb:1MFQ|rcsb pdb:1QB2|rcsb pdb:5L3Q|rcsb pdb:6Y2Z|rcsb pdb:6Y30|rcsb pdb:6Y31|rcsb pdb:6Y32|rcsb pdb:7NFX|ensembl:ENST00000216774(transcript)|reactome:R-HSA-1799339|ensembl:ENST00000556994(transcript)|ensembl:ENST00000677647(transcript)	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:8iRlU+NvhLEJNv7B90TAZyRqwiY9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q99956	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-3906678|uniprotkb:D3DWU5|ensembl:ENSP00000345853|ensembl:ENSP00000359186	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:dus9_human(display_long)|uniprotkb:DUSP9(gene name)|psi-mi:DUSP9(display_short)|uniprotkb:MKP4(gene name synonym)|uniprotkb:Mitogen-activated protein kinase phosphatase 4(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:XP_011529426.1|refseq:NP_001386.1|refseq:NP_001305432.1|ensembl:ENSG00000130829(gene)|ensembl:ENST00000342782(transcript)|ensembl:ENST00000370167(transcript)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0060420"(regulation of heart growth)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|mint:Q99956|rcsb pdb:2HXP|rcsb pdb:3LJ8|reactome:R-HSA-112409|go:"GO:0000165"(MAPK cascade)|reactome:R-HSA-5675221|reactome:R-HSA-9652817|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:djC92fivazm9x5q4xDTlKje/fzQ9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P45985	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P49792	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-973138|intact:EBI-28970106|ensembl:ENSP00000283195|uniprotkb:Q13074|uniprotkb:Q15280|uniprotkb:Q53TE2|uniprotkb:Q59FH7	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rbp2_human(display_long)|uniprotkb:RANBP2(gene name)|psi-mi:RANBP2(display_short)|uniprotkb:NUP358(gene name synonym)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Nuclear pore complex protein Nup358(gene name synonym)|uniprotkb:Nucleoporin Nup358(gene name synonym)|uniprotkb:358 kDa nucleoporin(gene name synonym)|uniprotkb:p270(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000153201(gene)|ensembl:ENST00000283195(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|reactome:R-HSA-168271|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:P49792|reactome:R-HSA-168276|rcsb pdb:1RRP|reactome:R-HSA-168325|reactome:R-HSA-168333|rcsb pdb:1XKE|rcsb pdb:1Z5S|rcsb pdb:2LAS|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4GA0|rcsb pdb:4I9Y|rcsb pdb:4L6E|rcsb pdb:4LQW|rcsb pdb:5CLL|rcsb pdb:5CLQ|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-170822|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-180746|reactome:R-HSA-9648025|ensembl:ENSP00000283195|refseq:NP_006258.3|dip:DIP-37654N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:KB+rjfw8djVygvDpTncA0NO2MDY9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:O14980	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9H8S9	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-748229|uniprotkb:Q53S34|uniprotkb:Q9H3T5|uniprotkb:Q9HAI0|uniprotkb:Q9NVE2|ensembl:ENSP00000379364	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mob1a_human(display_long)|uniprotkb:MOB1A(gene name)|psi-mi:MOB1A(display_short)|uniprotkb:C2orf6(gene name synonym)|uniprotkb:MOB4B(gene name synonym)|uniprotkb:MOBK1B(gene name synonym)|uniprotkb:MOBKL1B(gene name synonym)|uniprotkb:Mob1 alpha(gene name synonym)|uniprotkb:Mob1 homolog 1B(gene name synonym)|uniprotkb:Mps one binder kinase activator-like 1B(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001304039.1|refseq:NP_001304040.1|refseq:NP_001304041.1|refseq:NP_060691.2|ensembl:ENSG00000114978(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0035329"(hippo signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005301(Mob1/phocein)|interpro:IPR036703|mint:Q9H8S9|rcsb pdb:1PI1|rcsb pdb:4J1V|rcsb pdb:4JIZ|rcsb pdb:5BRK|rcsb pdb:5BRM|rcsb pdb:5TWF|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:5XQZ|rcsb pdb:6MCP|rcsb pdb:6MCQ|reactome:R-HSA-2028269|ensembl:ENST00000396049(transcript)|dip:DIP-36594N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:Gup4pRYJH3cfC6+XkgI27yiF7g89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P50225	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-2814403|uniprotkb:Q9UGG7|uniprotkb:Q9BVU6|uniprotkb:Q92818|uniprotkb:Q86U58|uniprotkb:Q2NL71|ensembl:ENSP00000321988|ensembl:ENSP00000457912	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:st1a1_human(display_long)|uniprotkb:SULT1A1(gene name)|psi-mi:SULT1A1(display_short)|uniprotkb:STP(gene name synonym)|uniprotkb:STP1(gene name synonym)|uniprotkb:Aryl sulfotransferase 1(gene name synonym)|uniprotkb:HAST1/HAST2(gene name synonym)|uniprotkb:Phenol sulfotransferase 1(gene name synonym)|uniprotkb:Phenol-sulfating phenol sulfotransferase 1(gene name synonym)|uniprotkb:ST1A3(gene name synonym)|uniprotkb:Thermostable phenol sulfotransferase(gene name synonym)|uniprotkb:OK/SW-cl.88(orf name)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001046.2|refseq:NP_803565.1|refseq:NP_803566.1|refseq:NP_803878.1|refseq:NP_803880.1|refseq:XP_016879095.1|refseq:XP_016879100.1|refseq:XP_016879101.1|refseq:XP_016879102.1|ensembl:ENSG00000196502(gene)|ensembl:ENST00000314752(transcript)|ensembl:ENST00000569554(transcript)|go:"GO:0004062"(aryl sulfotransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006068"(ethanol catabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008146"(sulfotransferase activity)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0047894"(flavonol 3-sulfotransferase activity)|go:"GO:0050294"(steroid sulfotransferase activity)|go:"GO:0050427"(3'-phosphoadenosine 5'-phosphosulfate metabolic process)|go:"GO:0050656"(3'-phosphoadenosine 5'-phosphosulfate binding)|go:"GO:0051923"(sulfation)|interpro:IPR000863(Sulphotransferase)|interpro:IPR027417|rcsb pdb:1LS6|rcsb pdb:1Z28|rcsb pdb:2D06|rcsb pdb:3QVU|rcsb pdb:3QVV|rcsb pdb:3U3J|rcsb pdb:3U3K|rcsb pdb:3U3M|rcsb pdb:3U3O|rcsb pdb:3U3R|rcsb pdb:4GRA|reactome:R-HSA-156584	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:FweXcoVwTFvo9HJhsoiXfxx2nbo9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P52701	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-395529|uniprotkb:O43706|uniprotkb:O43917|uniprotkb:Q8TCX4|uniprotkb:Q9BTB5|ensembl:ENSP00000234420|uniprotkb:B4DF41|uniprotkb:B4E3I4|uniprotkb:F5H2F9	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:msh6_human(display_long)|uniprotkb:MSH6(gene name)|psi-mi:MSH6(display_short)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:GTBP(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_000170.1|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P52701|rcsb pdb:2GFU|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:6OQM|reactome:R-HSA-5358565|reactome:R-HSA-5632928|reactome:R-HSA-5632968|ensembl:ENSG00000116062(gene)|ensembl:ENST00000234420(transcript)|refseq:NP_001268421.1|refseq:NP_001268422.1|refseq:NP_001268423.1|dip:DIP-32972N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:YPpiWmh4fSjXapWgA/rXbMrLAGg9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P13010	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P36578	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-348313|ensembl:ENSP00000311430|uniprotkb:P39029|uniprotkb:Q4VBR0|uniprotkb:Q969Z9|uniprotkb:A8K502	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rl4_human(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:RPL1(gene name synonym)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL4(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000174444(gene)|ensembl:ENST00000307961(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR025755|mint:P36578|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|interpro:IPR023574|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OM0|refseq:NP_000959.2|dip:DIP-27559N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:34il/jyrW0Dqj0eA8GBFgUk05XU9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q86VP6	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-456077|uniprotkb:O94918|uniprotkb:Q6PIY4|uniprotkb:Q8NDJ4|uniprotkb:Q96JZ9|uniprotkb:Q96T19|uniprotkb:Q9BTC4|uniprotkb:Q9H0G2|uniprotkb:Q9P0H7|uniprotkb:Q9UF85|uniprotkb:B2RAU3|ensembl:ENSP00000442318	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:cand1_human(display_long)|uniprotkb:KIAA0829(gene name synonym)|uniprotkb:TIP120(gene name synonym)|uniprotkb:TIP120A(gene name synonym)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa A(gene name synonym)|uniprotkb:CAND1(gene name)|psi-mi:CAND1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_060918.2|dip:DIP-31608N|ensembl:ENSG00000111530(gene)|ensembl:ENST00000545606(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR039852|mint:Q86VP6|rcsb pdb:1U6G|rcsb pdb:4A0C|reactome:R-HSA-6798695|reactome:R-HSA-8951664|reactome:R-HSA-917937|interpro:IPR016024(Armadillo-type fold)	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:2lBY8xJXlGZL+xyo/dyB2WzuNqs9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q13418	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-747644|uniprotkb:P57043|uniprotkb:Q68DZ3|uniprotkb:B7Z1I0|uniprotkb:D3DQU0|uniprotkb:B7Z418|ensembl:ENSP00000299421|ensembl:ENSP00000379975|ensembl:ENSP00000403487	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ilk_human(display_long)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:ILK(gene name)|psi-mi:ILK(display_short)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001265370.1|refseq:NP_001014794.1|refseq:NP_001014795.1|refseq:NP_004508.1|refseq:XP_005252961.1|refseq:NP_001265371.1|refseq:XP_005252962.1|refseq:XP_011518367.1|dip:DIP-38657N|rcsb pdb:3IXE|rcsb pdb:3KMU|rcsb pdb:3KMW|rcsb pdb:3REP|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIB|reactome:R-HSA-446343|reactome:R-HSA-446353|ensembl:ENSG00000166333(gene)|ensembl:ENST00000299421(transcript)|ensembl:ENST00000396751(transcript)|ensembl:ENST00000420936(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:Q13418|rcsb pdb:2KBX|rcsb pdb:3F6Q|go:"GO:0045663"(positive regulation of myoblast differentiation)	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:FrK/MsW7IcVWT9VbkHAIVHEh1P89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q14974	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P35222	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:O95373	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q14008	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-310585|uniprotkb:Q0VAX8|uniprotkb:Q14668|uniprotkb:Q05D70|uniprotkb:Q0VAX7|uniprotkb:Q2TA89|uniprotkb:Q6NSH4|intact:EBI-28968667|ensembl:ENSP00000432768	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ckap5_human(display_long)|uniprotkb:CKAP5(gene name)|psi-mi:CKAP5(display_short)|uniprotkb:KIAA0097(gene name synonym)|uniprotkb:Colonic and hepatic tumor overexpressed gene protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENST00000312055|ensembl:ENSP00000310227|ensembl:ENST00000354558|ensembl:ENSP00000346566|ensembl:ENSP00000432768|refseq:NP_001008938.1|refseq:NP_055571.2|ensembl:ENSG00000175216(gene)|ensembl:ENST00000529230(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0050658"(RNA transport)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0061863"(microtubule plus end polymerase)|go:"GO:0090063"(positive regulation of microtubule nucleation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR024395|interpro:IPR034085|mint:Q14008|rcsb pdb:4QMI|rcsb pdb:4QMJ|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9648025	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:3bgwyNEucxXwXdbxbJkJ07PC90w9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q07960	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-602762|uniprotkb:D3DQQ6|ensembl:ENSP00000310491	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rhg01_human(display_long)|uniprotkb:Rho-type GTPase-activating protein 1(gene name synonym)|uniprotkb:Rho-related small GTPase protein activator(gene name synonym)|uniprotkb:p50-RhoGAP(gene name synonym)|uniprotkb:CDC42 GTPase-activating protein(gene name synonym)|uniprotkb:ARHGAP1(gene name)|psi-mi:ARHGAP1(display_short)|uniprotkb:CDC42GAP(gene name synonym)|uniprotkb:RHOGAP1(gene name synonym)|uniprotkb:GTPase-activating protein rhoGAP(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_004299.1|refseq:XP_011518397.1|dip:DIP-6081N|ensembl:ENSG00000175220(gene)|ensembl:ENST00000311956(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001136"(negative regulation of endocytic recycling)|interpro:IPR000198(RhoGAP)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR036865|mint:Q07960|rcsb pdb:1AM4|rcsb pdb:1GRN|rcsb pdb:1OW3|rcsb pdb:1RGP|rcsb pdb:1TX4|rcsb pdb:2NGR|rcsb pdb:5M6X|rcsb pdb:5M70|rcsb pdb:6R3V|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-9696270	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:ceA3oLsnddhLiSbylS89P64mYBo9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P23396	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-351193|uniprotkb:Q498B5|uniprotkb:Q8NI95|uniprotkb:B2R7N5|ensembl:ENSP00000433821|ensembl:ENSP00000434643|ensembl:ENSP00000436971|uniprotkb:J3KN86	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rs3_human(display_long)|uniprotkb:RPS3(gene name)|psi-mi:RPS3(display_short)|uniprotkb:Small ribosomal subunit protein uS3(gene name synonym)|uniprotkb:OK/SW-cl.26(orf name)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_000996.2|ensembl:ENSG00000149273(gene)|ensembl:ENST00000524851(transcript)|ensembl:ENST00000527446(transcript)|ensembl:ENST00000531188(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032358"(oxidized pyrimidine DNA binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045738"(negative regulation of DNA repair)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061481"(response to TNF agonist)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902546"(positive regulation of DNA N-glycosylase activity)|go:"GO:1905053"(positive regulation of base-excision repair)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR004044(K Homology, type 2)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|go:"GO:0071159"(NF-kappaB complex)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR018280|interpro:IPR036419|mint:P23396|rcsb pdb:1WH9|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|go:"GO:0072686"(mitotic spindle)|go:"GO:0097100"(supercoiled DNA binding)|rcsb pdb:6QZP|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|refseq:NP_001243731.1|refseq:NP_001247436.1|refseq:NP_001247435.1|dip:DIP-33177N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:fsDW18AMR3YyEEIhMVcngYRWkps9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P09874	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P33993	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P17844	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P11586	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-709638|uniprotkb:Q86VC9|uniprotkb:Q9BVP5|uniprotkb:B2R5Y2|uniprotkb:G3V2B8|intact:EBI-21358459|uniprotkb:A0A024R652|uniprotkb:A0A384N5Y3|ensembl:ENSP00000498336|ensembl:ENSP00000498511	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:c1tc_human(display_long)|uniprotkb:MTHFD1(gene name)|psi-mi:MTHFD1(display_short)|uniprotkb:MTHFC(gene name synonym)|uniprotkb:MTHFD(gene name synonym)|uniprotkb:Epididymis secretory sperm binding protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005947.3|dip:DIP-33682N|ensembl:ENSG00000100714(gene)|ensembl:ENST00000651537(transcript)|ensembl:ENST00000652337(transcript)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR027417|interpro:IPR036291|mint:P11586|rcsb pdb:1A4I|rcsb pdb:1DIA|rcsb pdb:1DIB|rcsb pdb:1DIG|rcsb pdb:6ECP|rcsb pdb:6ECQ|rcsb pdb:6ECR|reactome:R-HSA-196757	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:6ZizfpjVcaL5WNxKXL7qJpw59PI9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P84077	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:zray9asm6VonxpuJpv0dRBspPt89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P42224	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P46940	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P14618	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P55884	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P58107	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-297954|uniprotkb:Q76E58|ensembl:ENSP00000484472|uniprotkb:A0A087X1U6|uniprotkb:Q9NSU9	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:epipl_human(display_long)|uniprotkb:EPPK1(gene name)|psi-mi:EPPK1(display_short)|uniprotkb:EPIPL(gene name synonym)|uniprotkb:450 kDa epidermal antigen(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSP00000484472|ensembl:ENSG00000261150(gene)|ensembl:ENST00000615648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042995"(cell projection)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0071944"(cell periphery)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1905041"(regulation of epithelium regeneration)|go:"GO:1990254"(keratin filament binding)|interpro:IPR001101(Plectin repeat)|interpro:IPR035915|interpro:IPR043197|refseq:NP_112598.3|refseq:XP_016869379.1	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:5ThrRQj4JeRG4xjZxMgueWUrjuA9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P31689	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-347834|ensembl:ENSP00000369127|uniprotkb:Q5T7Q0|uniprotkb:Q86TL9	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:dnja1_human(display_long)|uniprotkb:DNAJA1(gene name)|psi-mi:DNAJA1(display_short)|uniprotkb:DNAJ2(gene name synonym)|uniprotkb:HDJ2(gene name synonym)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:HSPF4(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Human DnaJ protein 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:HSDJ(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000086061(gene)|ensembl:ENST00000330899(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P31689|rcsb pdb:2LO1|rcsb pdb:2M6Y|reactome:R-HSA-3371497|rcsb pdb:6E8M|refseq:NP_001530.1	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:YEHeLHYaG2ON2gwuFfqt9Le1Drg9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q00610	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P19338	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P62701	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-354303|uniprotkb:P12631|uniprotkb:P12750|uniprotkb:P27576|uniprotkb:Q14727|uniprotkb:P55831|uniprotkb:Q6IPY4|ensembl:ENSP00000362744	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:rs4x_human(display_long)|uniprotkb:RPS4X(gene name)|psi-mi:RPS4X(display_short)|uniprotkb:CCG2(gene name synonym)|uniprotkb:RPS4(gene name synonym)|uniprotkb:SCAR(gene name synonym)|uniprotkb:Single copy abundant mRNA protein(gene name synonym)|uniprotkb:SCR10(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS4(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_000998.1|rcsb pdb:6OLI|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000198034(gene)|ensembl:ENST00000316084(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005824(KOW)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR018199|interpro:IPR032277|interpro:IPR036986|interpro:IPR038237|interpro:IPR041982|mint:P62701|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|go:"GO:0045727"(positive regulation of translation)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:2ZuLXqBSDkK0CtN3mnIDoFAR8yI9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P53618	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-359063|uniprotkb:Q6GTT7|uniprotkb:Q9NTK2|uniprotkb:Q9UNW7|uniprotkb:D3DQX0|ensembl:ENSP00000249923|ensembl:ENSP00000397873	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:copb_human(display_long)|uniprotkb:COPB1(gene name)|psi-mi:COPB1(display_short)|uniprotkb:COPB(gene name synonym)|uniprotkb:MSTP026(orf name)|uniprotkb:Beta-coat protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001137533.1|refseq:NP_001137534.1|refseq:NP_057535.1|ensembl:ENSG00000129083(gene)|ensembl:ENST00000249923(transcript)|ensembl:ENST00000439561(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:P53618|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-265N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:EBxh2JlK3Z8HxbZXa3fG0nOgYu89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P17987	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P40763	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q13576	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-357571|uniprotkb:J3KR91|uniprotkb:A8K4V1|uniprotkb:B7Z8A4|ensembl:ENSP00000274364	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:iqga2_human(display_long)|uniprotkb:IQGAP2(gene name)|psi-mi:IQGAP2(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001272389.1|refseq:NP_001272390.1|refseq:NP_001272391.1|refseq:NP_006624.2|ensembl:ENSG00000145703(gene)|ensembl:ENST00000274364(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR036872|mint:Q13576|rcsb pdb:3IEZ|rcsb pdb:4EZA|rcsb pdb:5CJP|reactome:R-HSA-5626467|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013408|dip:DIP-27542N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:gmxbOFcisiWIsQrHFQCoI5y49T09606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P32119	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1266300|uniprotkb:P31945|uniprotkb:P32118|uniprotkb:P35701|uniprotkb:Q6FHG4|uniprotkb:Q92763|uniprotkb:Q9UC23|uniprotkb:A8K0C0|ensembl:ENSP00000301522	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:prdx2_human(display_long)|uniprotkb:PRDX2(gene name)|psi-mi:PRDX2(display_short)|uniprotkb:NKEFB(gene name synonym)|uniprotkb:TDPX1(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor B(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_005800.3|dip:DIP-39882N|ensembl:ENSG00000167815(gene)|ensembl:ENST00000301522(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P32119|rcsb pdb:1QMV|rcsb pdb:5B8A|rcsb pdb:5B8B|rcsb pdb:5IJT|rcsb pdb:7KIZ|rcsb pdb:7KJ0|rcsb pdb:7KJ1|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:F8+7/3HrAcJq7BjkZaig16mCOO89606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:O75914	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-3389553|uniprotkb:Q8WX23|uniprotkb:Q7Z2D6|uniprotkb:Q5JWX1|uniprotkb:A8K389|uniprotkb:Q9P0J8|uniprotkb:Q7Z2E4|uniprotkb:Q8WWK5|uniprotkb:Q5JWX2|uniprotkb:Q7Z3Z8|uniprotkb:B1GX78|uniprotkb:B1GX79|uniprotkb:B1GX77|ensembl:ENSP00000262836|ensembl:ENSP00000361080	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:pak3_human(display_long)|uniprotkb:PAK3(gene name)|psi-mi:PAK3(display_short)|uniprotkb:OPHN3(gene name synonym)|uniprotkb:Beta-PAK(gene name synonym)|uniprotkb:Oligophrenin-3(gene name synonym)|uniprotkb:p21-activated kinase 3(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001311255.1|refseq:NP_001121638.1|refseq:NP_001121639.1|refseq:NP_001121640.1|refseq:NP_001121644.1|refseq:NP_001121645.1|refseq:NP_002569.1|refseq:XP_016885046.1|refseq:XP_016885050.1|refseq:XP_016885052.1|refseq:NP_001311256.1|refseq:NP_001311257.1|refseq:NP_001311258.1|refseq:NP_001311259.1|refseq:NP_001311260.1|refseq:NP_001311261.1|refseq:NP_001311262.1|refseq:NP_001311263.1|refseq:NP_001311254.1|ensembl:ENSG00000077264(gene)|ensembl:ENST00000262836(transcript)|ensembl:ENST00000372010(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007409"(axonogenesis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035063|interpro:IPR036936|rcsb pdb:6FD3|reactome:R-HSA-202433|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-9013420	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:Hy2QKMjSZ2ZkNG6W1UTtSz3x/ps9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q00341	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-1049478|uniprotkb:Q9UCY3|uniprotkb:Q53QU2|uniprotkb:B4DTQ2|uniprotkb:E7EM71|intact:EBI-28974616|ensembl:ENSP00000399139	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:vigln_human(display_long)|uniprotkb:High density lipoprotein-binding protein(gene name synonym)|uniprotkb:HDLBP(gene name)|psi-mi:HDLBP(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:VGL(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	ensembl:ENSP00000399139|refseq:NP_005327.1|refseq:NP_976221.1|refseq:NP_001230829.1|refseq:XP_011509360.1|refseq:XP_011509362.1|refseq:XP_016859429.1|ensembl:ENSG00000115677(gene)|ensembl:ENST00000427183(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0045296"(cadherin binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|rcsb pdb:1VIG|rcsb pdb:1VIH|rcsb pdb:2CTE|rcsb pdb:2CTF|rcsb pdb:2CTJ|rcsb pdb:2CTK|rcsb pdb:2CTL|rcsb pdb:2CTM|reactome:R-HSA-8964011|refseq:NP_001307894.1|refseq:NP_001307895.1|refseq:XP_005247059.2|refseq:XP_006712538.1|refseq:XP_005247060.2	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:4NqKFEjUn5Fi5Ws3tirpanGqYwg9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P11940	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:XudTSPq2h9ckKAc48X88RVafPRU9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q8TEX9	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-395967|uniprotkb:Q2NL96|uniprotkb:Q86TZ9|uniprotkb:Q8NCG8|uniprotkb:Q96SJ3|uniprotkb:Q9BTI4|uniprotkb:Q9H5L0|uniprotkb:B2RN95|ensembl:ENSP00000346453|ensembl:ENSP00000494795	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ipo4_human(display_long)|uniprotkb:IPO4(gene name)|psi-mi:IPO4(display_short)|uniprotkb:IMP4B(gene name synonym)|uniprotkb:RANBP4(gene name synonym)|uniprotkb:Importin-4b(gene name synonym)|uniprotkb:Ran-binding protein 4(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_078934.3|dip:DIP-32944N|ensembl:ENSG00000196497(gene)|ensembl:ENSG00000285248(gene)|ensembl:ENST00000354464(transcript)|ensembl:ENST00000644546(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|interpro:IPR040122|mint:Q8TEX9|rcsb pdb:5XAH|rcsb pdb:5XBK	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:PVIcGG3WTf0QmYbS0vvy049EjlQ9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P12956	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q99832	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:P78347	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-359622|uniprotkb:Q75M88|uniprotkb:O14743|uniprotkb:O15359|uniprotkb:O43546|uniprotkb:O43588|uniprotkb:O43589|uniprotkb:Q9BSZ4|uniprotkb:Q86U51|uniprotkb:Q75M85|uniprotkb:Q75M86|uniprotkb:Q75M87|ensembl:ENSP00000460070	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:gtf2i_human(display_long)|uniprotkb:GTF2I(gene name)|psi-mi:GTF2I(display_short)|uniprotkb:BAP135(gene name synonym)|uniprotkb:WBSCR6(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)|uniprotkb:SRF-Phox1-interacting protein(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 6 protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001509.3|refseq:NP_127492.1|refseq:NP_127493.1|refseq:NP_127494.1|ensembl:ENSG00000263001(gene)|ensembl:ENST00000573035(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|mint:P78347|rcsb pdb:2D9B|rcsb pdb:2DN4|rcsb pdb:2ED2|rcsb pdb:2EJE|interpro:IPR036647|refseq:NP_001157108.1|refseq:NP_001267729.1|dip:DIP-24252N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:DqfrIS0Ey+XvZfTXmk9KQzBtQo49606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:Q9Y295	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-719554|uniprotkb:Q6FGP8|uniprotkb:Q8WW69|uniprotkb:Q9UGF2|uniprotkb:B2RDS8|ensembl:ENSP00000329715	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:drg1_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 3(gene name synonym)|uniprotkb:DRG1(gene name)|psi-mi:DRG1(display_short)|uniprotkb:NEDD3(gene name synonym)|uniprotkb:Translation factor GTPase DRG1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_004138.1|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|rcsb pdb:2EKI|go:"GO:0005844"(polysome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007275"(multicellular organism development)|ensembl:ENSG00000185721(gene)|ensembl:ENST00000331457(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:gVbgvaeulEwp7MdnP+qRgZ/aawA9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q13043	uniprotkb:O00571	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Rawat et al. (2013)	pubmed:23386615|imex:IM-23209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049645|imex:IM-23209-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N	-	-	-	figure legend:Suppl. Table S4|comment:"Extracts were prepared from HepG2 cells grown under oxidative stress conditions (H2O2-treated (CHEBI:16240))."|caution:The participants indicated by the gene symbols RANP1, ST39 and PC in table S4 could not be unambiguously identified, hence they are not captured as participants in the interaction curated here.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/14	2021/06/18	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606	intact-crc:F910591E92A62FF6|rigid:EQm50RACFSIXguCMj82LYtve7gs	false	sbp:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)